Kirschning Group

Chemoenzymatic Synthesis of Structurally Diverse Terpenoids from Farnesyl Pyrophosphates Modified at the Central Alkene Unit

Struwe, Henry; Slotman, Christopher; Höft, Laurent; Dräger, Gerald et al.

Part of Journal of the American Chemical Society, p. 525-536, 2026

• DOI for Chemoenzymatic Synthesis of Structurally Diverse Terpenoids from Farnesyl Pyrophosphates Modified at the Central Alkene Unit
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Time- and spatially resolved LNA delivery via thermally controlled SPION technology

Kenneweg, Franziska; Hempel, Katharina; Hoehne, Lukas Philipp Joachim; Draeger, Gerald et al.

Part of Molecular Therapy Nucleic Acids, 2026

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Nickel: Geochemistry, biochemistry and its role in chemical and biological evolutions

Neubeck, Anna; Kirschning, Andreas

Part of Earth-Science Reviews, 2026

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Cyclisations and hydrolysis of geranyl and farnesyl halides in water facilitated by ultrasound-induced emulsification

Budde, Jan Luca; Kirschning, Andreas; Draeger, Gerald

Part of Organic and biomolecular chemistry, p. 2893-2898, 2026

• DOI for Cyclisations and hydrolysis of geranyl and farnesyl halides in water facilitated by ultrasound-induced emulsification
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Gravity as a Physical Selector of Chemical Evolution and the Origin of Life

Roth, Bernhard; Kirschning, Andreas; Zeilinger, Carsten

Part of Physics of Life Reviews, p. 166-195, 2026

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Terpene synthases are highly substrate tolerant – among them BcBOT2 is a “jack of all trades”

Budde, Jan Luca; Davari, Mehdi D.; Hassanin, Ahmed; Karacam, Mikail et al.

Part of Natural Product Reports, p. 10-1039, 2026

• DOI for Terpene synthases are highly substrate tolerant – among them BcBOT2 is a “jack of all trades”

Introducing Small Rings into Farnesyl Pyrophosphates Paves the Way for the Enzymatic Generation of Unnatural Sesquiterpene Scaffolds

Taser, Daghan; Victoria, Catherine; von Garrel, Leon; Droste, Jorn et al.

Part of Journal of the American Chemical Society, p. 5496-5507, 2026

• DOI for Introducing Small Rings into Farnesyl Pyrophosphates Paves the Way for the Enzymatic Generation of Unnatural Sesquiterpene Scaffolds
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Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus

Ewert, Wiebke; Bartens, Christian; Ongouta, Jekaterina; Holmes, Monika et al.

Part of Nature Communications, 2025

• DOI for Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus
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Expanding the "Terpenome": Applications of Unspecific Peroxygenases (UPOs) in Oxidations of Unnatural Terpenoids

Struwe, Henry; Grimm, Christopher; Draeger, Gerald; Beutel, Sascha et al.

Part of ChemCatChem, 2025

• DOI for Expanding the "Terpenome": Applications of Unspecific Peroxygenases (UPOs) in Oxidations of Unnatural Terpenoids
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Expanding the "Terpenome": Diterpene Synthases Accept GGPP-Ether Substrates

Ravkina, Viktoria; Dräger, Gerald; Droste, Jörn; Schwörer, Svenja et al.

Part of ACS Catalysis, p. 6796-6811, 2025

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The "factory in a lab": telescoping the Matteson and Matteson-Hoppe-Aggarwal boronate chemistry under flow conditions

Fricke, Florian; Dräger, Gerald; Kirschning, Andreas

Part of Reaction Chemistry & Engineering, p. 1048-1053, 2025

• DOI for The "factory in a lab": telescoping the Matteson and Matteson-Hoppe-Aggarwal boronate chemistry under flow conditions
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Reprogramming the Cyclization of the Sesquiterpene Synthase BcBOT2 Using 2,3-Z-Configured FPP Derivatives and by Means of "Methyl Mapping"

Budde, Jan Luca; Cay, Muhammed-Yasin; Draeger, Gerald; Droste, Joern et al.

Part of ACS Catalysis, p. 8125-8139, 2025

• DOI for Reprogramming the Cyclization of the Sesquiterpene Synthase BcBOT2 Using 2,3-Z-Configured FPP Derivatives and by Means of "Methyl Mapping"
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Chemoenzymatic Generation of Thio-analogues of ÎŽ-Cadinene, ÎŽ-Cadinol, and a Thio-diquinane Using 8-Thio-farnesylpyrophosphate

Jäger, Birk; Budde, Jan Luca; Birke, Norman; Hauke, Maximilian et al.

Part of Journal of Natural Products, p. 1653-1662, 2025

• DOI for Chemoenzymatic Generation of Thio-analogues of ÎŽ-Cadinene, ÎŽ-Cadinol, and a Thio-diquinane Using 8-Thio-farnesylpyrophosphate
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Design, Synthesis, and Cytotoxic Evaluation of New Structurally Simplified and Highly Potent Third-Generation Tubulysin Derivatives

Yadav, Kratika; Kalita, Tapash; Sharma, Lekhnath; Pandit, Amit et al.

Part of Chemistry - A European Journal, 2025

• DOI for Design, Synthesis, and Cytotoxic Evaluation of New Structurally Simplified and Highly Potent Third-Generation Tubulysin Derivatives

Telescoping a Prenyltransferase and a Diterpene Synthase to Transform Unnatural FPP Derivatives to Diterpenoids

Struwe, Henry; Li, Heng; Schrödter, Finn; Höft, Laurent et al.

Part of Organic Letters, p. 5888-5892, 2024

• DOI for Telescoping a Prenyltransferase and a Diterpene Synthase to Transform Unnatural FPP Derivatives to Diterpenoids
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Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics

Stappert, Moritz; Kohnhäuser, Daniel; Seedorf, Tim; Coetzee, Janetta et al.

Part of Communications Chemistry, 2024

• DOI for Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics
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Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

Kohnhäuser, Daniel; Seedorf, Tim; Cirnski, Katarina; Heimann, Dominik et al.

Part of Journal of Medicinal Chemistry, p. 17162-17190, 2024

• DOI for Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
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Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives

Struwe, Henry; Nguyen, Trang; Schwoerer, Svenja; Droste, Jorn et al.

Part of Biochemistry, p. 498-508, 2024

• DOI for Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives
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Sesquiterpene Cyclase BcBOT2 Promotes the Unprecedented Wagner-Meerwein Rearrangement of the Methoxy Group

Moeller, Malte; Dhar, Dipendu; Draeger, Gerald; Oezbasi, Mikail et al.

Part of Journal of the American Chemical Society, p. 17838-17846, 2024

• DOI for Sesquiterpene Cyclase BcBOT2 Promotes the Unprecedented Wagner-Meerwein Rearrangement of the Methoxy Group
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Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism

Kirschning, Andreas

Part of RSC Chemical Biology, p. 508-517, 2024

• DOI for Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism
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YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

Risch, Timo; Kolling, Dominik; Mostert, Dietrich; Seedorf, Tim et al.

Part of npj Antimicrobials and Resistance, 2024

• DOI for YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli
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