Pär Gerwins

Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report

Winberg, Hans; Gerwins, Pär; Hagelsteen, Kristine

Part of EUROPEAN JOURNAL OF PEDIATRIC SURGERY REPORTS, 2024

• DOI for Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
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Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

Pavlovic, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of Life Sciences, 2021

• DOI for Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment
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Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype

Pavlović, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of International Journal of Molecular Sciences, 2020

• DOI for Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype
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Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Pavlovic, Natasa; Calitz, Carlemi; Thanapirom, Kess; Mazza, Guiseppe et al.

Part of eLIFE, 2020

• DOI for Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
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Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Part of Cellular Signalling, 2020

• DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
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Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report

Winberg, Hans; Gerwins, Pär; Hagelsteen, Kristine

Part of EUROPEAN JOURNAL OF PEDIATRIC SURGERY REPORTS, 2024

• DOI for Massive Chylous Ascites in a 9-Year-Old Girl with Malrotation-A Case Report
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Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

Pavlovic, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of Life Sciences, 2021

• DOI for Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment
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Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype

Pavlović, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Part of International Journal of Molecular Sciences, 2020

• DOI for Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype
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Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Pavlovic, Natasa; Calitz, Carlemi; Thanapirom, Kess; Mazza, Guiseppe et al.

Part of eLIFE, 2020

• DOI for Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
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Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Part of Cellular Signalling, 2020

• DOI for Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
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FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation

Heldin, Johan; O'Callaghan, Paul; Hernández Vera, Rodrigo; Fredlund Fuchs, Peder et al.

Part of Cellular Signalling, p. 125-132, 2017

• DOI for FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation

Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Heindryckx, Femke; Binet, Francois; Ponticos, Markella; Rombouts, Krista et al.

Part of EMBO Molecular Medicine, p. 729-744, 2016

• DOI for Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing
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Targeting the tumor stroma in hepatocellular carcinoma

Heindryckx, Femke; Gerwins, Pär

Part of World Journal of Hepatology, p. 165-176, 2015

• DOI for Targeting the tumor stroma in hepatocellular carcinoma

ER Stress Enhances Liver Fibrosis Through MIR-150 Degradation and XBP-1 Splicing

Heindryckx, Femke; Binet, F.; Kreuger, Johan; Gerwins, Pär

Part of Journal of Hepatology, 2015

Effect Of Extracellular Matrix On Cancer Stem Cells

Heindryckx, Femke; Rauer, D.; Bogaerts, E.; Gerwins, Pär et al.

Part of Journal of Hepatology, 2015

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

Massena, Sara; Christoffersson, Gustaf; Vågesjö, Evelina; Seignez, Cédric et al.

Part of Blood, p. 2016-2026, 2015

• DOI for Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Strese, Sara; Wickström, Malin; Fuchs, Peder Fredlund; Fryknäs, Mårten et al.

Part of Biochemical Pharmacology, p. 888-895, 2013

• DOI for The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Part of Journal of Biological Chemistry, p. 25956-25963, 2013

• DOI for MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Kilarski, Witold W; Petersson, Ludvig; Fuchs, Peder Fredlund; Zielinski, Marcin S et al.

Part of Angiogenesis, p. 643-655, 2012

• DOI for An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

Larsson, Erik; Fredlund Fuchs, Peder; Heldin, Johan; Barkefors, Irmeli et al.

Part of Genome Medicine, p. 108, 2009

• DOI for Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

Biomechanical regulation of blood vessel growth during tissue vascularization

Kilarski, Witold W.; Samolov, Branka; Petersson, Ludvig; Kvanta, Anders et al.

Part of Nature Medicine, p. 657-664, 2009

• DOI for Biomechanical regulation of blood vessel growth during tissue vascularization

A new mechanism of blood vessel growth - hope for new treatment strategies

Kilarski, Witold W.; Gerwins, Pär

Part of Discovery medicine, p. 23-27, 2009

Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer

Rennel, Emma; Mellberg, Sofie; Dimberg, Anna; Petersson, Ludvig et al.

Part of Experimental Cell Research, p. 1285-1294, 2007

• DOI for Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer

Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection

Peng, Siwei; Larsson, Annika; Wassberg, Erik; Gerwins, Pär et al.

Part of Laboratory Investigation, p. 1195-1205, 2007

• DOI for Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection

Lactadherin binds to elastin -a starting point for medin amyloid formation?

Larsson, Annika; Peng, Siwei; Persson, Helena; Rosenbloom, Joel et al.

Part of Amyloid, p. 78-85, 2006

• DOI for Lactadherin binds to elastin -a starting point for medin amyloid formation?

An ex vivo model for functional studies of myofibroblasts

Kilarski, Witold W.; Jura, Natalia; Gerwins, Pär

Part of Laboratory Investigation, p. 643-54, 2005

• DOI for An ex vivo model for functional studies of myofibroblasts

Efficient human interferon-alpha gene transfer to neuroendocrine tumor cells with long-term and stable expression

Liu, Minghui; Kilarski, Witold W.; Gerwins, Pär; Öberg, Kjell et al.

Part of Neuroendocrinology, p. 264-73, 2005

• DOI for Efficient human interferon-alpha gene transfer to neuroendocrine tumor cells with long-term and stable expression

Src family kinase-inhibitor PP2 reduces focal ischemic brain injury

Lennmyr, Fredrik; Ericsson, A.; Gerwins, Pär; Akterin, S. et al.

Part of Acta Neurologica Scandinavica, p. 175-9, 2004

• DOI for Src family kinase-inhibitor PP2 reduces focal ischemic brain injury

Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia

Lennmyr, Fredrik; Ericsson, A.; Gerwins, Pär; Ahlström, Håkan et al.

Part of Acta Neurologica Scandinavica, p. 339-45, 2003

• DOI for Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia

Regulation of endothelial cell differentiation and transformation by H-Ras

Rennel, Emma; Cross, Michael J.; Klint, Peter; Bai, Xianhe et al.

Part of Experimental Cell Research, p. 189-200, 2003

• DOI for Regulation of endothelial cell differentiation and transformation by H-Ras

Inactivation of Src family kinases inhibits angiogenesis in vivo. Implications for a mechanism involving organization of the actin cytoskeleton

Kilarski, Witold; Jura, Natalia; Gerwins, Pär

Part of Experimental Cell Research, p. 70-82, 2003

p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis

Matsumoto, Taro; Turesson, Ingela; Book, Majlis; Gerwins, Pär et al.

Part of Journal of Cell Biology, p. 149-160, 2002

• DOI for p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis

Activation of mitogen-activated protein kinases in experimental cerebral ischemia

Lennmyr, Fredrik; Karlsson, S.; Gerwins, Pär; Ata, K. A. et al.

Part of Acta Neurologica Scandinavica, p. 333-40, 2002

• DOI for Activation of mitogen-activated protein kinases in experimental cerebral ischemia

How to make tetracycline-regulated transgene expression go on and off

Rennel, Emma; Gerwins, Pär

Part of Analytical Biochemistry, p. 79-84, 2002

• DOI for How to make tetracycline-regulated transgene expression go on and off

Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes

Sakata, Naoki; Hamelmann, Eckhard; Siadak, Anthony W.; Terada, Naohiro et al.

Part of Cellular Immunology, p. 109-123, 2000

• DOI for Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes

Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

Gerwins, Pär; Sköldenberg, E; Claesson-Welsh, Lena

Part of Critical reviews in oncology/hematology, p. 185-194, 2000

Differential activation and regulation of mitogen activated protein kinases through the antigen receptor and CD40 in human B cells

Sakata, Naoki; Kawasome, Hideki; Terada, Naohiro; Gerwins, Pär et al.

Part of European Journal of Immunology, p. 2999-3008, 1999

• DOI for Differential activation and regulation of mitogen activated protein kinases through the antigen receptor and CD40 in human B cells

Platelets as Key Factors in Hepatocellular Carcinoma

Pavlovic, Natasa; Rani, Bhavna; Gerwins, Pär; Heindryckx, Femke

Part of Cancers, 2019

• DOI for Platelets as Key Factors in Hepatocellular Carcinoma
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Anti-Vascular endothelial growth factor-based angiostatics

Gerwins, Pär; Claesson-Welsh, Lena

Part of Encyclopedia of Cancer, p. 135, Elsevier, 2002

A quantitative neovascularization assay for screening pro- and anti-angiogenic factors

Kilarski, Witold; Petersson, Ludvig; Gerwins, Pär

The role of growth factor receptor signaling for angiogenesis and vessel stability in an experimental wound healing model

Petersson, Ludvig; Fredlund Fuchs, Peder; Kilarski, Witold; Gerwins, Pär

Identification of VEGF-A-induced genes in human microvascular endothelial cells using an in vitro model of invasive angiogenesis

Rennel, Emma; Mellberg, Sofie; Ameur, Adam; Orzechowski Westholm, Jakub et al.

VEGF-A-mediated gene expression in differentiating human microvascular endothelial cells

Mellberg, Sofie; Rennel, Emma; Dimberg, Anna; Bohman, Svante et al.

Neovascularization is directed by tensile forces generated during tissue remodelling

Kilarski, Witold; Samolov, Branka; Kvanta, Anders; Gerwins, Pär

A quantitative in vivo avian neovascularization assay that allows live monitoring of neovascularization processes

Kilarski, Witold; Gerwins, Pär

Medin and medin-amyloid in thoracic aortic aneurysm and dissection

Peng, Siwei; Wassberg, Erik; Gerwins, Pär; Thelin, Stefan et al.

FGD5 promotes VEGF-A signaling via inhibition of VEGF-receptor ubiquitination and degradation

Heldin, Johan; Fredlund Fuchs *, Peder; O’Callaghan *, Paul; Kasza, Zsolt et al.