Alzahra Hamdan

Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

Hamdan, Alzahra; Traschütz, Andreas; Beichert, Lukas; Chen, Xiaomei et al.

Part of CPT, p. 1857-1868, 2025

• DOI for Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases
• Download full text (pdf) of Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Ryeznik, Yevgen; Hilgers, Ralf-Dieter; Heussen, Nicole; Comets, Emmanuelle et al.

Part of CPT, p. 1705-1714, 2025

• DOI for A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders
• Download full text (pdf) of A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Hendrickx, Niels; Mentré, France; Hamdan, Alzahra; Karlsson, Mats O. et al.

Part of BMC Medical Research Methodology, 2025

• DOI for Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score
• Download full text (pdf) of Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

A fully automatic tool for development of population pharmacokinetic models

Chen, Xiaomei; Nordgren, Rikard; Belin, Stella; Hamdan, Alzahra et al.

Part of CPT, p. 1784-1797, 2024

• DOI for A fully automatic tool for development of population pharmacokinetic models
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Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory

Hamdan, Alzahra; Hendrickx, Niels; Hooker, Andrew C.; Chen, Xiaomei et al.

Part of Clinical Pharmacology and Therapeutics, p. 1593-1605, 2024

• DOI for Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory
• Download full text (pdf) of Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory

Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

Hamdan, Alzahra; Traschütz, Andreas; Beichert, Lukas; Chen, Xiaomei et al.

Part of CPT, p. 1857-1868, 2025

• DOI for Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases
• Download full text (pdf) of Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Ryeznik, Yevgen; Hilgers, Ralf-Dieter; Heussen, Nicole; Comets, Emmanuelle et al.

Part of CPT, p. 1705-1714, 2025

• DOI for A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders
• Download full text (pdf) of A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders

Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Hendrickx, Niels; Mentré, France; Hamdan, Alzahra; Karlsson, Mats O. et al.

Part of BMC Medical Research Methodology, 2025

• DOI for Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score
• Download full text (pdf) of Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

A fully automatic tool for development of population pharmacokinetic models

Chen, Xiaomei; Nordgren, Rikard; Belin, Stella; Hamdan, Alzahra et al.

Part of CPT, p. 1784-1797, 2024

• DOI for A fully automatic tool for development of population pharmacokinetic models
• Download full text (pdf) of A fully automatic tool for development of population pharmacokinetic models

Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory

Hamdan, Alzahra; Hendrickx, Niels; Hooker, Andrew C.; Chen, Xiaomei et al.

Part of Clinical Pharmacology and Therapeutics, p. 1593-1605, 2024

• DOI for Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory
• Download full text (pdf) of Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory

Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias

Hamdan, Alzahra; Hooker, Andrew C.; Chen, Xiaomei; Traschütz, Andreas et al.

Part of CPT, p. 1327-1340, 2024

• DOI for Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias
• Download full text (pdf) of Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias