Gustaf Christoffersson

The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes

Christoffersson, Gustaf; Muntjewerff, Elke M.

Part of Frontiers in Clinical Diabetes and Healthcare, 2026

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Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity

Muntjewerff, Elke M.; Josyula, Vijay Sai; Lehmair, Franziska; Christoffersson, Gustaf

Part of Frontiers in Immunology, 2025

• DOI for Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity
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Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Muntjewerff, Elke M.; Epremidze, Dali; Nezhyva, Mariya; Kal, Satadeepa et al.

Part of Communications Biology, 2025

• DOI for Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
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Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support

Amoedo-Leite, Catarina; Parv, Kristel; Testini, Chiara; Herrera-Hidalgo, Carmen et al.

Part of Nature Cardiovascular Research, p. 685-700, 2024

• DOI for Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support
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Microgravity Effect on Pancreatic Islets

Zeger, Lukas; Barasa, Povilas; Han, Yilin; Hellgren, Josefin et al.

Part of Cells, 2024

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Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling

Muntjewerff, Elke M.; Epremidze, Dali; Nezhyva, Mariya; Kal, Satadeepa et al.

Part of Communications Biology, 2025

• DOI for Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
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Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support

Amoedo-Leite, Catarina; Parv, Kristel; Testini, Chiara; Herrera-Hidalgo, Carmen et al.

Part of Nature Cardiovascular Research, p. 685-700, 2024

• DOI for Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support
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Microgravity Effect on Pancreatic Islets

Zeger, Lukas; Barasa, Povilas; Han, Yilin; Hellgren, Josefin et al.

Part of Cells, 2024

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Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes

Vyakaranam, Achyut Ram; Mahamed, Maryama M.; Hellman, Per; Eriksson, Olof et al.

Part of Diabetologia, p. 199-208, 2024

• DOI for Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
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Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds

Trolle, Carl; Han, Yilin; Jagalur Mutt, Shivaprakash; Christoffersson, Gustaf et al.

Part of Neuroscience Letters, 2024

• DOI for Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Footprints of immune cells in the type 1 diabetic pancreas, volume II

Christoffersson, Gustaf; Fousteri, Georgia

Part of Frontiers in Endocrinology, 2024

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Three-dimensional Co-culture Model for Live Imaging of Pancreatic Islets, Immune Cells, and Neurons in Agarose Gel

Muntjewerff, Elke M.; Josyula, Vijay S.; Christoffersson, Gustaf

Part of Bio-protocol, 2023

• DOI for Three-dimensional Co-culture Model for Live Imaging of Pancreatic Islets, Immune Cells, and Neurons in Agarose Gel
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Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology

Lauren, Ida; Havervall, Sebastian; Ng, Henry; Lord, Martin et al.

Part of Immunity, Inflammation and Disease, 2022

• DOI for Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
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The anti-inflammatory peptide Catestatin blocks chemotaxis

Muntjewerff, Elke M.; Parv, Kristel; Mahata, Sushil K.; van Riessen, N. Koen et al.

Part of Journal of Leukocyte Biology, p. 273-278, 2022

• DOI for The anti-inflammatory peptide Catestatin blocks chemotaxis
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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

Muntjewerff, Elke M.; Tang, Kechun; Lutter, Lisanne; Christoffersson, Gustaf et al.

Part of Acta Physiologica, 2021

• DOI for Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas

Parv, Kristel; Westerlund, Nestori; Merchant, Kevin; Komijani, Milad et al.

Part of Frontiers in Endocrinology, 2021

• DOI for Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas
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The effect of Toll-like receptor stimulation on the motility of regulatory T cells

Chodaczek, Grzegorz; Pagni, Philippe P; Christoffersson, Gustaf; Ratliff, Sowbarnika S et al.

Part of Journal of Autoimmunity, 2021

• DOI for The effect of Toll-like receptor stimulation on the motility of regulatory T cells

Perivascular macrophages regulate blood flow following tissue damage

Vågesjö, Evelina; Parv, Kristel; Ahl, David; Seignez, Cedric et al.

Part of Circulation Research, p. 1694-1707, 2021

• DOI for Perivascular macrophages regulate blood flow following tissue damage

An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses

Mangsbo, Sara; Havervall, Sebastian; Laurén, Ida; Lindsay, Robin et al.

Part of PLOS ONE, 2021

• DOI for An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses
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Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice

Christoffersson, Gustaf; Ratliff, Sowbarnika S.; von Herrath, Matthias G.

Part of Science Advances, 2020

• DOI for Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice

Turning Up the Heat: Local Temperature Control During in vivo Imaging of Immune Cells

Ahl, David; Eriksson, Olle; Sedin, John; Seignez, Cedric et al.

Part of Frontiers in Immunology, 2019

• DOI for Turning Up the Heat: Local Temperature Control During in vivo Imaging of Immune Cells
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Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets

Grapensparr, Liza; Christoffersson, Gustaf; Carlsson, Per-Ola

Part of Cell Transplantation, p. 948-956, 2018

• DOI for Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets
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Perivascular macrophages regulate blood flow following tissue damage

Vågesjö, Evelina; Seignez, Cedric; Christoffersson, Gustaf; Herrera Hidalgo, Carmen et al.

Part of European Journal of Clinical Investigation, p. 44-45, 2018

• DOI for Perivascular macrophages regulate blood flow following tissue damage

Elucidating the dynamics and role of peri-vascular macrophages

Parv, Kristel; Christoffersson, Gustaf; Herrera Hidalgo, Carmen; Seignez, Cedric et al.

Part of European Journal of Clinical Investigation, p. 82-83, 2018

• DOI for Elucidating the dynamics and role of peri-vascular macrophages

Vascular sprouts induce local attraction of proangiogenic neutrophils

Christoffersson, Gustaf; Lomei, Jalal; O'Callaghan, Paul; Kreuger, Johan et al.

Part of Journal of Leukocyte Biology, p. 741-751, 2017

• DOI for Vascular sprouts induce local attraction of proangiogenic neutrophils

Rapid Restoration of Vascularity and Oxygenation in Mouse and Human Islets Transplanted to Omentum May Contribute to Their Superior Function Compared to Intraportally Transplanted Islets

Espes, Daniel; Lau, J.; Quach, My; Ullsten, Sara et al.

Part of American Journal of Transplantation, p. 3246-3254, 2016

• DOI for Rapid Restoration of Vascularity and Oxygenation in Mouse and Human Islets Transplanted to Omentum May Contribute to Their Superior Function Compared to Intraportally Transplanted Islets

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

Massena, Sara; Christoffersson, Gustaf; Vågesjö, Evelina; Seignez, Cédric et al.

Part of Blood, p. 2016-2026, 2015

• DOI for Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

Part of Cell Transplantation, p. 263-276, 2015

• DOI for Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle

Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

Part of Cell Transplantation, p. 263-276, 2015

• DOI for Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle

Matrix Metalloproteinase-9 Is Essential for Physiological Beta Cell Function and Islet Vascularization in Adult Mice

Christoffersson, Gustaf; Waldén, Tomas; Sandberg, Monica; Opdenakker, Ghislain et al.

Part of American Journal of Pathology, p. 1094-1103, 2015

• DOI for Matrix Metalloproteinase-9 Is Essential for Physiological Beta Cell Function and Islet Vascularization in Adult Mice

Strategical steering of the immune system: induction of leukocyte vascular chaperoning increases functional blood flow responses in ischemic muscle

Vågesjö, Evelina; Christoffersson, Gustaf; Korsgren, Olle; Essand, Magnus et al.

Part of The FASEB Journal, 2014

Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils

Christoffersson, Gustaf; Vågesjö, Evelina; Pettersson, Ulrika S.; Massena, Sara et al.

Part of Brain, behavior, and immunity, p. 162-172, 2014

• DOI for Acute sleep deprivation in healthy young men: Impact on population diversity and function of circulating neutrophils

Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Benedict, Christian; Cedernaes, Jonathan; Giedraitis, Vilmantas; Nilsson, Emil K et al.

Part of Sleep, p. 195-198, 2014

• DOI for Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Part of Cellular Signalling, p. 85-92, 2013

• DOI for Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
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A distinct subset of proangiogenic CD11b(+)/Gr-1(+)/CXCR4(+)/MMP-9(hi) neutrophils are recruited by VEGF-A to transplanted hypoxic tissue

Christoffersson, Gustaf; Vågesjö, Evalina; Giraud, Antoine; Massena, Sara et al.

Part of European Journal of Clinical Investigation, p. 9-9, 2013

Strategic recruitment of proangiogenic leukocytes to the ischemic hindlimb increases functional tissue perfusion

Vågesjö, Evalina; Christoffersson, Gustaf; Korsgren, Olle; Essand, Magnus et al.

Part of European Journal of Clinical Investigation, p. 27-27, 2013

The mechanisms of VEGF-A-induced recruitment of pro-angiogenic neutrophils

Massena, Sara; Christoffersson, Gustaf; Vågesjö, Evelina; Gustafsson, Karin et al.

Part of European Journal of Clinical Investigation, p. 27-27, 2013

Restored Vascular Density and Blood Fow in Mouse and Human Islets Experimentally Transplanted to The Greater Omentum

Espes, Daniel; Lau, Joey; Christoffersson, Gustaf; Quach, My et al.

Part of Transplantation, 2013

Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice

Drott, Carl Johan; Olerud, Johan; Emanuelsson, Hanna; Christoffersson, Gustav et al.

Part of PLOS ONE, 2012

• DOI for Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice
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VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

Christoffersson, Gustaf; Vågesjö, Evelina; Vandooren, Jennifer; Liden, Majken et al.

Part of Blood, p. 4653-4662, 2012

• DOI for VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency

Christoffersson, Gustav; Zang, Guangxiang; Zhuang, Zhen W.; Vågesjö, Evelina et al.

Part of Angiogenesis, p. 469-480, 2012

• DOI for Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency
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Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes

Pettersson, Ulrika Sofia; Christoffersson, Gustaf; Massena, Sara; Ahl, David et al.

Part of PLOS ONE, 2011

• DOI for Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes

Intramuscular islet transplantation promotes restored islet vascularity

Christoffersson, Gustaf; Carlsson, Per-Ola; Phillipson, Mia

Part of Islets, p. 69-71, 2011

• DOI for Intramuscular islet transplantation promotes restored islet vascularity

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to that in Native Islets

Christoffersson, Gustaf; Henriksnäs, Johanna; Johansson, Lars; Rolny, Charlotte et al.

Part of Diabetes, p. 2569-2578, 2010

• DOI for Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to that in Native Islets

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

Massena, Sara; Christoffersson, Gustaf; Hjertström, Elina; Zcharia, Eyal et al.

Part of Blood, p. 1924-1931, 2010

• DOI for A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

Altered leukocyte recruitment during inflammation in type 1 and type 2 diabetes models

Pettersson, Ulrika; Santos, S. M.; Christoffersson, Gustaf; Jansson, Leif et al.

Part of Diabetologia, 2010

• DOI for Altered leukocyte recruitment during inflammation in type 1 and type 2 diabetes models

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

Petersson, Joel; Carlström, Mattias; Schreiber, Olof; Phillipson, Mia et al.

Part of Free Radical Biology & Medicine, p. 1068-1075, 2009

• DOI for Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes

Christoffersson, Gustaf; Muntjewerff, Elke M.

Part of Frontiers in Clinical Diabetes and Healthcare, 2026

• DOI for The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes
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Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity

Muntjewerff, Elke M.; Josyula, Vijay Sai; Lehmair, Franziska; Christoffersson, Gustaf

Part of Frontiers in Immunology, 2025

• DOI for Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity
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Putative regulation of macrophage-mediated inflammation by catestatin

Muntjewerff, Elke M.; Christoffersson, Gustaf; Mahata, Sushil K.; van den Bogaart, Geert

Part of Trends in immunology, p. 41-50, 2022

• DOI for Putative regulation of macrophage-mediated inflammation by catestatin

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Rodriguez-Calvo, Teresa; Christoffersson, Gustaf; Bender, Christine; von Herrath, Matthias G. et al.

Part of Frontiers in Immunology, 2021

• DOI for Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
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Regulatory Immune Mechanisms beyond Regulatory T Cells

Christoffersson, Gustaf; von Herrath, Matthias

Part of Trends in immunology, p. 482-491, 2019

• DOI for Regulatory Immune Mechanisms beyond Regulatory T Cells

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

von Herrath, Matthias; Pagni, Philippe P.; Grove, Kevin; Christoffersson, Gustaf et al.

Part of Cell Metabolism, p. 795-802, 2019

• DOI for Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

The neutrophil: one cell on many missions or many cells with different agendas?

Christoffersson, Gustaf; Phillipson, Mia

Part of Cell and Tissue Research, p. 415-423, 2018

• DOI for The neutrophil: one cell on many missions or many cells with different agendas?

Leukocytes in Angiogenesis: Learning from Transplanted Pancreatic Islets

Christoffersson, Gustaf

2013

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Pro-angiogenic neutrophils are potentiated by hypoxia

Lomei, Jalal; Christoffersson, Gustaf; Phillipson, Mia

Characterization of pro-angiogenic neutrophils

Lomei, Jalal; Seignez, Cedric; Giraud, Antoine; Herrera Hidalgo, Carmen et al.

Uncovering a new role for immune cells: macrophages assist in regulation of blood flow in ischemic muscle

Vågesjö, Evelina; Seignez, Cedric; Christoffersson, Gustaf; Korsgren, Olle et al.

Transcriptomic analysis of pancreatic islet immune cells in NOD micereveals a set of resident nerve-associated macrophages

Josyula, Vijay Sai; Kinsella, Cormac M.; Christoffersson, Gustaf

Loss of the chemokine receptor CX3CR1 affects pancreatic islet innervation and neuro-immune interactions

Josyula, Vijay Sai; Merchant, Kevin; Reiche, Myrthe E.; Bootsma, Marleen et al.

Imaging CX3CR1-dependent macrophage behavior in live pancreas slicesfrom a mouse model of type 1 diabetes

Josyula, Vijay Sai; Christoffersson, Gustaf

Tissue ischemia induces mobilization of pro-angiogenic neutrophils from the spleen.

Amoedo-Leite, Catarina; Parv, Kristel; Seignez, Cedric; Seidler, Anna et al.