Globisch Group

The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project

Abualia, Khawla; Cediel-Ulloa, Andrea; Allsopp, Philip; Augustine, Angelika et al.

Part of Frontiers in Psychiatry, 2026

• DOI for The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project
• Download full text (pdf) of The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project

Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Dovhalyuk, Vladyslav; Bui, Quang-Dong; Ripoll, Vincent; Rutkowski, Wiktor et al.

Part of Analysis & Sensing, 2026

• DOI for Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation
• Download full text (pdf) of Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Torregrosa-Chinillach, Alejandro; Tsiara, Ioanna; Haberek, Wawrzyniec; Lin, Weifeng et al.

Part of Angewandte Chemie International Edition, 2026

• DOI for Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
• Download full text (pdf) of Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Impact of Preparation Methods and Storage Conditions for Optimization of the Fecal Metabolome Storage Stability

Dovhalyuk, Vladyslav; Globisch, Daniel

Part of The Analyst, p. 4027-4037, 2026

• DOI for Impact of Preparation Methods and Storage Conditions for Optimization of the Fecal Metabolome Storage Stability
• Download full text (pdf) of Impact of Preparation Methods and Storage Conditions for Optimization of the Fecal Metabolome Storage Stability

Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles

Bergholtz, Alexandra; Lin, Weifeng; Kaur, Amanpreet; Bhetwal, Anjeela et al.

Part of Gut microbes, 2026

• DOI for Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles
• Download full text (pdf) of Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles

Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery

Tsiara, Ioanna; Hervás Povo, Belén; Alotaibi, Wafa; Young Tie Yang, Paul et al.

Part of Journal of Agricultural and Food Chemistry, p. 6702-6710, 2025

• DOI for Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery
• Download full text (pdf) of Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery

Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples

Tsiara, Ioanna; Correia, Mario S. P.; Yang, Fan; Zeng, Weiming et al.

Part of Analytical and Bioanalytical Chemistry, 2025

• DOI for Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples
• Download full text (pdf) of Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples

A universal language for finding mass spectrometry data patterns

Damiani, Tito; Jarmusch, Alan K.; Aron, Allegra T.; Petras, Daniel et al.

Part of Nature Methods, 2025

• DOI for A universal language for finding mass spectrometry data patterns
• Download full text (pdf) of A universal language for finding mass spectrometry data patterns

Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients

Dovhalyuk, Vladyslav; Yang, Fan; Nikolic, Sara; Vujasinovic, Miroslav et al.

Part of United European Gastroenterology journal, p. 1560-1570, 2025

• DOI for Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
• Download full text (pdf) of Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
• Download full text (pdf) of NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain

Vallianatou, Theodosia; de Souza Anselmo, Carina; Tsiara, Ioanna; Bechet, Nicholas B. et al.

Part of ACS Chemical Neuroscience, p. 1335-1341, 2024

• DOI for Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
• Download full text (pdf) of Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain

The protective role of commensal gut microbes and their metabolites against bacterial pathogens

Cheng, Liqin; Correia, Mario S. P.; Higdon, Shawn M.; Garcia, Fabricio Romero et al.

Part of Gut microbes, 2024

• DOI for The protective role of commensal gut microbes and their metabolites against bacterial pathogens
• Download full text (pdf) of The protective role of commensal gut microbes and their metabolites against bacterial pathogens

Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug

McCoubrey, Laura E.; Shen, Chenghao; Mwasambu, Sydney; Favaron, Alessia et al.

Part of European Journal of Pharmaceutical Sciences, 2024

• DOI for Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
• Download full text (pdf) of Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
• Download full text (pdf) of Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine

Lin, Weifeng; Gerullat, Lars; Braadland, Peder R.; Fournier, Anaïs et al.

Part of Angewandte Chemie International Edition, 2024

• DOI for Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
• Download full text (pdf) of Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine

A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken

Bi, Huijuan; Tranell, Jonas; Harper, Dawn C.; Lin, Weifeng et al.

Part of PLOS Genetics, 2023

• DOI for A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
• Download full text (pdf) of A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken

Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics

Lin, Weifeng; Mellinghaus, Kiana; Rodriguez-Mateos, Ana; Globisch, Daniel

Part of Food Chemistry, 2023

• DOI for Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
• Download full text (pdf) of Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics

Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

Kaur, Amanpreet; Lin, Weifeng; Dovhalyuk, Vladyslav; Driutti, Léna et al.

Part of Chemical Science, p. 5291-5301, 2023

• DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
• Download full text (pdf) of Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers

Nyström, Niklas; Prast-Nielsen, Stefanie; Correia, Mario; Globisch, Daniel et al.

Part of Journal of Crohn's & Colitis, p. 418-432, 2023

• DOI for Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
• Download full text (pdf) of Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers

Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures

Lin, Weifeng; Garcia, Fabricio Romero; Norin, Elisabeth Lissa; Kart, Didem et al.

Part of Chemical Communications, p. 5843-5846, 2023

• DOI for Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures

Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes

Tsiara, Ioanna; Riemer, Amelie; Correia, Mario S. P.; Rodriguez-Mateos, Ana et al.

Part of Analytical Chemistry, p. 12565-12571, 2023

• DOI for Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
• Download full text (pdf) of Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes

Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Joffré, Enrique; Xiao, Xue; Correia, Mário S. P.; Nookaew, Intawat et al.

Part of Microbiology Spectrum, 2022

• DOI for Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
• Download full text (pdf) of Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

Vallianatou, Theodosia; Bechet, Nicholas B.; Correia, Mario S. P.; Lundgaard, Iben et al.

Part of Metabolites, 2022

• DOI for Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
• Download full text (pdf) of Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Part of Biochemical Pharmacology, 2022

• DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
• Download full text (pdf) of Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep

Vallianatou, Theodosia; Lin, Weifeng; Bèchet, Nicholas B; Correia, Mario SP et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 3324-3338, 2021

• DOI for Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
• Download full text (pdf) of Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep

Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites

Lin, Weifeng; Conway, Louis P.; Vujasinovic, Miroslav; Löhr, J.‐Matthias et al.

Part of Angewandte Chemie International Edition, p. 23232-23240, 2021

• DOI for Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
• Download full text (pdf) of Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021

• DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
• Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency

Correia, Mario S. P.; Thapa, Bhawana; Vujasinovic, Miroslav; Löhr, J.-Matthias et al.

Part of RSC Advances, p. 34788-34794, 2021

• DOI for Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
• Download full text (pdf) of Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency

Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites

Jain, Abhishek; Correia, Mario S. P.; Meistermann, Hannes; Vujasinovic, Miroslav et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2021

• DOI for Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
• Download full text (pdf) of Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Lin, Weifeng; Yang, Zhen; Kaur, Amanpreet; Block, Annika et al.

Part of RSC Chemical Biology, p. 1479-1483, 2021

• DOI for Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
• Download full text (pdf) of Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples

Correia, Mario S. P.; Lin, Weifeng; Aria, Arash J.; Jain, Abhishek et al.

Part of Metabolites, 2020

• DOI for Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
• Download full text (pdf) of Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples

Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification

Lin, Weifeng; Conway, Louis P.; Block, Annika; Sommi, Greta et al.

Part of The Analyst, p. 3822-3831, 2020

• DOI for Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
• Download full text (pdf) of Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification

Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host

Correia, Mario S. P.; Jain, Abhishek; Alotaibi, Wafa; Yang, Paul Young Tie et al.

Part of Free Radical Biology & Medicine, p. 745-754, 2020

• DOI for Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
• Download full text (pdf) of Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host

Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World

Nainyte, Milda; Müller, Felix; Ganazzoli, Giacomo; Chan, Chun-Yin et al.

Part of Chemistry - A European Journal, p. 14856-14860, 2020

• DOI for Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
• Download full text (pdf) of Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Conway, Louis P.; Rendo, Verónica; Correia, Mario S. P.; Bergdahl, Ingvar A et al.

Part of Angewandte Chemie International Edition, p. 14342-14346, 2020

• DOI for Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
• Download full text (pdf) of Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

DNA surface exploration and operator bypassing during target search

Marklund, Emil; van Oosten, Brad; Mao, Guanzhong; Amselem, Elias et al.

Part of Nature, p. 858-+, 2020

• DOI for DNA surface exploration and operator bypassing during target search
• Download full text (pdf) of DNA surface exploration and operator bypassing during target search

Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples

Correia, Mario S. P.; Rao, Menghua; Ballet, Caroline; Globisch, Daniel

Part of ChemBioChem, p. 1678-1683, 2019

• DOI for Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples

Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples

Conway, Louis P.; Garg, Neeraj; Lin, Weifeng; Vujasinovic, Miroslav et al.

Part of Chemical Communications, p. 9080-9083, 2019

• DOI for Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
• Download full text (pdf) of Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples

Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry

Correia, Mário S. P.; Ballet, Caroline; Meistermann, Hannes; Conway, Louis P. et al.

Part of Bioorganic & Medicinal Chemistry, p. 955-962, 2019

• DOI for Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

Garg, Neeraj; Hansson, Annelie; Knych, Heather K.; Stanley, Scott D. et al.

Part of Organic and biomolecular chemistry, p. 698-702, 2018

• DOI for Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis

Shirey, Ryan J.; Globisch, Daniel; Eubanks, Lisa M.; Hixon, Mark S. et al.

Part of ACS - Infectious Diseases, p. 1423-1431, 2018

• DOI for Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
• Download full text (pdf) of Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

Ballet, Caroline; Correia, Mario S. P.; Conway, Louis P.; Locher, Theresa L. et al.

Part of Chemical Science, p. 6233-6239, 2018

• DOI for New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
• Download full text (pdf) of New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism

Garg, Neeraj; Conway, Louis P.; Ballet, Caroline; Correia, Mario S. P. et al.

Part of Angewandte Chemie International Edition, p. 13805-13809, 2018

• DOI for Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)

Globisch, Daniel; Eubanks, Lisa M.; Shirey, Ryan J.; Pfarr, Kenneth M. et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 3436-3440, 2017

• DOI for Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)

Effect of Antibiotic Treatment on the Gut Metabolome of Pigs

Mwasambu, Sydney; Giakoumis, Theodoros; Kořínek, Jan; O'Shea, Joey et al.

NaN

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.

NaN

Multi-omics uncovers interaction in the vaginal microbiome and a type II secretion/Tad pilus system in Gardnerella vaginalis

García, Fabricio Romero; Dovhalyuk, Vladyslav; Kuilboer, Sen; van Dijk, Karlijn Johanna et al.

NaN