Anca Dragomir
Adjunct senior lecturer Associate Professor at Department of Immunology, Genetics and Pathology; Research programme: Cancer Precision Medicine; Research group Fredrik Pontén
- Telephone:
- +46 18 611 38 36
- E-mail:
- anca.dragomir@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
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Short presentation
Docent i patologi
"doctrina perpetua"
Senior Consultant M.D. (surgical pathology) @Uppsala University Hospital and Adj. Senior Lecturer (pathology) @Uppsala University.
- Head of the Unit for Diagnostic Electron Microscopy
- Research into (1) cancer biomarkers (research group F. Pontén) and (2) ultrastructural pathology.
- Coordinator of pathology undergraduate teaching and lecturer
- Guest lecturer (Anatomy for medical students)
Biography
Appointments:
Adj. Seior Lecturer (pathology) - Uppsala University: June 2018 - present (associate professor/docent since 2020)
Consultant M.D. (surgical pathology) - Uppsala University Hospital: 2014 – present (senior consultant/överläkare since 2020).
- Special interest in diagnostic electron microscopy, urologic pathology and renal transplant pathology.
- Head of the Unit for Diagnostic Electron Microscopy
- Research into (1) cancer biomarkers (research group F. Pontén) and (2) ultrastructural pathology.
- Coordinator of pathology undergraduate teaching (2015-present) and lecturer (Pathology courses for medical/biomedical students since 2008)
Resident M.D. (surgical pathology) - Uppsala University Hospital: 2008 – 2013.
Guest lecturer (Anatomy for medical students): 2009 -2021
Assistant Professor (Anatomy) - Uppsala University: 2007 – 2008
Post.Doc. Researcher (cell biology) Uppsala University: 2004 – 2007
Ph.D. student (anatomy) Uppsala University: 1998 – 2004. PhD Thesis 2004: Towards pharmacological treatment and gene therapy in cystic fibrosis. Thesis advisor: Professor Godfried M. Roomans.
Publications
Selection of publications
- Effects of hyperosmotic stress on cultured airway epithelial cells (2007)
- X-ray microanalysis in the scanning electron microscope (2007)
- A modified technique for the impregnation of lanthanum tracer to study the integrity of tight junctions on cells grown on a permeable substrate (2006)
- Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione (2006)
- Composition of nasal airway surface liquid in cystic fibrosis and other airway diseases determined by X-ray microanalysis. (2006)
- Measurement of chloride transport in nasal epithelial cells by X-ray microanalysis. (2004)
- Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells. (2004)
- Heparin improves the viability of transfected cyctic fibrosis cell lines. (2004)
- Increased chloride efflux in colchicine-resistant airway epithelial cell lines. (2004)
- Assessment of CFTR locatisation in native airway epithelial cells obtained by nasal brushing. (2004)
- Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators. (2004)
Recent publications
- The Compartmentalization of Amyloid-β in Idiopathic Normal Pressure Hydrocephalus Brain Biopsies (2024)
- Multiplex protein analysis and ensemble machine learning methods of fine needle aspirates from prostate cancer patients reveal potential diagnostic signatures associated with tumour grade (2023)
- P-score in preoperative biopsies accurately predicts P-score in final pathology at radical prostatectomy in patients with localized prostate cancer (2023)
- Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress. (2022)
- Bi-parametric MRI/TRUS fusion targeted repeat biopsy after systematic 10-12 core TRUS-guided biopsy reveals more significant prostate cancer especially in anteriorly located tumors (2022)
All publications
Articles
- The Compartmentalization of Amyloid-β in Idiopathic Normal Pressure Hydrocephalus Brain Biopsies (2024)
- Multiplex protein analysis and ensemble machine learning methods of fine needle aspirates from prostate cancer patients reveal potential diagnostic signatures associated with tumour grade (2023)
- P-score in preoperative biopsies accurately predicts P-score in final pathology at radical prostatectomy in patients with localized prostate cancer (2023)
- Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress. (2022)
- Bi-parametric MRI/TRUS fusion targeted repeat biopsy after systematic 10-12 core TRUS-guided biopsy reveals more significant prostate cancer especially in anteriorly located tumors (2022)
- Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations (2021)
- Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer (2021)
- CDX2 (2020)
- Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia (2020)
- Metastatic colorectal carcinomas with high SATB2 expression are associated with better prognosis and response to chemotherapy (2020)
- Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis (2020)
- Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors (2019)
- Glandular Segmentation of Prostate Cancer (2019)
- Tumoral pyruvate kinase L/R as a predictive marker for the treatment of renal cancer patients with sunitinib and sorafenib (2019)
- Facilitating Ultrastructural Pathology through Automated Imaging and Analysis (2019)
- Tubular aggregates in congenital myasthenic syndrome (2018)
- Identification of mutations in SDR9C7 in six families with autosomal recessive congenital ichthyosis (2018)
- Homozygosity for CREB3L1 premature stop codon in first case of recessive osteogenesis imperfecta associated with OASIS-deficiency to survive infancy (2018)
- Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer (2018)
- Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice. (2017)
- Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients (2017)
- Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib (2017)
- High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer (2017)
- Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer (2016)
- Whole-exome sequencing identifies novel autosomal recessive DSG1 mutations associated with mild SAM syndrome (2016)
- High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort (2015)
- The role of SATB2 as a diagnostic marker for tumors of colorectal origin (2014)
- A Scandinavian case of skin fragility, alopecia and cardiomyopathy caused by DSP mutations (2014)
- Ultrastructure of desmosomes as a diagnostic clue in a case of congenital skin fragility syndrome (2014)
- Ultrastructure of desmosomes as a diagnostic clue in a case of congenital skin fragility syndrome (2014)
- The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epithelial cells (2011)
- CFTR and tight junctions in cultured bronchial epithelial cells (2010)
- Chitosan as a carrier for non-viral gene transfer in a cystic-fibrosis cell line (2008)
- Effects of hyperosmotic stress on cultured airway epithelial cells (2007)
- A modified technique for the impregnation of lanthanum tracer to study the integrity of tight junctions on cells grown on a permeable substrate (2006)
- Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione (2006)
- Composition of nasal airway surface liquid in cystic fibrosis and other airway diseases determined by X-ray microanalysis. (2006)
- Measurement of chloride transport in nasal epithelial cells by X-ray microanalysis. (2004)
- Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells. (2004)
- Heparin improves the viability of transfected cyctic fibrosis cell lines. (2004)
- Increased chloride efflux in colchicine-resistant airway epithelial cell lines. (2004)
- Assessment of CFTR locatisation in native airway epithelial cells obtained by nasal brushing. (2004)
- Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators. (2004)
- The tumour microenvironment across tumour evolution in bladder cancer profiled by single-cell RNA-sequencing analysis and spatial transcriptomics
Books
- Biomedical applications of lanthanum (2010)
- Assessment of chloride transport in epithelial cells with reference to cystic fibrosis (2001)
Chapters
- X-ray microanalysis in the scanning electron microscope (2014)
- X-ray microanalysis in the scanning electron microscope (2007)
Conferences
- Expression of podocalyxin-like protein and epidermal growth factor receptor in metastatic colorectal cancer: Prognostic impact and relationship with response to cetuximab. (2018)
- Prognostic significance of SATB1 expression in metastatic colorectal cancer: A Nordic prospective cohort study. (2018)
- False positive reduction of cilia detected in low resolution TEM images using a convolutional neural network (2017)
- Convolutional neural networks for false positive reduction of automatically detected cilia in low magnification TEM images (2017)
- Introducing MiniTEM for ultrastructural pathology (2017)
- Cilia ultrastructural visibility enhancement by multiple instance registration and super-resolution reconstruction (2017)
- Enhancement of cilia sub-structures by multiple instance registration and super-resolution reconstruction (2017)
- Automated detection of cilia in low magnification transmission electron microscopy images using template matching (2016)
- MiniTEM - making ultra-structural pathology easier and accessible (2014)
