Astrid Olivefors
PhD student at Department of Materials Science and Engineering; Biomedical Engineering
- E-mail:
- astrid.olivefors@angstrom.uu.se
- Visiting address:
- Ångströmlaboratoriet, Lägerhyddsvägen 1
- Postal address:
- Box 35
751 03 UPPSALA
- ORCID:
- 0009-0000-2335-9938
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Short presentation
Astrid joined the EMBLA research group as a PhD student in November 2022.
Keywords
- 2 photon 3d printing
- 2 photon printing
- brain-on-chip
- cerebral organoids
- hydrogels
- microfabrication
- microfluidics
- precision medicine
- vascularization
Biography
- 2022 - current, PhD student, Uppsala University
- 2020 - 2022, Global Graduate Associate at AstraZeneca (Sweden)
- 2019, MScEng Chemical Engineering and Engineering Physics, Nanotechnology, Chalmers University of Technology (Sweden)
Research
Microfabrication of biomimetic vascular systems in organoids
Organoids are of interest in applications such as drug development, where they can provide more physiologically relevant data than a two-dimensional cell culture. Additionally, there is a possibility for organoid-based models to supplement and in time replace data from experiments that are currently performed on animals. However, since organoids lack an internal vascular system, there is no way for oxygen and nutrients to reach the core and for waste products to efficiently be removed from the core. Eventually this leads to e.g., hypoxia in the organoid core. My research project is focused on fabricating a biomimetic vasculature-like system that can perform the transport of oxygen, nutrients, and waste products to and from the organoid core.
