Fredrik Öberg

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Part of Blood Advances, p. 4825-4841, 2025

• DOI for Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
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Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

Atienza Párraga, Alba; Nylund, Patrick; Diamanti, Klev; Garrido-Zabala, Berta et al.

Part of Scientific Reports, 2025

• DOI for Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
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PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Part of Blood Advances, p. 4825-4841, 2025

• DOI for Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
• Download full text (pdf) of Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

Atienza Párraga, Alba; Nylund, Patrick; Diamanti, Klev; Garrido-Zabala, Berta et al.

Part of Scientific Reports, 2025

• DOI for Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
• Download full text (pdf) of Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
• Download full text (pdf) of PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Part of Oncotarget, p. 6809-6923, 2016

• DOI for Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Part of Biochemical Pharmacology, p. 284-291, 2014

• DOI for AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Part of Blood, 2014

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Part of BMC Cancer, p. 318, 2012

• DOI for Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Part of PLOS ONE, 2010

• DOI for Polycomb target genes are silenced in multiple myeloma
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Herbal melanin activates TLR4/NF-kappaB signaling pathway

Öberg, Fredrik; Haseeb, Adil; Ahnfelt, Matilda; Pontén, Fredrik et al.

Part of Phytomedicine, p. 477-84, 2009

• DOI for Herbal melanin activates TLR4/NF-kappaB signaling pathway

TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Wu, Siqin; Hultquist, Anne; Hydbring, Per; Cetinkaya, Cihan et al.

Part of Experimental Cell Research, p. 3099-3111, 2009

• DOI for TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Tshuikina, Marina; Nilsson, Kenneth; Öberg, Fredrik

Part of Gene, p. 259-267, 2008

• DOI for Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Part of Experimental Hematology, p. 1673-1681, 2008

• DOI for Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Part of International Journal of Cancer, p. 189-195, 2007

• DOI for STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Part of Molecular Immunology, p. 615-624, 2007

• DOI for IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Part of International Journal of Cancer, p. 1577-1580, 2006

• DOI for Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Part of Blood, p. 1346-1354, 2005

• DOI for Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Part of Anti-Cancer Drugs, p. 45-54, 2004

PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells

Tenno, Taavo; Öberg, Fredrik; Mackman, Nigel; Nilsson, Kenneth et al.

Part of Thrombosis and Haemostasis, p. 930-9, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Part of Blood, p. 254, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines.

Dimberg, A; Oberg, F

Part of Leuk Lymphoma, p. 1641, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Part of Blood, p. 2199, 2002

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

Öberg, Fredrik; Wu, S.; Bahram, Fuad; Nilsson, Kenneth et al.

Part of Leukemia, p. 217-227, 2001

The role of RAR and RXR activation in retinoid-induced tissue factor suppression

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Jossan, S. et al.

Part of Leukemia, p. 1105-11, 2000

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Part of Blood, p. 2870, 2000

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts

Bahram, Fuad; Wu, Siqin; Öberg, Fredrik; Luscher, Bernhard et al.

Part of Blood, p. 3900-3912, 1999

Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production

Tenno, Taavo; Öberg, Fredrik; Nilsson, Kenneth; Siegbahn, Agneta

Part of European Journal of Haematology, p. 112-119, 1999

Serglycin expression during differentiation of U937-1 cells

Kulseth, Mari Ann; Mustorp, Stina Lund; Uhlin-Hansen, Lars; Öberg, Fredrik et al.

Part of Glycobiology, p. 747-753, 1998

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Botling, Johan; Castro, Diogo S.; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Journal of Biological Chemistry, p. 9443-9, 1997

• DOI for Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
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Tissue and differentiation specific expression of the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.; Andersson, A-C.; Fan, W. et al.

Part of Leukemia, p. 142-4, 1997

Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)

Johansson, M; Patarroyo, M; Öberg, Fredrik; Siegbahn, Agneta et al.

Part of Journal of Cell Science, p. 1133-1139, 1997

Tissue factor expression in human monocytic cell lines

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Thrombosis Research, p. 215-28, 1997

Vitamin D3 and retinoic acid induced monocytic differentiation: Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells

Botling, Johan; Öberg, Fredrik; Törmä, Hans; Tuohimaa, Pentti et al.

Part of Cell growth & differentiation, p. 1239-49, 1996

Expression of the endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.J.W.; Andersson, Ann-Catrin; Wansheng, F et al.

Part of Int. J. Cancer, p. 451, 1996

CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation

Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth

Part of Leukemia, p. 2034-41, 1995

Stat1 involvement in retinoic acid induced differentiation of myeloid cells

Dimberg, Anna; Nilsson, Kenneth; Oberg, Fredrik

Part of Molecular mechanisms of signal transduction, p. 211, IOS press, Amsterdam, The Netherlands, 2000

Monocytes and Macrophages

Öberg, Fredrik; Nilsson, Kenneth

Part of Transplantation Biology, p. 241, Lippincott-Raven, 1996

Cytokine induced inhibition of Myc activity in monocytic cells

Larsson, Lars-Gunnar; Bahram, F.; Wu, S.; Öberg, Fredrik et al.

Part of C-myc in B-cell neoplasia, p. 191, 1997

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

The lncRNA PCAT1 recruits the Polycomb repressive complex 2 to target genomic regions and induce H3K27me3-mediated gene silencing in multiple myeloma

Garrido-Zabala, Berta; Tziola, Stefania Iliana; Nylund, Patrick; Karlsson, Torbjörn et al.

Single-cell transcriptomic profiling identifies developmental haematopoietic program enrichment in KMT2A-rearranged infant acute lymphoblastic leukaemia

Garrido-Zabala, Berta; Pushkaran Pulinkala, Girish; Nylund, Patrick; Tziola, Stefania Iliana et al.

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

Prokunina, Ludmila; Castillejo-Lopez, Casimiro; Öberg, Fredrik; Gunnarsson, Iva et al.

Part of Nature Genetics, p. 666-669, 2002

• DOI for A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans