Åsa Konradsson Geuken

Short presentation

My research focuses on finding new treatments that could reduce the recurring psychoses, increase the quality of life and longevity of patients with schizophrenia. The purpose of my studies is to use unique techniques to clarify how drugs, drug candidates and new combinations of molecules affect higher cognitive processes in the brain. These studies may increase our understanding of the neurobiology behind schizophrenia and thereby facilitate the development of new effective drugs.

Biography

Peer-reviewed manuscripts

1. Joep Titulaer, Carl Björkholm, Kristin Feltmann, Torun Malmlöf, Devesh Mishra, Carolina Bengtsson Gonzales, Björn Schilström, Åsa Konradsson-Geuken. The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory. Front Behav Neurosci. 2021 Apr 13;15:667244.
2. Bikovski L, Robinson L, Konradsson-Geuken A, Kullander K, Viereckel T, Winberg S, Roman E, Tsoory M. Lessons, insights and newly developed tools emerging from behavioral phenotyping core facilities. J Neurosci Methods. 2020 Jan 24;334. Review.
3. Adem A, Madjid N, Stiedl O, Bonito-Oliva A, Konradsson-Geuken Å, Holst S, Fisone G, Ögren SO. Atypical but not typical antipsychotic drugs ameliorate phencyclidine-induced emotional memory impairments in mice. Eur Neuropsychopharmacol. 2019 May;29(5):616-628.
4. Diana Campos-Beltrán, Åsa Konradsson-Geuken, Jorge E. Quintero, Lisa Marshall. Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection. Biosensors (Basel). 2018 Mar 6;8(1).
5. Thomas Viereckel, Åsa Konradsson-Geuken# and Åsa Wallén-Mackenzie#. Real-time recordings of glutamate release in the globus pallidus upon optogenetic stimulation of the subthalamic nucleus in anaesthesized mice in vivo. J Neurochem. 2018 Apr;145(2):125-138. Epub 2018 Mar 13. #Shared last authorship.
6. Dong V. Wang, Thomas Viereckel, Åsa Konradsson-Geuken, Carl J. Broker, Aleksandr Talishinsky, Emma Arvidsson, Ji Hoon Yoo Melissa H. Galinato, Thomas S. Hnasko, Åsa Wallen-Mackenzie, and Satoshi Ikemoto. Co-release of glutamate from VTA dopamine neurons is not necessary for reinforcement. Cell Rep. 2017 Mar 14;18(11):2584-2591.
7. Carl Björkholm, Monica M. Marcus, Åsa Konradsson-Geuken, Kent Jardemark and Torgny H. Svensson The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism. Eur Neuropsychopharmacol. 2017 Apr;27(4):411-417.
8. Nadine Schweizer, Thomas Viereckel, Casey J.A. Smith-Anttila, Karin Nordenankar, Emma Arvidsson, Souha Mahmoudi, André Zampera, Hanna Wärner Jonsson, Jonas Bergquist Daniel Lévesque, Åsa Konradsson-Geuken, Malin Andersson, Sylvie Dumas and Åsa Wallén-Mackenzie. Reduced sugar consumption identifies regulatory roles for Pitx2/Vglut2 co-expressing neurons in the mouse subthalamic nucleus circuitry. eNeuro. 2016 Sep 29;3(5).
9. Thomas Viereckel, Sylvie Dumas, Casey J.A. Smith-Anttila, Bianca Vlcek, Zisis Bimpisidis, Malin C. Lagerström, Åsa Konradsson-Geuken, Åsa Wallén-Mackenzie.. Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson’s Disease. Sci Rep. 2016 Oct 20;6:35203.
10. Monica M. Marcus, Carl Björkholm, Anna Malmerfelt, Annie Möller, Ninni Påhlsson, Vladimir Ivanov, Åsa Konradsson-Geuken, Kristin Feltmann, Kent Jardemark, Björn Schilström, Torgny H. Svensson. Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study. Eur Neuropsychopharmacol. 2016 Sep;26(9):1401-1411
11. Feltmann K., Konradsson-Geuken Å., De Bundel D., Lindskog M., Schilström B. Antidepressant drugs specifically inhibiting noradrenaline reuptake enhance recognition memory in rats. Behav Neurosci. 2015 Dec;129(6):701-8.
12. Stiedl O., Pappa E., Konradsson-Geuken Å., and Ögren SO. The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory. Front Pharmacol. 2015 Aug 7;6:162.
13. Devesh Mishra, Nicholas R. Harrison, Carolina B. Gonzales, Björn Schilström, Åsa Konradsson-Geuken. Effects of age and acute ethanol on glutamatergic neurotransmission in the medial prefrontal cortex of freely moving rats using enzyme-based microelectrode amperometry. PLoS ONE 2015 Apr 30;10(4).
14. Björkholm C, Frånberg O, Malmerfelt A, Marcus MM, Konradsson-Geuken Å, Schilström B, Jardemark K, Svensson TH. Adjunctive treatment with asenapine augments the escitalopram-induced effects on monoaminergic outflow and glutamatergic neurotransmission in the medial prefrontal cortex of the rat. nt J Neuropsychopharmacol. 2014 Oct 31;18(3)
15. Malmlöf T, Feltmann K, Konradsson-Geuken Å, Svensson T.H, Schilström B. Deuterium enriched L-Dopa displays increased behavioral potency and dopamine output in an animal model of Parkinson’s disease: relation to the effects produced by L-DOPA and MAO-B inhibitor. J Neural Transm. 2015 Feb;122 (2):259-72.
16. De Bundel D, Femenía T, Dupont CM, Konradsson-Geuken A, Feltmann K, Schilström B, Lindskog M.. Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memory-enhancing effect of reboxetine. Int J Neuropsychopharmacol. 2013 May 14:1-11.
17. Marcus MM, Jardemark KE, Malmerfelt A, Gertow J, Konradsson-Geuken Å and Svensson TH. Augmentation by escitalopram, but not citalopram or R-citalopram, of low dose risperidone. Behavioral, biochemical and electrophysiological evidence. Synapse. 2012 Apr; 66 (4):277-90.
18. Konradsson-Geuken Å, Gash CR, Wu HQ, Alexander KS, Scwarcz R, & Bruno JP. Changes in cortical kynurenic acid bidirectionally modulate prefrontal glutamate levels assessed by microdialysis and rapid electrochemistry. Neuroscience. 2010 Sep; 169 (4):1848-59.
19. B Schilström, Å Konradsson-Geuken , V Ivanov, J Gertow, KE Jardemark, MM Marcus MM and TH Svensson . Effects of S-citalopram, citalopram and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area and on NMDA receptor-mediated transmission in the medial prefrontal cortex in the rat. Synapse. 2011 May; 65 (5):357-67.
20. Marcus MM, Wiker C, Frånberg O, Konradsson-Geuken Å, Langlois X, Jardemark KE and Svensson TH. Adjunctive α2 adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission. Int J Neuropsychopharmacol. 2009 Oct; 19:1-13.
21. Konradsson-Geuken Å, Gash CR, Alexander K, Pomerleau F, Huettl P, Gerhardt GA, Bruno JP. Second-by-second analysis of alpha7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats. Synapse 2009 Dec; 63 (12):1069-1082.
22. Jardemark KE, Konradsson Å, Marcus MM, Schilström B and Svensson TH. Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. Synapse 2009 Oct; 63(10):913-20.
23. Frånberg O, Wiker C, Marcus MM, Konradsson Å, Jardemark KE, Schilström B, Shahid M, Wong EHF, Svensson TH. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb; 196(3):417-29.
24. Konradsson Å, Marcus MM, Hertel P, Svensson TH and Jardemark KE. Inhibition of the glycine transporter GlyT1 potentiates the effect of risperidone, but not clozapine, on glutamatergic transmission in the rat medial prefrontal cortex. Synapse 2006 Aug; 60 (2):102-8.
25. Jardemark KE, Marcus MM, Konradsson Å and Svensson TH. The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a Clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex. Int J Neuropsychopharmacol. 2005 Jun; 8 (2): 157-62.

Research

Åsa Konradsson-Geuken has considerable expertise in experimental neuropsychopharmacology, animal models of psychiatric disease, electrophysiology in vitro, cognitive tasks and several techniques for neurochemical analysis. She is one out of three researchers in Europe that use the enzyme-based microelectrode array in freely moving animals, and combines this with optogenetic techniques. Her focus is the neurochemistry in the neuronal networks involved in cognitive symptoms found in severe psychiatric diseases, i.e. schizophrenia.

Media

Books

• https://www.gothiakompetens.se/alla-psykologi-psykiatri/schizofreni-p77412243

Artiklar

Articles

• https://arkiv.kit.se/2016/04/01/40345/jag-smittar-inte-och-ar-inte-farlig-jag-ar-ratt-rolig-faktiskt/
• https://www.dn.se/insidan/min-bror-ar-fortfarande-min-idol/
• https://modernpsykologi.se/2019/12/12/broderns-schizofreni-gjorde-asa-till-forskare/
• https://kkuriren.se/nyheter/eskilstuna/det-man-inte-forstar-ar-man-radd-for-sm4540205.aspx
• https://pt.se/nyheter/pitea/broderns-schizofreni-styrde-hennes-liv-10660619.aspx

Debate articles

• https://www.dagensmedicin.se/opinion/debatt/alla-som-har-psykossjukdom-ska-erbjudas-evidensbaserad-vard/
• https://www.svd.se/samhallet-sviker-dem-med-schizofreni

Interview (webb)

• https://alvikbasket.nu/2021/03/06/asa-konradsson-geuken-basketen-stod-under-mina-tuffaste-ar-for-trygghet-struktur-laganda-och-gemenskap/
• https://ki.se/forskning/tre-forskare-berattar-det-hogst-personliga

Interview (movie)

• https://www.equalsthlm.se/artiklar/asa-konradsson-geuken-om-schizofreni-ta-medicinen-trots-biverkningar/

Intervju (magazine)

• https://www.vk.se/2019-06-18/debatt-nytt-lakemedel-mot-schizofreni

Talks

• https://urplay.se/program/215069-ur-samtiden-hjarndagen-2019-schizofreni-en-framling-i-familjen
• https://urplay.se/program/207009-ur-samtiden-schizofrenidagen-2018-min-bror-och-jag

Pods:

• https://www.podplay.com/sv-se/podcasts/dokumentara-berattelser-125274/episodes/att-leva-med-schizofreni-62430771
• Vet Ni! Schizofreni – Livet med en psykossjukdom av FINSAM i Malmö (soundcloud.com)
• https://sinnessjukt.se/tag/asa-konradsson-geuken/