Gunnar Pejler

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches

Derakhshani, Afshin; Mahajan, Leela; Lesack, Kyle; Saranjam, Navid et al.

Part of Pharmacological Reviews, 2026

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Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Vraila, Marianthi; Frisk, Jun Mei Hu; Mayavannan, Animamalar; Grujic, Mirjana et al.

Part of Cell Death Discovery, 2026

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Serglycin modulates inflammation and metabolism in macrophages

Porteymour, Shirin; Das Sajib, Saikat; von Hofsten, Susannah; Doncheva, Atanaska I. et al.

Part of iScience, 2026

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Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma

Pejler, Gunnar; Paivandy, Aida; Melo, Fabio R.; Allam, Venkata et al.

Part of Inflammation, 2026

• DOI for Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
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Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Pano, Filip; Bub, Laura; Parrine, Debora; Paivandy, Aida et al.

Part of Cell Death Discovery, 2025

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Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Vraila, Marianthi; Frisk, Jun Mei Hu; Mayavannan, Animamalar; Grujic, Mirjana et al.

Part of Cell Death Discovery, 2026

• DOI for Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway
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Serglycin modulates inflammation and metabolism in macrophages

Porteymour, Shirin; Das Sajib, Saikat; von Hofsten, Susannah; Doncheva, Atanaska I. et al.

Part of iScience, 2026

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Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma

Pejler, Gunnar; Paivandy, Aida; Melo, Fabio R.; Allam, Venkata et al.

Part of Inflammation, 2026

• DOI for Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
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Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Pano, Filip; Bub, Laura; Parrine, Debora; Paivandy, Aida et al.

Part of Cell Death Discovery, 2025

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Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

von Beek, Christopher; Prensa, Grisna I.; Andersson, Julia H. M.; Pejler, Gunnar et al.

Part of European Journal of Immunology, 2025

• DOI for Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
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Melanoma cells suppress mast cell function via a melanin-dependent mechanism

Melo, Fabio R.; Nyman, Lea; Österman Menander, Ida; Grujic, Mirjana et al.

Part of The FEBS Journal, p. 6075-6099, 2025

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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

Allam, Venkata; Akula, Srinivas; Waern, Ida; Taha, Sowsan et al.

Part of Inflammation, p. 806-819, 2025

• DOI for Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
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Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma

Allam, Venkata Sita Rama Raju; Montpeyó, David; Beau, Fabrice; Taha, Sowsan et al.

Part of Inflammation Research, 2025

• DOI for Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma
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Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors

Alvarado-Vazquez, Perla Abigail; Méndez-Enriquez, Erika; Salomonsson, Maya; Kopac, Peter et al.

Part of Journal of Allergy and Clinical Immunology, p. 1310-1320, 2025

• DOI for Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors
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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Part of Inflammation, p. 1820-1836, 2024

• DOI for Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Part of Nature Communications, 2024

• DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells

Zhao, Xinran O.; Melo, Fabio Rabelo; Sommerhoff, Christian P.; Paivandy, Aida et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 2524-2527, 2024

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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells

Pejler, Gunnar; Zhao, Xinran O.; Fagerström, Ella; Paivandy, Aida

Part of Journal of Allergy and Clinical Immunology, p. 940-951, 2024

• DOI for Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells
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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta

Kardeby, Caroline; Evans, Alice; Campos, Joana; Al-Wahaibi, Afraa Moosa et al.

Part of Journal of Thrombosis and Haemostasis, p. 101-116, 2023

• DOI for Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta
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Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Lapointe, Catherine; Vincent, Laurence; Giguere, Hugo; Auger-Messier, Mannix et al.

Part of Journal of the American Heart Association, 2023

• DOI for Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model
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Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation

Vangansewinkel, Tim; Lemmens, Stefanie; Tiane, Assia; Geurts, Nathalie et al.

Part of The FASEB Journal, 2023

• DOI for Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation
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Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata; Waern, Ida; Taha, Sowsan; Akula, Srinivas et al.

Part of Frontiers in Immunology, 2023

• DOI for Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
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Monensin induces secretory granule-mediated cell death in eosinophils

Vraila, Marianthi; Asp, Elin; Melo, Fabio R.; Grujic, Mirjana et al.

Part of Journal of Allergy and Clinical Immunology, 2023

• DOI for Monensin induces secretory granule-mediated cell death in eosinophils
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Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis

Dahlberg, Josef; Johnzon, Carl-Fredrik; Sun, Li; Pejler, Gunnar et al.

Part of Veterinary research (Print), 2023

• DOI for Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
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Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects

Grujic, Mirjana; Nguyen, Thanh; Héchard, Tifaine; Wang, Helen et al.

Part of Anticancer Research, p. 1415-1426, 2023

• DOI for Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects
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Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue

Meen, Astri J.; Doncheva, Atanaska I.; Boettcher, Yvonne; Dankel, Simon N. et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.

Cedervall, Jessica; Herre, Melanie; Dragomir, Anca; Rabelo-Melo, F et al.

Part of Oncoimmunology, 2022

• DOI for Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.
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Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.

Maccarana, Marco; Liu, Jielu; Lampinen, Maria; Rollman, Ola et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1025-1028, 2022

• DOI for Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus

Vitte, Joana; Sjölander, Anders; Rydell, Niclas; Molin, Magnus et al.

Part of Clinical and Experimental Allergy, p. 1330-1333, 2022

• DOI for Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus
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Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

Zhao, Xinran; Lampinen, Maria; Rollman, Ola; Sommerhoff, Christian P et al.

Part of Journal of Allergy and Clinical Immunology, p. 718-727, 2022

• DOI for Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
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Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells

Zhao, xinzh765; Sommerhoff, Christian P.; Paivandy, Aida; Pejler, Gunnar

Part of Journal of Allergy and Clinical Immunology, p. 1534-1544, 2022

• DOI for Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells
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Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

Frisk, Junmei Hu; Orn, Stefan; Pejler, Gunnar; Eriksson, Staffan et al.

Part of BMC Neuroscience, 2022

• DOI for Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
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Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway

Lampinen, Maria; Hagforsen, Eva; Weström, Simone; Bergström, Anna et al.

Part of Experimental dermatology, p. 1729-1740, 2022

• DOI for Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway
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Mast cell tryptase potentiates neutrophil extracellular trap formation

Pejler, Gunnar; Alanazi, Sultan; Grujic, Mirjana; Adler, Jeremy et al.

Part of Journal of Innate Immunity, p. 433-446, 2022

• DOI for Mast cell tryptase potentiates neutrophil extracellular trap formation
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Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase

Hu Frisk, Junmei; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 1305-1317, 2022

• DOI for Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
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Structural and functional analysis of human thymidylate kinase isoforms

Frisk, Junmei Hu; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 321-332, 2022

• DOI for Structural and functional analysis of human thymidylate kinase isoforms
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Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Liu, Jielu; Nie, Mu; Dong, Caijuan; Säfholm, Jesper et al.

Part of Scientific Reports, 2022

• DOI for Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Part of Matrix Biology, p. 1-19, 2022

• DOI for Mast cell chymase has a negative impact on human osteoblasts
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Doncheva, Atanaska; Norheim, Frode A.; Hjorth, Marit; Grujic, Mirjana et al.

Part of Journal of Immunology, p. 121-132, 2022

• DOI for Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells

Alanazi, Sultan; Melo, Fabio Rabelo; Pejler, Gunnar

Part of Frontiers in Immunology, 2021

• DOI for Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Part of PLOS ONE, 2021

• DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Chanzu, Harry; Lykins, Joshua; Wigna-Kumar, Subershan; Joshi, Smita et al.

Part of Journal of Thrombosis and Haemostasis, p. 1082-1095, 2021

• DOI for Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Frisk, Junmei Hu; Vanoevelen, Jo M.; Bierau, Jorgen; Pejler, Gunnar et al.

Part of ACS Omega, p. 33943-33952, 2021

• DOI for Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
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Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

Alim, Abdul; Grujic, Mirjana; Ackerman, Paul W; Kristiansson, Per et al.

Part of Cellular & Molecular Immunology, p. 2383-2392, 2021

• DOI for Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells
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Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Vincent, Laurence; Lapointe, Catherine; Lo, Modou; Gagnon, Hugo et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 213-221, 2021

• DOI for Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.

Part of Journal of Neuroinflammation, 2020

• DOI for Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
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Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

Alanazi, Sultan; Grujic, Mirjana; Lampinen, Maria; Rollman, Ola et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
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Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

Alanazi, Sultan; Melo, Fabio R.; Pejler, Gunnar

Part of Anticancer Research, p. 2525-2536, 2020

• DOI for Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

DNA demethylation regulates gene expression in IgE-activated mouse mast cells.

Paivandy, Aida; Grujic, Mirjana; Rafati, Nima; Pejler, Gunnar

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1776-1780, 2020

• DOI for DNA demethylation regulates gene expression in IgE-activated mouse mast cells.
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Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Part of Pigment Cell & Melanoma Research, p. 579-590, 2020

• DOI for Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Identification of a novel thymidylate kinase activity.

Frisk, Junmei Hu; Eriksson, Staffan; Pejler, Gunnar; Wang, Liya

Part of Nucleosides, Nucleotides & Nucleic Acids, p. 1359-1368, 2020

• DOI for Identification of a novel thymidylate kinase activity.

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of Cells, 2020

• DOI for How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
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Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 707-708, 2020

• DOI for Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
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Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of CELLS, 2020

• DOI for Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
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Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Madjene, Lydia Celia; Danelli, Luca; Dahdah, Albert; Vibhushan, Shamila et al.

Part of Kidney International, p. 516-527, 2020

• DOI for Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism

von Beek, Christopher; Waern, Ida; Eriksson, Jens; Melo, Fabio R. et al.

Part of Cellular Microbiology, 2019

• DOI for Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
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Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression

Melo, Fabio R.; Martin, Sebastin Santosh; Sommerhoff, Christian P.; Pejler, Gunnar

Part of Cell Death and Disease, 2019

• DOI for Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression
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Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury

Vangansewinkel, Tim; Lemmens, Stefanie; Geurts, Nathalie; Quanten, Kirsten et al.

Part of Scientific Reports, 2019

• DOI for Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury
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The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells

Martin, Sebastin Santosh; Melo, Fabio R.; Pejler, Gunnar

Part of Cells, 2019

• DOI for The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production

Paivandy, Aida; Eriksson, Jens; Melo, Fabio R.; Sellin, Mikael E. et al.

Part of Cell Death Discovery, 2019

• DOI for Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
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The emerging role of mast cell proteases in asthma

Pejler, Gunnar

Part of European Respiratory Journal, 2019

Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

Succar, Julien; Giatsidis, Giorgio; Yu, Nanze; Hassan, Kazi et al.

Part of ADVANCES IN WOUND CARE, p. 469-475, 2019

• DOI for Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

Desbiens, Louisane; Lapointe, Catherine; Gendron, Louis; Gharagozloo, Marjan et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 437-446, 2019

• DOI for Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT

Karlsson, I; Veevnik, D.; Fedulov, A.; Yurkshtovich, N. et al.

Part of Neoplasma (Bratislava), p. 288-293, 2019

• DOI for Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT

Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

Houde, Martin; Schwertani, Adel; Touil, Hanene; Desbiens, Louisane et al.

Part of Frontiers in Pharmacology, 2018

• DOI for Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction
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Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Frisk, Jun Mei Hu; Kjellén, Lena; Melo, Fabio R.; Öhrvik, Helena et al.

Part of Frontiers in Immunology, 2018

• DOI for Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules
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The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach

Johnzon, Carl-Fredrik; Dahlberg, Josef; Gustafson, Ann-Marie; Waern, Ida et al.

Part of Frontiers in Immunology, 2018

• DOI for The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach
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Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment

Nyekel, Flavie Ngo; Pacreau, Emeline; Benadda, Samira; Msallam, Rasha et al.

Part of Frontiers in Immunology, 2018

• DOI for Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment
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Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Roers, Axel; Hartmann, Karin et al.

Part of Molecular Pain, 2018

• DOI for Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin
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Mast cell chymase decreases the severity of group B Streptococcus infections

Gendrin, Claire; Shubin, Nicholas J; Boldenow, Erica; Merillat, Sean et al.

Part of Journal of Allergy and Clinical Immunology, p. 120-129, 2018

• DOI for Mast cell chymase decreases the severity of group B Streptococcus infections

Acidic pH is essential for maintaining mast cell secretory granule homeostasis

Pejler, Gunnar; Frisk, Jun Mei Hu; Sjöström, Daniel; Paivandy, Aida et al.

Part of Cell Death and Disease, 2017

• DOI for Acidic pH is essential for maintaining mast cell secretory granule homeostasis
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The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung

Grujic, Mirjana; Paivandy, Aida; Gustafson, Ann-Marie; Thomsen, Allan R. et al.

Part of Oncotarget, p. 25066-25079, 2017

• DOI for The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung
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Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

Paivandy, Aida; Sandelin, Martin; Igelström, Helena; Landelius, Per et al.

Part of Frontiers in Immunology, 2017

• DOI for Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells
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Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction

Pons, Maguelonne; Ali, Liza; Beghdadi, Walid; Danelli, Luca et al.

Part of Frontiers in Immunology, 2017

• DOI for Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction
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Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation

Shubin, Nicholas J.; Glukhova, Veronika A.; Clauson, Morgan; Truong, Phuong et al.

Part of Journal of Allergy and Clinical Immunology, p. 323-334, 2017

• DOI for Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation

Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

Melo, Fabio R.; Wallerman, Ola; Paivandy, Aida; Calounova, Gabriela et al.

Part of Journal of Allergy and Clinical Immunology, p. 474-485, 2017

• DOI for Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Hu Frisk, Jun Mei; Kjellén, Lena; Kaler, Stephen G; Pejler, Gunnar et al.

Part of Journal of Immunology, p. 4132-4141, 2017

• DOI for Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Excessive dietary intake of vitamin A reduces skull bone thickness in mice

Lind, Thomas; Öhman, Caroline; Calounova, Gabriela; Rasmusson, Annica et al.

Part of PLOS ONE, 2017

• DOI for Excessive dietary intake of vitamin A reduces skull bone thickness in mice
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Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture

Alim, Md Abdul; Ackermann, Paul W; Eliasson, Pernilla; Blomgran, Parmis et al.

Part of Cell and Tissue Research, p. 451-460, 2017

• DOI for Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture
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Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions

Hagforsen, Eva; Lampinen, Maria; Paivandy, Aida; Weström, Simone et al.

Part of British Journal of Dermatology, p. 179-187, 2017

• DOI for Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions
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Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents

Wernersson, S.; Riihimäki, M.; Pejler, Gunnar; Waern, I.

Part of Scandinavian Journal of Immunology, p. 30-34, 2017

• DOI for Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents

Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells

Garcia-Faroldi, Gianni; Rönnberg, Elin; Grujic, Mirjana; Pejler, Gunnar

Part of Immunity, Inflammation and Disease, p. 141-150, 2017

• DOI for Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells
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IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Tejada, Thor; Tan, Lin; Torres, Rebecca A.; Calvert, John W. et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 6949-6954, 2016

• DOI for IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

Johnzon, Carl-Fredrik; Rönnberg, Elin; Guss, Bengt; Pejler, Gunnar

Part of Frontiers in Immunology, 2016

• DOI for Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

Mast cells promote melanoma colonization of lungs

Öhrvik, Helena; Grujic, Mirjana; Waern, Ida; Gustafson, Ann-Marie et al.

Part of Oncotarget, p. 68990-69001, 2016

• DOI for Mast cells promote melanoma colonization of lungs

Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo

Johnzon, Carl-Fredrik; Artursson, Karin; Söderlund, Robert; Guss, Bengt et al.

Part of Frontiers in Immunology, 2016

• DOI for Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo
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Activated mast cells promote differentiation of B cells into effector cells

Palm, Anna-Karin E.; Garcia-Faroldi, Gianni; Lundberg, Marcus; Pejler, Gunnar et al.

Part of Scientific Reports, 2016

• DOI for Activated mast cells promote differentiation of B cells into effector cells

Increased Bone Mass in Female Mice Lacking Mast Cell Chymase

Lind, Thomas; Gustafson, Ann-Marie; Calounova, Gabriela; Hu, Lijuan et al.

Part of PLOS ONE, 2016

• DOI for Increased Bone Mass in Female Mice Lacking Mast Cell Chymase
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Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

Houde, Martin; Desbiens, Louisane; Schwertani, Adel; Pejler, Gunnar et al.

Part of Life Sciences, p. 71-75, 2016

• DOI for Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

IL-6 and IL-17A degradation by mast cells is mediated by a serglycin: serine protease axis

Waern, Ida; Karlsson, Iulia; Pejler, Gunnar; Wernersson, Sara

Part of Immunity, Inflammation and Disease, p. 70-79, 2016

• DOI for IL-6 and IL-17A degradation by mast cells is mediated by a serglycin: serine protease axis
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis

Desbiens, Louisane; Lapointe, Catherine; Gharagozloo, Marjan; Mahmoud, Shaimaa et al.

Part of Mediators of Inflammation, 2016

• DOI for Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis
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Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Sutton, Vivien R.; Brennan, Amelia J.; Ellis, Sarah; Danne, Jill et al.

Part of The FEBS Journal, p. 947-961, 2016

• DOI for Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6

Vangansewinkel, Tim; Geurts, Nathalie; Quanten, Kirsten; Nelissen, Sofie et al.

Part of The FASEB Journal, p. 2040-2057, 2016

• DOI for Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Öhrvik, Helena; Logeman, Brandon; Noguchi, Glyn; Eriksson, Inger et al.

Part of Journal of Immunology, p. 3654-3664, 2015

• DOI for Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans
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Induction of mast cell apoptosis by a novel secretory granule-mediated pathway.

Melo, Fabio R; Wernersson, Sara; Pejler, Gunnar

Part of Methods in Molecular Biology, p. 325-37, 2015

• DOI for Induction of mast cell apoptosis by a novel secretory granule-mediated pathway.

Serglycin protects against high fat diet-induced increase in plasma LDL in mice

Pejler, Gunnar

Part of Glycoconjugate Journal, 2015

Approaches for analyzing the roles of mast cells and their proteases in vivo

Galli, Stephen J; Tsai, Mindy; Marichal, Thomas; Tchougounova, Elena et al.

Part of Advances in Immunology, p. 45-127, 2015

• DOI for Approaches for analyzing the roles of mast cells and their proteases in vivo

Serglycin protects against high fat diet-induced increase in serum LDL in mice

Meen, Astri J; Drevon, Christian A; Pejler, Gunnar; Jenssen, Trond G et al.

Part of Glycoconjugate Journal, p. 703-714, 2015

• DOI for Serglycin protects against high fat diet-induced increase in serum LDL in mice

Damnacanthal inhibits IgE receptor-mediated activation of mast cells

Garcia-Vilas, Javier A.; Medina, Miguel A.; Melo, Fabio R.; Pejler, Gunnar et al.

Part of Molecular Immunology, p. 86-93, 2015

• DOI for Damnacanthal inhibits IgE receptor-mediated activation of mast cells

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Semaan, Walid; Desbiens, Louisane; Houde, Martin; Labonte, Julie et al.

Part of Biochemical Pharmacology, p. 91-100, 2015

• DOI for Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Ablation of human skin mast cells in situ by lysosomotropic agents

Hagforsen, Eva; Paivandy, Aida; Lampinen, Maria; Weström, Simone et al.

Part of Experimental dermatology, p. 516-521, 2015

• DOI for Ablation of human skin mast cells in situ by lysosomotropic agents

MAST CELL GRANULES: ARMED WITH HISTAMINE AND FRIENDS

Pejler, Gunnar

Part of Inflammation Research, 2015

Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content

Garcia-Faroldi, Gianni; Melo, Fabio R.; Bruemmer, Dennis; Conneely, Orla M. et al.

Part of PLOS ONE, 2014

• DOI for Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content

Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo

Ronnberg, Elin; Johnzon, Carl-Fredrik; Calounova, Gabriela; Faroldi, Gianni Garcia et al.

Part of Immunology, p. 155-163, 2014

• DOI for Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo

Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

Melo, Fabio R.; Vita, Francesca; Berent-Maoz, Beata; Levi-Schaffer, Francesca et al.

Part of Journal of Biological Chemistry, p. 7682-7690, 2014

• DOI for Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

Melo, Fabio R.; Grujic, Mirjana; Spirkoski, Jane; Calounova, Gabriela et al.

Part of Journal of Biological Chemistry, p. 18142-18152, 2012

• DOI for Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing.

Henningsson, Frida; Ledin, Johan; Lunderius, Carolina; Wilén, M et al.

Part of Biological Chemistry, p. 793-801, 2002

Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Lützelschwab, Claudia; Pejler, Gunnar; Aveskogh, Maria; Hellman, Lars

Part of Journal of Experimental Medicine, p. 13-29, 1997

• DOI for Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches

Derakhshani, Afshin; Mahajan, Leela; Lesack, Kyle; Saranjam, Navid et al.

Part of Pharmacological Reviews, 2026

• DOI for Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
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Tendon pain: what are the mechanisms behind it?

Ackermann, Paul W.; Alim, Md Abdul; Pejler, Gunnar; Peterson, Magnus

Part of Scandinavian Journal of Pain, p. 14-24, 2023

• DOI for Tendon pain: what are the mechanisms behind it?
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Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D. et al.

Part of Critical reviews in food science and nutrition, p. 7576-7590, 2022

• DOI for Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S.; Maurer, Marcus; Metcalfe, Dean D.; Pejler, Gunnar et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 83-99, 2022

• DOI for The ingenious mast cell: Contemporary insights into mast cell behavior and function
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Novel Strategies to Target Mast Cells in Disease

Paivandy, Aida; Pejler, Gunnar

Part of Journal of Innate Immunity, p. 131-147, 2021

• DOI for Novel Strategies to Target Mast Cells in Disease
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Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Abdul; Peterson, Magnus; Pejler, Gunnar

Part of Cells, 2020

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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Pejler, Gunnar

Part of Journal of Innate Immunity, p. 357-372, 2020

• DOI for Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
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Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Maurer, Marcus; Eyerich, Kilian; Eyerich, Stefanie; Ferrer, Marta et al.

Part of International Archives of Allergy and Immunology, p. 321-333, 2020

• DOI for Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
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The emerging role of mast cell proteases in asthma

Pejler, Gunnar

Part of European Respiratory Journal, 2019

• DOI for The emerging role of mast cell proteases in asthma

The controversial role of mast cells in fibrosis

Bradding, Peter; Pejler, Gunnar

Part of Immunological Reviews, p. 198-231, 2018

• DOI for The controversial role of mast cells in fibrosis

The Role of Mast Cells in Bacterial Infection

Johnzon, Carl-Fredrik; Ronnberg, Elin; Pejler, Gunnar

Part of American Journal of Pathology, p. 4-14, 2016

• DOI for The Role of Mast Cells in Bacterial Infection

Compound 48/80-induced itch is attenuated by mouse mast cell tryptase and carboxypeptidase A3

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Pejler, Gunnar; Lagerström, Malin C.

Mouse mast cell tryptase and carboxypeptidase A3 play a protective role in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.