Ram Kumar Selvaraju
Researcher at Department of Medicinal Chemistry; Preclinical PET-MRI Platform
- E-mail:
- ramkumar.selvaraju@ilk.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postal address:
- Dag Hammarskjöldsv 14C, 3 tr
751 83 Uppsala
- CV:
- Download CV
- ORCID:
- 0000-0001-9219-1497
Short presentation
I’m a translational imaging specialist with 12 years of experience in molecular imaging. At Uppsala University, I lead multimodal translational imaging studies (PET, SPECT, MRI, CT), supporting projects from design to publication. My focus is on clinical translation in diabetes, oncology, inflammation, and regenerative medicine. I’ve contributed to the development of tracers such as [⁶⁸Ga]Exendin-4, [¹¹C]5-HTP, and [¹¹C]NES, and I regularly teach imaging and analysis to students and researchers.
Keywords
- Translational molecular imaging
- PET
- SPECT
- CT
- MR
- diabetes
- oncology
- inflammation
- regenerative medicine
- Dosimetry
- PMOD
- InterView Fusion
Biography
2017- Researcher, Uppsala University (UU), Sweden
2016-2017 Postdoctoral researcher, UU, Sweden.
2011-2015 Ph. D. in Pharmacy, UU, Sweden.
Thesis Title: [68Ga]Exendin-4: Bench-to-Bedside.
2009-2011 M. Sc. in Medical Nuclide Techniques, UU, Sweden.
2005-2009 B.Tech in Biotechnology, VIT University, India.
---------------------------------------------------
Research routines are translational-oriented, with the use of
* Short lived positron emitting radionuclide such as [11C] ,[18F] & [68Ga]
* Long lived SPECT radionuclides such as [99mTc], [111In] & [177Lu]
* Human islets and cancer cell lines of pancreatic origin.
* Autoradiography
* Small animal and translational models
* In vivo imaging in small animals with PET, SPECT, CT, and MR
* Image analysis using software such as PMOD, InterView Fusion, and Image J.

Publications
Selection of publications
-
Part of Scientific Reports, 2024
- DOI for Assessment of spectral ghost artifacts in echo-planar spectroscopic micro-imaging with flyback readout
- Download full text (pdf) of Assessment of spectral ghost artifacts in echo-planar spectroscopic micro-imaging with flyback readout
-
Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
Part of Nuclear Medicine and Biology, p. 62-71, 2022
- DOI for Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
- Download full text (pdf) of Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
-
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Part of Diabetes, p. 966-975, 2021
-
Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
Part of International Journal of Molecular Sciences, 2019
- DOI for Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
- Download full text (pdf) of Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
-
Part of Theranostics, p. 4462-4476, 2018
- DOI for Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
- Download full text (pdf) of Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
-
Part of Journal of Controlled Release, p. 178-186, 2018
- DOI for Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept
- Download full text (pdf) of Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept
-
In Vivo Visualization of beta-Cells by Targeting of GPR44
Part of Diabetes, p. 182-192, 2018
-
Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
Part of Acta Diabetologica, p. 1039-1045, 2017
- DOI for Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
- Download full text (pdf) of Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
-
Positron Emission Tomography to assess the outcome of intraportal islet transplantation
Part of Diabetes, p. 2482-2489, 2016
-
2015
-
Part of EJNMMI Research, 2014
- DOI for Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects
- Download full text (pdf) of Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects
-
Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma
Part of Nuclear Medicine and Biology, p. 471-476, 2014
-
Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas
Part of Journal of Nuclear Medicine, p. 460-465, 2014
-
Part of Diabetes, p. 3428-3437, 2014
-
Part of Journal of Clinical Endocrinology and Metabolism, p. 1519-1524, 2014
-
Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human
Part of Journal of Nuclear Medicine, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Part of Journal of Nuclear Medicine, p. 1458-1463, 2013
Recent publications
-
Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
Part of Nuclear medicine communications, p. 401-410, 2026
- DOI for Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
- Download full text (pdf) of Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
-
Part of Journal of Nuclear Medicine, p. 269-275, 2026
- DOI for Preclinical Validation of [177Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
- Download full text (pdf) of Preclinical Validation of [177Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
-
Part of Scientific Reports, 2025
- DOI for Ghost peaks simulation and reduction in high-resolution echo-planar spectroscopic imaging with flyback readout
- Download full text (pdf) of Ghost peaks simulation and reduction in high-resolution echo-planar spectroscopic imaging with flyback readout
-
Part of Molecular Cancer Therapeutics, p. 753-762, 2025
- DOI for Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
- Download full text (pdf) of Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
-
Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Part of Scientific Reports, 2025
- DOI for Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
- Download full text (pdf) of Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
All publications
Articles in journal
-
Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
Part of Nuclear medicine communications, p. 401-410, 2026
- DOI for Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
- Download full text (pdf) of Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
-
Part of Journal of Nuclear Medicine, p. 269-275, 2026
- DOI for Preclinical Validation of [177Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
- Download full text (pdf) of Preclinical Validation of [177Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
-
Part of Scientific Reports, 2025
- DOI for Ghost peaks simulation and reduction in high-resolution echo-planar spectroscopic imaging with flyback readout
- Download full text (pdf) of Ghost peaks simulation and reduction in high-resolution echo-planar spectroscopic imaging with flyback readout
-
Part of Molecular Cancer Therapeutics, p. 753-762, 2025
- DOI for Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
- Download full text (pdf) of Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
-
Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Part of Scientific Reports, 2025
- DOI for Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
- Download full text (pdf) of Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
-
Part of Scientific Reports, 2024
- DOI for Assessment of spectral ghost artifacts in echo-planar spectroscopic micro-imaging with flyback readout
- Download full text (pdf) of Assessment of spectral ghost artifacts in echo-planar spectroscopic micro-imaging with flyback readout
-
Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
Part of Nuclear Medicine and Biology, p. 62-71, 2022
- DOI for Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
- Download full text (pdf) of Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
-
Part of Advanced Therapeutics, 2022
- DOI for Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
- Download full text (pdf) of Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
-
18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand
Part of European Journal of Pharmaceutical Sciences, 2021
-
Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Part of Diabetes, p. 966-975, 2021
-
Part of Nuclear Medicine and Biology, p. 1-10, 2019
- DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
- Download full text (pdf) of Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
-
Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
Part of International Journal of Molecular Sciences, 2019
- DOI for Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
- Download full text (pdf) of Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
-
Part of Theranostics, p. 4462-4476, 2018
- DOI for Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
- Download full text (pdf) of Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
-
Part of EJNMMI Research, 2018
- DOI for The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.
- Download full text (pdf) of The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.
-
Part of Acta Diabetologica, p. 49-57, 2018
- DOI for Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4
- Download full text (pdf) of Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4
-
Part of Journal of Controlled Release, p. 178-186, 2018
- DOI for Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept
- Download full text (pdf) of Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept
-
In Vivo Visualization of beta-Cells by Targeting of GPR44
Part of Diabetes, p. 182-192, 2018
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017
-
Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
Part of Acta Diabetologica, p. 1039-1045, 2017
- DOI for Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
- Download full text (pdf) of Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
-
Positron Emission Tomography to assess the outcome of intraportal islet transplantation
Part of Diabetes, p. 2482-2489, 2016
-
Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.
Part of International journal of oncology, p. 2124-2134, 2016
-
Part of International journal of oncology, p. 461-470, 2016
- DOI for Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
- Download full text (pdf) of Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 974-982, 2016
- DOI for Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
- Download full text (pdf) of Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
-
Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
Part of Transplantation Direct, 2016
- DOI for Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
- Download full text (pdf) of Quantification of Beta-Cell Mass in Intramuscular Islet Grafts using Radiolabeled Exendin-4
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2015
-
Dosimetry of [Ga-68]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
-
Part of Journal of labelled compounds & radiopharmaceuticals, 2015
-
Part of Molecular Imaging, p. 1-12, 2014
-
Part of EJNMMI Research, 2014
- DOI for Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects
- Download full text (pdf) of Strategy to develop a MAO-A-resistant 5-hydroxy-L-[beta-C-11]tryptophan isotopologue based on deuterium kinetic isotope effects
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma
Part of Nuclear Medicine and Biology, p. 471-476, 2014
-
Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes.
Part of PLOS ONE, 2014
- DOI for Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes.
- Download full text (pdf) of Histidine-Rich Glycoprotein Uptake and Turnover Is Mediated by Mononuclear Phagocytes.
-
Part of Bioconjugate chemistry, p. 82-92, 2014
- DOI for Incorporation of a Triglutamyl Spacer Improves the Biodistribution of Synthetic Affibody Molecules Radiofluorinated at the N-Terminus via Oxime Formation with (18)F-4-Fluorobenzaldehyde
- Download full text (pdf) of Incorporation of a Triglutamyl Spacer Improves the Biodistribution of Synthetic Affibody Molecules Radiofluorinated at the N-Terminus via Oxime Formation with (18)F-4-Fluorobenzaldehyde
-
Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas
Part of Journal of Nuclear Medicine, p. 460-465, 2014
-
Characterization of CD44 variant expression in head and neck squamous cell carcinomas
Part of Tumor Biology, p. 2053-2062, 2014
- DOI for Characterization of CD44 variant expression in head and neck squamous cell carcinomas
- Download full text (pdf) of Characterization of CD44 variant expression in head and neck squamous cell carcinomas
-
Part of Diabetes, p. 3428-3437, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1450-1459, 2014
- DOI for Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3 08699 affibody molecule
- Download full text (pdf) of Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3 08699 affibody molecule
-
Part of Journal of Clinical Endocrinology and Metabolism, p. 1519-1524, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1800-1810, 2014
-
PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs
Part of Journal of Nuclear Medicine, p. 387, 2014
-
Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rat, non-human primate and human
Part of Journal of Nuclear Medicine, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2014
-
Part of Journal of labelled compounds & radiopharmaceuticals, 2013
-
Part of PLOS ONE, 2013
- DOI for Influence of Macrocyclic Chelators on the Targeting Properties of 68Ga-Labeled Synthetic Affibody Molecules: Comparison with 111In-Labeled Counterparts
- Download full text (pdf) of Influence of Macrocyclic Chelators on the Targeting Properties of 68Ga-Labeled Synthetic Affibody Molecules: Comparison with 111In-Labeled Counterparts
-
Part of Bioconjugate chemistry, p. 1102-1109, 2013
- DOI for Influence of Nuclides and Chelators on Imaging Using Affibody Molecules: Comparative Evaluation of Recombinant Affibody Molecules Site-Specifically Labeled with 68Ga and 111In via Maleimido Derivatives of DOTA and NODAGA
- Download full text (pdf) of Influence of Nuclides and Chelators on Imaging Using Affibody Molecules: Comparative Evaluation of Recombinant Affibody Molecules Site-Specifically Labeled with 68Ga and 111In via Maleimido Derivatives of DOTA and NODAGA
-
Part of Nuclear Medicine and Biology, p. 567-575, 2013
-
Part of Bioconjugate chemistry, p. 1144-1153, 2013
- DOI for Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
- Download full text (pdf) of Synthesis and Characterization of a High-Affinity NOTA-Conjugated Bombesin Antagonist for GRPR-Targeted Tumor Imaging
-
Part of Journal of Nuclear Medicine, p. 1458-1463, 2013
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013
-
Part of Journal of labelled compounds & radiopharmaceuticals, 2013
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2013
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
-
Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012
-
Part of Bioconjugate chemistry, p. 1661-1670, 2012
-
Part of European Journal of Nuclear Medicine and Molecular Imaging, 2012