Max Backman

Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy

Nwadozi, Emmanuel; Strell, Carina; Nordling, Sofia; Lindberg, Amanda et al.

Part of Cancer Letters, 2026

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In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC

Lindberg, Amanda; Hellberg, Louise; Grandon, Anaïs; Yu, Hui et al.

Part of Cell Communication and Signaling, 2026

• DOI for In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC
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Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer

Yu, Hui; Magoulopoulou, Anastasia; Amini, Rose-Marie; Chatzinikolaou, Maria Paraskevi et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer
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In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC

Lindberg, Amanda; Muhl, Lars; Yu, Hui; Hellberg, Louise et al.

Part of Journal of Thoracic Oncology, p. 625-640, 2025

• DOI for In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC
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Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.

Elfving, Hedvig; Yu, Hui; Kassete Fessehatsio, Kaleab; Brunnström, Hans et al.

Part of Cellular Oncology, p. 801-808, 2025

• DOI for Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.
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Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy

Nwadozi, Emmanuel; Strell, Carina; Nordling, Sofia; Lindberg, Amanda et al.

Part of Cancer Letters, 2026

• DOI for Vascular leakage in non-small cell lung cancer is associated with immune evasion and poor response to immunotherapy
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In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC

Lindberg, Amanda; Hellberg, Louise; Grandon, Anaïs; Yu, Hui et al.

Part of Cell Communication and Signaling, 2026

• DOI for In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC
• Download full text (pdf) of In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC

Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer

Yu, Hui; Magoulopoulou, Anastasia; Amini, Rose-Marie; Chatzinikolaou, Maria Paraskevi et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer
• Download full text (pdf) of Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer

In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC

Lindberg, Amanda; Muhl, Lars; Yu, Hui; Hellberg, Louise et al.

Part of Journal of Thoracic Oncology, p. 625-640, 2025

• DOI for In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC
• Download full text (pdf) of In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC

Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.

Elfving, Hedvig; Yu, Hui; Kassete Fessehatsio, Kaleab; Brunnström, Hans et al.

Part of Cellular Oncology, p. 801-808, 2025

• DOI for Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.
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Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies

Elfving, Hedvig; Thurfjell, Viktoria; Mattsson, Johanna Sofia Margareta; Backman, Max et al.

Part of Archives of Pathology & Laboratory Medicine, 2024

• DOI for Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies
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Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer

Hikmet Noraddin, Feria; Rassy, Marc; Backman, Max; Méar, Loren et al.

Part of Molecular Oncology, p. 2603-2617, 2023

• DOI for Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of eBioMedicine, 2023

• DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features

Pellinen, Teijo; Paavolainen, Lassi; Martín-Bernabé, Alfonso; Papatella Araujo, Renata et al.

Part of Journal of the National Cancer Institute, p. 71-82, 2023

• DOI for Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features
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Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer

Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S. M. et al.

Part of European Journal of Cancer, p. 40-52, 2023

• DOI for Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer
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Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer

Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 243-256, 2021

• DOI for Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
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PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung

Goldmann, Torsten; Marwitz, Sebastian; Nitschkowski, Dorte; Krupar, Rosemarie et al.

Part of Cancer Immunology and Immunotherapy, p. 2577-2587, 2021

• DOI for PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
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The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

Micke, Patrick; Strell, Carina; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of eBioMedicine, 2021

• DOI for The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types
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Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer

Elfving, Hedvig; Broström, Erika; Moens, Lotte N.J.; Almlöf, Jonas et al.

Part of Lung Cancer, p. 53-59, 2021

• DOI for Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer

FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response

Bogatyrova, Olga; Mattsson, Johanna S M; Ross, Edith M.; Sanderson, Michael P. et al.

Part of European Journal of Cancer, p. 136-149, 2021

• DOI for FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response
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Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation

Moreno-Ruiz, Pablo; Corvigno, Sara; te Grootenhuis, Nienke C.; La Fleur, Linnéa et al.

Part of Lung Cancer, p. 10-19, 2021

• DOI for Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation
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The Immune Landscape of Colorectal Cancer

Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max et al.

Part of Cancers, 2021

• DOI for The Immune Landscape of Colorectal Cancer
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Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues

Lindskog, Cecilia; Backman, Max; Zieba, Agata; Asplund, Anna et al.

Part of Journal of Histochemistry and Cytochemistry, p. 515-529, 2020

• DOI for Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues

ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma

Miyashita, Naoya; Horie, Masafumi; Mikami, Yu; Urushiyama, Hirokazu et al.

Part of Cancer Letters, p. 121-132, 2020

• DOI for ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma

Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray

Elfving, Hedvig; Mattsson, Johanna Sofia Margareta; Lindskog, Cecilia; Backman, Max et al.

Part of Clinical Lung Cancer, p. 258-2620, 2019

• DOI for Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray

Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 421-431, 2018

• DOI for Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2018

• DOI for Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability

Brunnstrom, Hans; Johansson, Anna; Westbom-Fremer, Sofia; Backman, Max et al.

Part of Modern Pathology, p. 1411-1421, 2017

• DOI for PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability

PD-L1 immunohistochemistry in clinical diagnostics: Inter-pathologist variability is as high as assay variability

Micke, Patrick; Johansson, Anna; Westbom-Fremer, Anna; Backman, Max et al.

Part of Journal of Clinical Oncology, 2017

• DOI for PD-L1 immunohistochemistry in clinical diagnostics: Inter-pathologist variability is as high as assay variability

Spatial immune analyses in clinical cancer tissue

Backman, Max

2022

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Spatial immunophenotyping of the tumor microenvironment in non-small cell lung cancer

Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S. M. et al.