Mohanraj Ramachandran

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
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Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

Wicher, Grzegorz; Roy, Ananya; Vaccaro, Alessandra; Vemuri, Kalyani et al.

Part of Neuro-Oncology Advances, 2025

• DOI for Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
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Immunotherapy for Neuroendocrine Neoplasms

Essand, Magnus; Ramachandran, Mohanraj

Part of Neuroendocrine Tumours, p. 665-676, Springer Nature, 2024

• DOI for Immunotherapy for Neuroendocrine Neoplasms

VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Martikainen, Miika; Lugano, Roberta; Pietilä, Ilkka; Brosch, Sofie et al.

Part of Nature Communications, 2024

• DOI for VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Part of Cancer Cell, p. 1134-1151, 2023

• DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
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Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

Wicher, Grzegorz; Roy, Ananya; Vaccaro, Alessandra; Vemuri, Kalyani et al.

Part of Neuro-Oncology Advances, 2025

• DOI for Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression
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VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier

Martikainen, Miika; Lugano, Roberta; Pietilä, Ilkka; Brosch, Sofie et al.

Part of Nature Communications, 2024

• DOI for VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Part of Cancer Cell, p. 1134-1151, 2023

• DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Part of Clinical Cancer Research, p. 4139-4152, 2023

• DOI for Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
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Complementarity-determining region clustering may cause CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Marti Torrell, Paula; Zhu, Xu et al.

Part of Nature Communications, 2023

• DOI for Complementarity-determining region clustering may cause CAR-T cell dysfunction
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Ixovex-1, a novel oncolytic E1B-mutated adenovirus

Anwar, Mohiemen; Arendt, Maja-Louise; Ramachandran, Mohanraj; Carlsson, Anette et al.

Part of Cancer Gene Therapy, p. 1628-1635, 2022

• DOI for Ixovex-1, a novel oncolytic E1B-mutated adenovirus
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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Part of Nature Biomedical Engineering, p. 830-841, 2022

• DOI for CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
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Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos et al.

Part of Nature Communications, 2021

• DOI for Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
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ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.

Huang, Hua; Georganaki, Maria; Conze, Lei Liu; Laviña, Bàrbara et al.

Part of Neuro-Oncology, p. 398-411, 2021

• DOI for ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
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Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus

Ma, Jing; Jin, Chuan; Čančer, Matko; Wang, Hai et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 356-366, 2021

• DOI for Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
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IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma

Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 37-46, 2021

• DOI for IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
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Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Quijano-Rubio, Clara et al.

Part of Cell Death and Disease, 2020

• DOI for Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
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Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo et al.

Part of Oncoimmunology, 2020

• DOI for Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
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Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Fotaki, Grammatiki; Jin, Chuan; Ramachandran, Mohanraj; Kerzeli, Iliana Kyriaki et al.

Part of Oncoimmunology, 2018

• DOI for Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

Part of Oncoimmunology, 2018

• DOI for Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
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Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Ramachandran, Mohanraj; Yu, Di; Dyczynski, Matheus; Baskaran, Sathishkumar et al.

Part of Clinical Cancer Research, p. 1519-1530, 2017

• DOI for Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-detargeted oncolytic Semliki Forest virus

Adenovirus, Semliki Forest virus and vaccinia virus-induced immunogenic cell death augments oncolytic virus immunotherapy

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Essand, Magnus et al.

Part of Scandinavian Journal of Immunology, p. 341-341, 2017

Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity

Sarén, Tina; Ramachandran, Mohanraj; Martikainen, Miika; Yu, Di

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 67-75, 2017

• DOI for Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity
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CAR T-Cells with Induced Secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) Yields Improved Anti-Tumor Activity and Reduced Immunosuppression

Essand, Magnus; Ma, Jing; Jin, Chuan; Ramachandran, Mohanraj et al.

Part of Molecular Therapy, p. 288-288, 2017

Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Berith et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016

• DOI for Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Jin, Chuan; Fotaki, Grammatiki; Ramachandran, Mohanraj; Nilsson, Berith et al.

Part of EMBO Molecular Medicine, p. 702-711, 2016

• DOI for Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
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Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Bo et al.

Part of Human Gene Therapy, 2014

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Hillerdal, Victoria; Ramachandran, Mohanraj; Leja, Justyna; Essand, Magnus

Part of BMC Cancer, p. 30, 2014

• DOI for Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
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Adenovirus Encoded Helicobacter pylori Neutrophil Activating Protein Promotes Maturation of DCs with Th-1 Polarization, Improved Antigen Presentation and Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Molecular Therapy, 2014

Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Journal of Immunology, p. 2287-2296, 2014

• DOI for Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors

Ramachandran, Mohanraj; Yu, Di; Wanders, Alkwin; Essand, Magnus et al.

Part of Molecular Therapy, p. 2008-2018, 2013

• DOI for An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
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Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Part of PLOS ONE, 2013

• DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Vaccaro, Alessandra; van de Walle, Tiarne; Ramachandran, Mohanraj; Essand, Magnus et al.

Part of Frontiers in Immunology, 2023

• DOI for Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
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Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

van de Walle, Tiarne; Vaccaro, Alessandra; Ramachandran, Mohanraj; Pietilä, Ilkka et al.

Part of Frontiers in Immunology, 2021

• DOI for Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma
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Tumor angiogenesis: causes, consequences, challenges and opportunities

Lugano, Roberta; Ramachandran, Mohanraj; Dimberg, Anna

Part of Cellular and Molecular Life Sciences (CMLS), p. 1745-1770, 2020

• DOI for Tumor angiogenesis: causes, consequences, challenges and opportunities
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The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells

Ramachandran, Mohanraj; Dimberg, Anna; Essand, Magnus

Part of Seminars in Cancer Biology, p. 23-35, 2017

• DOI for The cancer-immunity cycle as rational design for synthetic cancer drugs: Novel DC vaccines and CAR T-cells
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Immunotherapy for Neuroendocrine Neoplasms

Essand, Magnus; Ramachandran, Mohanraj

Part of Neuroendocrine Tumours, p. 665-676, Springer Nature, 2024

• DOI for Immunotherapy for Neuroendocrine Neoplasms

Cancer Immunotherapy: Evolving Oncolytic viruses and CAR T-cells

Ramachandran, Mohanraj

2016

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Tumor antigen-loaded allogeneic dendritic cells augment therapeutic effect of adoptively transferred T-cells by altering tumor immune-microenvironment

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

CD19 CAR T-cells with induced secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) yields improved anti-tumor activity and reduced immunosuppression

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma

Sarén, Tina; Ramachandran, Mohanraj; Saronio, Giulia; Thelander, Josefin et al.

Complementary-determining region clustering causes CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Zhu, Xu; Thelander, Josefin et al.

CRISPR/Cas9 as a tool to disrupt wild-type and A53T SNCA in sporadic and familial Parkinson’s disease

Molisak, Agnieszka; Konstantinidis, Evangelos; Aguilar, Ximena; Giedraitis, Vilmantas et al.