Daniel Globisch
Professor at Department of Chemistry for Life Sciences; Analytical Chemistry; Globisch group
- Telephone:
- +46 70 425 01 39, +46 18 471 36 30
- E-mail:
- daniel.globisch@kemi.uu.se
- Visiting address:
- Husargatan 3 (D5)
752 37 Uppsala - Postal address:
- Box 599
75124 Uppsala
- ORCID:
- 0000-0002-4526-5788
Short presentation
Professor with focus on Biomarker Discovery using techniques at the interface of Chemistry and Biology including Chemical Biology, Organic Chemistry, mass spectrometry-based investigation of human samples, and metabolomics-methodologies. Former SciLifeLab Fellow.
- My research group: https://www.globischlab.org/
Keywords
- mass spectrometry
- biomarker discovery
- metabolomics
- bioorganic chemistry
- organic chemistry
- chemical biology
- gut microbiota
- microbiome
Biography
- 11/23 – present Uppsala University, Sweden; Full Professor
- 12/20 – 10/23 Uppsala University, Sweden; Associate Professor (tenured)
- 04/17 – 12/20 Uppsala University, Sweden; Associate Professor
- 08/15 – 04/17 Uppsala University, Sweden; Assistant Professor
- 04/11 – 08/15 The Scripps Research Institute, La Jolla, USA; PostDoc with Professor Kim D. Janda, Ph.D.
- 03/07 – 03/11 Ludwig-Maximilians-University Munich, Germany; PhD student with Professor Dr. Thomas Carell
- 04/06 – 01/07 & 04/05 – 07/05 University of Southern Denmark, Odense, Denmark
- 10/01 – 03/06 Technical University Kaiserslautern, Germany

Publications
Selection of publications
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Part of Angewandte Chemie International Edition, 2024
- DOI for Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
- Download full text (pdf) of Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Part of Gut microbes, 2024
- DOI for The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- Download full text (pdf) of The protective role of commensal gut microbes and their metabolites against bacterial pathogens
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Part of Analytical Chemistry, p. 12565-12571, 2023
- DOI for Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
- Download full text (pdf) of Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
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Part of Chemical Science, p. 5291-5301, 2023
- DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Download full text (pdf) of Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Part of Food Chemistry, 2023
- DOI for Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
- Download full text (pdf) of Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Part of Angewandte Chemie International Edition, p. 23232-23240, 2021
- DOI for Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
- Download full text (pdf) of Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
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DNA surface exploration and operator bypassing during target search
Part of Nature, p. 858-+, 2020
- DOI for DNA surface exploration and operator bypassing during target search
- Download full text (pdf) of DNA surface exploration and operator bypassing during target search
-
Part of The Analyst, p. 3822-3831, 2020
- DOI for Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
- Download full text (pdf) of Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
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Part of Chemical Communications, p. 9080-9083, 2019
- DOI for Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
- Download full text (pdf) of Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
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Part of Angewandte Chemie International Edition, p. 13805-13809, 2018
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Part of Chemical Science, p. 6233-6239, 2018
- DOI for New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
- Download full text (pdf) of New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
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Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Part of ACS - Infectious Diseases, p. 1423-1431, 2018
- DOI for Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
- Download full text (pdf) of Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Recent publications
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Part of Analysis & Sensing, 2026
- DOI for Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation
- Download full text (pdf) of Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation
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Part of Frontiers in Psychiatry, 2026
- DOI for The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project
- Download full text (pdf) of The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
- Download full text (pdf) of NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
Part of United European Gastroenterology journal, p. 1560-1570, 2025
- DOI for Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
- Download full text (pdf) of Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
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A universal language for finding mass spectrometry data patterns
Part of Nature Methods, 2025
- DOI for A universal language for finding mass spectrometry data patterns
- Download full text (pdf) of A universal language for finding mass spectrometry data patterns
All publications
Articles in journal
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Part of Analysis & Sensing, 2026
- DOI for Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation
- Download full text (pdf) of Metabolic Fingerprints of High-Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
- Download full text (pdf) of NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
Part of United European Gastroenterology journal, p. 1560-1570, 2025
- DOI for Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
- Download full text (pdf) of Differences in the Fecal Metabolome of Autoimmune Pancreatitis Patients
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A universal language for finding mass spectrometry data patterns
Part of Nature Methods, 2025
- DOI for A universal language for finding mass spectrometry data patterns
- Download full text (pdf) of A universal language for finding mass spectrometry data patterns
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Part of Analytical and Bioanalytical Chemistry, 2025
- DOI for Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples
- Download full text (pdf) of Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples
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Part of Journal of Agricultural and Food Chemistry, p. 6702-6710, 2025
- DOI for Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery
- Download full text (pdf) of Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery
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Part of Angewandte Chemie International Edition, 2024
- DOI for Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
- Download full text (pdf) of Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine
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Part of EBioMedicine, 2024
- DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
- Download full text (pdf) of Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Part of European Journal of Pharmaceutical Sciences, 2024
- DOI for Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
- Download full text (pdf) of Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens
Part of Gut microbes, 2024
- DOI for The protective role of commensal gut microbes and their metabolites against bacterial pathogens
- Download full text (pdf) of The protective role of commensal gut microbes and their metabolites against bacterial pathogens
-
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
Part of ACS Chemical Neuroscience, p. 1335-1341, 2024
- DOI for Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
- Download full text (pdf) of Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain
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Part of Analytical Chemistry, p. 12565-12571, 2023
- DOI for Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
- Download full text (pdf) of Immobilized Enzymes on Magnetic Beads for Separate Mass Spectrometric Investigation of Human Phase II Metabolite Classes
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Part of Chemical Communications, p. 5843-5846, 2023
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Part of Journal of Crohn's & Colitis, p. 418-432, 2023
- DOI for Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
- Download full text (pdf) of Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
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Part of Chemical Science, p. 5291-5301, 2023
- DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Download full text (pdf) of Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
-
Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
Part of Food Chemistry, 2023
- DOI for Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
- Download full text (pdf) of Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics
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A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
Part of PLOS Genetics, 2023
- DOI for A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
- Download full text (pdf) of A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
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Part of Biochemical Pharmacology, 2022
- DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
- Download full text (pdf) of Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
Part of Metabolites, 2022
- DOI for Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
- Download full text (pdf) of Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle
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Part of Microbiology Spectrum, 2022
- DOI for Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
- Download full text (pdf) of Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors
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Part of RSC Chemical Biology, p. 1479-1483, 2021
- DOI for Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
- Download full text (pdf) of Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
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Part of RSC Advances, p. 34788-34794, 2021
- DOI for Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
- Download full text (pdf) of Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
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Part of Journal of Pharmaceutical and Biomedical Analysis, 2021
- DOI for Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
- Download full text (pdf) of Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites
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Part of Journal of Experimental & Clinical Cancer Research, 2021
- DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
- Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Part of Journal of Cerebral Blood Flow and Metabolism, p. 3324-3338, 2021
- DOI for Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
- Download full text (pdf) of Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Part of Angewandte Chemie International Edition, p. 23232-23240, 2021
- DOI for Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
- Download full text (pdf) of Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
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Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
Part of Angewandte Chemie International Edition, p. 14342-14346, 2020
- DOI for Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
- Download full text (pdf) of Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
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Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
Part of Chemistry - A European Journal, p. 14856-14860, 2020
- DOI for Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
- Download full text (pdf) of Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World
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Part of Free Radical Biology & Medicine, p. 745-754, 2020
- DOI for Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
- Download full text (pdf) of Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host
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Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
Part of Metabolites, 2020
- DOI for Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
- Download full text (pdf) of Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples
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DNA surface exploration and operator bypassing during target search
Part of Nature, p. 858-+, 2020
- DOI for DNA surface exploration and operator bypassing during target search
- Download full text (pdf) of DNA surface exploration and operator bypassing during target search
-
Part of The Analyst, p. 3822-3831, 2020
- DOI for Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
- Download full text (pdf) of Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification
-
Part of Bioorganic & Medicinal Chemistry, p. 955-962, 2019
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Part of Chemical Communications, p. 9080-9083, 2019
- DOI for Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
- Download full text (pdf) of Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples
-
Part of ChemBioChem, p. 1678-1683, 2019
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Part of Angewandte Chemie International Edition, p. 13805-13809, 2018
-
Part of Chemical Science, p. 6233-6239, 2018
- DOI for New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
- Download full text (pdf) of New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
-
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Part of ACS - Infectious Diseases, p. 1423-1431, 2018
- DOI for Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
- Download full text (pdf) of Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
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Part of Organic and biomolecular chemistry, p. 698-702, 2018
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Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)
Part of Bioorganic & Medicinal Chemistry Letters, p. 3436-3440, 2017
Articles, review/survey
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Part of Frontiers in Psychiatry, 2026
- DOI for The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project
- Download full text (pdf) of The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project