Anzhelika Vorobyeva

Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Part of Journal of Biological Engineering, 2026

• DOI for Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents

Rinne, Sara S.; Yin, Wen; Li, Ruonan; Ding, Haozhong et al.

Part of ACS Pharmacology & Translational Science, p. 3872-3885, 2025

• DOI for Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

Tolmachev, Vladimir M.; Vorobyeva, Anzhelika; Rosly, Alia Hani Binti; Garousi, Javad et al.

Part of International Journal of Molecular Sciences, 2025

• DOI for Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture
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Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression

Vorobyeva, Anzhelika; Ud-din, Moeen; Schulga, Alexey; Konovalova, Elena et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
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Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Part of Journal of Biological Engineering, 2026

• DOI for Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents

Rinne, Sara S.; Yin, Wen; Li, Ruonan; Ding, Haozhong et al.

Part of ACS Pharmacology & Translational Science, p. 3872-3885, 2025

• DOI for Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

Tolmachev, Vladimir M.; Vorobyeva, Anzhelika; Rosly, Alia Hani Binti; Garousi, Javad et al.

Part of International Journal of Molecular Sciences, 2025

• DOI for Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture
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Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression

Vorobyeva, Anzhelika; Ud-din, Moeen; Schulga, Alexey; Konovalova, Elena et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
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Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024

• DOI for Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Part of Journal of Controlled Release, p. 468-478, 2024

• DOI for Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts

Zhang, Jie; Rinne, Sara S.; Yin, Wen; Leitao, Charles Dahlsson et al.

Part of ACS Pharmacology & Translational Science, p. 3228-3240, 2024

• DOI for Affibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor-3 Demonstrate Therapeutic Efficacy in Mice Bearing Low Expressing Xenografts
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Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting

Westerlund, Kristina; Oroujeni, Maryam; Gestin, Maxime; Clinton, Jacob et al.

Part of ACS Pharmacology & Translational Science, p. 1595-1611, 2024

• DOI for Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
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Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer

Zelchan, Roman; Chernov, Vladimir; Medvedeva, Anna; Rybina, Anastasia et al.

Part of Cancers, 2024

• DOI for Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [^99mTc]Tc(CO)₃-(HE)₃-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
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Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion

Deyev, Sergey M.; Oroujeni, Maryam; Garousi, Javad; Graeslund, Torbjoern et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
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Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Larkina, Maria; Varvashenya, Ruslan; Yuldasheva, Feruza; Plotnikov, Evgenii et al.

Part of Molecular Pharmaceutics, p. 1919-1932, 2024

• DOI for Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors

Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker

Lundmark, Fanny; Vorobyeva, Anzhelika; Liu, Yongsheng; Lindbo, Sarah et al.

Part of Molecular Medicine Reports, 2024

• DOI for Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125

Tolmachev, Vladimir; Bodenko, Vitalina; Orlova, Anna; Schulga, Alexey et al.

Part of Oncology Letters, 2023

• DOI for Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with Tc-99m and I-125
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Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of Cancers, 2023

• DOI for Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Leitao, Charles Dahlsson; Borras, Anna Mestre; Xu, Tianqi; Oroujeni, Maryam et al.

Part of Journal of Controlled Release, p. 185-195, 2023

• DOI for Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model

Xu, Tianqi; Schulga, Alexey; Konovalova, Elena; Rinne, Sara S. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
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Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells

Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey; Konovalova, Elena et al.

Part of Oncology Reports, 2022

• DOI for Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells
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Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Part of Pharmaceutics, 2022

• DOI for Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
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Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Liu, Yongsheng; Gueler, Rezan; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of Pharmaceutics, 2022

• DOI for Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
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Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S. et al.

Part of Pharmaceutics, 2022

• DOI for Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
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Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules

Rinne, Sara S.; Yin, Wen; Borras, Anna Mestre; Abouzayed, Ayman et al.

Part of Biomedicines, 2022

• DOI for Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules
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Radionuclides in Diagnostics and Therapy of Malignant Tumors: New Development

Tolmachev, Vladimir; Vorobyeva, Anzhelika

Part of Cancers, 2022

• DOI for Radionuclides in Diagnostics and Therapy of Malignant Tumors: New Development
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Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Liu, Yongsheng; Yu, Shengze; Xu, Tianqi; Bodenko, Vitalina et al.

Part of Pharmaceutics, 2022

• DOI for Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
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Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

Garousi, Javad; Xu, Tianqi; Liu, Yongsheng; Vorontsova, Olga et al.

Part of Pharmaceutics, 2022

• DOI for Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart
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Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

Tolmachev, Vladimir; Bodenko, Vitalina; Oroujeni, Maryam; Deyev, Sergey et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
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Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with Tc-99m for Radionuclide Imaging of HER2 Expression in Cancer

Larkina, Mariia; Plotnikov, Evgenii; Bezverkhniaia, Ekaterina; Shabanova, Yulia et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with Tc-99m for Radionuclide Imaging of HER2 Expression in Cancer
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Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Oroujeni, Maryam; Tano, Hanna; Vorobyeva, Anzhelika; Liu, Yongsheng et al.

Part of Journal of Nuclear Medicine, p. 1046-1051, 2022

• DOI for Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

Bragina, Olga; Chernov, Vladimir; Schulga, Alexey; Konovalova, Elena et al.

Part of Journal of Nuclear Medicine, p. 528-535, 2022

• DOI for Phase I Trial of ^99mTc-(HE)₃-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Part of Pharmaceutics, 2021

• DOI for Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
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Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Garousi, Javad; Ding, Haozhong; von Witting, Emma; Xu, Tianqi et al.

Part of Pharmaceutics, 2021

• DOI for Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein
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Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

Xu, Tianqi; Ding, Haozhong; Vorobyeva, Anzhelika; Oroujeni, Maryam et al.

Part of Cancers, 2021

• DOI for Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
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Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle

Garousi, Javad; von Witting, Emma; Borin, Jesper; Vorobyeva, Anzhelika et al.

Part of Biomaterials, 2021

• DOI for Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle
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The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Yin, Wen; Xu, Tianqi; Altai, Mohamed; Oroujeni, Maryam et al.

Part of Pharmaceutics, 2021

• DOI for The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
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Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Ding, Haozhong; Xu, Tianqi; Zhang, Jie; Tolmachev, Vladimir et al.

Part of Pharmaceutics, 2021

• DOI for Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
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Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
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Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Deyev, Sergey M.; Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey et al.

Part of Cancers, 2021

• DOI for Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1
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Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

Xu, Tianqi; Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena et al.

Part of Cancers, 2021

• DOI for Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model
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Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Tano, Hanna; Oroujeni, Maryam; Vorobyeva, Anzhelika; Westerlund, Kristina et al.

Part of Cancers, 2021

• DOI for Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting
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HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers

Rinne, Sara S.; Dahlsson Leitao, Charles; Abouzayed, Ayman; Vorobyeva, Anzhelika et al.

Part of Cancers, p. 4791-4791, 2021

• DOI for HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers
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Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer

Bragina, Olga; von Witting, Emma; Garousi, Javad; Zelchan, Roman et al.

Part of Journal of Nuclear Medicine, p. 493-499, 2021

• DOI for Phase I study of ^99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer

Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use

Bragina, O. D.; Chernov, V. I.; Garbukov, E. Yu; Doroshenko, A. V. et al.

Part of Bûlleten' sibirskoj mediciny, p. 23-30, 2021

• DOI for Possibilities of radionuclide diagnostics of Her2-positive breast cancer using technetium-99m-labeled target molecules: the first experience of clinical use
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In vitro and in vivo evaluation of the radiochemical compound based on 99mtechnetium labelled DARPin9_29 for molecular visualization of malignancies overexpressing Her2/neu

Bragina, O. D.; Vorobyeva, Anzhelika; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of Medical Radiology and Radiation Safety, p. 37-41, 2020

• DOI for In vitro and in vivo evaluation of the radiochemical compound based on 99mtechnetium labelled DARPin9_29 for molecular visualization of malignancies overexpressing Her2/neu

Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules

Garousi, Javad; Vorobyeva, Anzhelika; Altai, Mohamed

Part of Molecules, 2020

• DOI for Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules
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Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

Rinne, Sara S.; Xu, Tianqi; Leitao, Charles Dahlsson; Stahl, Stefan et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules
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Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein

Vorobyeva, Anzhelika; Oroujeni, Maryam; Lindbo, Sarah; Hober, Sophia et al.

Part of Molecules, 2020

• DOI for Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein
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Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

Vorobyeva, Anzhelika; Bezverkhniaia, Ekaterina; Konovalova, Elena; Schulga, Alexey et al.

Part of Molecules, 2020

• DOI for Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1
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Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting

Myrhammar, Anders; Vorobyeva, Anzhelika; Westerlund, Kristina; Yoneoka, Shuichiro et al.

Part of Scientific Reports, 2020

• DOI for Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
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On the prevention of kidney uptake of radiolabeled DARPins

Altai, Mohamed; Garousi, Javad; Rinne, Sara S.; Schulga, Alexey et al.

Part of EJNMMI Research, 2020

• DOI for On the prevention of kidney uptake of radiolabeled DARPins
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Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

Vorobyeva, Anzhelika; Konovalova, Elena; Xu, Tianqi; Schulga, Alexey et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1
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Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1

Deyev, Sergey M.; Vorobyeva, Anzhelika; Schulga, Alexey; Abouzayed, Ayman et al.

Part of International Journal of Biological Macromolecules, p. 216-225, 2020

• DOI for Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1
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Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of ⁶⁸Ga-Labeled Tracers

Dahlsson Leitao, Charles; Rinne, Sara S.; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of ⁶⁸Ga-Labeled Tracers
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Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates

Ding, Haozhong; Altai, Mohamed; Rinne, Sara S.; Vorobyeva, Anzhelika et al.

Part of Cancers, 2019

• DOI for Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates
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Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

Garousi, Javad; Huizing, Fokko J.; Vorobyeva, Anzhelika; Mitran, Bogdan et al.

Part of Scientific Reports, 2019

• DOI for Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
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Optimal composition and position of histidine-containing tags improves biodistribution of Tc-99m-labeled DARP in G3

Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena; Guler, Rezan et al.

Part of Scientific Reports, 2019

• DOI for Optimal composition and position of histidine-containing tags improves biodistribution of Tc-99m-labeled DARP in G3
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Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake

Rosestedt, Maria; Andersson, Ken G.; Rinne, Sara S.; Leitao, Charles Dahlsson et al.

Part of Scientific Reports, 2019

• DOI for Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake
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Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

Vorobyeva, Anzhelika; Schulga, Alexey; Rinne, Sara S.; Günther, Tyran et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging
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Comparison of tumor-targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2

Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena; Güler, Rezan et al.

Part of International Journal of Oncology, p. 1209-1220, 2019

• DOI for Comparison of tumor-targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2
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Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26

Mitran, Bogdan; Rinne, Sara S.; Konijnenberg, Mark W.; Maina, Theodosia et al.

Part of International Journal of Cancer, p. 3347-3358, 2019

• DOI for Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177Lu-DOTAGA-PEG2-RM26
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Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6

von Witting, Emma; Garousi, Javad; Lindbo, Sarah; Vorobyeva, Anzhelika et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 109-120, 2019

• DOI for Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6
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Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting

Westerlund, Kristina; Vorobyeva, Anzhelika; Mitran, Bogdan; Orlova, Anna et al.

Part of Biomaterials, p. 73-85, 2019

• DOI for Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting
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Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties

Deyev, Sergey; Vorobyeva, Anzhelika; Schulga, Alexey; Proshkina, Galina et al.

Part of Molecular Pharmaceutics, p. 995-1008, 2019

• DOI for Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties

Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

Garousi, Javad; Lindbo, Sarah; Borin, Jesper; von Witting, Emma et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 37-48, 2019

• DOI for Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours
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Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors

Vorobyeva, Anzhelika; Bragina, Olga; Altai, Mohamed; Mitran, Bogdan et al.

Part of Contrast Media & Molecular Imaging, p. 1-11, 2018

• DOI for Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors
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Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

Altai, Mohamed; Leitao, Charles Dahlsson; Rinne, Sara S.; Vorobyeva, Anzhelika et al.

Part of Cells, 2018

• DOI for Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs
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Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy

Vorobyeva, Anzhelika; Westerlund, Kristina; Mitran, Bogdan; Altai, Mohamed et al.

Part of Scientific Reports, 2018

• DOI for Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy
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PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Summer, D; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of EJNMMI Research, 2018

• DOI for PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules

Oroujeni, Maryam; Andersson, Ken G.; Steinhardt, Xenia; Altai, Mohamed et al.

Part of Amino Acids, p. 981-994, 2018

• DOI for Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules
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Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

Summer, Dominik; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of Molecular Pharmaceutics, p. 175-185, 2018

• DOI for Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression
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Selection of the most optimal ADAPT6-based probe for imaging of HER2 using PET and SPECT

Garousi, Javad; Lindbo, S.; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Lindbo, Sarah; Garousi, Javad; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of Molecular Pharmaceutics, p. 2674-2683, 2018

• DOI for Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Molecular Imaging of HER2 Expression in Cancer Using SPECT

Vorobyeva, Anzhelika; Bragina, O.; Altai, Mohamed; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Molecular Imaging of HER2 Expression in Cancer Using SPECT

Development of a PET Imaging Approach for Selection of Patients for Affibody-Based PNA-Mediated Pretargeted Radionuclide Therapy

Vorobyeva, Anzhelika; Westerlund, K.; Mitran, Bogdan; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Development of a PET Imaging Approach for Selection of Patients for Affibody-Based PNA-Mediated Pretargeted Radionuclide Therapy

Imaging contrast of HER3 expression using monomeric affibody-based imaging probe can be improved by co-injection of affibody trimer

Orlova, Anna; Rosestedt, Maria; Rinne, Sara S.; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Imaging contrast of HER3 expression using monomeric affibody-based imaging probe can be improved by co-injection of affibody trimer

Optimization of molecular design of Ga-68-labeled affibody molecule for PET imaging of HER3 expression

Rinne, Sara S.; Mitran, Bogdan; Vorobyeva, Anzhelika; Leitao, C. Dahlsson et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Optimization of molecular design of Ga-68-labeled affibody molecule for PET imaging of HER3 expression

GRPR-targeted radiotherapy using the Lu-177-labeled GRPR-antagonist DOTAGA-PEG(2)-RM26

Mitran, Bogdan; Rinne, Sara S.; Azamy, F.; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m

Garousi, Javad; Lindbo, Sarah; Mitran, Bogdan; Buijs, Jos et al.

Part of Scientific Reports, 2017

• DOI for Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m
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Influence of composition of cysteine-containing peptide based chelators on biodistribution of Tc-99m-labelled anti-EGFR affibody molecules

Oroujeni, Maryam; Anderson, K. G.; Garousi, Javad; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Feasibility of Z Domain-Mediated Conjugation of PNA to Antibodies for Radionuclide Pretargeting

Vorobyeva, Anzhelika; Altai, Mohamed; Westerlund, K.; Al-Ramadan, Afkar et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting

Altai, Mohamed; Vorobyeva, Anzhelika; Tolmachev, Vladimir M.; Karlström, Amelie Eriksson et al.

Part of Peptide Nucleic Acids, p. 283-304, Springer Nature, 2020

• DOI for Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting