Fredrik Öberg

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Part of Oncotarget, p. 6809-6923, 2016

• DOI for Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
• Download full text (pdf) of PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
• Download full text (pdf) of A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
• Download full text (pdf) of The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
• Download full text (pdf) of EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Part of Oncotarget, p. 6809-6923, 2016

• DOI for Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Part of Biochemical Pharmacology, p. 284-291, 2014

• DOI for AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Part of Blood, 2014

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Part of BMC Cancer, p. 318, 2012

• DOI for Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Part of PLOS ONE, 2010

• DOI for Polycomb target genes are silenced in multiple myeloma
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Herbal melanin activates TLR4/NF-kappaB signaling pathway

Öberg, Fredrik; Haseeb, Adil; Ahnfelt, Matilda; Pontén, Fredrik et al.

Part of Phytomedicine, p. 477-84, 2009

• DOI for Herbal melanin activates TLR4/NF-kappaB signaling pathway

TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Wu, Siqin; Hultquist, Anne; Hydbring, Per; Cetinkaya, Cihan et al.

Part of Experimental Cell Research, p. 3099-3111, 2009

• DOI for TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Tshuikina, Marina; Nilsson, Kenneth; Öberg, Fredrik

Part of Gene, p. 259-267, 2008

• DOI for Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Part of Experimental Hematology, p. 1673-1681, 2008

• DOI for Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Part of International Journal of Cancer, p. 189-195, 2007

• DOI for STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Part of Molecular Immunology, p. 615-624, 2007

• DOI for IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Part of Int J Cancer, p. 1577-1580, 2006

• DOI for Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Part of Blood, 2005

• DOI for Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Part of Anti-Cancer Drugs, p. 45-54, 2004

PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells

Tenno, Taavo; Öberg, Fredrik; Mackman, Nigel; Nilsson, Kenneth et al.

Part of Thrombosis and Haemostasis, p. 930-9, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Part of Blood, p. 254, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines.

Dimberg, A; Oberg, F

Part of Leuk Lymphoma, p. 1641, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Part of Blood, p. 2199, 2002

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

Öberg, Fredrik; Wu, S.; Bahram, Fuad; Nilsson, Kenneth et al.

Part of Leukemia, p. 217-227, 2001

The role of RAR and RXR activation in retinoid-induced tissue factor suppression

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Jossan, S. et al.

Part of Leukemia, p. 1105-11, 2000

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Part of Blood, p. 2870, 2000

Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production

Tenno, Taavo; Öberg, Fredrik; Nilsson, Kenneth; Siegbahn, Agneta

Part of European Journal of Haematology, p. 112-119, 1999

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts

Bahram, Fuad; Wu, Siqin; Öberg, Fredrik; Luscher, Bernhard et al.

Part of Blood, p. 3900-3912, 1999

Serglycin expression during differentiation of U937-1 cells

Kulseth, Mari Ann; Mustorp, Stina Lund; Uhlin-Hansen, Lars; Öberg, Fredrik et al.

Part of Glycobiology, p. 747-753, 1998

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Botling, Johan; Castro, Diogo S.; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Journal of Biological Chemistry, p. 9443-9, 1997

• DOI for Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
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Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)

Johansson, M; Patarroyo, M; Öberg, Fredrik; Siegbahn, Agneta et al.

Part of Journal of Cell Science, p. 1133-1139, 1997

Tissue and differentiation specific expression of the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.; Andersson, A-C.; Fan, W. et al.

Part of Leukemia, p. 142-4, 1997

Tissue factor expression in human monocytic cell lines

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth et al.

Part of Thrombosis Research, p. 215-28, 1997

Vitamin D3 and retinoic acid induced monocytic differentiation: Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells

Botling, Johan; Öberg, Fredrik; Törmä, Hans; Tuohimaa, Pentti et al.

Part of Cell growth & differentiation, p. 1239-49, 1996

Expression of the endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.J.W.; Andersson, Ann-Catrin; Wansheng, F et al.

Part of Int. J. Cancer, p. 451, 1996

CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation

Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth

Part of Leukemia, p. 2034-41, 1995

Stat1 involvement in retinoic acid induced differentiation of myeloid cells

Dimberg, Anna; Nilsson, Kenneth; Oberg, Fredrik

Part of Molecular mechanisms of signal transduction, p. 211, IOS press, Amsterdam, The Netherlands, 2000

Monocytes and Macrophages

Öberg, Fredrik; Nilsson, Kenneth

Part of Transplantation Biology, p. 241, Lippincott-Raven, 1996

Cytokine induced inhibition of Myc activity in monocytic cells

Larsson, Lars-Gunnar; Bahram, F.; Wu, S.; Öberg, Fredrik et al.

Part of C-myc in B-cell neoplasia, p. 191, 1997

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

Prokunina, Ludmila; Castillejo-Lopez, Casimiro; Öberg, Fredrik; Gunnarsson, Iva et al.

Part of Nature Genetics, p. 666-669, 2002

• DOI for A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans