Helena Nordström

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Part of iScience, 2024

• DOI for Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
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Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Wegrzyniak, Olivia; Zhang, Bo; Rokka, Johanna; Rosestedt, Maria et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2023

• DOI for Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of NATURE CANCER, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Part of Protein Science, p. 991-1003, 2020

• DOI for Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
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The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

Part of MedChemComm, p. 432-442, 2013

• DOI for The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Wegrzyniak, Olivia; Lechi, Francesco; Mitran, Bogdan; Cheung, Pierre et al.

Part of iScience, 2024

• DOI for Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule
• Download full text (pdf) of Non-invasive PET imaging of liver fibrogenesis using a RESCA-conjugated Affibody molecule

Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Wegrzyniak, Olivia; Zhang, Bo; Rokka, Johanna; Rosestedt, Maria et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2023

• DOI for Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β
• Download full text (pdf) of Imaging of fibrogenesis in the liver by [¹⁸F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of NATURE CANCER, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
• Download full text (pdf) of Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

Part of Protein Science, p. 991-1003, 2020

• DOI for Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery
• Download full text (pdf) of Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

Part of MedChemComm, p. 432-442, 2013

• DOI for The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

Part of Journal of Biomolecular Screening, p. 15-25, 2011

• DOI for Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Lundquist, Anna; Hansen, Søren B; Nordström, Helena; Danielson, U Helena et al.

Part of Analytical Biochemistry, p. 153-159, 2010

• DOI for Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Elinder, Malin; Nordström, Helena; Geitmann, Matthis; Hämäläinen, Markku et al.

Part of Journal of Biomolecular Screening, p. 395-403, 2009

• DOI for Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Nordström, Helena; Gossas, Thomas; Hämäläinen, Markku; Källblad, Per et al.

Part of Journal of Medicinal Chemistry, p. 3449-3459, 2008

• DOI for Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

Nordström, Helena

2013

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From Temperature Dependence of Drug-Target Interactions to Thermodynamics and HIV Drug Resistance

Nordström, Helena; Lindgren, Maria; Önell, Annica; Shuman, Cynthia et al.

Characterization of fragment hits interacting with MMP-12 reveals a dimerised adduct of a fragment hit in the active site

Nordström, Helena; Derbyshire, Dean; Gossas, Thomas; Danielson, Helena