Thomas Juan
Associate senior lecturer/Assistant Professor at Department of Immunology, Genetics and Pathology; Research programme: Vascular Biology; Research group Thomas Juan
- E-mail:
- thomas.juan@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
- ORCID:
- 0000-0002-9654-3717
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Short presentation
My research focuses on cardiovascular disease, the leading cause of death worldwide. Specifically, how blood flow forces, sensed by endothelial cells, shape cardiovascular development and function. Using zebrafish as a model organism, my work integrates genetic tools, high-resolution live imaging, single-cell omics, and technology optimization. Overall, I aim to unravel key processes essential for cardiovascular function and develop tools with broad research and therapeutic applications.
Keywords
- cardiovascular diseases
- developmental genetics
- genome editing
- mechanobiology
- zebrafish
Research
My laboratory aims to understand how blood flow forces shape the development and function of the cardiovascular system. We generate genetic tools to control cardiac contractions and modulate the function of mechanosensor proteins in cardiovascular subpopulations.
Publications
Recent publications
- Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy (2025)
- A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish (2025)
- egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. (2024)
- Control of cardiac contractions using Cre-lox and degron strategies in zebrafish. (2024)
- In preprints: Shh signaling activity predicts cardiac laterality in Astyanax mexicanus populations. (2024)
All publications
Articles
- Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy (2025)
- A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish (2025)
- egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. (2024)
- Control of cardiac contractions using Cre-lox and degron strategies in zebrafish. (2024)
- In preprints: Shh signaling activity predicts cardiac laterality in Astyanax mexicanus populations. (2024)
- flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response (2024)
- Pathway to Independence: the future of developmental biology. (2023)
- Pathway to independence - an interview with Thomas Juan (2023)
- Multiple pkd and piezo gene family members are required for atrioventricular valve formation. (2023)
- Parental mutations influence wild-type offspring via transcriptional adaptation. (2022)
- Biogenesis and function of ESCRT-dependent extracellular vesicles. (2018)
- Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. (2018)
- The ESCRT complex: from endosomal transport to the development of multicellular organisms. (2015)
- Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis. (2015)
