Thomas Juan
Associate senior lecturer/Assistant Professor at Department of Immunology, Genetics and Pathology; Research programme: Vascular Biology; Research group Thomas Juan
- E-mail:
- thomas.juan@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
- ORCID:
- 0000-0002-9654-3717
Short presentation
My research focuses on cardiovascular disease, the leading cause of death worldwide. Specifically, how blood flow forces, sensed by endothelial cells, shape cardiovascular development and function. Using zebrafish as a model organism, my work integrates genetic tools, high-resolution live imaging, single-cell omics, and technology optimization. Overall, I aim to unravel key processes essential for cardiovascular function and develop tools with broad research and therapeutic applications.
Keywords
- zebrafish
- developmental genetics
- genome editing
- mechanobiology
- cardiovascular diseases
Research
My laboratory aims to understand how blood flow forces shape the development and function of the cardiovascular system. We generate genetic tools to control cardiac contractions and modulate the function of mechanosensor proteins in cardiovascular subpopulations.

Publications
Recent publications
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Time-resolved single-cell transcriptomics maps zebrafish heart development
Part of Cell Reports, 2026
- DOI for Time-resolved single-cell transcriptomics maps zebrafish heart development
- Download full text (pdf) of Time-resolved single-cell transcriptomics maps zebrafish heart development
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Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Part of Science Advances, 2026
- DOI for Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
- Download full text (pdf) of Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
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Induction of a transcriptional adaptation response by RNA destabilization events
Part of EMBO Reports, p. 2262-2279, 2025
- DOI for Induction of a transcriptional adaptation response by RNA destabilization events
- Download full text (pdf) of Induction of a transcriptional adaptation response by RNA destabilization events
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Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Part of Nature, p. 493-502, 2025
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A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
Part of PLOS Genetics, 2025
All publications
Articles in journal
-
Time-resolved single-cell transcriptomics maps zebrafish heart development
Part of Cell Reports, 2026
- DOI for Time-resolved single-cell transcriptomics maps zebrafish heart development
- Download full text (pdf) of Time-resolved single-cell transcriptomics maps zebrafish heart development
-
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Part of Science Advances, 2026
- DOI for Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
- Download full text (pdf) of Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
-
Induction of a transcriptional adaptation response by RNA destabilization events
Part of EMBO Reports, p. 2262-2279, 2025
- DOI for Induction of a transcriptional adaptation response by RNA destabilization events
- Download full text (pdf) of Induction of a transcriptional adaptation response by RNA destabilization events
-
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Part of Nature, p. 493-502, 2025
-
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
Part of PLOS Genetics, 2025
-
egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis
Part of Science Advances, 2024
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Part of Development, 2024
- DOI for flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
- Download full text (pdf) of flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
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Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.
Part of Proceedings of the National Academy of Sciences of the United States of America, 2024
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In preprints: Shh signaling activity predicts cardiac laterality in Astyanax mexicanus populations.
Part of Development, 2024
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Pathway to Independence: the future of developmental biology.
Part of Development, 2023
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Multiple pkd and piezo gene family members are required for atrioventricular valve formation.
Part of Nature Communications, p. 214, 2023
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Pathway to independence - an interview with Thomas Juan
Part of Development, 2023
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Parental mutations influence wild-type offspring via transcriptional adaptation.
Part of Science Advances, 2022
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Biogenesis and function of ESCRT-dependent extracellular vesicles.
Part of Seminars in Cell and Developmental Biology, p. 66-77, 2018
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Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.
Part of Nature Communications, p. 1942, 2018
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Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis.
Part of Cell Reports, p. 546-560, 2015
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The ESCRT complex: from endosomal transport to the development of multicellular organisms.
Part of Biologie aujourd'hui, p. 111-24, 2015