Olof Idevall

Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function

Incedal Nilsson, Ceren; Dumral, Özge; Sanchez, Gonzalo; Xie, Beichen et al.

Part of EMBO Journal, 2025

• DOI for Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function
• Download full text (pdf) of Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Part of Cell Reports, 2024

• DOI for OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Download full text (pdf) of OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

“Blue Light, Camera, Action!”

O'Callaghan, Paul; Idevall Hagren, Olof

Part of ACS Central Science, p. 514-516, 2024

• DOI for “Blue Light, Camera, Action!”

Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Schubert, Erik; Mun, Kwangchol; Larsson, Mårten; Panagiotou, Styliani et al.

Part of Journal of Virology, 2024

• DOI for Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Keeping pace: the primary cilium as the conducting baton of the islet

Idevall Hagren, Olof; Incedal Nilsson, Ceren; Sanchez, Gonzalo

Part of Diabetologia, p. 773-782, 2024

• DOI for Keeping pace: the primary cilium as the conducting baton of the islet
• Download full text (pdf) of Keeping pace: the primary cilium as the conducting baton of the islet

Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function

Incedal Nilsson, Ceren; Dumral, Özge; Sanchez, Gonzalo; Xie, Beichen et al.

Part of EMBO Journal, 2025

• DOI for Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function
• Download full text (pdf) of Somatostatin triggers local cAMP and Ca²⁺ signaling in primary cilia to modulate pancreatic β-cell function

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Part of Cell Reports, 2024

• DOI for OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Download full text (pdf) of OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

“Blue Light, Camera, Action!”

O'Callaghan, Paul; Idevall Hagren, Olof

Part of ACS Central Science, p. 514-516, 2024

• DOI for “Blue Light, Camera, Action!”

Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Schubert, Erik; Mun, Kwangchol; Larsson, Mårten; Panagiotou, Styliani et al.

Part of Journal of Virology, 2024

• DOI for Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Part of Journal of Cell Biology, 2023

• DOI for The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
• Download full text (pdf) of The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Part of Cellular Signalling, 2023

• DOI for Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
• Download full text (pdf) of Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Part of Frontiers in Endocrinology, 2023

• DOI for Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
• Download full text (pdf) of Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis

Xie, Beichen; Panagiotou, Styliani; Cen, Jing; Gilon, Patrick et al.

Part of Journal of Cell Science, 2022

• DOI for The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis
• Download full text (pdf) of The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis

Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

O'Callaghan, Paul; Engberg, Adam; Eriksson, Olle; Fatsis-Kavalopoulos, Nikos et al.

Part of Journal of Cell Science, 2022

• DOI for Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
• Download full text (pdf) of Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Mousavy Gharavy, S. Neda; Owen, Bryn M.; Millership, Steven J.; Chabosseau, Pauline et al.

Part of Diabetologia, p. 850-864, 2021

• DOI for Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
• Download full text (pdf) of Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Dual Function of PI(4,5)P₂ in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes

Li, Hanbing; Shentu, Ping; Xiao, Mei; Zhao, Xuqin et al.

Part of Journal of Molecular Biology, p. 4341-4357, 2020

• DOI for Dual Function of PI(4,5)P₂ in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes

The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Nguyen, Phuoc My; Gandasi, Nikhil; Xie, Beichen; Sugahara, Sari et al.

Part of Journal of Cell Biology, p. 3714-3729, 2019

• DOI for The PI(4)P phosphatase Sac2 controls insulin granule docking and release
• Download full text (pdf) of The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Feedback regulation of insulin secretion by extended synaptotagmin-1

Xie, Beichen; Nguyen, Phuoc My; Idevall-Hagren, Olof

Part of The FASEB Journal, p. 4716-4728, 2019

• DOI for Feedback regulation of insulin secretion by extended synaptotagmin-1

Cortical mitochondria regulate insulin secretion by local Ca2+ buffering in rodent beta cells

Griesche, Nadine; Sanchez, Gonzalo; Hermans, Cedric; Idevall Hagren, Olof

Part of Journal of Cell Science, 2019

• DOI for Cortical mitochondria regulate insulin secretion by local Ca2+ buffering in rodent beta cells

Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Fatsis-Kavalopoulos, Nikos; O'Callaghan, Paul; Xie, Beichen; Hernández Vera, Rodrigo et al.

Part of Lab on a Chip, p. 1071-1081, 2019

• DOI for Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution
• Download full text (pdf) of Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities

Qi, Yuankai; Chen, Junye; Liu, Xuechun; Zhou, Xiaoxu et al.

Part of ENGINEERING, p. 745-747, 2018

• DOI for Development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities
• Download full text (pdf) of Development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities

The lipid phosphatase INPP5F regulates insulin secretion

Nguyen, Phuoc My; Gandasi, Nikhil R; Idevall-Hagren, Olof

Part of Diabetologia, 2018

A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, 2018

Extended synaptotagmin-1 controls insulin secretion through diacylglycerol transport at ER-PM contact sites

Xie, Beichen; Idevall-Hagren, Olof

Part of Diabetologia, 2018

Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Xie, Beichen; Nguyen, Phuoc My; Gucek, Alenka; Thonig, Antje et al.

Part of CELL CHEMICAL BIOLOGY, p. 816-826, 2016

• DOI for Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Plasma membrane PI(4,5)P-2 is required for normal glucose-stimulated insulin secretion

Xie, Beichen; Nguyen, Phuoc My; Thonig, Antje; Idevall-Hagren, Olof

Part of Diabetologia, 2016

Plasma membrane PI(4,5)P-2 controls Ca2+-influx in clonal beta cells

Nguyen, Phuoc My; Xie, Beichen; Idevall-Hagren, Olof

Part of Diabetologia, 2016

Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

Idevall Hagren, Olof; Lue, Alice; Xie, Beichen; De Camilli, Pietro

Part of EMBO Journal, p. 2291-2305, 2015

• DOI for Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering

Optogenetic Manipulation of Phosphoinositides

Idevall-Hagren, Olof

Part of The FASEB Journal, 2015

Ca2+-dependent expansion of cortical ER in insulin-secreting beta cells

Xie, Beichen; Idevall-Hagren, Olof

Part of Diabetologia, 2015

Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Idevall-Hagren, Olof; Jakobsson, Ida; Xu, Yunjian; Tengholm, Anders

Part of Science Signaling, 2013

• DOI for Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of The FASEB Journal, p. 1610-1620, 2013

• DOI for P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Part of Diabetologia, p. 1327-1338, 2013

• DOI for Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
• Download full text (pdf) of Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 23005-23016, 2010

• DOI for cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Hafizi, Sassan; Gustafsson, Anna; Oslakovic, Cecilia; Idevall-Hagren, Olof et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 396-401, 2010

• DOI for Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Zeller, Kathrin S.; Idevall Hagren, Olof; Stefansson, Anne; Velling, Teet et al.

Part of Cellular Signalling, p. 1838-1848, 2010

• DOI for PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Dyachok, Oleg; Idevall-Hagren, Olof; Sågetorp, Jenny; Tian, Geng et al.

Part of Cell Metabolism, p. 26-37, 2008

• DOI for Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
• Download full text (pdf) of Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Keeping pace: the primary cilium as the conducting baton of the islet

Idevall Hagren, Olof; Incedal Nilsson, Ceren; Sanchez, Gonzalo

Part of Diabetologia, p. 773-782, 2024

• DOI for Keeping pace: the primary cilium as the conducting baton of the islet
• Download full text (pdf) of Keeping pace: the primary cilium as the conducting baton of the islet

Insulin granule biogenesis and exocytosis

Omar-Hmeadi, Muhmmad; Idevall Hagren, Olof

Part of Cellular and Molecular Life Sciences (CMLS), p. 1957-1970, 2021

• DOI for Insulin granule biogenesis and exocytosis
• Download full text (pdf) of Insulin granule biogenesis and exocytosis

Metabolic regulation of calcium signaling in beta cells

Idevall Hagren, Olof; Tengholm, Anders

Part of Seminars in Cell and Developmental Biology, p. 20-30, 2020

• DOI for Metabolic regulation of calcium signaling in beta cells

Detection and manipulation of phosphoinositides

Idevall-Hagren, Olof; De Camilli, Pietro

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 736-745, 2015

• DOI for Detection and manipulation of phosphoinositides

Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Tengholm, Anders; Idevall-Hagren, Olof

Part of Vitamines and Hormones, p. 287-311, 2009

• DOI for Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Dyachok, Oleg; Xu, Yunjian; Idevall, Olof; Tengholm, Anders

Part of cAMP Signaling, p. 319-338, Humana Press, 2022

• DOI for Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Tengholm, Anders; Idevall-Hagren, Olof

Part of cAMP Signaling, p. 85-101, Springer-Verlag New York, 2015

• DOI for Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters
• Download full text (pdf) of Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Imaging phosphoinositide dynamics in living cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of Inositol Phosphates and Lipids, p. 219-235, Humana Press, 2010

• DOI for Imaging phosphoinositide dynamics in living cells
• Download full text (pdf) of Imaging phosphoinositide dynamics in living cells

Oscillatory Signaling and Insulin Secretion from Single ß-cells

Idevall Hagren, Olof

2010

• Download full text (pdf) of Oscillatory Signaling and Insulin Secretion from Single ß-cells

Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of Minutes Of The 46th General Assembly Of The European Association For The Study Of Diabetes, 2011

• DOI for Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

cGMP signaling in the primary cilium of islet cells

Incedal Nilsson, Ceren; Dumral, Özge; Idevall-Hagren, Olof