Lars Hellman

Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Part of Frontiers in Cellular and Infection Microbiology, 2025

• DOI for Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Part of Inflammation, p. 1820-1836, 2024

• DOI for Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Valentini, Paolo; Akula, Srinivas; Alvarado-Vazquez, Perla Abigail; Hallgren, Jenny et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)
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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Thorpe, Michael; Akula, Srinivas; Fu, Zhirong; Hellman, Lars

Part of International Journal of Molecular Sciences, 2024

• DOI for The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells
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Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Part of Frontiers in Cellular and Infection Microbiology, 2025

• DOI for Recirculating glass pipettes constitute a high risk when working with freshly isolated immune cells - the presence of bacterial pyrogenic material
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Part of Inflammation, p. 1820-1836, 2024

• DOI for Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

Valentini, Paolo; Akula, Srinivas; Alvarado-Vazquez, Perla Abigail; Hallgren, Jenny et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)
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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

Thorpe, Michael; Akula, Srinivas; Fu, Zhirong; Hellman, Lars

Part of International Journal of Molecular Sciences, 2024

• DOI for The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells
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Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

Akula, Srinivas; Tripathi, Shiva Raj; Franke, Kristin; Wernersson, Sara et al.

Part of Cells, 2024

• DOI for Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
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Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Aybay, Erdem; Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas et al.

Part of Frontiers in Immunology, 2023

• DOI for Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity
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Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Aybay, Erdem; Elkhalifa, Mamoun; Akula, Srinivas; Wernersson, Sara et al.

Part of Developmental and Comparative Immunology, 2023

• DOI for Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity
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Identification of the Major Protein Components of Human and Cow Saliva

Akula, Srinivas; Welinder, Charlotte; Fu, Zhirong; Olsson, Anna-Karin et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Identification of the Major Protein Components of Human and Cow Saliva
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Phenotypic and Functional Heterogeneity of Monocytes and Macrophages

Hellman, Lars

Part of International Journal of Molecular Sciences, 2023

• DOI for Phenotypic and Functional Heterogeneity of Monocytes and Macrophages
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Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.

Riihimäki, Miia; Fegraeus, K. Jaderkvist; Nordlund, Jessica; Waern, Ida et al.

Part of Scientific Reports, p. 16261, 2023

• DOI for Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Ramos-Ramirez, Patricia; Liu, Jielu; Mogren, Sofia; Gregory, Joshua et al.

Part of Journal of Immunology Research, 2023

• DOI for House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model
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Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

Ryu, Jinhye; Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin et al.

Part of Developmental and Comparative Immunology, 2022

• DOI for Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

Akula, Srinivas; Lara, Sandra; Olsson, Anna-Karin; Hellman, Lars

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
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Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment

Zhang, Yanyu; Doulabi, Ehsan Manouchehri; Herre, Melanie; Cedervall, Jessica et al.

Part of Cancers, 2022

• DOI for Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf beta Signaling in the Tumor Microenvironment
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The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

Lara, Sandra; Akula, Srinivas; Fu, Zhirong; Olsson, Anna-Karin et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for The Human Monocyte: A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation
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Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

Akula, Srinivas; Hellman, Lars; Aviles, Francesc Xavier; Wernersson, Sara

Part of Developmental and Comparative Immunology, 2022

• DOI for Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases
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Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Hellman, Lars

Part of Developmental and Comparative Immunology, 2022

• DOI for Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes
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Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

Akula, Srinivas; Riihimaki, Miia; Waern, Ida; Abrink, Magnus et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses
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Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Femel, Julia; van Hooren, Luuk; Herre, Melanie; Cedervall, Jessica et al.

Part of Cancer Immunology and Immunotherapy, p. 2029-2040, 2022

• DOI for Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden
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Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

Fu, Zhirong; Akula, Srinivas; Qiao, Chang; Ryu, Jinhye et al.

Part of PLOS ONE, 2021

• DOI for Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity
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Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Part of Biological chemistry (Print), p. 861-867, 2021

• DOI for Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
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Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Fu, Zhirong; Akula, Srinivas; Olsson, Anna-Karin; Kervinen, Jukka et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases
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Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

Berglund, Petter; Akula, Srinivas; Fu, Zhirong; Thorpe, Michael et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
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Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Part of International Journal of Molecular Sciences, 2020

• DOI for Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme
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Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

Teufelberger, Andrea R.; Van Nevel, Sharon; Hulpiau, Paco; Nordengrun, Maria et al.

Part of Frontiers in Immunology, 2020

• DOI for Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
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Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Part of International Journal of Molecular Sciences, 2020

• DOI for Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
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Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Part of Pigment Cell & Melanoma Research, p. 579-590, 2020

• DOI for Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of Cells, 2020

• DOI for How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
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Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 707-708, 2020

• DOI for Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
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Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Part of CELLS, 2020

• DOI for Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
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Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Hellman, Lars

Part of International Journal of Molecular Sciences, 2019

• DOI for Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity
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Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

Zhongwei, Yuan; Akula, Srinivas; Fu, Zhirong; de Garavilla, Lawrence et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases
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Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Fu, Zhirong; Akula, Srinivas; Thorpe, Michael; Chahal, Gurdeep et al.

Part of Developmental and Comparative Immunology, p. 160-169, 2019

• DOI for Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Liu, Jingyi; Fu, Zhirong; Hellman, Lars; Svärd, Staffan G.

Part of Molecular and biochemical parasitology (Print), p. 29-38, 2019

• DOI for Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins

Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5

Thorpe, Michael; Fu, Zhirong; Albat, Emanuelle; Akula, Srinivas et al.

Part of PLOS ONE, 2018

• DOI for Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5
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Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Thorpe, Michael; Fu, Zhirong; Chahal, Gurdeep; Akula, Srinivas et al.

Part of PLOS ONE, 2018

• DOI for Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Chahal, Gurdeep et al.

Part of Frontiers in Immunology, 2018

• DOI for Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability
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Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

Liu, Jingyi; Ma'ayeh, Showgy Y.; Peirasmaki, Dimitra; Lundstrom-Stadelmann, Britta et al.

Part of Virulence, p. 879-894, 2018

• DOI for Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
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Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

Part of The FASEB Journal, p. 1204-1214, 2017

• DOI for Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Fu, Zhirong; Thorpe, Michael; Alemayehu, Rahel; Roy, Ananya et al.

Part of Journal of Immunology, p. 1474-1483, 2017

• DOI for Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

Fu, Zhirong; Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Part of PLOS ONE, 2016

• DOI for Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution
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Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Thorpe, Michael; Akula, Srinivas; Hellman, Lars

Part of Developmental And Comparative Immunology, p. 84-95, 2016

• DOI for Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Klein, O.; Ngo-Nyekel, F.; Stefanache, T.; Torres, R. et al.

Part of Scandinavian Journal of Immunology, p. 465-472, 2016

• DOI for Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets

Elimination Of Il-33 Inhibits Airways Hyperresponsiveness

Frodella, C. M.; Smith, B. J.; Hellman, Lars T.; Poynter, M. E. et al.

Part of American Journal of Respiratory and Critical Care Medicine, 2016

rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins

Fu, Zhirong; Thorpe, Michael; Hellman, Lars

Part of PLOS ONE, 2015

• DOI for rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins
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Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution

Akula, Srinivas; Thorpe, Michael; Boinapally, Vamsi; Hellman, Lars

Part of PLOS ONE, 2015

• DOI for Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution
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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Chahal, Gurdeep; Thorpe, Michael; Hellman, Lars

Part of PLOS ONE, 2015

• DOI for The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
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Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

Lei, Ying; Boinapally, Vamsi; Zoltowska, Anna; Adner, Mikael et al.

Part of PLOS ONE, 2015

• DOI for Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma
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IgA deficiency in wolves from Canada and Scandinavia

Frankowiack, Marcel; Olsson, Mia; Cluff, H. Dean; Evans, Alina L. et al.

Part of Developmental and Comparative Immunology, p. 26-28, 2015

• DOI for IgA deficiency in wolves from Canada and Scandinavia

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Femel, Julia; Huijbers, Elisabeth JM; Saupe, Falk; Cedervall, Jessica et al.

Part of Oncotarget, p. 12418-12427, 2014

• Download full text (pdf) of Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Progression of metastatic breast cancer can be attenuated by therapeutic vaccination against the tumor vascular marker ED-A

Femel, Julia; Huijbers, Elisabeth J. M.; Saupe, Falk; Cedervall, Jessica et al.

Part of Angiogenesis, p. 769-769, 2014

Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution

Akula, Srinivas; Mohammadamin, Sayran; Hellman, Lars

Part of PLOS ONE, 2014

• DOI for Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution
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Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Roy, Ananya; Ganesh, Goutham; Sippola, Helena; Bolin, Sara et al.

Part of Journal of Biological Chemistry, p. 237-250, 2014

• DOI for Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

Characterization of an Experimental Vaccine for Bovine Respiratory Syncytial Virus

Hagglund, Sara; Hu, Kefei; Blodorn, Krister; Makabi-Panzu, Boby et al.

Part of Clinical and Vaccine Immunology, p. 997-1004, 2014

• DOI for Characterization of an Experimental Vaccine for Bovine Respiratory Syncytial Virus

Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors

Ahooghalandari, Parvin; Hanke, Nina; Thorpe, Michael; Witte, Andreas et al.

Part of PLOS ONE, 2013

• DOI for Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors
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IgA deficiency in wolves

Frankowiack, Marcel; Hellman, Lars; Zhao, Yaofeng; Arnemo, Jon M. et al.

Part of Developmental and Comparative Immunology, p. 180-184, 2013

• DOI for IgA deficiency in wolves

The Extended Cleavage Specificity of Human Thrombin

Gallwitz, Maike; Enoksson, Mattias; Thorpe, Michael; Hellman, Lars

Part of PLOS ONE, 2012

• DOI for The Extended Cleavage Specificity of Human Thrombin
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Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins

Grundström, Jeanette; Reimer, Jenny M.; Magnusson, Sofia E.; Nilsson, Gunnar et al.

Part of PLOS ONE, 2012

• DOI for Human Cord Blood Derived Immature Basophils Show Dual Characteristics, Expressing Both Basophil and Eosinophil Associated Proteins
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Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

Waern, Ida; Karlsson, Iulia; Thorpe, Michael; Schlenner, Susan M. et al.

Part of Biological chemistry (Print), p. 1555-1567, 2012

• DOI for Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B-a prerequisite for clinical development

Huijbers, Elisabeth J M; Femel, Julia; Andersson, Karl; Björkelund, Hanna et al.

Part of Vaccine, p. 225-230, 2012

• DOI for The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B-a prerequisite for clinical development

Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase

Thorpe, Michael; Yu, Jing; Boinapally, Vamsi; Ahooghalandari, Parvin et al.

Part of International Immunology, p. 771-782, 2012

• DOI for Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase

Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates

Korkmaz, Brice; Jegot, Gwenhael; Lau, Laurie C.; Thorpe, Michael et al.

Part of The FEBS Journal, p. 2635-2646, 2011

• DOI for Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates

Vaccination against the extra domain-B of fibronectin as a novel tumor therapy

Huijbers, Elisabeth J. M.; Ringvall, Maria; Femel, Julia; Kalamajski, Sebastian et al.

Part of The FASEB Journal, p. 4535-4544, 2010

• DOI for Vaccination against the extra domain-B of fibronectin as a novel tumor therapy

High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution

Reimer, Jenny; Samollow, Paul; Hellman, Lars

Part of Immunogenetics, p. 369-382, 2010

• DOI for High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution

Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates

Andersson, Mattias K.; Thorpe, Michael; Hellman, Lars

Part of The FEBS Journal, p. 2255-2267, 2010

• DOI for Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Vernersson, Molly; Belov, K.; Aveskogh, Maria; Hellman, Lars

Part of Molecular Immunology, p. 785-791, 2010

• DOI for Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Vernersson, Molly; Belov, K.; Aveskogh, Maria; Hellman, Lars

Part of Molecular Immunology, p. 785-791, 2010

• DOI for Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

Charles, Nicolas; Watford, T; Ramos, L; Hellman, Lars et al.

Part of Immunity, p. 533-543, 2009

• DOI for Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

Identification of potent biodegradable adjuvants that efficiently break self-tolerance: a key issue in the development of therapeutic vaccines

Ringvall, Maria; Huijbers, Elisabeth J. M.; Ahooghalandari, Parvin; Alekseeva, Ludmila et al.

Part of Vaccine, p. 48-52, 2009

• DOI for Identification of potent biodegradable adjuvants that efficiently break self-tolerance: a key issue in the development of therapeutic vaccines

The extended substrate cleavage specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

Andersson, Mattias K.; Enoksson, Mattias; Gallwitz, Maike; Hellman, Lars

Part of International Immunology, p. 95-104, 2009

• DOI for The extended substrate cleavage specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods

Zhao, Yaofeng; Cui, Huiting; Whittington, Camilla M.; Wei, Zhiguo et al.

Part of Journal of Immunology, p. 3285-3293, 2009

• DOI for Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods

The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major fumctional similarities to the human mast cell chymase

Andersson, Mattias K.; Karlson, Ulrika; Hellman, Lars

Part of Molecular Immunology, p. 766-775, 2008

• DOI for The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major fumctional similarities to the human mast cell chymase

Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity

Andersson, Mattias K.; Pemberton, Alan D.; Miller, Hugh R. P.; Hellman, Lars

Part of Molecular Immunology, p. 2548-2558, 2008

• DOI for Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity

Extended substrate specificity of opossum chymase: Implications for the origin of mast cell chymases

Reimer, Jenny; Enoksson, Mattias; Samollow, Paul; Hellman, Lars

Part of Molecular Immunology, p. 2116-2125, 2008

• DOI for Extended substrate specificity of opossum chymase: Implications for the origin of mast cell chymases

High plasma IgE levels within the Scandinavian wolf population, and its implications for mammalian IgE homeostasis

Ledin, Anna; Arnemo, Jon M.; Liberg, Olof; Hellman, Lars

Part of Molecular Immunology, p. 1976-1980, 2008

• DOI for High plasma IgE levels within the Scandinavian wolf population, and its implications for mammalian IgE homeostasis

Therapeutic vaccines against IgE-mediated allergies.

Hellman, Lars

Part of Expert Rev Vaccines, p. 193-208, 2008

Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8

Gallwitz, Maike; Enoksson, Mattias; Hellman, Lars

Part of Immunogenetics, p. 391-405, 2007

• DOI for Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

Braga, Tiago; Grujic, Mirjana; Lukinius, Agneta; Hellman, Lars et al.

Part of Biochemical Journal, p. 49-57, 2007

• DOI for Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

Modifications increasing the efficacy of recombinant vaccines: marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine

Johansson, Jeannette; Hellman, Lars

Part of Vaccine, p. 1676-1682, 2007

• DOI for Modifications increasing the efficacy of recombinant vaccines: marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine

Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels.

Ledin, Anna; Bergvall, Kerstin; Salmon Hillbertz, Nicolette; Hansson, Helene et al.

Part of Vaccine, p. 66-74, 2006

• DOI for Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels.

Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution

Gallwitz, Maike; Reimer, Jenny; Hellman, Lars

Part of Immunogenetics, p. 655-669, 2006

• DOI for Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution

Isolation of transcriptionally active umbilical cord blood-derived basophils expressing FcεRI, HLA-DR and CD203c

Reimer, Jenny; Magnusson, Sofia; Juremalm, Mikael; Nilsson, Gunnar et al.

Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1063-1070, 2006

• DOI for Isolation of transcriptionally active umbilical cord blood-derived basophils expressing FcεRI, HLA-DR and CD203c

Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution

Wernersson, Sara; Reimer, Jenny; Poorafshar, Maryam; Karlson, Ulrika et al.

Part of Developmental and Comparative Immunology, p. 901-918, 2006

• DOI for Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution

TCR gamma chain diversity in the spleen of the duckbill platypus (Ornithorhynchus anatinus).

Parra, Zuly E.; Arnold, Tamara; Nowak, Melissa A.; Hellman, Lars et al.

Part of Developmental and Comparative Immunology, p. 699-710, 2006

Rapid species-specific diversification of the mast cell chymase locus during mammalian evolution.

Gallwitz, Maike; Hellman, Lars

Part of Immunogenetics, p. 641-654, 2006

High variability in complementarity-determining regions compensates for a low number of V gene families in the lambda light chain locus of the platypus.

Johansson, Jeannette; Salazar, Janice N; Aveskogh, Maria; Munday, Barry et al.

Part of Eur J Immunol, p. 3008-19, 2005

Identification of Adjuvants that Enhance the Therapeutic Antibody Response to Host IgE

Johansson, Jeannette; Ledin, Anna; Vernersson, Molly; Lövgren-Bengtsson, Karin et al.

Part of Vaccine, p. 2873-2880, 2004

• DOI for Identification of Adjuvants that Enhance the Therapeutic Antibody Response to Host IgE

The complexity of expressed kappa light chains in egg-laying mammals.

Nowak, Melissa A; Parra, Zuly E; Hellman, Lars; Miller, Robert D

Part of Immunogenetics, p. 555-63, 2004

Cloning of IgE from the echidna (Tachyglossus aculeatus) and a comparative analysis of e chains from all three extant mammalian lineages

Vernersson, Molly; Aveskogh, Maria; Hellman, Lars

Part of Dev Comp Immunol, p. 61-75, 2004

A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins

Looman, Camilla; Hellman, Lars; Abrink, Magnus

Part of Mamm Genome, p. 35-40, 2004

Isolation of monotreme T-cell receptor alpha and beta chains.

Belov, Katherine; Miller, Robert D; Ilijeski, Aron; Hellman, Lars et al.

Part of Immunogenetics, p. 164-9, 2004

Platypus IgM and the divergence of the two extant monotreme lineages.

Belov, Katherine; Hellman, Lars

Part of Australian Mammology, p. 87-94, 2003

MZF6D, a novel KRAB zinc finger gene expressed exclusively in meiotic male germ cells.

Looman, Camilla; Åbrink, Magnus; Mark, Charlotta; Hellman, Lars

Part of DNA and Cell Biology, p. 489-496, 2003

Evolution of the major histocompatibility complex: Isolation of class II _ cDNAs from two monotremes, the platypus and the short-beaked echidna.

Belov, Katherine; Lam, MKP; Hellman, Lars; Colgan, DJ.

Part of Immunogenetics, p. 402-411, 2003

Characterization of b2-microglobulin coding sequence from three non-placental mammals; the duck billed platypus, the short beaked echidna, and the grey short-tailed opossum.

Miska, K.B; Hellman, Lars; Miller, Robert D.

Part of Developmental and Comparative Immunology, p. 247-256, 2003

MZF6D, a novel KRAB zinc-finger gene expressed exclusively in meiotic male germ cells.

Looman, Camilla; Mark, Charlotta; Abrink, Magnus; Hellman, Lars

Part of DNA and Cell Biology, p. 489-96, 2003

Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna).

Belov, Katherine; Hellman, Lars

Part of Comp Biochem Physiol A Mol Integr Physiol, p. 811-9, 2003

Evolution of the major histocompatibility complex: Isolation of class II beta cDNAs from two monotremes, the platypus and the short-beaked echidna.

Belov, Katherine; Lam, Mary K P; Hellman, Lars; Colgan, Donald J

Part of Immunogenetics, p. 402-11, 2003

Extended substrate specificity of rat mast cell protease 5, a rodent alpha chymase with elastase-like primary specificity

Karlson, Ulrika; Pejler, Gunnar; Tomasini-Johansson, Bianca; Hellman, Lars

Part of Journal of Biological Chemistry, p. 39625-39631, 2003

• DOI for Extended substrate specificity of rat mast cell protease 5, a rodent alpha chymase with elastase-like primary specificity

Characterization of of echidna IgM provides insight into the time of divergence of extant mammals.

Belov, Katherine; Hellman, Lars; Cooper, D.W.

Part of Developmental and Comparative Immunology, p. 831-839, 2002

Echidna IgA supports mammalian unity and traditional Therian relationship

Belov, Katherine; Zenger, K.R.; Hellman, Lars; Cooper, D.W.

Part of Mammalian Genome, p. 656-663, 2002

Characterization of IgG from a monotreme, Tachyglossus aculeatus

Belov, Katherine; Hellman, Lars; Cooper, D.W.

Part of Immunogenetics, p. 1065-1071, 2002

Generation of therapeutic antibody responses against IgE through vaccination

Vernersson, Molly; Ledin, Anna; Johansson, Jeannette; Hellman, Lars

Part of The FASEB J:, p. 875-877 + On Line, 2002

Heavy chain V region diversity in the duck-billed platypus (Ornithorhynchus anatinus): Long and highly variable complementarity-determining region 3 compensates for limited germ line diversity.

Johansson, Jeannette; Aveskogh, Maria; Munday, Barry; Hellman, Lars

Part of J. Immunol., p. 5155-5162, 2002

Rat mast cell protease 4, a beta chymase with a unusually stringent substrate specificity.

Karlson, Ulrika; Pejler, Gunnar; Fröman, Gunnar; Hellman, Lars

Part of J. Biol. Chem., p. 18579-18585, 2002

The major histocompatibility complex in monotremes; an analysis of the evolution of the MHC Class I genes across all three mammalian subclasses.

Miska, K.B; Hellman, Lars; Miller, Robert D.

Part of Immunogenetics, p. 381-393, 2002

KRAB zinc finger proteins; an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution.

Looman, Camilla; Åbrink, Magnus; Mark, Charlotta; Hellman, Lars

Part of Molecular Biology and Evolution, p. 2118-2130, 2002

Evidence for an early appearance of modern post switch immunoglobulin isotypes in mammalian evolution (II), cloning of IgE, IgG1 and IgG2 from a monotreme, the duck billed platypus Ornithorhynchus anatinus.

Vernersson, Molly; Aveskogh, Maria; Munday, Barry; Hellman, Lars

Part of European Journal of Immunology, p. 2145-2155, 2002

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing.

Henningsson, Frida; Ledin, Johan; Lunderius, Carolina; Wilén, M et al.

Part of Biological Chemistry, p. 793-801, 2002

Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica

Aveskogh, Maria; Pilström, Lars; Hellman, Lars

Part of Developmental and Comparative Immunology, p. 597-606, 1999

• DOI for Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica

Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Lützelschwab, Claudia; Pejler, Gunnar; Aveskogh, Maria; Hellman, Lars

Part of Journal of Experimental Medicine, p. 13-29, 1997

• DOI for Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate

Nilsson, G; Blom, T; Harvima, I; Kusche-Gullberg, M et al.

Part of Immunology, p. 308-314, 1996

Characterization of a human basophil-like cell line (LAMA-84)

Blom, T; Nilsson, G; Sundström, C; Nilsson, K et al.

Part of Scand. J. Immunol., p. 54-61, 1996

A single major transcript encodes the membrane-bound form of rat immunoglobulin E

Aveskogh, Maria; Hellman, Lars

Part of Scandinavian Journal of Immunology, p. 535-539, 1995

• DOI for A single major transcript encodes the membrane-bound form of rat immunoglobulin E

Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte

Blom, Thomas; Huang, Ryanyang; Aveskogh, Maria; Nilsson, Kenneth et al.

Part of European Journal of Immunology, p. 2025-2032, 1992

• DOI for Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte

Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein: Analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome

Angerth, Tomas; Huang, Ranyang; Aveskogh, Maria; Pettersson, Inger et al.

Part of Gene, p. 235-240, 1990

• DOI for Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein: Analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome

Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function

Hellman, Lars; Akula, Srinivas; Fu, Zhirong; Wernersson, Sara

Part of Frontiers in Immunology, 2022

• DOI for Mast Cell and Basophil Granule Proteases-In Vivo Targets and Function
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The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

Akula, Srinivas; Fu, Zhirong; Wernersson, Sara; Hellman, Lars

Part of International Journal of Molecular Sciences, 2021

• DOI for The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases
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Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

Hellman, Lars T.; Akula, Srinivas; Thorpe, Michael; Fu, Zhirong

Part of Frontiers in Immunology, 2017

• DOI for Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals
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Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution

Hellman, Lars; Thorpe, Michael

Part of Biological chemistry (Print), p. 15-49, 2014

• DOI for Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators - an update on their cleavage specificity, in vivo substrates, and evolution

Therapeutic vaccines against IgE-mediated allergies

Hellman, Lars

Part of Expert Review of Vaccines, p. 193-208, 2008

• DOI for Therapeutic vaccines against IgE-mediated allergies

Regulation of IgE homeostasis, and the identification of potential targets for therapeutic intervention

Hellman, Lars

Part of Biomedicine and Pharmacotherapy, p. 34-49, 2007

• DOI for Regulation of IgE homeostasis, and the identification of potential targets for therapeutic intervention

The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

Akula, Srinivas; Hellman, Lars

Part of IGM AND ITS RECEPTORS AND BINDING PROTEINS, p. 1-23, SPRINGER-VERLAG BERLIN, 2017

• DOI for The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

Development of a therapeutic vaccine targeting blood vessels in primary tumors and metastases

Huijbers, Elisabeth JM; Femel, Julia; Cedervall, Jessica; Hein, Tobias et al.

2012

The mouse mast cell transcriptome

Akula, Srinivas; Paivandy, Aida; Thorpe, Michael; Pjeler, Gunnar et al.