Doreen Dobritzsch

Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity

van Kuilenburg, Andre B. P.; Mandel, Hanna; Moady, Tameemi Abdalla; Sloma, Ronen et al.

Part of Molecular Genetics and Metabolism, 2026

• DOI for Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity
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Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

FitzGerald, Edward; Cederfelt, Daniela; Kovryzhenko, Daria; Boronat, Pierre et al.

Part of RSC Chemical Biology, p. 1625-1639, 2025

• DOI for Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography
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CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders

van Karnebeek, Clara D.M.; Tarailo-Graovac, Maja; Leen, René; Meinsma, Rutger et al.

Part of Genetics in Medicine, 2024

• DOI for CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders
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Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Fekry, Mostafa; Stenberg, Gun; Dobritzsch, Doreen; Danielson, U. Helena

Part of Protein Expression and Purification, 2024

• DOI for Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
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Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

FitzGerald, Edward A.; Cederfelt, Daniela; Lund, Bjarte Aarmo; Myers, Nadine et al.

Part of RSC Medicinal Chemistry, p. 1982-1990, 2024

• DOI for Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
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Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity

van Kuilenburg, Andre B. P.; Mandel, Hanna; Moady, Tameemi Abdalla; Sloma, Ronen et al.

Part of Molecular Genetics and Metabolism, 2026

• DOI for Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity
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Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

FitzGerald, Edward; Cederfelt, Daniela; Kovryzhenko, Daria; Boronat, Pierre et al.

Part of RSC Chemical Biology, p. 1625-1639, 2025

• DOI for Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography
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CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders

van Karnebeek, Clara D.M.; Tarailo-Graovac, Maja; Leen, René; Meinsma, Rutger et al.

Part of Genetics in Medicine, 2024

• DOI for CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders
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Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein

Fekry, Mostafa; Stenberg, Gun; Dobritzsch, Doreen; Danielson, U. Helena

Part of Protein Expression and Purification, 2024

• DOI for Production of stable and pure ZC3H11A-An extensively disordered RNA binding protein
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Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

FitzGerald, Edward A.; Cederfelt, Daniela; Lund, Bjarte Aarmo; Myers, Nadine et al.

Part of RSC Medicinal Chemistry, p. 1982-1990, 2024

• DOI for Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening
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CIAO1 and MMS19 de fi ciency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders

van Karnebeek, Clara D. M.; Tarailo-Graovac, Maja; Leen, Rene; Meinsma, Rutger et al.

Part of Genetics in Medicine, 2024

• DOI for CIAO1 and MMS19 de fi ciency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders
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Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants

van Kuilenburg, Andre B. P.; Pleunis-van Empel, Marjolein C. H.; Brouwer, Rick B.; Sijben, Angelique E. J. et al.

Part of JCO PRECISION ONCOLOGY, 2024

• DOI for Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; Rubin Sander, Marie et al.

Part of Nature Communications, 2023

• DOI for Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
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Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Kliche, Johanna; Garvanska, Dimitriya Hristoforova; Simonetti, Leandro; Badgujar, Dilip et al.

Part of Molecular Systems Biology, 2023

• DOI for Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions
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Engineered Aldolases Catalyzing Stereoselective Aldol Reactions Between Aryl-Substituted Ketones and Aldehydes

Cornelius Chukwu, Eugenia; Bartl, Michael; Persson, Louise; Xiong, Ruisheng et al.

Part of Catalysis Science & Technology, p. 4978-4987, 2023

• DOI for Engineered Aldolases Catalyzing Stereoselective Aldol Reactions Between Aryl-Substituted Ketones and Aldehydes
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The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Cederfelt, Daniela; Badgujar, Dilip; Au Musse, Ayan; Lohkamp, Bernhard et al.

Part of Biomolecules, 2023

• DOI for The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
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The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase

Fekry, Mostafa; Dave, Khyati K.; Badgujar, Dilip; Hamnevik, Emil et al.

Part of Biomolecules, 2023

• DOI for The Crystal Structure of Tyrosinase from Verrucomicrobium spinosum Reveals It to Be an Atypical Bacterial Tyrosinase
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Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

Ge, Changrong; Tong, Dongmei; Loennblom, Erik; Liang, Bibo et al.

Part of Arthritis & Rheumatology, p. 961-971, 2022

• DOI for Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis
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beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger; Maurer, Dirk et al.

Part of Molecular Genetics and Metabolism, p. 177-185, 2022

• DOI for beta-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity
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Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Ge, Changrong; Weisse, Sylvia; Xu, Bingze; Dobritzsch, Doreen et al.

Part of Annals of the Rheumatic Diseases, p. 480-489, 2022

• DOI for Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor
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Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

Part of RSC Advances, p. 7527-7537, 2021

• DOI for Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
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Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase

Talibov, Vladimir O; Fabini, Edoardo; FitzGerald, Edward; Tedesco, Daniele et al.

Part of ChemBioChem, p. 1597-1608, 2021

• DOI for Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase
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Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

Lenherr, Nina; Christodoulou, John; Duley, John; Dobritzsch, Doreen et al.

Part of Molecular Genetics and Metabolism Reports, 2021

• DOI for Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)
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Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

Part of ACS Omega, p. 3979-3995, 2020

• DOI for Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
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Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

Puusepp, Sanna; Reinson, Karit; Pajusalu, Sander; van Kuilenburg, Andre B. P. et al.

Part of Molecular Genetics and Metabolism Reports, 2020

• DOI for Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene
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Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

Part of Arthritis & Rheumatology, p. 210-221, 2019

• DOI for Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

Part of New England Journal of Medicine, p. 1433-1441, 2019

• DOI for Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Maurer, Dirk; Enugala, Thilak Reddy; Hamnevik, Emil; Bauer, Paul et al.

Part of ACS Catalysis, p. 7526-7538, 2018

• DOI for Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases
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Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

Part of Biochemistry, p. 1059-1062, 2018

• DOI for Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

Part of Biochemical Journal, p. 2395-2416, 2018

• DOI for Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

Part of ChemBioChem, p. 2283-2292, 2018

• DOI for Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

Part of IUCrJ, p. 269-282, 2018

• DOI for Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme
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Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

Part of Human Mutation, p. 947-953, 2018

• DOI for Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

Part of The FEBS Journal, p. 3895-3914, 2017

• DOI for Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer
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Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

Part of American Journal of Medical Genetics. Part A, p. 2736-2742, 2017

• DOI for Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

Part of Biochimica et Biophysica Acta, p. 721-730, 2017

• DOI for Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Part of Molecular Genetics and Metabolism, p. 216-222, 2017

• DOI for Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

Part of JCI INSIGHT, 2017

• DOI for Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

Part of ChemBioChem, p. 1693-1697, 2016

• DOI for Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis
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Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

Part of Organic and biomolecular chemistry, p. 5639-5651, 2016

• DOI for Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1
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Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

Kuilenburg, André B P van; Meijer, Judith; Tanck, Michael W T; Dobritzsch, Doreen et al.

Part of Biochimica et Biophysica Acta, p. 754-762, 2016

• DOI for Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.

Nakajima, Yoko; Meijer, Judith; Zhang, Chunhua; Wang, Xu et al.

Part of International Journal of Molecular Sciences, 2016

• DOI for Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.
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How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Doak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan

Part of Journal of Medicinal Chemistry, p. 2312-2327, 2016

• DOI for How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

Part of Organic and biomolecular chemistry, p. 6203-6216, 2015

• DOI for Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes
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Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

Part of Journal of Immunology, p. 2539-2550, 2015

• DOI for Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

Part of Journal of Inherited Metabolic Disease, p. 801-812, 2014

• DOI for Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation
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Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

Part of Journal of Experimental Medicine, p. 405-411, 2014

• DOI for Epitope-specific antibody response is controlled by immunoglobuline V_H polymorphisms

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

Part of Biochemical Journal, p. 441-452, 2014

• DOI for Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Krumpel, Michael et al.

Part of Biochimica et Biophysica Acta, p. 1096-108, 2012

• DOI for ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

Claesson, Magnus; Siitonen, Vilja; Dobritzsch, Doreen; Metsä-Ketelä, Mikko et al.

Part of The FEBS Journal, p. 3251-3263, 2012

• DOI for Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

Crystal structure of an arthritogenic anticollagen immune complex

Dobritzsch, Doreen; Lindh, Ingrid; Uysal, Hüseyin; Nandakumar, Kutty S et al.

Part of Arthritis and Rheumatism, p. 3740-3748, 2011

• DOI for Crystal structure of an arthritogenic anticollagen immune complex

Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

Lohkamp, Bernhard; Voevodskaya, Nina; Lindqvist, Ylva; Dobritzsch, Doreen

Part of Biochimica et Biophysica Acta, p. 2198-2206, 2010

• DOI for Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, p. 639-648, 2010

• DOI for Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

van Kuilenburg, André B P; Meijer, Judith; Mul, Adri N P M; Meinsma, Rutger et al.

Part of Human Genetics, p. 529-538, 2010

• DOI for Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

Schnackerz, K D; Andersen, G; Dobritzsch, Doreen; Piskur, J

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 794-799, 2008

• DOI for Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

van Kuilenburg, A B P; Meijer, J; Dobritzsch, Doreen; Lohkamp, B et al.

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 809-815, 2008

• DOI for Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

A recruited protease is involved in catabolism of pyrimidines

Andersen, Birgit; Lundgren, Stina; Dobritzsch, Doreen; Piskur, Jure

Part of Journal of Molecular Biology, p. 243-250, 2008

• DOI for A recruited protease is involved in catabolism of pyrimidines

The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

Lundgren, Stina; Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure et al.

Part of Journal of Molecular Biology, p. 1544-1559, 2008

• DOI for The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

Lohkamp, Bernhard; Dobritzsch, Doreen

Part of Acta Crystallographica Section D, p. 407-415, 2008

• DOI for A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

Andersen, Gorm; Andersen, Birgit; Dobritzsch, Doreen; Schnackerz, Klaus D et al.

Part of The FEBS Journal, p. 1804-1017, 2007

• DOI for A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

van Kuilenburg, André B P; Meijer, Judith; Dobritzsch, Doreen; Meinsma, Rutger et al.

Part of Molecular Genetics and Metabolism, p. 157-164, 2007

• DOI for Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Part of Journal of Biological Chemistry, p. 36037-36047, 2007

• DOI for Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Part of Acta Crystallographica. Section F, p. 874-877, 2007

• DOI for Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

Koskiniemi, Hanna; Metsä-Ketelä, Mikko; Dobritzsch, Doreen; Kallio, Pauli et al.

Part of Journal of Molecular Biology, p. 633-648, 2007

• DOI for Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Part of Journal of Biological Chemistry, p. 13762-13776, 2006

• DOI for The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

Part of Acta Crystallographica. Section F, p. 36-38, 2006

• DOI for Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

Andersen, G; Merico, A; Björnberg, O; Andersen, B et al.

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 991-996, 2006

• DOI for Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Van Kuilenburg, André B P; Meinsma, Rutger; Beke, Eva; Bobba, Barbara et al.

Part of Biological chemistry (Print), p. 319-324, 2005

• DOI for Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

Dobritzsch, Doreen; Andersen, Birgit; Piskur, Jure

Part of Acta Crystallographica. Section F, p. 359-362, 2005

• DOI for Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

Schnackerz, Klaus D; Dobritzsch, Doreen; Lindqvist, Ylva; Cook, Paul F

Part of Biochimica et Biophysica Acta, p. 61-74, 2004

• DOI for Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

Lundgren, Stina; Gojković, Zoran; Piskur, Jure; Dobritzsch, Doreen

Part of Journal of Biological Chemistry, p. 51851-51862, 2003

• DOI for Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

Dobritzsch, Doreen; Gojković, Zoran; Andersen, Birgit; Piskur, Jure

Part of Acta Crystallographica Section D, p. 1267-1269, 2003

• DOI for Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

van Kuilenburg, André B P; Dobritzsch, Doreen; Meinsma, Rutger; Haasjes, Janet et al.

Part of Biochemical Journal, p. 157-163, 2002

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

Dobritzsch, Doreen; Ricagno, Stefano; Schneider, Gunter; Schnackerz, Klaus D et al.

Part of Journal of Biological Chemistry, p. 13155-13166, 2002

• DOI for Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

Dobritzsch, Doreen; Persson, K; Schneider, G; Lindqvist, Y

Part of Acta Crystallographica Section D, p. 153-155, 2001

• DOI for Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

Dobritzsch, Doreen; Schneider, G; Schnackerz, K D; Lindqvist, Y

Part of EMBO Journal, p. 650-660, 2001

• DOI for Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

Lu, G; Dobritzsch, Doreen; Baumann, S; Schneider, G et al.

Part of European Journal of Biochemistry, p. 861-868, 2000

• DOI for The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

Dobritzsch, Doreen; König, S; Schneider, G; Lu, G

Part of Journal of Biological Chemistry, p. 20196-20204, 1998

• DOI for High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form

Lu, G; Dobritzsch, Doreen; König, S; Schneider, G

Part of FEBS Letters, p. 249-253, 1997

• DOI for Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form

Saccharomyces kluyveri as a model organism to study pyrimidine degradation

Beck, Halfdan; Dobritzsch, Doreen; Piskur, Jure

Part of FEMS yeast research (Print), p. 1209-1213, 2008

• DOI for Saccharomyces kluyveri as a model organism to study pyrimidine degradation

Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

Schnackerz, Klaus D; Dobritzsch, Doreen

Part of Biochimica et Biophysica Acta, p. 431-444, 2008

• DOI for Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

Characterization and structure determination of human β-ureidopropionase reveal pH-dependent regulation by ligand-induced changes in oligomerization

Maurer, Dirk; Bernhard, Lohkamp; Krumpel, Michael; Widersten, Mikael et al.