Irena Loryan

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Part of Pharmaceutical research, p. 1321-1341, 2022

• DOI for Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
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Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Part of Molecular Psychiatry, p. 7732-7745, 2021

• DOI for Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Part of Scientific Reports, 2019

• DOI for Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
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In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Part of Molecular Psychiatry, p. 1527-1536, 2016

• DOI for In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

Part of Molecular Pharmaceutics, p. 520-532, 2015

• DOI for Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

Part of Pharmaceutical research, p. 2203-2219, 2014

• DOI for Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

The brain slice method for studying drug distribution in the CNS

Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

Part of Fluids and Barriers of the CNS, p. 6, 2013

• DOI for The brain slice method for studying drug distribution in the CNS
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Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.

Part of Antimicrobial Agents and Chemotherapy, 2026

• DOI for Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo
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Evaluation of sNfL as a biomarker for paclitaxel-induced peripheral neurotoxicity through an integrated PKPD model

Ibrahim, Eman I.K.; Girdenytė, Milda; Hu, Yang; Di Cesare Mannelli, Lorenzo et al.

Part of Pharmaceutical research, p. 1071-1088, 2026

• DOI for Evaluation of sNfL as a biomarker for paclitaxel-induced peripheral neurotoxicity through an integrated PKPD model
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Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation

Bällgren, Frida; Svane, Nana; Ginosyan, Aghavni; Pedersen, Alberte Bay Villekjaer et al.

Part of Fluids and Barriers of the CNS, 2025

• DOI for Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation
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Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Expert Opinion on Drug Delivery, p. 421-439, 2025

• DOI for Assessing central nervous system drug delivery
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Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
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Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.

Part of Antimicrobial Agents and Chemotherapy, 2026

• DOI for Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo
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Evaluation of sNfL as a biomarker for paclitaxel-induced peripheral neurotoxicity through an integrated PKPD model

Ibrahim, Eman I.K.; Girdenytė, Milda; Hu, Yang; Di Cesare Mannelli, Lorenzo et al.

Part of Pharmaceutical research, p. 1071-1088, 2026

• DOI for Evaluation of sNfL as a biomarker for paclitaxel-induced peripheral neurotoxicity through an integrated PKPD model
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Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation

Bällgren, Frida; Svane, Nana; Ginosyan, Aghavni; Pedersen, Alberte Bay Villekjaer et al.

Part of Fluids and Barriers of the CNS, 2025

• DOI for Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation
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Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
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The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)

Micheli, Laura; Balayssac, David; Busserolles, Jérôme; Dalbos, Cristelle et al.

Part of Toxicology, 2025

• DOI for The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)
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Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Fluids and Barriers of the CNS, 2024

• DOI for Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
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Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Part of Frontiers in Pharmacology, 2024

• DOI for Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
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Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Part of Fluids and Barriers of the CNS, 2024

• DOI for Active CNS delivery of oxycodone in healthy and endotoxemic pigs
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Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates

Bällgren, Frida; Hu, Yang; Li, Shannuo; van de Beek, Lara et al.

Part of Frontiers in Cellular Neuroscience, 2024

• DOI for Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates
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Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Svane, Nana; Bällgren, Frida; Ginosyan, Aghavni; Kristensen, Mie et al.

Part of Journal of Headache and Pain, 2024

• DOI for Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Kurtyka, Magdalena; Wessely, Frank; Bau, Sarah; Ifie, Eseoghene et al.

Part of European Journal of Cell Biology, 2024

• DOI for The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
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Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Hu, Yang; Girdenyte, Milda; Roest, Lieke; Liukkonen, Iida et al.

Part of Fluids and Barriers of the CNS, 2024

• DOI for Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
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Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia et al.

Part of Pharmaceutics, 2023

• DOI for Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Pharmaceutical research, p. 2715-2730, 2023

• DOI for Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
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Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution

Spreitzer, Iva; Keife, Josefin; Strasser, Tobias; Kalaba, Predrag et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution
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Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project

Balayssac, David; Busserolles, Jérôme; Broto, Catherine; Dalbos, Cristelle et al.

Part of Biomedicine and Pharmacotherapy, 2023

• DOI for Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project
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Brain barriers virtual: an interim solution or future opportunity?

Holder, Brianna M.; Tolan, Shaina E.; Heinrich, Kaleb K.; Miller, Kaitlin C. et al.

Part of Fluids and Barriers of the CNS, 2022

• DOI for Brain barriers virtual: an interim solution or future opportunity?
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Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Part of Pharmaceutical research, p. 1321-1341, 2022

• DOI for Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
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Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Part of Pharmaceutical research, p. 1283-1289, 2022

• DOI for Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Part of Molecular Psychiatry, p. 7732-7745, 2021

• DOI for Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
• Download full text (pdf) of Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Andronis, Christos; Silva, João Pedro; Lekka, Eftychia; Virvilis, Vassilis et al.

Part of Archives of Toxicology, p. 2829-2845, 2020

• DOI for Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
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Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Mantas, Athanasios; Labbe, Valentine; Loryan, Irena; Mihranyan, Albert

Part of Pharmaceutics, 2019

• DOI for Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility
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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Part of Scientific Reports, 2019

• DOI for Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
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Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

Part of Addiction Biology, p. 935-945, 2019

• DOI for Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

Part of Molecular Pharmaceutics, p. 3261-3274, 2019

• DOI for Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

Part of Molecular Pharmaceutics, p. 4362-4373, 2017

• DOI for Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Part of Molecular Psychiatry, p. 1527-1536, 2016

• DOI for In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

Part of Molecular Pharmaceutics, p. 520-532, 2015

• DOI for Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Effect of transporter inhibition on the distribution of cefadroxil in rat brain

Chen, Xiaomei; Loryan, Irena; Payan, Maryam; Keep, Richard et al.

Part of Fluids and Barriers of the CNS, 2014

• DOI for Effect of transporter inhibition on the distribution of cefadroxil in rat brain
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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

Part of Pharmaceutical research, p. 2203-2219, 2014

• DOI for Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

The brain slice method for studying drug distribution in the CNS

Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

Part of Fluids and Barriers of the CNS, p. 6, 2013

• DOI for The brain slice method for studying drug distribution in the CNS
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Sex difference in formation of propofol metabolites: a replication study

Choong, Eva; Loryan, Irena; Lindqvist, Marja; Nordling, Åsa et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 126-131, 2013

• DOI for Sex difference in formation of propofol metabolites: a replication study

UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

Haslemo, T; Loryan, Irena; Ueda, N; Mannheimer, B et al.

Part of Clinical Pharmacology and Therapeutics, p. 221-227, 2012

• DOI for UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

Loryan, Irena; Lindqvist, Marja; Johansson, Inger; Hiratsuka, Masahiro et al.

Part of European Journal of Clinical Pharmacology, p. 397-406, 2012

• DOI for Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Expert Opinion on Drug Delivery, p. 421-439, 2025

• DOI for Assessing central nervous system drug delivery
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Brain Distribution of Drugs: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Part of Handbook of Experimental Pharmacology, p. 121-150, Springer, 2022

• DOI for Brain Distribution of Drugs: Pharmacokinetic Considerations

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Syvänen, Stina; Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Handbook of Experimental Pharmacology, p. 223-244, Springer, 2022

• DOI for In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Drug discovery methods for studying brain drug delivery and distribution

Loryan, Irena; Hammarlund-Udenaes, Margareta

Part of Drug delivery to the brain, p. 271-316, Springer, 2016

• DOI for Drug discovery methods for studying brain drug delivery and distribution

Dual behavior of cyclic peptides at the blood-brain barrier vs brain cellular uptake: Importance for CNS drug development

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Culot, Maxime et al.

Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters

Melander, Erik; Hosseini, Kimia; Eriksson, Camilla; Fredriksson, Robert et al.

Pharmacokinetic-pharmacodynamic modelling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.