Joakim Näsvall

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Part of Molecular biology and evolution, p. 2918-2930, 2020

• DOI for Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
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Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Part of Frontiers in Microbiology, 2020

• DOI for Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
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Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa M; Lundin, Erik et al.

Part of Frontiers in Microbiology, 2018

• DOI for Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica
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Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Lundin, Erik; Tang, Po-Cheng; Guy, Lionel; Näsvall, Joakim et al.

Part of Molecular biology and evolution, p. 704-718, 2018

• DOI for Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
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Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Näsvall, Joakim

Part of PLOS ONE, 2017

• DOI for Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes
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Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Näsvall, Joakim; Knöppel, Anna; Andersson, Dan I.

Part of Nucleic Acids Research, 2017

• DOI for Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria
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Evolution of New Functions De Novo and from Preexisting Genes

Andersson, Dan I.; Jerlström-Hultqvist, Jon; Näsvall, Joakim

Part of Cold Spring Harbor Perspectives in Biology, 2015

• DOI for Evolution of New Functions De Novo and from Preexisting Genes

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Näsvall, Joakim; Sun, Lei; Roth, John R.; Andersson, Dan I.

Part of Science, p. 384-387, 2012

• DOI for Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Activation of cryptic aminoglycoside resistance in Salmonella enterica

Koskiniemi, Sanna; Pränting, Maria; Gullberg, Erik; Näsvall, Joakim et al.

Part of Molecular Microbiology, p. 1464-1478, 2011

• DOI for Activation of cryptic aminoglycoside resistance in Salmonella enterica

Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Part of Molecular biology and evolution, p. 2918-2930, 2020

• DOI for Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
• Download full text (pdf) of Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Part of Frontiers in Microbiology, 2020

• DOI for Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
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Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I.

Part of Frontiers in Microbiology, 2020

• DOI for Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence
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Selection for novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Part of Evolution, p. 990-1000, 2019

• DOI for Selection for novel metabolic capabilities in Salmonella enterica
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Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Stern, Ana Laura; Van der Verren, Sander Egbert; Kanchugal Puttaswamy, Sandesh; Näsvall, Joakim et al.

Part of Journal of Biological Chemistry, p. 11481-11490, 2018

• DOI for Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
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Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Abdalaal, Hind; Pundir, Shreya; Ge, Xueliang; Sanyal, Suparna et al.

Part of Molecular biology and evolution, p. 2918-2930, 2020

• DOI for Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence
• Download full text (pdf) of Collateral toxicity limits the evolution of bacterial Release Factor 2 towards total omnipotence

Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Knöppel, Anna; Andersson, Dan I; Näsvall, Joakim

Part of Frontiers in Microbiology, 2020

• DOI for Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA
• Download full text (pdf) of Synonymous mutations in rpsT lead to ribosomal assembly defects that can be compensated by mutations in fis and rpoA

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I.

Part of Frontiers in Microbiology, 2020

• DOI for Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence
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Selection for novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Part of Evolution, p. 990-1000, 2019

• DOI for Selection for novel metabolic capabilities in Salmonella enterica
• Download full text (pdf) of Selection for novel metabolic capabilities in Salmonella enterica

Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Stern, Ana Laura; Van der Verren, Sander Egbert; Kanchugal Puttaswamy, Sandesh; Näsvall, Joakim et al.

Part of Journal of Biological Chemistry, p. 11481-11490, 2018

• DOI for Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
• Download full text (pdf) of Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica

Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa M; Lundin, Erik et al.

Part of Frontiers in Microbiology, 2018

• DOI for Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica
• Download full text (pdf) of Genetic adaptation to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Lundin, Erik; Tang, Po-Cheng; Guy, Lionel; Näsvall, Joakim et al.

Part of Molecular biology and evolution, p. 704-718, 2018

• DOI for Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
• Download full text (pdf) of Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Näsvall, Joakim

Part of PLOS ONE, 2017

• DOI for Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes
• Download full text (pdf) of Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes

Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Näsvall, Joakim; Knöppel, Anna; Andersson, Dan I.

Part of Nucleic Acids Research, 2017

• DOI for Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria
• Download full text (pdf) of Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria

Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes

Newton, Matilda S.; Guo, Xiaohu; Söderholm, Annika; Näsvall, Joakim et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 4727-4732, 2017

• DOI for Structural and functional innovations in the real-time evolution of new (βα)₈ barrel enzymes

Evolution of antibiotic resistance without antibiotic exposure

Knöppel, Anna; Näsvall, Joakim; Andersson, Dan I.

Part of Antimicrobial Agents and Chemotherapy, 2017

• DOI for Evolution of antibiotic resistance without antibiotic exposure
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Compensating the fitness costs of synonymous mutations

Knöppel, Anna; Näsvall, Joakim; Andersson, Dan I.

Part of Molecular biology and evolution, p. 1461-1477, 2016

• DOI for Compensating the fitness costs of synonymous mutations
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Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA

Söderholm, Annika; Guo, Xiaohu; Newton, Matilda S.; Evans, Gary B. et al.

Part of Journal of Biological Chemistry, p. 24657-24668, 2015

• DOI for Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound Structures Shed New Light on the Catalytic Cycle of HisA

Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase

Chen, Yang; Näsvall, Joakim; Wu, Shiying; Andersson, Dan I. et al.

Part of Acta Crystallographica Section D, p. 2267-2277, 2015

• DOI for Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
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Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria

Knöppel, Anna; Lind, Peter A.; Lustig, Ulrika; Näsvall, Joakim et al.

Part of Molecular biology and evolution, p. 1220-1227, 2014

• DOI for Minor Fitness Costs in an Experimental Model of Horizontal Gene Transfer in Bacteria

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Näsvall, Joakim; Sun, Lei; Roth, John R.; Andersson, Dan I.

Part of Science, p. 384-387, 2012

• DOI for Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Activation of cryptic aminoglycoside resistance in Salmonella enterica

Koskiniemi, Sanna; Pränting, Maria; Gullberg, Erik; Näsvall, Joakim et al.

Part of Molecular Microbiology, p. 1464-1478, 2011

• DOI for Activation of cryptic aminoglycoside resistance in Salmonella enterica

Evolution of New Functions De Novo and from Preexisting Genes

Andersson, Dan I.; Jerlström-Hultqvist, Jon; Näsvall, Joakim

Part of Cold Spring Harbor Perspectives in Biology, 2015

• DOI for Evolution of New Functions De Novo and from Preexisting Genes

Synonymous mutations that reduce S20 levels can be compensated by mutations in fis and rpoA 

Knöppel, Anna; Joakim, Näsvall; Andersson, Dan I

Genetic adaptations to growth under laboratory conditions in Escherichia coli and Salmonella enterica

Knöppel, Anna; Knopp, Michael; Albrecht, Lisa; Lundin, Erik et al.

Functional trade-offs during evolution of new functions in the HisA-TrpF system

Lundin, Erik; Näsvall, Joakim; Andersson, Dan I

Experimental evolution of novel metabolic capabilities in Salmonella enterica

Warsi, Omar M.; Lundin, Erik; Lustig, Ulrika; Näsvall, Joakim et al.

Ribosomal protein L1 is required for balanced formation of ribosomal subunits

Tobin, Christina; Nord, Stefan; Wikström, P. Mikael; Näsvall, Joakim et al.

Crystal structure of AadA at 2.5 Å resolution - an aminoglycoside 3" adenyltransferase

Chen, Yang; Näsvall, Joakim; Andersson, Dan I.; Selmer, Maria

Intermittent selection directs evolution of a specialist enzyme to become a generalist

Abdalaal, Hind; Näsvall, Joakim

Evolvability of orthologous genes

Abdalaal, Hind; Näsvall, Joakim