Di Yu
Researcher at Department of Immunology, Genetics and Pathology; Research programme: Cancer Immunotherapy; Research group Di Yu
- Mobile phone:
- +46 70 720 41 96
- E-mail:
- di.yu@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
Short presentation
Post Doc at Dept. Immunolgy, Genetics and Pathology
My research is focused on viruses-/T cell- based cancer therapy. Group leader: Magnus Essand

Publications
Selection of publications
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Part of PLOS ONE, 2013
- DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
- Download full text (pdf) of Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Part of Journal of Virology, p. 13114-13123, 2011
- DOI for Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
- Download full text (pdf) of Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
Recent publications
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Part of Molecular Cancer Therapeutics, p. 469-479, 2026
- DOI for Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
- Download full text (pdf) of Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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Part of Cancer Gene Therapy, p. 297-305, 2025
- DOI for Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
- Download full text (pdf) of Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Part of New England Journal of Medicine, p. 887-894, 2025
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Part of Cancer Immunology and Immunotherapy, 2025
- DOI for Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
- Download full text (pdf) of Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Part of Upsala Journal of Medical Sciences, 2025
- DOI for Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
- Download full text (pdf) of Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
All publications
Articles in journal
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Part of Molecular Cancer Therapeutics, p. 469-479, 2026
- DOI for Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
- Download full text (pdf) of Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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Part of Cancer Gene Therapy, p. 297-305, 2025
- DOI for Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
- Download full text (pdf) of Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Part of New England Journal of Medicine, p. 887-894, 2025
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Part of Cancer Immunology and Immunotherapy, 2025
- DOI for Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
- Download full text (pdf) of Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Part of Upsala Journal of Medical Sciences, 2025
- DOI for Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
- Download full text (pdf) of Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
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VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
Part of Nature Communications, 2024
- DOI for VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
- Download full text (pdf) of VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
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Part of Molecular Therapy Nucleic Acids, 2024
- DOI for Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
- Download full text (pdf) of Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
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Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis
Part of Advanced Functional Materials, 2024
- DOI for Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis
- Download full text (pdf) of Enhanced Cellular Uptake through Nanotopography-Induced Macropinocytosis
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
Part of Cancer Cell, p. 1134-1151, 2023
- DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
- Download full text (pdf) of Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Part of Frontiers in Immunology, 2023
- DOI for Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
- Download full text (pdf) of Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
Part of Nature, p. 1033-1040, 2023
- DOI for CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
- Download full text (pdf) of CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
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Complementarity-determining region clustering may cause CAR-T cell dysfunction
Part of Nature Communications, 2023
- DOI for Complementarity-determining region clustering may cause CAR-T cell dysfunction
- Download full text (pdf) of Complementarity-determining region clustering may cause CAR-T cell dysfunction
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A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
Part of Frontiers in Molecular Biosciences, 2022
- DOI for A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
- Download full text (pdf) of A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
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Part of Oncoimmunology, 2022
- DOI for Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
- Download full text (pdf) of Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
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Part of Acta Pharmacologica Sinica, p. 977-991, 2022
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Part of Nature Biomedical Engineering, p. 830-841, 2022
- DOI for CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
- Download full text (pdf) of CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
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Part of MOLECULAR THERAPY-ONCOLYTICS, p. 356-366, 2021
- DOI for Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
- Download full text (pdf) of Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
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Part of Nano Letters, p. 2224-2231, 2021
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Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19
Part of ACS Nano, p. 14347-14359, 2021
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Part of MOLECULAR THERAPY-ONCOLYTICS, p. 37-46, 2021
- DOI for IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
- Download full text (pdf) of IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
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Part of Cell Death and Disease, 2020
- DOI for Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
- Download full text (pdf) of Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
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Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis
Part of Molecules, 2018
- DOI for Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis
- Download full text (pdf) of Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis
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CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis
Part of Journal of Clinical Investigation, p. 3280-3297, 2018
- DOI for CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis
- Download full text (pdf) of CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis
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Part of Oncoimmunology, 2018
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Part of Oncoimmunology, 2018
- DOI for Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
- Download full text (pdf) of Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
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Part of Experimental dermatology, 2018
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Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth
Part of Proceedings of the National Academy of Sciences of the United States of America, 2018
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Part of Clinical Cancer Research, p. 1519-1530, 2017
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Part of Neuroendocrinology, p. 54-66, 2017
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Part of Molecular Cancer Therapeutics, p. 1705-1716, 2017
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Part of Scandinavian Journal of Immunology, p. 341-341, 2017
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Part of MOLECULAR THERAPY-ONCOLYTICS, p. 67-75, 2017
- DOI for Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity
- Download full text (pdf) of Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity
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Part of Molecular Therapy, p. 288-288, 2017
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Part of Virology, p. 44-50, 2016
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Part of PLOS ONE, 2016
- DOI for A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
- Download full text (pdf) of A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
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Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors
Part of Immunotherapy, p. 1355-1361, 2016
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Part of CANCER IMMUNOLOGY RESEARCH, 2016
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Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer
Part of CANCER IMMUNOLOGY RESEARCH, 2016
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Part of EMBO Molecular Medicine, p. 702-711, 2016
- DOI for Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
- Download full text (pdf) of Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
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Part of Science Signaling, 2015
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Part of Advanced Functional Materials, p. 3907-3915, 2015
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Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer
Part of Human Gene Therapy, 2014
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Part of Journal of immunotherapy (1997), p. 155-162, 2014
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Part of Journal of Immunology, p. 2287-2296, 2014
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Part of Molecular Therapy Methods & Clinical Development, 2014
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Part of Molecular Therapy, 2014
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Part of Molecular Therapy, 2014
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Part of Molecular Therapy, p. 2008-2018, 2013
- DOI for An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
- Download full text (pdf) of An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
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Part of PLOS ONE, 2013
- DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
- Download full text (pdf) of Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Part of Human Gene Therapy, p. 766-775, 2013
- DOI for Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy
- Download full text (pdf) of Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy
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Part of Gene Therapy, p. 1052-1062, 2011
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Part of Journal of Virology, p. 13114-13123, 2011
- DOI for Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
- Download full text (pdf) of Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
Comprehensive doctoral thesis
Manuscripts (preprints)
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Multiple viruses rely on the stress-induced protein ZC3H11A for efficient replication
2017
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Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma
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Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma
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Complementary-determining region clustering causes CAR-T cell dysfunction