Omar Hmeadi

Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site

Liu, Liangwen; Echeverry, Santiago; Omar-Hmeadi, Muhmmad; Česnokova, Irina et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2026

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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Part of Diabetologia, p. 1642-1662, 2024

• DOI for RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
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Quantification of Secretory Granule Exocytosis by TIRF Imaging and Capacitance Measurements

Omar-Hmeadi, Muhmmad; Liu, Liangwen; Echeverry, Santiago; Barg, Sebastian

Part of Chromaffin cells, p. 179-186, Springer Nature, 2023

• DOI for Quantification of Secretory Granule Exocytosis by TIRF Imaging and Capacitance Measurements

Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Part of Cell Reports, 2023

• DOI for Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI for Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site

Liu, Liangwen; Echeverry, Santiago; Omar-Hmeadi, Muhmmad; Česnokova, Irina et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2026

• DOI for Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site
• Download full text (pdf) of Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Part of Diabetologia, p. 1642-1662, 2024

• DOI for RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Download full text (pdf) of RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Part of Cell Reports, 2023

• DOI for Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
• Download full text (pdf) of Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI for Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Part of Nature Biotechnology, p. 1042-1055, 2022

• DOI for Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Part of Nature Communications, 2020

• DOI for Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Part of eLIFE, 2019

• DOI for Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Part of Diabetes, p. 747-760, 2019

• DOI for The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Part of Cell Metabolism, p. 470-478, 2018

• DOI for Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Part of Traffic, p. 436-445, 2018

• DOI for PtdIns(4,5)P₂ is not required for secretory granule docking

Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Part of Molecular Biology of the Cell, p. 2700-2708, 2018

• DOI for Syntaxin clusters at secretory granules in a munc18-bound conformation
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Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Part of Molecular Biology of the Cell, p. 3727-3727, 2017

• DOI for Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Insulin granule biogenesis and exocytosis

Omar-Hmeadi, Muhmmad; Idevall Hagren, Olof

Part of Cellular and Molecular Life Sciences (CMLS), p. 1957-1970, 2021

• DOI for Insulin granule biogenesis and exocytosis
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Quantification of Secretory Granule Exocytosis by TIRF Imaging and Capacitance Measurements

Omar-Hmeadi, Muhmmad; Liu, Liangwen; Echeverry, Santiago; Barg, Sebastian

Part of Chromaffin cells, p. 179-186, Springer Nature, 2023

• DOI for Quantification of Secretory Granule Exocytosis by TIRF Imaging and Capacitance Measurements

Regulation of docking and priming in pancreatic α- and β-cells

Omar-Hmeadi, Muhmmad

2019

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Fusion pore regulation by transient local generation of PI(4,5)P₂ in pancreatic in β-cells

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.