Richard Svensson

Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines

Ravi Shankar, Abishek Laxmanan; Irwan, Jenny; Spaenig, Max; Carlier, Maxim et al.

Part of Archives of Toxicology, p. 1877-1901, 2026

• DOI for Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays

Munic Kos, Vesna; Arvidsson McShane, Staffan; Islam, Barira; Nikiforova, Violetta et al.

Part of Environmental Toxicology and Pharmacology, 2025

• DOI for The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023

• DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines

Ravi Shankar, Abishek Laxmanan; Irwan, Jenny; Spaenig, Max; Carlier, Maxim et al.

Part of Archives of Toxicology, p. 1877-1901, 2026

• DOI for Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Part of Scientific Reports, 2026

• DOI for Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays

Munic Kos, Vesna; Arvidsson McShane, Staffan; Islam, Barira; Nikiforova, Violetta et al.

Part of Environmental Toxicology and Pharmacology, 2025

• DOI for The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023

• DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

Dionysopoulou, Stavroula; Wikstrom, Per; Bucolo, Claudio; Romano, Giovanni Luca et al.

Part of Diabetes, p. 638-652, 2023

• DOI for Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Part of Journal of Medicinal Chemistry, p. 3968-3994, 2023

• DOI for New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of Nature Cancer, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Part of Biomedicine and Pharmacotherapy, 2022

• DOI for Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
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Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

Part of Nucleic Acids Research, 2022

• DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
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Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase

Lindgren, Cecilia; Forsgren, Nina; Hoster, Norman; Akfur, Christine et al.

Part of Chemistry - A European Journal, 2022

• DOI for Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase
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Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Rendo, Verónica; Kundu, Snehangshu; Rameika, Natallia; Ljungström, Viktor et al.

Part of Scientific Reports, 2020

• DOI for Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020

• DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
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Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim et al.

Part of MedChemComm, p. 1966-1987, 2019

• DOI for Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, Marcus J. G. W.; van Leeuwen, Ingeborg M. M.; Drummond, Catherine J.; Chu, Su et al.

Part of Nature Communications, 2018

• DOI for A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
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Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Part of Scientific Reports, 2018

• DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
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An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018

• DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

Ladds, Marcus J. G. W.; Pastor-Fernandez, Andres; Popova, Gergana; van Leeuwen, Ingeborg M. M. et al.

Part of PLOS ONE, 2018

• DOI for Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
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N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Sunduru, Naresh; Svensson, Mona; Cipriano, Mariateresa; Marwaha, Sania et al.

Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 513-521, 2017

• DOI for N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
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Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Spahiu, Linda; Alander, Johan; Ottosson-Wadlund, Astrid; Svensson, Richard et al.

Part of Biochemistry, p. 3089-3098, 2017

• DOI for Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 345-351, 2017

• DOI for Importance of N-and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Skogh, Anna; Lesniak, Anna; Gaugaz, Fabienne Z.; Svensson, Richard et al.

Part of European Journal of Pharmaceutical Sciences, p. 533-540, 2017

• DOI for Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016

• DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Part of Journal of Medicinal Chemistry, p. 1140-1148, 2016

• DOI for Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Part of Journal of Medicinal Chemistry, p. 2094-2108, 2016

• DOI for Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015

• DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Part of European Journal of Medicinal Chemistry, p. 191-209, 2015

• DOI for Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014

• DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014

• DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014

• DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Part of Nature, p. 215-221, 2014

• DOI for MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Part of Cell, p. 313-328, 2014

• DOI for Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014

• DOI for Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014

• DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013

• DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013

• DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Structure-Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

Vodnala, Suman K.; Lundback, Thomas; Yeheskieli, Esther; Sjoberg, Birger et al.

Part of Journal of Medicinal Chemistry, p. 9861-9873, 2013

• DOI for Structure-Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Part of Toxicology in Vitro, p. 1357-1376, 2013

• DOI for The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis

Vodnala, Suman K.; Lundback, Thomas; Sjoberg, Birger; Svensson, Richard et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1012-1018, 2013

• DOI for In Vitro and In Vivo Activities of 2-Aminopyrazines and 2-Aminopyridines in Experimental Models of Human African Trypanosomiasis

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012

• DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010

Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ

Al-Amin, Rasel A.; Johansson, Lars; Landegren, Nils; Löf, Liza et al.