Markus Fridén

Translational PK/PD: a retrospective analysis of performance and impact from a drug portfolio

Jansson-Lofmark, Rasmus; Fridén, Markus; Badolo, Lassina; Ahlstrom, Christine et al.

Part of Drug Discovery Today, 2025

• DOI for Translational PK/PD: a retrospective analysis of performance and impact from a drug portfolio
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Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Backstrom, E.; Erngren, T.; Fihn, B-M; Sadiq, M. W. et al.

Part of Journal of Pharmaceutical Sciences, p. 852-858, 2022

• DOI for Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Part of Pharmaceutical research, p. 1321-1341, 2022

• DOI for Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
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Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Part of Pharmaceutical research, p. 1291-1296, 2022

• DOI for Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya et al.

Part of IEEE journal of biomedical and health informatics, p. 371-380, 2021

• DOI for Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images
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Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Backstrom, E.; Erngren, T.; Fihn, B-M; Sadiq, M. W. et al.

Part of Journal of Pharmaceutical Sciences, p. 852-858, 2022

• DOI for Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Part of Pharmaceutical research, p. 1321-1341, 2022

• DOI for Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
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Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Part of Pharmaceutical research, p. 1291-1296, 2022

• DOI for Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya et al.

Part of IEEE journal of biomedical and health informatics, p. 371-380, 2021

• DOI for Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images
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Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Sadiq, Muhammad Waqas; Holz, Olaf; Ellinghusen, Birthe D.; Faulenbach, Cornelia et al.

Part of British Journal of Pharmacology, p. 4440-4451, 2021

• DOI for Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

Nyman, Elin; Lindh, Maria; Lövfors, William; Simonsson, Christian et al.

Part of CPT, p. 707-717, 2020

• DOI for Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling
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Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Hamm, Gregory R.; Bäckström, Erica; Brülls, Mikael; Nilsson, Anna et al.

Part of Journal of Aerosol Medicine, p. 43-53, 2020

• DOI for Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

Hu, Yang; Hammarlund-Udenaes, Margareta; Fridén, Markus

Part of Journal of Pharmaceutical Sciences, p. 3425-3433, 2019

• DOI for Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

Schou, Magnus; Ewing, Par; Cselenyi, Zsolt; Fridén, Markus et al.

Part of EJNMMI Research, 2019

• DOI for Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator
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Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Boger, Elin; Fridén, Markus

Part of Journal of Aerosol Medicine, p. 1-12, 2018

• DOI for Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Uncovering the regional localization of inhaled salmeterol retention in the lung

Bäckström, Erica; Hamm, Gregory; Nilsson, Anna; Fihn, Britt-Marie et al.

Part of Drug Delivery, p. 838-845, 2018

• DOI for Uncovering the regional localization of inhaled salmeterol retention in the lung
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Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Ehrhardt, Carsten; Backman, Per; Couet, William; Edwards, Chris et al.

Part of Journal of Pharmaceutical Sciences, p. 2234-2244, 2017

• DOI for Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Ericsson, Therese; Fridén, Markus; Kärrman-Mårdh, Carina; Dainty, Ian et al.

Part of Pharmaceutical research, p. 2557-2567, 2017

• DOI for Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Lindqvist, Annika; Fridén, Markus; Hammarlund-Udenaes, Margareta

Part of European Journal of Pharmaceutical Sciences, p. 173-182, 2016

• DOI for Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Systems Pharmacology Approach for Prediction of Pulmonary and Systemic Pharmacokinetics and Receptor Occupancy of Inhaled Drugs

Boger, E.; Evans, N.; Chappell, M.; Lundqvist, A. et al.

Part of CPT, p. 201-210, 2016

• DOI for Systems Pharmacology Approach for Prediction of Pulmonary and Systemic Pharmacokinetics and Receptor Occupancy of Inhaled Drugs
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Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Bäckström, Erica; Boger, Elin; Lundqvist, Anders; Hammarlund-Udenaes, Margareta et al.

Part of Journal of Pharmaceutical Sciences, p. 3432-3439, 2016

• DOI for Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Bäckström, Erica; Lundqvist, Anders; Boger, Elin; Svanberg, Petter et al.

Part of Journal of Pharmaceutical Sciences, p. 838-845, 2016

• DOI for Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

A Novel In Vivo Receptor Occupancy Methodology for the Glucocorticoid Receptor: Toward An Improved Understanding of Lung Pharmacokinetic/Pharmacodynamic Relationships

Boger, Elin; Ewing, Par; Eriksson, Ulf G.; Fihn, Britt-Marie et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 279-287, 2015

• DOI for A Novel In Vivo Receptor Occupancy Methodology for the Glucocorticoid Receptor: Toward An Improved Understanding of Lung Pharmacokinetic/Pharmacodynamic Relationships

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Fridén, Markus; Wennerberg, Marie; Antonsson, Madeleine; Sandberg-Stall, Maria et al.

Part of EJNMMI Research, p. 1-8, 2014

• DOI for Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain
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Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

Sällström, Johan; Fridén, Markus

Part of Journal of pharmacological and toxicological methods, p. 187-193, 2013

• DOI for Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Fridén, Markus; Bergström, Fredrik; Wan, Hong; Rehngren, Mikael et al.

Part of Drug Metabolism And Disposition, p. 353-362, 2011

• DOI for Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

Chen, Hongming; Winiwarter, Susanne; Fridén, Markus; Antonsson, Madeleine et al.

Part of Journal of Molecular Graphics and Modelling, p. 985-995, 2011

• DOI for In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Fridén, Markus; Ljungqvist, Helena; Middleton, Brian; Bredberg, Ulf et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 150-161, 2010

• DOI for Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Fridén, Markus; Ducrozet, Frederic; Middleton, Brian; Antonsson, Madeleine et al.

Part of Drug Metabolism And Disposition, p. 1226-1233, 2009

• DOI for Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

Fridén, Markus; Winiwarter, Susanne; Jerndal, Gunilla; Bengtsson, Ola et al.

Part of Journal of Medicinal Chemistry, p. 6233-6243, 2009

• DOI for Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Fridén, Markus; Gupta, Anubha; Antonsson, Madeleine; Bredberg, Ulf et al.

Part of Drug Metabolism And Disposition, p. 1711-1719, 2007

• DOI for In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Translational PK/PD: a retrospective analysis of performance and impact from a drug portfolio

Jansson-Lofmark, Rasmus; Fridén, Markus; Badolo, Lassina; Ahlstrom, Christine et al.

Part of Drug Discovery Today, 2025

• DOI for Translational PK/PD: a retrospective analysis of performance and impact from a drug portfolio
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Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Ganguly, Koustav; Carlander, Ulrika; Garessus, Estella D. G.; Fridén, Markus et al.

Part of Critical reviews in toxicology, p. 160-173, 2019

• DOI for Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data
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Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Colcloughl, Nicola; Chen, Kan; Johnstrom, Peter; Fridén, Markus et al.

Part of Drug Discovery Today, p. 1067-1073, 2019

• DOI for Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Methodologies to assess brain drug delivery in lead optimization

Hammarlund-Udenaes, Margareta; Bredberg, Ulf; Fridén, Markus

Part of Current Topics in Medicinal Chemistry, p. 148-162, 2009

• DOI for Methodologies to assess brain drug delivery in lead optimization

On the rate and extent of drug delivery to the brain

Hammarlund-Udenaes, Margareta; Fridén, Markus; Syvänen, Stina; Gupta, Anubha

Part of Pharmaceutical research, p. 1737-1750, 2008

• DOI for On the rate and extent of drug delivery to the brain

C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats

Stridh, Sara; Sällström, Johan; Fridén, Markus; Hansell, Peter et al.

Part of Oxygen transport to tissue xxx, p. 219-225, Springer, 2009

• DOI for C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats

Development of Methods for Assessing Unbound Drug Exposure in the Brain: In vivo, in vitro and in silico

Fridén, Markus

2010

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