Sören Lehmann

Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study

Hernandez-Sanchez, Alberto; Villaverde Ramiro, Angela; Sträng, Eric; Turki, Amin T. et al.

Part of Leukemia, p. 418-428, 2026

• DOI for Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study
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Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

Struyf, Nona; Gezelius, Henrik; Lundmark, Anders; Barizza, Chiara et al.

Part of npj Precision Oncology, 2026

• DOI for Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
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Landscape of circular RNAs in acute myeloid leukemia and their clinical significance

Nguyen, Thi-Hau; Nguyen, Manh-Hung; Nguyen, Ha-Nam; Erkers, Tom et al.

Part of npj Precision Oncology, 2026

• DOI for Landscape of circular RNAs in acute myeloid leukemia and their clinical significance
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HDAC Inhibition Triggers Release of RNA Polymerase II from Promoter-Proximal Pausing in Healthy Blood Progenitors and Primary Acute Myeloid Leukemia Myeloblasts

Xing, Yanzi; Pfab, Alexander; Hunt, George; Ax, Kajsa et al.

Part of Molecular Cancer Therapeutics, p. 244-256, 2025

• DOI for HDAC Inhibition Triggers Release of RNA Polymerase II from Promoter-Proximal Pausing in Healthy Blood Progenitors and Primary Acute Myeloid Leukemia Myeloblasts

Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study

Liew‐Littorin, Markus; Deleskog‐Spångberg, Linn; Deneberg, Stefan; Janosi, Judit et al.

Part of European Journal of Haematology, p. 423-432, 2025

• DOI for Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study
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Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study

Hernandez-Sanchez, Alberto; Villaverde Ramiro, Angela; Sträng, Eric; Turki, Amin T. et al.

Part of Leukemia, p. 418-428, 2026

• DOI for Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study
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Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

Struyf, Nona; Gezelius, Henrik; Lundmark, Anders; Barizza, Chiara et al.

Part of npj Precision Oncology, 2026

• DOI for Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
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Landscape of circular RNAs in acute myeloid leukemia and their clinical significance

Nguyen, Thi-Hau; Nguyen, Manh-Hung; Nguyen, Ha-Nam; Erkers, Tom et al.

Part of npj Precision Oncology, 2026

• DOI for Landscape of circular RNAs in acute myeloid leukemia and their clinical significance
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HDAC Inhibition Triggers Release of RNA Polymerase II from Promoter-Proximal Pausing in Healthy Blood Progenitors and Primary Acute Myeloid Leukemia Myeloblasts

Xing, Yanzi; Pfab, Alexander; Hunt, George; Ax, Kajsa et al.

Part of Molecular Cancer Therapeutics, p. 244-256, 2025

• DOI for HDAC Inhibition Triggers Release of RNA Polymerase II from Promoter-Proximal Pausing in Healthy Blood Progenitors and Primary Acute Myeloid Leukemia Myeloblasts

Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study

Liew‐Littorin, Markus; Deleskog‐Spångberg, Linn; Deneberg, Stefan; Janosi, Judit et al.

Part of European Journal of Haematology, p. 423-432, 2025

• DOI for Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory AML: A Population‐Based Study
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Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia

Zhong, Xiangfu; Cordeddu, Lina; Gamboa Cedeno, Angelica; Bengtzen, Sofia et al.

Part of Genome Medicine, 2025

• DOI for Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
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MALNC: a new mutant NPM1/IDH2^R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response

Cozzi, Elisabetta; Neddermeyer, Anne; Zhong, Xiangfu; Gamboa-Cedeño, Angelica María et al.

Part of Cancer Gene Therapy, p. 1191-1205, 2025

• DOI for MALNC: a new mutant NPM1/IDH2^R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
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Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study

Tesi, Bianca; Robelius, Anna; Baskin, Berivan; Lazarevic, Vladimir et al.

Part of Clinical Cancer Research, p. 3062-3071, 2025

• DOI for Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study
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Pathway activation model for personalized prediction of drug synergy

Trac, Quang Thinh; Huang, Yue; Erkers, Tom; Östling, Päivi et al.

Part of eLIFE, 2025

• DOI for Pathway activation model for personalized prediction of drug synergy
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Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance

Sobas, Marta Anna; Turki, Amin T.; Ramiro, Angela Villaverde; Hernandez-Sanchez, Alberto et al.

Part of Haematologica, p. 1126-1140, 2025

• DOI for Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
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Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

Voso, Maria Teresa; Guarnera, Luca; Lehmann, Sören; Doehner, Konstanze et al.

Part of Blood, p. 234-243, 2025

• DOI for Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia

Miliara, Sophia; Cozzi, Elisabetta; Zhong, Xiangfu; Chan, Isaac et al.

Part of Leukemia, p. 663-666, 2024

• DOI for The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
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Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

Ramos, Anderson Daniel; Liang, Ying Yu; Surova, Olga; Bacanu, Smaranda et al.

Part of Cell Reports, 2024

• DOI for Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
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Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data

Abé, Christoph; Keto, Jaana; Lilja, Mathias; Konradsen, Mie et al.

Part of Leukemia and Lymphoma, p. 1493-1501, 2024

• DOI for Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine

Struyf, Nona; Österroos, Albin; Vesterlund, Mattias; Arnroth, Cornelia et al.

Part of npj Precision Oncology, 2024

• DOI for Delineating functional and molecular impact of ex vivo sample handling in precision medicine
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Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells

Palau, Anna; Segerberg, Filip; Lidschreiber, Michael; Lidschreiber, Katja et al.

Part of Leukemia, p. 1830-1841, 2023

• DOI for Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
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Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective

Moreno Berggren, Daniel; Garelius, Hege; Willner Hjelm, Petter; Nilsson, Lars et al.

Part of Leukemia, p. 1103-1112, 2023

• DOI for Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
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Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option

Dolinska, Monika; Cai, Huan; Mansson, Alma; Shen, Jingyi et al.

Part of Blood, p. 73-89, 2023

• DOI for Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
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Prediction model for drug response of acute myeloid leukemia patients

Trac, Quang Thinh; Pawitan, Yudi; Mou, Tian; Erkers, Tom et al.

Part of npj Precision Oncology, 2023

• DOI for Prediction model for drug response of acute myeloid leukemia patients
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Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications

Nilsson, Christer; Linde, Fredrika; Hulegardh, Erik; Garelius, Hege et al.

Part of Haematologica, p. 1015-1025, 2023

• DOI for Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
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Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays

Chen, Lei; Eriksson, Anna; Weström, Simone; Pandzic, Tatjana et al.

Part of Nature Communications, 2022

• DOI for Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays
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Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial

Jadersten, Martin; Lilienthal, Ingrid; Tsesmetzis, Nikolaos; Lourda, Magda et al.

Part of Journal of Internal Medicine, p. 925-940, 2022

• DOI for Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

Ali, Muhammad; Giannakopoulou, Eirini; Li, Yingqian; Lehander, Madeleine et al.

Part of Nature Biotechnology, p. 488-498, 2022

• DOI for T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
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A risk score based on real-world data to predict early death in acute promyelocytic leukemia

Österroos, Albin; Maia, Tania; Eriksson, Anna; Jädersten, Martin et al.

Part of Haematologica, p. 1528-1537, 2022

• DOI for A risk score based on real-world data to predict early death in acute promyelocytic leukemia
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Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study

Rosso, Aldana; Juliusson, Gunnar; Lorenz, Fryderyk; Lehmann, Sören et al.

Part of Leukemia and Lymphoma, p. 1973-1981, 2021

• DOI for Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study
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Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study

Orsmark-Pietras, Christina; Landberg, Niklas; Lorenz, Fryderyk; Uggla, Bertil et al.

Part of Genes, Chromosomes and Cancer, p. 426-433, 2021

• DOI for Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study
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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Sanjiv, Kumar; Calderón-Montaño, José Manuel; Pham, Therese M.; Erkers, Tom et al.

Part of Cancer Research, p. 5733-5744, 2021

• DOI for MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
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Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study

Moreno Berggren, Daniel; Kjellander, Matilda; Backlund, Ellen; Engvall, Marie et al.

Part of British Journal of Haematology, p. 474-483, 2021

• DOI for Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study
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The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia

Mou, Tian; Pawitan, Yudi; Stahl, Matthias; Vesterlund, Mattias et al.

Part of American Journal of Hematology, p. 580-588, 2021

• DOI for The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
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Impact of treatment delay in acute myeloid leukemia revisited

Juliusson, Gunnar; Hagberg, Oskar; Lazarevic, Vladimir Lj; Lehmann, Sören et al.

Part of Blood Advances, p. 787-790, 2021

• DOI for Impact of treatment delay in acute myeloid leukemia revisited

Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML

Mareschal, Sylvain; Palau, Anna; Lindberg, Johan; Ruminy, Philippe et al.

Part of Blood Advances, p. 1003-1016, 2021

• DOI for Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML

RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia

Anande, Govardhan; Deshpande, Nandan P.; Mareschal, Sylvain; Batcha, Aarif M. N. et al.

Part of Clinical Cancer Research, p. 3597-3607, 2020

• DOI for RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia

Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia

Österroos, Albin; Björklund, My; Eriksson, Anna; Lindberg, Johan et al.

Part of Blood Cancer Journal, 2020

• DOI for Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
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Real-world data on treatment patterns and outcomes of hypomethylating therapy in patients with newly diagnosed acute myeloid leukaemia aged ≥ 60 years

Österroos, Albin; Eriksson, Anna; Antunovic, Petar; Cammenga, Jörg et al.

Part of British Journal of Haematology, 2020

• DOI for Real-world data on treatment patterns and outcomes of hypomethylating therapy in patients with newly diagnosed acute myeloid leukaemia aged ≥ 60 years

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy

Rudd, Sean G.; Tsesmetzis, Nikolaos; Sanjiv, Kumar; Paulin, Cynthia B.J. et al.

Part of EMBO Molecular Medicine, 2020

• DOI for Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
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The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting

Juliusson, Gunnar; Jädersten, Martin; Deneberg, Stefan; Lehmann, Sören et al.

Part of Blood Advances, p. 1094-1101, 2020

• DOI for The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting

AML displays increased CTCF occupancy associated with aberrant gene expression and transcription factor binding

Mujahed, Huthayfa; Miliara, Sophia; Neddermeyer, Anne H.; Bengtzen, Sofia et al.

Part of Blood, p. 339-352, 2020

• DOI for AML displays increased CTCF occupancy associated with aberrant gene expression and transcription factor binding

Hypo, Hyper, or Combo: new paradigm for treatment of acute myeloid leukemia in older people

Juliusson, Gunnar; Höglund, Martin; Lehmann, Sören

Part of Haematologica, p. 249-251, 2020

• DOI for Hypo, Hyper, or Combo: new paradigm for treatment of acute myeloid leukemia in older people

Decreasing early mortality in acute myeloid leukaemia in Sweden 1997-2014: improving performance status is a major contributing factor

Derolf, Åsa; Juliusson, Gunnar; Benson, Lina; Flöisand, Yngvar et al.

Part of British Journal of Haematology, p. 187-191, 2020

• DOI for Decreasing early mortality in acute myeloid leukaemia in Sweden 1997-2014: improving performance status is a major contributing factor

Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period

Juliusson, Gunnar; Hagberg, Oskar; Lazarevic, Vladimir Lj; Ölander, Emma et al.

Part of Blood, p. 1558-1561, 2019

• DOI for Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

Angenendt, Linus; Röllig, Christoph; Montesinos, Pau; Martinez-Cuadron, David et al.

Part of Journal of Clinical Oncology, p. 2632-2642, 2019

• DOI for Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

Expression levels of long non-coding RNAs are prognostic for AML outcome

Mer, Arvind Singh; Lindberg, Johan; Nilsson, Christer; Klevebring, Daniel et al.

Part of Journal of Hematology & Oncology, 2018

• DOI for Expression levels of long non-coding RNAs are prognostic for AML outcome
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Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting: a report from the Swedish MDS register

Berggren, Daniel Moreno; Folkvaljon, Yasin; Engvall, Marie; Sundberg, Johan et al.

Part of British Journal of Haematology, p. 614-627, 2018

• DOI for Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting: a report from the Swedish MDS register

Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia

Hornung, Roman; Jurinovic, Vindi; Batcha, Aarif M. N.; Bamopoulos, Stefanos A. et al.

Part of Scientific Reports, 2018

• DOI for Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
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Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis

Khalkar, Prajakta; Ali, Hani Abdulkadir; Codó, Paula; Argelich, Nuria Díaz et al.

Part of Free Radical Biology & Medicine, p. 247-257, 2018

• DOI for Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
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Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia

Wang, Mei; Lindberg, Johan; Klevebring, Daniel; Nilsson, Christer et al.

Part of Journal of the National Cancer Institute, p. 1094-1101, 2018

• DOI for Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
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CRISPR Screen Identifies MAD1L1, CDC27 and CDC42 as Determinants of Sensitivity to Sonic Hedgehog Inhibitor Sonidegib in Medulloblastoma Cell Lines

Rudd, S. G.; Paulin, C. B.; Nikolaos, T.; Sanjiv, K. et al.

Part of Pediatric Blood & Cancer, 2018

Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease

Tobiasson, Magnus; Abdulkadir, Hani; Lennartsson, Andreas; Katayama, Shintaro et al.

Part of Oncotarget, p. 28812-28825, 2017

• DOI for Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease
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Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia

Mujahed, H.; Jansson, M.; Bengtzen, S.; Lehmann, Sören

Part of Blood Cancer Journal, 2017

• DOI for Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia
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Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells

Liu, Lisa L.; Beziat, Vivien; Oei, Vincent Y. S.; Pfefferle, Aline et al.

Part of CANCER IMMUNOLOGY RESEARCH, p. 654-665, 2017

• DOI for Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells

Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden

Juliusson, Gunnar; Abrahamsson, J; Lazarevic, V; Antunovic, P et al.

Part of Leukemia, p. 728-731, 2017

• DOI for Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden

Cancer specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

Qu, Ying; Siggens, Lee; Cordeddu, Lina; Gaidzik, Verena I et al.

Part of Blood, 2017

• DOI for Cancer specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

Lazarevic, Vladimir Lj; Rosso, Aldana; Juliusson, Gunnar; Antunovic, Petar et al.

Part of European Journal of Haematology, p. 493-500, 2017

• DOI for Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997-2013

Lehmann, Sören; Deneberg, S.; Antunovic, P.; Rangert-Derolf, A. et al.

Part of Leukemia, p. 1457-1459, 2017

• DOI for Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997-2013

Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.

Ilander, M; Olsson-Strömberg, Ulla; Schlums, H; Guilhot, J et al.

Part of Leukemia, p. 1108-1116, 2017

• DOI for Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
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Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling

Wang, M.; Lindberg, J.; Klevebring, D.; Nilsson, C. et al.

Part of Leukemia, p. 2029-2036, 2017

• DOI for Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

Herold, Nikolas; Rudd, Sean G.; Ljungblad, Linda; Sanjiv, Kumar et al.

Part of Nature Medicine, p. 256-263, 2017

• DOI for Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

An open-label phase I dose-finding study of APR-246 in hematological malignancies

Deneberg, S.; Cherif, Honar; Lazarevic, V.; Andersson, P-O et al.

Part of Blood Cancer Journal, 2016

• DOI for An open-label phase I dose-finding study of APR-246 in hematological malignancies
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Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells

Ali, Dina; Mohammad, Dara K.; Mujahed, Huthayfa; Jonson-Videsater, Kerstin et al.

Part of British Journal of Haematology, p. 117-126, 2016

• DOI for Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells

Differential Dna Methylation In Cytogenetically Normal Acute Myeloid Leukemia Is Linked To Altered Gene Expression Of Enhancer Target Genes

Qu, Y.; Siggens, L.; Cordeddu, L.; Ekwall, K. et al.

Part of Haematologica, p. 209-210, 2016

Validation Of Prognostic Scoring Systems For Myelodysplastic Syndromes In The Swedish Mds-Register

Berggren, Daniel Moreno; Folkvaljon, Y.; Engvall, M.; Sundberg, J. et al.

Part of Haematologica, p. 243-243, 2016

Characterization and prognostic features of secondary acute myeloid leukemia (AML) in a population-based setting: A report from the Swedish Acute Leukemia Registry

Hulegårdh, Erik; Nilsson, Christer; Lazarevic, Vladimir; Garelius, Hege et al.

Part of American Journal of Hematology, p. 208-214, 2015

• DOI for Characterization and prognostic features of secondary acute myeloid leukemia (AML) in a population-based setting: A report from the Swedish Acute Leukemia Registry

Failure matters: unsuccessful cytogenetics and unperformed cytogenetics are associated with a poor prognosis in a population-based series of acute myeloid leukaemia

Lazarevic, Vladimir; Hörstedt, Ann-Sofi; Johansson, Bertil; Antunovic, Petar et al.

Part of European Journal of Haematology, p. 419-423, 2015

• DOI for Failure matters: unsuccessful cytogenetics and unperformed cytogenetics are associated with a poor prognosis in a population-based series of acute myeloid leukaemia

Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis

Eriksson, Anna; Lennartsson, Andreas; Lehmann, Sören

Part of Experimental Hematology, p. 609-624, 2015

• DOI for Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis

Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia

Lazarevic, Vladimir; Rosso, Aldana; Juliusson, Gunnar; Antunovic, Petar et al.

Part of American Journal of Hematology, p. 800-805, 2015

• DOI for Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia

Mature, Adaptive-like CD56(DIM) NK Cells in Chronic Myeloid Leukemia Patients in Treatment Free Remission

Ilander, Mette; Schlums, Heinrich; Olsson-Strömberg, Ulla; Lahteenmaki, Hanna et al.

Part of Blood, 2015

Prevalence and Characteristics of Survivors from Adult Acute Myeloid Leukemia (AML) in Sweden 2014

Juliusson, Gunnar; Lazarevic, Vladimir; Antunovic, Petar; Derolf, Asa Rangert et al.

Part of Blood, 2015

Reasons for Decreasing Early Mortality in Acute Myeloid Leukemia: An Epidemiological Study from the Swedish Acute Leukemia Registry

Deneberg, Stefan; Lundin, Ebba; Lazarevic, Vladimir; Benson, Lina et al.

Part of Blood, 2015

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes

Qu, Ying; Lennartsson, Andreas; Gaidzik, Verena I.; Deneberg, Stefan et al.

Part of Epigenetics, p. 1108-1119, 2014

• DOI for Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Genovese, Giulio; Kaehler, Anna K.; Handsaker, Robert E.; Lindberg, Johan et al.

Part of New England Journal of Medicine, p. 2477-2487, 2014

• DOI for Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry

Höglund, Martin; Sandin, Fredrik; Hellstrom, Karin; Bjoreman, Mats et al.

Part of Blood, p. 1284-1292, 2013

• DOI for Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry

Integrated multi-omic profiling of azacitidine-venetoclax in AML reveals additional targetable pathways to improve the treatment

Österroos, Albin; Zhong, Xiangfu; Gamboa Cedeno, Angelica; Junkunlo, Kingkamon et al.