Gerrit Brandis

Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Part of Molecular biology and evolution, p. 1029-1039, 2017

• DOI for Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
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The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Brandis, Gerrit; Hughes, Diarmaid

Part of PLOS Genetics, 2016

• DOI for The Selective Advantage of Synonymous Codon Usage Bias in Salmonella
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Autoregulation of the tufB operon in Salmonella

Brandis, Gerrit; Bergman, Jessica M.; Hughes, Diarmaid

Part of Molecular Microbiology, p. 1004-1016, 2016

• DOI for Autoregulation of the tufB operon in Salmonella

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Brandis, Gerrit; Pietsch, Franziska; Alemayehu, Rahel; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 680-685, 2015

• DOI for Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Optimization of the genetic code expansion technology for intracellular labelling and single-molecule tracking of proteins in genomically re-coded E. coli

Ilievski, Filip; Wikström, Linnea; Borg, Anneli; Volkov, Ivan et al.

Part of RSC Chemical Biology, 2026

• DOI for Optimization of the genetic code expansion technology for intracellular labelling and single-molecule tracking of proteins in genomically re-coded E. coli

Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens

Chauhan, Vatsala; Enkvist, Lisa; Chukhareva, Yuliia; Damell, Carl et al.

Part of Communications Biology, 2026

• DOI for Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens
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High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Yang, Yan; Li, Xue; Sun, Lang; Wang, Xiu-Kun et al.

Part of Microbiology Spectrum, 2025

• DOI for High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre

Bao, Letian; Liljeruhm, Josefine; Blanco, Ruben Crespo; Brandis, Gerrit et al.

Part of RNA Biology, p. 31-41, 2024

• DOI for Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
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Antibiotic perseverance increases the risk of resistance development

Brandis, Gerrit; Larsson, Jimmy; Elf, Johan

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI for Antibiotic perseverance increases the risk of resistance development
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Optimization of the genetic code expansion technology for intracellular labelling and single-molecule tracking of proteins in genomically re-coded E. coli

Ilievski, Filip; Wikström, Linnea; Borg, Anneli; Volkov, Ivan et al.

Part of RSC Chemical Biology, 2026

• DOI for Optimization of the genetic code expansion technology for intracellular labelling and single-molecule tracking of proteins in genomically re-coded E. coli

Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens

Chauhan, Vatsala; Enkvist, Lisa; Chukhareva, Yuliia; Damell, Carl et al.

Part of Communications Biology, 2026

• DOI for Evolutionary trajectories determine feasibility of collateral sensitivity-based antibiotic treatment strategies in critical bacterial pathogens
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High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Yang, Yan; Li, Xue; Sun, Lang; Wang, Xiu-Kun et al.

Part of Microbiology Spectrum, 2025

• DOI for High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre

Bao, Letian; Liljeruhm, Josefine; Blanco, Ruben Crespo; Brandis, Gerrit et al.

Part of RNA Biology, p. 31-41, 2024

• DOI for Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
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Antibiotic perseverance increases the risk of resistance development

Brandis, Gerrit; Larsson, Jimmy; Elf, Johan

Part of Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI for Antibiotic perseverance increases the risk of resistance development
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Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Part of Molecular biology and evolution, 2022

• DOI for Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
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Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of Genome Biology and Evolution, 2022

• DOI for Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
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Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 77-83, 2021

• DOI for Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
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Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Part of Molecular biology and evolution, p. 1472-1481, 2021

• DOI for Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
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Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Garmendia, Eva; Brandis, Gerrit; Guy, Lionel; Cao, Sha et al.

Part of mBio, 2021

• DOI for Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
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Reconstructing the Evolutionary History of a Highly Conserved Operon Cluster in Gammaproteobacteria and Bacilli

Brandis, Gerrit

Part of Genome Biology and Evolution, 2021

• DOI for Reconstructing the Evolutionary History of a Highly Conserved Operon Cluster in Gammaproteobacteria and Bacilli
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Expression of the qepA1 gene is induced under antibiotic exposure

Brandis, Gerrit; Gockel, Jonas; Garoff, Linnéa; Guy, Lionel et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1433-1440, 2021

• DOI for Expression of the qepA1 gene is induced under antibiotic exposure
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Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Part of Journal of Antimicrobial Chemotherapy, p. 606-615, 2021

• DOI for Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
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The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Brandis, Gerrit; Hughes, Diarmaid

Part of PLOS Genetics, 2020

• DOI for The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation
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Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Part of Molecular biology and evolution, p. 1637-1646, 2020

• DOI for Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
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Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3185-3191, 2020

• DOI for Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
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Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Bio-protocol, 2019

• DOI for Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Molecular biology and evolution, p. 1990-2000, 2019

• DOI for Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes
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Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Part of Molecular Microbiology, p. 697-710, 2018

• DOI for Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella
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Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Brandis, Gerrit; Hughes, Diarmaid

Part of Scientific Reports, 2018

• DOI for Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
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Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Garmendia, Eva; Brandis, Gerrit; Hughes, Diarmaid

Part of mBio, 2018

• DOI for Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella
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Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Part of Molecular biology and evolution, p. 1029-1039, 2017

• DOI for Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
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Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Pietsch, Franziska; Bergman, Jessica M.; Brandis, Gerrit; Marcusson, Linda L. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 75-84, 2017

• DOI for Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Praski Alzrigat, Lisa; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 3016-3024, 2017

• DOI for Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs
• Download full text (pdf) of Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Brandis, Gerrit; Cao, Sha; Huseby, Douglas L.; Hughes, Diarmaid

Part of MICROBIAL CELL, p. 275-277, 2017

• DOI for Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance
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Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Part of mBio, 2017

• DOI for Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
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The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Brandis, Gerrit; Hughes, Diarmaid

Part of PLOS Genetics, 2016

• DOI for The Selective Advantage of Synonymous Codon Usage Bias in Salmonella
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Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Meftahi, Nedra; Namouchi, Amine; Mhenni, Besma; Brandis, Gerrit et al.

Part of Journal of Antimicrobial Chemotherapy, p. 324-332, 2016

• DOI for Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Autoregulation of the tufB operon in Salmonella

Brandis, Gerrit; Bergman, Jessica M.; Hughes, Diarmaid

Part of Molecular Microbiology, p. 1004-1016, 2016

• DOI for Autoregulation of the tufB operon in Salmonella

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Brandis, Gerrit; Pietsch, Franziska; Alemayehu, Rahel; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 680-685, 2015

• DOI for Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Brandis, Gerrit; Hughes, Diarmaid

Part of Journal of Antimicrobial Chemotherapy, p. 2493-2497, 2013

• DOI for Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Brandis, Gerrit; Wrande, Marie; Liljas, Lars; Hughes, Diarmaid

Part of Molecular Microbiology, p. 142-151, 2012

• DOI for Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

IncP-1β plasmids of Comamonas sp. and Delftia sp. strains isolated from a wastewater treatment plant mediate resistance to and decolorization of the triphenylmethane dye crystal violet

Stolze, Yvonne; Eikmeyer, Felix; Wibberg, Daniel; Brandis, Gerrit et al.

Part of Microbiology, p. 2060-2072, 2012

• DOI for IncP-1β plasmids of Comamonas sp. and Delftia sp. strains isolated from a wastewater treatment plant mediate resistance to and decolorization of the triphenylmethane dye crystal violet

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

Hughes, Diarmaid; Brandis, Gerrit

Part of Antibiotics, p. 206-216, 2013

• DOI for Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution
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Biased Evolution: Causes and Consequences

Brandis, Gerrit

2016

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Single-molecule tracking of Elongation factor G in re-coded E. coli

Ilievski, Filip; Borg, Anneli; Brandis, Gerrit; Johansson, Magnus