Sören Lehmann
Professor at Department of Medical Sciences; Haematology
- Mobile phone:
- +46 70 760 48 82
- E-mail:
- soren.lehmann@medsci.uu.se
- Visiting address:
- Akademiska sjukhuset, ing 101, plan 4
751 85 Uppsala - Postal address:
- Akademiska sjukhuset, ing 100, plan 2
751 85 Uppsala
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Publications
Recent publications
Pathway activation model for personalized prediction of drug synergy
Part of eLIFE, 2025
- DOI for Pathway activation model for personalized prediction of drug synergy
- Download full text (pdf) of Pathway activation model for personalized prediction of drug synergy
Part of Haematologica, p. 1126-1140, 2025
- DOI for Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
- Download full text (pdf) of Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Acute promyelocytic leukemia: long-term outcomes from the HARMONY project
Part of Blood, p. 234-243, 2025
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Part of Leukemia, p. 663-666, 2024
- DOI for The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
- Download full text (pdf) of The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Part of Cell Reports, 2024
- DOI for Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
- Download full text (pdf) of Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
All publications
Articles in journal
Pathway activation model for personalized prediction of drug synergy
Part of eLIFE, 2025
- DOI for Pathway activation model for personalized prediction of drug synergy
- Download full text (pdf) of Pathway activation model for personalized prediction of drug synergy
Part of Haematologica, p. 1126-1140, 2025
- DOI for Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
- Download full text (pdf) of Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Acute promyelocytic leukemia: long-term outcomes from the HARMONY project
Part of Blood, p. 234-243, 2025
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Part of Leukemia, p. 663-666, 2024
- DOI for The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
- Download full text (pdf) of The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Part of Cell Reports, 2024
- DOI for Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
- Download full text (pdf) of Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
Part of Leukemia and Lymphoma, p. 1493-1501, 2024
- DOI for Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
- Download full text (pdf) of Cytarabine dose intensification improves survival in older patients with secondary/high-risk acute myeloid leukemia in matched real-world versus clinical trial data
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Part of npj Precision Oncology, 2024
- DOI for Delineating functional and molecular impact of ex vivo sample handling in precision medicine
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Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
Part of Leukemia, p. 1103-1112, 2023
- DOI for Therapy-related MDS dissected based on primary disease and treatment: a nationwide perspective
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Part of Blood, p. 73-89, 2023
- DOI for Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
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Prediction model for drug response of acute myeloid leukemia patients
Part of npj Precision Oncology, 2023
- DOI for Prediction model for drug response of acute myeloid leukemia patients
- Download full text (pdf) of Prediction model for drug response of acute myeloid leukemia patients
Part of Haematologica, p. 1015-1025, 2023
- DOI for Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
- Download full text (pdf) of Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Part of Nature Biotechnology, p. 488-498, 2022
- DOI for T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
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A risk score based on real-world data to predict early death in acute promyelocytic leukemia
Part of Haematologica, p. 1528-1537, 2022
- DOI for A risk score based on real-world data to predict early death in acute promyelocytic leukemia
- Download full text (pdf) of A risk score based on real-world data to predict early death in acute promyelocytic leukemia
Part of Journal of Internal Medicine, p. 925-940, 2022
- DOI for Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
- Download full text (pdf) of Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
Part of Genes, Chromosomes and Cancer, p. 426-433, 2021
- DOI for Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study
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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Part of Cancer Research, p. 5733-5744, 2021
- DOI for MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
- Download full text (pdf) of MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Part of British Journal of Haematology, p. 474-483, 2021
- DOI for Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study
- Download full text (pdf) of Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study
Part of Leukemia and Lymphoma, p. 1973-1981, 2021
- DOI for Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study
- Download full text (pdf) of Is there an impact of measurable residual disease as assessed by multiparameter flow cytometry on survival of AML patients treated in clinical practice?: A population-based study
Part of American Journal of Hematology, p. 580-588, 2021
- DOI for The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
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Impact of treatment delay in acute myeloid leukemia revisited
Part of Blood Advances, p. 787-790, 2021
Part of Blood Advances, p. 1003-1016, 2021
Part of Clinical Cancer Research, p. 3597-3607, 2020
Part of Blood Cancer Journal, 2020
- DOI for Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
- Download full text (pdf) of Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
Part of British Journal of Haematology, 2020
Part of EMBO Molecular Medicine, 2020
- DOI for Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
- Download full text (pdf) of Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Part of Blood Advances, p. 1094-1101, 2020
Part of Blood, p. 339-352, 2020
Hypo, Hyper, or Combo: new paradigm for treatment of acute myeloid leukemia in older people
Part of Haematologica, p. 249-251, 2020
Part of British Journal of Haematology, p. 187-191, 2020
Improved survival of men 50 to 75 years old with acute myeloid leukemia over a 20-year period
Part of Blood, p. 1558-1561, 2019
Part of Journal of Clinical Oncology, p. 2632-2642, 2019
Expression levels of long non-coding RNAs are prognostic for AML outcome
Part of Journal of Hematology & Oncology, 2018
- DOI for Expression levels of long non-coding RNAs are prognostic for AML outcome
- Download full text (pdf) of Expression levels of long non-coding RNAs are prognostic for AML outcome
Part of British Journal of Haematology, p. 614-627, 2018
Part of Scientific Reports, 2018
- DOI for Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
- Download full text (pdf) of Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
Part of Free Radical Biology & Medicine, p. 247-257, 2018
- DOI for Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
- Download full text (pdf) of Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
Part of Journal of the National Cancer Institute, p. 1094-1101, 2018
- DOI for Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
- Download full text (pdf) of Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
Part of Pediatric Blood & Cancer, 2018
Part of Oncotarget, p. 28812-28825, 2017
- DOI for Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease
- Download full text (pdf) of Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease
Part of Blood Cancer Journal, 2017
- DOI for Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia
- Download full text (pdf) of Bone marrow stroma cells derived from mononuclear cells at diagnosis as a source of germline control DNA for determination of somatic mutations in acute myeloid leukemia
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Part of CANCER IMMUNOLOGY RESEARCH, p. 654-665, 2017
Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden
Part of Leukemia, p. 728-731, 2017
Part of Blood, 2017
Part of Leukemia, p. 1108-1116, 2017
- DOI for Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
- Download full text (pdf) of Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
Part of European Journal of Haematology, p. 493-500, 2017
Part of Leukemia, p. 1457-1459, 2017
Part of Leukemia, p. 2029-2036, 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Part of Nature Medicine, p. 256-263, 2017
An open-label phase I dose-finding study of APR-246 in hematological malignancies
Part of Blood Cancer Journal, 2016
- DOI for An open-label phase I dose-finding study of APR-246 in hematological malignancies
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Part of British Journal of Haematology, p. 117-126, 2016
Part of Haematologica, p. 209-210, 2016
Validation Of Prognostic Scoring Systems For Myelodysplastic Syndromes In The Swedish Mds-Register
Part of Haematologica, p. 243-243, 2016
Part of American Journal of Hematology, p. 208-214, 2015
Part of European Journal of Haematology, p. 419-423, 2015
Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis
Part of Experimental Hematology, p. 609-624, 2015
Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia
Part of American Journal of Hematology, p. 800-805, 2015
Part of Blood, 2015
Prevalence and Characteristics of Survivors from Adult Acute Myeloid Leukemia (AML) in Sweden 2014
Part of Blood, 2015
Part of Blood, 2015
Part of Epigenetics, p. 1108-1119, 2014
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Part of New England Journal of Medicine, p. 2477-2487, 2014
Part of Blood, p. 1284-1292, 2013