Anthony Forster
Professor at Department of Cell and Molecular Biology; Molecular Biology
- Telephone:
- +46 18 471 46 18
- E-mail:
- anthony.forster@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 Uppsala
Short presentation
Biography
Anthony C. Forster (Ph.D. Biochem., U. Adelaide; M.D., Harvard U.) heads the Program in Molecular Biology at the Department of Cell and Molecular Biology and researches RNA, protein synthesis and applications thereof (synthetic biology). He discovered the hammerhead catalytic RNA structure, invented external guide sequences for ribonuclease P, and created unnatural genetic codes de novo, all of which founded biotech companies. He has published in journals including Cell, Nature and Science, edited volumes of Methods and Biotechnology J., and coauthored "Synthetic Biology: A Lab Manual."

Publications
Recent publications
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Synthetic biology: A lab manual
World Scientific, 2025
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Fast peptide bond formation and release by the ribosomal large subunit
Part of Journal of Biological Chemistry, 2025
- DOI for Fast peptide bond formation and release by the ribosomal large subunit
- Download full text (pdf) of Fast peptide bond formation and release by the ribosomal large subunit
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Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
Part of RNA Biology, p. 31-41, 2024
- DOI for Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
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Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
Part of Journal of Biological Chemistry, 2022
- DOI for Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
- Download full text (pdf) of Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
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Part of RNA, p. 796-807, 2022
All publications
Articles in journal
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Fast peptide bond formation and release by the ribosomal large subunit
Part of Journal of Biological Chemistry, 2025
- DOI for Fast peptide bond formation and release by the ribosomal large subunit
- Download full text (pdf) of Fast peptide bond formation and release by the ribosomal large subunit
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Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
Part of RNA Biology, p. 31-41, 2024
- DOI for Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
- Download full text (pdf) of Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre
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Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
Part of Journal of Biological Chemistry, 2022
- DOI for Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
- Download full text (pdf) of Rate-limiting hydrolysis in ribosomal release reactions revealed by ester activation
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Part of RNA, p. 796-807, 2022
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Revisiting the Extinction of the RNA World
Part of Biochemistry, p. 749-751, 2022
- DOI for Revisiting the Extinction of the RNA World
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Tales of the unexpected in Sidney Altman's laboratory
Part of RNA, p. 1406-1408, 2022
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Part of Scientific Reports, 2021
- DOI for In vitro synthesis of 32 translation-factor proteins from a single template reveals impaired ribosomal processivity
- Download full text (pdf) of In vitro synthesis of 32 translation-factor proteins from a single template reveals impaired ribosomal processivity
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Overcoming chromoprotein limitations by engineering a red fluorescent protein
Part of Analytical Biochemistry, 2020
- DOI for Overcoming chromoprotein limitations by engineering a red fluorescent protein
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Part of ENGINEERING REPORTS, 2020
- DOI for Rationally designed Spot 42 RNAs with an inhibition/toxicity profile advantageous for engineering E. coli
- Download full text (pdf) of Rationally designed Spot 42 RNAs with an inhibition/toxicity profile advantageous for engineering E. coli
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Kinetics of D-amino acid incorporation in translation
Part of ACS Chemical Biology, p. 204-213, 2019
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Engineering a palette of eukaryotic chromoproteins for bacterial synthetic biology
Part of Journal of Biological Engineering, 2018
- DOI for Engineering a palette of eukaryotic chromoproteins for bacterial synthetic biology
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De novo design and synthesis of a 30-cistron translation-factor module
Part of Nucleic Acids Research, p. 10895-10905, 2017
- DOI for De novo design and synthesis of a 30-cistron translation-factor module
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Part of Scientific Reports, 2017
- DOI for Translational roles of the C75 2 ' OH in an in vitro tRNA transcript at the ribosomal A, P and E sites
- Download full text (pdf) of Translational roles of the C75 2 ' OH in an in vitro tRNA transcript at the ribosomal A, P and E sites
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Part of Biotechnology and Bioengineering, p. 1552-1559, 2016
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Part of Journal of the American Chemical Society, p. 15587-15595, 2016
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Part of ACS Chemical Biology, p. 2187-2192, 2015
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Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNAPro
Part of ACS Chemical Biology, p. 1303-1311, 2014
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Facile Synthesis of N-Acyl-aminoacyl-pCpA for Preparation of Mischarged Fully Ribo tRNA
Part of Bioconjugate chemistry, p. 2086-2091, 2014
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A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
Part of RNA, p. 632-643, 2014
- DOI for A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
- Download full text (pdf) of A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
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Differential Translation Tunes Uneven Production of Operon-Encoded Proteins
Part of Cell Reports, p. 938-944, 2013
- DOI for Differential Translation Tunes Uneven Production of Operon-Encoded Proteins
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Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Part of Nucleic Acids Research, p. 9537-9548, 2013
- DOI for Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
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Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Part of Nucleic Acids Research, p. 10507-20, 2012
- DOI for Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
- Download full text (pdf) of Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
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Multigene expression in vivo: Supremacy of large versus small terminators for T7 RNA polymerase
Part of Biotechnology and Bioengineering, p. 1043-1050, 2012
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Editorial: NextGen SynBio has arrived...
Part of Biotechnology Journal, p. 827-827, 2012
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Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation
Part of Journal of the American Chemical Society, p. 17955-17962, 2012
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Multiplexed in Vivo His-Tagging of Enzyme Pathways for in Vitro Single-Pot Multienzyme Catalysis
Part of ACS Synthetic Biology, p. 43-52, 2012
Articles, review/survey
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Part of Current opinion in chemical biology, p. 180-187, 2018
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Synthetic biology challenges long-held hypotheses in translation, codon bias and transcription
Part of Biotechnology Journal, p. 835-845, 2012
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Update on pure translation display with unnatural amino acid incorporation
Part of Methods in Molecular Biology, p. 349-365, 2012
Books
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Synthetic biology: A lab manual
World Scientific, 2025
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Synthetic Biology: A Lab Manual
World Scientific, 2014