Nikhil Gandasi

Repair of amyloid-β–induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion

Valappil, Deepak Kunhi; Veerabhadraswamy, Priyadarshini; Hegde, Prakhyath; Pandey, Shruthi et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2026

• DOI for Repair of amyloid-β–induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion
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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

Sharma, Preeti; Pallavi, Anuma; Chatterjee, Ananya; Prasad, Vidya Mangala et al.

Part of Autophagy, p. 3024-3038, 2025

• DOI for Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
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Dynamic recruitment of Munc13 primes docked secretory granules for exocytosis

Echeverry, Santiago; Saras, Jan; Lund, Per-Eric; Dunevall, Johan et al.

Part of Cell Reports, 2025

• DOI for Dynamic recruitment of Munc13 primes docked secretory granules for exocytosis
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Protocol for the detection of large dense-core vesicle exocytosis using an automated image-processing algorithm

Makam, Aishwarya; Ramadas, Vishnu; Tollan, Anly; Dubey, Ishan Abhimanyu et al.

Part of STAR Protocols, 2025

• DOI for Protocol for the detection of large dense-core vesicle exocytosis using an automated image-processing algorithm
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Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes

Pallavi, Anuma; Sinha, Neha; ArunKumar, Nagapriya K.; Kothegala, Lakshmi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2025

• DOI for Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes
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Repair of amyloid-β–induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion

Valappil, Deepak Kunhi; Veerabhadraswamy, Priyadarshini; Hegde, Prakhyath; Pandey, Shruthi et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2026

• DOI for Repair of amyloid-β–induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion
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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

Sharma, Preeti; Pallavi, Anuma; Chatterjee, Ananya; Prasad, Vidya Mangala et al.

Part of Autophagy, p. 3024-3038, 2025

• DOI for Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
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Dynamic recruitment of Munc13 primes docked secretory granules for exocytosis

Echeverry, Santiago; Saras, Jan; Lund, Per-Eric; Dunevall, Johan et al.

Part of Cell Reports, 2025

• DOI for Dynamic recruitment of Munc13 primes docked secretory granules for exocytosis
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Protocol for the detection of large dense-core vesicle exocytosis using an automated image-processing algorithm

Makam, Aishwarya; Ramadas, Vishnu; Tollan, Anly; Dubey, Ishan Abhimanyu et al.

Part of STAR Protocols, 2025

• DOI for Protocol for the detection of large dense-core vesicle exocytosis using an automated image-processing algorithm
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Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes

Pallavi, Anuma; Sinha, Neha; ArunKumar, Nagapriya K.; Kothegala, Lakshmi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2025

• DOI for Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes
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Role of the extracellular matrix in amylin aggregation: Opportunities for improved therapy in type 2 diabetes mellitus

Prabhakar, Sagarika; Veerabhadraswamy, Priyadarshini; Gandasi, Nikhil R.

Part of Journal of Biosciences, 2025

• DOI for Role of the extracellular matrix in amylin aggregation: Opportunities for improved therapy in type 2 diabetes mellitus

Single-Vesicle Microelectroanalysis Reveals the Role of PIP2 Phospholipid in Vesicle Opening Dynamics and Its Potential Role in Exocytosis

Makam, Aishwarya A.; Wahlund, Jonathan; Gandasi, Nikhil R.; Hatamie, Amir

Part of ACS Omega, p. 18889-18898, 2025

• DOI for Single-Vesicle Microelectroanalysis Reveals the Role of PIP2 Phospholipid in Vesicle Opening Dynamics and Its Potential Role in Exocytosis
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tPA-GFP is a reliable probe for detecting compound exocytosis in human pancreatic β-cells

Makam, Aishwarya A.; Sharma, Shruti; Nagle, Prajwal; Sundaram, Nandhini M. et al.

Part of FASEB BioAdvances, 2025

• DOI for tPA-GFP is a reliable probe for detecting compound exocytosis in human pancreatic β-cells
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Algorithm for semi-automatic detection of insulin granule exocytosis in human pancreatic β-cells

Makam, Aishwarya A.; Dubey, Abhimanyu; Maharana, Shovamayee; Gandasi, Nikhil

Part of Heliyon, 2024

• DOI for Algorithm for semi-automatic detection of insulin granule exocytosis in human pancreatic β-cells
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Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type-2 diabetes

Veerabhadraswamy, Priyadarshini; Lata, Kiran; Dey, Sristi; Belekar, Prajakta et al.

Part of JOURNAL OF EXTRACELLULAR BIOLOGY, 2024

• DOI for Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type-2 diabetes
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Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis

Paul, Saptadipa; Pallavi, Anuma; Gandasi, Nikhil R.

Part of Frontiers in Endocrinology, 2024

• DOI for Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis
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Pancreatic Islet Biobanking Facilities in India: The Need of the Hour to Deal with Diabetes?

Gandasi, Nikhil R.; Rangarajan, Annapoorni; Rao, Harshavardhan; Singh, Meetu et al.

Part of Journal of The Indian Institute of Science, p. 381-385, 2023

• DOI for Pancreatic Islet Biobanking Facilities in India: The Need of the Hour to Deal with Diabetes?
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Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes

Kothegala, Lakshmi; Miranda, Caroline; Singh, Meetu; Krieger, Jean-Philippe et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Part of Nature Communications, 2020

• DOI for Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
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In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2484-2495, 2020

• DOI for In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
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The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Nguyen, Phuoc My; Gandasi, Nikhil; Xie, Beichen; Sugahara, Sari et al.

Part of Journal of Cell Biology, p. 3714-3729, 2019

• DOI for The PI(4)P phosphatase Sac2 controls insulin granule docking and release
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Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Part of eLIFE, 2019

• DOI for Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
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Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Part of EBioMedicine, 2018

• DOI for Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Part of Traffic, p. 436-445, 2018

• DOI for PtdIns(4,5)P₂ is not required for secretory granule docking

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Part of Cell Metabolism, p. 470-478, 2018

• DOI for Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Part of Molecular Biology of the Cell, p. 2700-2708, 2018

• DOI for Syntaxin clusters at secretory granules in a munc18-bound conformation
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The lipid phosphatase INPP5F regulates insulin secretion

Nguyen, Phuoc My; Gandasi, Nikhil R; Idevall-Hagren, Olof

Part of Diabetologia, 2018

MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Salunkhe, Vishal A.; Ofori, Jones K.; Gandasi, Nikhil R; Salo, Sofia A. et al.

Part of Physiological Reports, 2017

• DOI for MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
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Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Part of Diabetes, p. 2610-2622, 2017

• DOI for Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Part of Molecular Biology of the Cell, p. 3727-3727, 2017

• DOI for Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Part of Journal of Clinical Investigation, p. 2353-2364, 2017

• DOI for Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
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Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Cortese, Giuliana; Gandasi, Nikhil R.; Barg, Sebastian; Pedersen, Morten Gram

Part of PLOS ONE, 2016

• DOI for Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells
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Quantitative Imaging of the Exocytosis Machinery Assembly

Gandasi, Nikhil R.; Barg, Sebastian

Part of Biophysical Journal, 2015

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

Gandasi, Nikhil R.; Vesto, Kim; Helou, Maria; Yin, Peng et al.

Part of PLOS ONE, 2015

• DOI for Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
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MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells

Salunkhe, V. A.; Ofori, J.; Gandasi, Nikhil R.; Salo, S. A. et al.

Part of Diabetologia, 2015

CD59 is required for pancreatic beta cell insulin exocytosis

Krus, Ulrika; King, Benjamin C.; Nagaraj, Vini; Gandasi, Nikhil et al.

Part of Molecular Immunology, p. 279-279, 2014

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Part of Nature Communications, 2014

• DOI for Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Krus, Ulrika; King, Ben C; Nagaraj, Vini; Gandasi, Nikhil R et al.

Part of Cell Metabolism, p. 883-890, 2014

• DOI for The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Barg, Sebastian; Gandasi, Nikhil

Part of Diabetologia, 2010

• DOI for Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Setting the Stage for Insulin Granule Dysfunction during Type-l-Diabetes: Is ER Stress the Culprit?

Makam, Aishwarya A.; Biswas, Anusmita; Kothegala, Lakshmi; Gandasi, Nikhil

Part of Biomedicines, 2022

• DOI for Setting the Stage for Insulin Granule Dysfunction during Type-l-Diabetes: Is ER Stress the Culprit?
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Molecular mechanisms of biphasic insulin secretion

Gandasi, Nikhil R.

2015

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Dynamic clustering of L-ˇ‐type Ca2+ -ˇ‐channels enables fast synchronized insulin secretion through localized Ca2+  nanodomains

Gandasi R., Nikhil; Yin, Peng; Riz, Michela; Cortese, Guiliana et al.

Granule docking is rate limiting during sustained insulin secretion in human β-cells

Gandasi R., Nikhil; Yin, Peng; Barg, Sebastian

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.