Kirschning Group

Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus

Ewert, Wiebke; Bartens, Christian; Ongouta, Jekaterina; Holmes, Monika et al.

Part of Nature Communications, 2025

• DOI for Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus
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Expanding the "Terpenome": Applications of Unspecific Peroxygenases (UPOs) in Oxidations of Unnatural Terpenoids

Struwe, Henry; Grimm, Christopher; Draeger, Gerald; Beutel, Sascha et al.

Part of ChemCatChem, 2025

• DOI for Expanding the "Terpenome": Applications of Unspecific Peroxygenases (UPOs) in Oxidations of Unnatural Terpenoids
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Expanding the "Terpenome": Diterpene Synthases Accept GGPP-Ether Substrates

Ravkina, Viktoria; Dräger, Gerald; Droste, Jörn; Schwörer, Svenja et al.

Part of ACS Catalysis, p. 6796-6811, 2025

• DOI for Expanding the "Terpenome": Diterpene Synthases Accept GGPP-Ether Substrates
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The "factory in a lab": telescoping the Matteson and Matteson-Hoppe-Aggarwal boronate chemistry under flow conditions

Fricke, Florian; Dräger, Gerald; Kirschning, Andreas

Part of Reaction Chemistry & Engineering, p. 1048-1053, 2025

• DOI for The "factory in a lab": telescoping the Matteson and Matteson-Hoppe-Aggarwal boronate chemistry under flow conditions
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Reprogramming the Cyclization of the Sesquiterpene Synthase BcBOT2 Using 2,3-Z-Configured FPP Derivatives and by Means of "Methyl Mapping"

Budde, Jan Luca; Cay, Muhammed-Yasin; Draeger, Gerald; Droste, Joern et al.

Part of ACS Catalysis, p. 8125-8139, 2025

• DOI for Reprogramming the Cyclization of the Sesquiterpene Synthase BcBOT2 Using 2,3-Z-Configured FPP Derivatives and by Means of "Methyl Mapping"
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Chemoenzymatic Generation of Thio-analogues of ÎŽ-Cadinene, ÎŽ-Cadinol, and a Thio-diquinane Using 8-Thio-farnesylpyrophosphate

Jäger, Birk; Budde, Jan Luca; Birke, Norman; Hauke, Maximilian et al.

Part of Journal of Natural Products, p. 1653-1662, 2025

• DOI for Chemoenzymatic Generation of Thio-analogues of ÎŽ-Cadinene, ÎŽ-Cadinol, and a Thio-diquinane Using 8-Thio-farnesylpyrophosphate
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Telescoping a Prenyltransferase and a Diterpene Synthase to Transform Unnatural FPP Derivatives to Diterpenoids

Struwe, Henry; Li, Heng; Schrödter, Finn; Höft, Laurent et al.

Part of Organic Letters, p. 5888-5892, 2024

• DOI for Telescoping a Prenyltransferase and a Diterpene Synthase to Transform Unnatural FPP Derivatives to Diterpenoids
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Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics

Stappert, Moritz; Kohnhäuser, Daniel; Seedorf, Tim; Coetzee, Janetta et al.

Part of Communications Chemistry, 2024

• DOI for Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics
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Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism

Kirschning, Andreas

Part of RSC Chemical Biology, p. 508-517, 2024

• DOI for Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism
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Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

Kohnhäuser, Daniel; Seedorf, Tim; Cirnski, Katarina; Heimann, Dominik et al.

Part of Journal of Medicinal Chemistry, p. 17162-17190, 2024

• DOI for Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
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Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives

Struwe, Henry; Nguyen, Trang; Schwoerer, Svenja; Droste, Jorn et al.

Part of Biochemistry, p. 498-508, 2024

• DOI for Chemoenzymatic Formation of Oxa-Terpenoids by Sesqui- and Diterpene Synthase-Mediated Biotransformations with 9-Oxy-FPP Ether Derivatives
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Sesquiterpene Cyclase BcBOT2 Promotes the Unprecedented Wagner-Meerwein Rearrangement of the Methoxy Group

Moeller, Malte; Dhar, Dipendu; Draeger, Gerald; Oezbasi, Mikail et al.

Part of Journal of the American Chemical Society, p. 17838-17846, 2024

• DOI for Sesquiterpene Cyclase BcBOT2 Promotes the Unprecedented Wagner-Meerwein Rearrangement of the Methoxy Group
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