Finn Hallböök
- Telephone:
- +46 18 471 49 44
- Mobile phone:
- +46 72 999 94 19
- E-mail:
- finn.hallbook@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
- Academic merits:
- PhD, Associate Professor, Excellent teacher
- CV:
- Download CV
- ORCID:
- 0000-0001-7552-187X
Short presentation
The principal tasks are research and teaching. We study normal and pathological cell generation with focus on neurogenesis in retina. We grow human embryonic stem cell-derived organoids/retinoids in which retinoblastoma carcinogenesis is modelled. The teaching is medical and biomedical students in embryology.
Head of Department (2015 - 2018, 2018 - 2020 )
Keywords
- embryonal development
- retina
- cell differentiation
- glia cells
- retinoblastom
- stem cells
- chicken embryo
- neuronal regeneration
- developmental biology
- gene expression
- cell cycle regulation
- transcription factor
- retinal progenitors
- embryoid body
- cell culture
- visual system
- retinal ganglion cell
- horizontal cells
- müller cells
- carcinogenesis
- organoids
- ocular cancer
- photoreceptors

Publications
Recent publications
-
Part of Cellular Oncology, p. 209-227, 2024
- DOI for Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
- Download full text (pdf) of Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
-
Part of Oncogenesis, 2022
- DOI for MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
- Download full text (pdf) of MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
-
Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
Part of Genes, 2020
- DOI for Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
- Download full text (pdf) of Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
-
Part of Genome Biology and Evolution, p. 1918-1928, 2020
-
Aniridia with PAX6 mutations and narcolepsy
Part of Journal of Sleep Research, 2020
All publications
Articles in journal
-
Part of Cellular Oncology, p. 209-227, 2024
- DOI for Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
- Download full text (pdf) of Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
-
Part of Oncogenesis, 2022
- DOI for MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
- Download full text (pdf) of MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma
-
Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
Part of Genes, 2020
- DOI for Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
- Download full text (pdf) of Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs
-
Part of Genome Biology and Evolution, p. 1918-1928, 2020
-
Aniridia with PAX6 mutations and narcolepsy
Part of Journal of Sleep Research, 2020
-
High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
Part of Frontiers in Molecular Biosciences, 2020
- DOI for High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
- Download full text (pdf) of High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy
-
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
Part of PLOS Genetics, 2019
- DOI for An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
- Download full text (pdf) of An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease
-
Part of Current Eye Research, p. 34-45, 2019
-
Part of Developmental Dynamics, p. 630-641, 2018
-
Changes in brain architecture are consistent with altered fear processing in domestic rabbits
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7380-7385, 2018
-
Part of PLOS Genetics, 2017
- DOI for The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
- Download full text (pdf) of The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A
-
Part of Molecular Vision, p. 1405-1420, 2016
-
Part of PLOS ONE, 2016
- DOI for Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors
- Download full text (pdf) of Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors
-
Part of PLOS ONE, 2016
- DOI for Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
- Download full text (pdf) of Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina
-
Lineage tracing of horizontal and photoreceptor cells in the embryonic chicken retina
Part of Investigative Ophthalmology and Visual Science, 2016
-
Part of PLOS Genetics, 2015
- DOI for A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes
- Download full text (pdf) of A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes
-
Adding another piece to the retinoblastoma puzzle
Part of Cell Death and Disease, 2015
- DOI for Adding another piece to the retinoblastoma puzzle
- Download full text (pdf) of Adding another piece to the retinoblastoma puzzle
-
Whole Retinal Explants from Chicken Embryos for Electroporation and Chemical Reagent Treatments
Part of Journal of Visualized Experiments, 2015
-
Part of Cell Death Discovery, 2015
-
Part of Investigative Ophthalmology and Visual Science, p. 5933-5945, 2015
- DOI for Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
- Download full text (pdf) of Alpha2-Adrenergic-Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells
-
Specific spatial distribution of caspase-3 in normal lenses
Part of Acta Ophthalmologica, p. 289-292, 2014
-
Part of Cell Cycle, p. 3698-3706, 2014
- DOI for The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
- Download full text (pdf) of The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest
-
Part of Investigative Ophthalmology and Visual Science, p. 3385-3394, 2014
-
Part of Cell Cycle, p. 408-417, 2014
-
Part of PLOS ONE, 2013
- DOI for Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
- Download full text (pdf) of Heterogenic Final Cell Cycle by Chicken Retinal Lim1 Horizontal Progenitor Cells Leads to Heteroploid Cells with a Remaining Replicated Genome
-
Part of Physiological Genomics, p. 367-376, 2013
-
Part of Differentiation, p. 11-19, 2013
-
Part of Journal of Molecular Neuroscience, p. 615-628, 2013
-
Evolution of TUNEL-labeling in the Rat Lens After In Vivo Exposure to Just Above Threshold Dose UVB
Part of Current Eye Research, p. 880-885, 2013
-
Part of PLOS ONE, 2012
- DOI for GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
- Download full text (pdf) of GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:
-
Part of PLOS ONE, 2012
- DOI for Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
- Download full text (pdf) of Sonic Hedgehog-Signalling Patterns the Developing Chicken Comb as Revealed by Exploration of the Pea-comb Mutation
-
Part of PLOS Genetics, 2012
- DOI for The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
- Download full text (pdf) of The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility
-
Part of PLOS ONE, 2012
- DOI for Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
- Download full text (pdf) of Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation
-
Part of Neurogenetics, p. 211-221, 2011
-
Part of PLoS Genetics, 2011
-
Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation
Part of PLoS Genetics, 2011
-
Whole genome resequencing reveals loci under selection during chicken domestication
Part of Nature, p. 587-591, 2010
-
Part of Visual Neuroscience, p. 149-157, 2010
-
Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
Part of Developmental Dynamics, p. 1858-1866, 2010
-
Part of Upsala Journal of Medical Sciences, p. 65-80, 2010
-
Part of Retrovirology, p. 68, 2009
-
Part of Journal of neuroendocrinology, p. 208-216, 2009
-
Part of Investigative Ophthalmology and Visual Science, p. 424-431, 2009
-
The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
Part of Veterinary Ophthalmology, p. 292-298, 2009
-
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
Part of PLoS Genetics, 2009
-
Part of Developmental Biology, p. 105-113, 2009
-
Part of BMC Developmental Biology, p. 46, 2008
-
Part of Molecular Vision, p. 1050-1063, 2008
-
Part of Gene Expression Patterns, p. 117-123, 2008
-
The amphioxus genome illuminates vertebrate origins and cephalochordate biology
Part of Genome Research, p. 1100-1111, 2008
-
Part of Developmental Neurobiology, p. 1777-1788, 2007
-
Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
Part of Molecular and Cellular Neuroscience, p. 397-408, 2007
-
Part of European journal of histochemistry, p. 147-154, 2006
-
Formation and evolution of the chordate neurotrophin and Trk receptor genes
Part of Brain, behavior, and evolution, p. 133-144, 2006
-
A genomic view of the sea urchin nervous system
Part of Developmental Biology, p. 434-460, 2006
-
Part of Molecular biology and evolution, p. 10-22, 2006
-
Three insulin-relaxin-like genes in Ciona intestinalis
Part of Peptides, p. 2535-2546, 2006
-
The genome of the sea urchin Strongylocentrotus purpuratus
Part of Science, p. 941-952, 2006
-
Formation and evolution of the chordate neurotrophin and Trk receptor genes.
Part of Brain Behav Evol, p. 133-44, 2006
-
Part of Ann N Y Acad Sci, p. 357-9, 2005
-
Part of Ann N Y Acad Sci, p. 426-428, 2005
-
Part of Development, p. 1343-1251, 2004
-
GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection
Part of Experimental Neurology, p. 487-489, 2004
-
Part of Pharmaceutical research, p. 373-381, 2003
-
Part of Brain Research. Molecular Brain Research, p. 30-37, 2003
-
Generation of retinal ganglion cells is modulated by caspase-dependent programmed cell death
Part of European Journal of Neuroscience, p. 1744-1750, 2003
-
Part of Pharmaceutical research, p. 373-381, 2003
-
Part of Journal of Structural and Functional Genomics, p. 53-63, 2003
-
Part of European Journal of Pharmacology, p. 85-94, 2003
-
Biotin decreases retinal apoptosis and induces eye malformations in the early chick embryo
Part of NeuroReport, p. 297-299, 2002
-
Part of Mechanisms of Development, p. 161-165, 2002
-
Part of Genome Research, p. 1910-1920, 2002
-
Part of Development, p. 471-479, 2001
-
Gene functional analysis in nervous system
Part of Methods in Enzymology, p. 148-167, 2000
-
Analysis of subcellular location of bestrophin in transfected RPE cell lines
Part of Gene Function and Disease, p. 128-133, 2000
-
Evolution of the vertebrate neurotrophin and Trk receptor gene families
Part of Current Opinion in Neurobiology, p. 616-621, 1999
-
Evolution of the vertebrate neurotrophin and Trk receptor gene families
Part of Current Opinion in Neurobiology, p. 616-621, 1999
-
Part of Journal of Comparative Neurology, p. 408-416, 1998
-
Part of Brain Research. Molecular Brain Research, p. 256-267, 1998
-
Part of Neuroscience, p. 137-150, 1998
-
Part of Journal of Neuroscience, p. 8700-8711, 1998
-
Part of J. Comp. Neurol., p. 408-416, 1998
-
Human mast cells express functional TrkA and are a source of nerve growth factor
Part of European Journal of Immunology, p. 2295-2301, 1997
-
Part of International Journal of Developmental Biology, p. 725-732, 1997
-
Part of Journal of Neurobiology, p. 1019-1033, 1997
-
Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
Part of Journal of Molecular Evolution, p. 311-321, 1997
-
Part of Antisense and Nucleic Acid Drug Development, p. 89-100, 1997
-
Part of Biotechnic & Histochemistry, p. 289-94, 1996
-
Expression of neurotrophins and trk receptors in the avian retina
Part of Journal of Comparative Neurology, p. 664-676, 1996
-
Neurotrophins and their receptors in chicken neuronal development
Part of International Journal of Developmental Biology, p. 855-868, 1995
-
Part of European Journal of Neuroscience, p. 116-128, 1995
-
Differential actions of neurotrophins in the locus coeruleus and basal forebrain.
Part of Experimental Neurology, p. 72-8, 1993
-
Expression of neurotrophin-4 mRNA during oogenesis in Xenopus laevis.
Part of International Journal of Developmental Biology, p. 239-45, 1992
-
Part of Advances in Experimental Medicine and Biology, p. 207-25, 1991
-
Part of EMBO Journal, p. 269-75, 1991
-
Part of Neuron, p. 845-58, 1991
-
Part of Development, p. 693-704, 1990
-
Part of EMBO Journal, p. 1477-83, 1990
-
Part of Journal of Neuroscience Research, p. 665-77, 1990
-
Part of Journal of Neuroscience Research, p. 142-51, 1989
-
Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2628-32, 1988
-
Production and characterization of biologically active recombinant beta nerve growth factor
Part of Molecular and Cellular Biology, p. 452-456, 1988
Articles, review/survey
-
Heterogeneity in retinoblastoma: a tale of molecules and models
Part of CLINICAL AND TRANSLATIONAL MEDICINE, 2017
- DOI for Heterogeneity in retinoblastoma: a tale of molecules and models
- Download full text (pdf) of Heterogeneity in retinoblastoma: a tale of molecules and models
-
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
Part of Frontiers in Neuroanatomy, 2016
- DOI for Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
- Download full text (pdf) of Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
Books
-
Evolution of the neurotrophins and their receptors
Sulburger & Graham Publishing NY, 1999