Xueliang Ge

Researcher at Department of Cell and Molecular Biology; Molecular Biology

E-mail:: xueliang.ge@icm.uu.se
Visiting address:: Husargatan 3
752 37 Uppsala
Postal address:: Box 596
751 24 Uppsala

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Short presentation

Senior Researcher in Molecular Biology and Biochemistry. I investigate the molecular mechanisms of bacterial protein synthesis, with a focus on how ribosomes and translation factors regulate protein production and adapt to changing cellular conditions. My research also explores how antibiotics interact with the ribosome, providing critical insights into the mechanisms of antibiotics action and resistance.

Keywords

protein synthesis
Ribosome
Antibiotics

Biography

2014 to now Senior researcher, Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden

2010 to 2014 Post doc. Dept. of Cell & Molecular biology, BMC Uppsala University, Sweden

2007 to 2010 Ph.D. Molecular Cell Biology, Northeast Forestry University, PR China

Research

My research studies mechanisms of protein synthesis in bacteria and the effect of antibiotics on protein translation. I am particularly interested in the research project below.

The molecular mechanisms of protein synthesis in E. coli and M. smegmatis .
Design and application of high throughput in vitro reconstituted protein translation system to low molecular weight compound screening.
Characterization of ribosomal stalk bL12 on protein translation and the development of anti-L12 drug.
Mechanism of ribosome assembly in E. coli .
The mechanism of methylation and phosphorylation of translation factor on the regulation of translation in bacteria.
The mechanism of bacterial environmental stress factors on the regulation of protein translation.