Maria Karlgren

Animal product–free formation and cultivation of three-dimensional primary hepatocyte spheroids

Mickols, Evgeniya; Mohammedamin, Rejeen; Primpas, Lazaros; Oredsson, Stina et al.

Part of Drug Metabolism And Disposition, 2025

• DOI for Animal product–free formation and cultivation of three-dimensional primary hepatocyte spheroids
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Rahman Ansari, Shaquib; Suárez-López, Yael del Carmen; Thersleff, Thomas; Häggström, Lennart et al.

Part of ACS Nano, p. 15284-15302, 2024

• DOI for Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia
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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021

• DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
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Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria et al.

Part of ACS Chemical Neuroscience, p. 1811-1823, 2021

• DOI for Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain
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Animal product–free formation and cultivation of three-dimensional primary hepatocyte spheroids

Mickols, Evgeniya; Mohammedamin, Rejeen; Primpas, Lazaros; Oredsson, Stina et al.

Part of Drug Metabolism And Disposition, 2025

• DOI for Animal product–free formation and cultivation of three-dimensional primary hepatocyte spheroids
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Part of Scientific Reports, 2024

• DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
• Download full text (pdf) of OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Rahman Ansari, Shaquib; Suárez-López, Yael del Carmen; Thersleff, Thomas; Häggström, Lennart et al.

Part of ACS Nano, p. 15284-15302, 2024

• DOI for Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia
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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021

• DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
• Download full text (pdf) of Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria et al.

Part of ACS Chemical Neuroscience, p. 1811-1823, 2021

• DOI for Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain
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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Part of Pharmaceutics, 2020

• DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

Part of Molecular Pharmaceutics, p. 4636-4650, 2019

• DOI for The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018

• DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability

Vallianatou, Theodosia; Strittmatter, Nicole; Nilsson, Anna; Shariatgorji, Mohammadreza et al.

Part of NeuroImage, p. 808-816, 2018

• DOI for A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Part of Scientific Reports, p. 1-12, 2017

• DOI for Intracellular drug bioavailability: a new predictor of system dependent drug disposition
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A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren, Maria; Simoff, Ivailo; Backlund, Maria; Wegler, Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 2909-2913, 2017

• DOI for A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Pellegrini, Paola; Dyczynski, Matheus; Sbrana, Francesca Vittoria; Karlgren, Maria et al.

Part of Oncotarget, p. 35703-35723, 2016

• DOI for Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016

• DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 147-147, 2016

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug metabolism reviews (Softcover ed.), p. 56-57, 2016

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 96-96, 2016

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug Metabolism And Disposition, p. 505-516, 2016

• DOI for Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Part of Journal of Proteome Research, p. 3305-3314, 2015

• DOI for Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Part of Drug Metabolism And Disposition, p. 1210-1218, 2014

• DOI for Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Part of Molecular Pharmaceutics, p. 4252-4262, 2013

• DOI for Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Part of Molecular Pharmaceutics, p. 3152-3163, 2013

• DOI for An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012

• DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012

• DOI for Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010

The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer: a pilot study.

Edler, David; Stenstedt, Kristina; Ohrling, Katarina; Hallström, Marja et al.

Part of European Journal of Cancer, p. 705-712, 2009

• DOI for The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer: a pilot study.

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Part of Drug Metabolism And Disposition, p. 1776-1786, 2018

• DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment

Rodriguez-Antona, Cristina; Gomez, Alvin; Karlgren, Maria; Sim, Sarah C et al.

Part of Human Genetics, p. 1-17, 2010

• DOI for Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment

How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

Karlgren, Maria; Bergström, Christel

Part of New Horizons in Predictive Drug Metabolism and Pharmacokinetics, p. 1-26, Royal Society of Chemistry, 2016

• DOI for How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

In vitro characterization of interactions with drug transporting proteins

Artursson, Per; Matsson, Pär; Karlgren, Maria

Part of Transporters in Drug Development , p. 37-65, Springer, 2013

• DOI for In vitro characterization of interactions with drug transporting proteins

Imaging age-induced perturbations of mitochondrial function, neurotransmission and lipid signaling in specific brain regions

Vallianatou, Theodosia; Shariatgorji, Mohammadreza; Nilsson, Anna; Karlgren, Maria et al.

Improved prediction of orally administered budesonide by including the mucus as an absorption barrier

Tjakra, Marco; Alkakaei, Moamin; Karlgren, Maria; Kesisoglou, Filippos et al.