Alan Faraj

A noninvasive BCG skin challenge model for assessing tuberculosis vaccine efficacy

Krishnan, Nitya; Priestman, Miles; Uhia, Iria; Charitakis, Natalie et al.

Part of PLoS biology, 2024

• DOI for A noninvasive BCG skin challenge model for assessing tuberculosis vaccine efficacy
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Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors

Faraj, Alan; Nyberg, Joakim; Blouse, Grant E.; Knudsen, Tom et al.

Part of Clinical Pharmacology and Therapeutics, p. 498-505, 2024

• DOI for Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors
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Pharmacometric models to inform dose selection and study design: Applied in hemophilia and tuberculosis

Faraj, Alan

2024

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Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Faraj, Alan; Van Wijk, Rob C; Neuman, Linda; Desai, Shraddha et al.

Part of CPT, p. 977-987, 2023

• DOI for Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy
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Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study

Janssen, Saskia; Upton, Caryn M.; De Jager, Veronique R.; Faraj, Alan et al.

Part of Annals of the American Thoracic Society, p. 1822-1825, 2023

• DOI for Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study

A noninvasive BCG skin challenge model for assessing tuberculosis vaccine efficacy

Krishnan, Nitya; Priestman, Miles; Uhia, Iria; Charitakis, Natalie et al.

Part of PLoS biology, 2024

• DOI for A noninvasive BCG skin challenge model for assessing tuberculosis vaccine efficacy
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Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors

Faraj, Alan; Nyberg, Joakim; Blouse, Grant E.; Knudsen, Tom et al.

Part of Clinical Pharmacology and Therapeutics, p. 498-505, 2024

• DOI for Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors
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Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Faraj, Alan; Van Wijk, Rob C; Neuman, Linda; Desai, Shraddha et al.

Part of CPT, p. 977-987, 2023

• DOI for Model-informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy
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Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study

Janssen, Saskia; Upton, Caryn M.; De Jager, Veronique R.; Faraj, Alan et al.

Part of Annals of the American Thoracic Society, p. 1822-1825, 2023

• DOI for Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study

Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Mockeliunas, Laurynas; Faraj, Alan; Van Wijk, Rob C; Upton, Caryn M. et al.

Part of Frontiers in Pharmacology, 2023

• DOI for Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development
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Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients

Faraj, Alan; Le Moan, Natacha; Gorina, Eduard; Blouse, Grant E. E. et al.

Part of Advances in Therapy, p. 3739-3750, 2023

• DOI for Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients
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Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Faraj, Alan; Knudsen, Tom; Desai, Shraddha; Neuman, Linda et al.

Part of CPT, p. 1628-1637, 2022

• DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

De Jager, Veronique; Gupte, Nikhil; Nunes, Silvia; Barnes, Grace L. et al.

Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022

• DOI for Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

Faraj, Alan; Clewe, Oskar; Svensson, Robin J.; Mukamolova, Galina V. et al.

Part of Scientific Reports, 2020

• DOI for Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions
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A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

Clewe, Oskar; Faraj, Alan; Hu, Yanmin; Coates, Anthony R M et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 421-430, 2020

• DOI for A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.
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Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients
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Pharmacometric models to inform dose selection and study design: Applied in hemophilia and tuberculosis

Faraj, Alan

2024

• Download full text (pdf) of Pharmacometric models to inform dose selection and study design: Applied in hemophilia and tuberculosis

Drug effect of clofazimine on persisters explain an unexpected increase in bacterial load from patients

Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

Model-based approaches to prospectively power pediatric pharmacokinetic trials with limited sample size

Faraj, Alan; Ayoun Alsoud, Rami; Nyberg, Joakim; Simonsson, Ulrika S. H.