Ingela Lanekoff
Professor at Department of Chemistry - BMC; Analytical Chemistry; Lanekoff group
- Telephone:
- +46 18 471 36 73
- E-mail:
- ingela.lanekoff@kemi.uu.se
- Visiting address:
- Husargatan 3 (D5)
752 37 Uppsala - Postal address:
- Box 599
75124 Uppsala
Short presentation
Professor Lanekoff works with innovative mass spectrometry and specializes in developing and applying advanced mass spectrometry techniques for spatial and cellular metabolomics. Her work includes developing surface sampling capillary electrophoresis (SS-CE), direct infusion probe (DIP), pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI), ion-to-image (i2i) data-handling software, single-cell metabolomics, and silver-doped methods for isomer differentiation.
Keywords
- analytical chemistry
- mass spectrometry
- mass spectrometry imaging (msi)
- nanospray desorption electrospray ionization (nano-desi)
- surface sampling capillary electrophoresis mass spectrometry
- direct infusion probe (dip)
- spatial metabolomics
- single-cell metabolomics
- ion-to-image (i2i)
Biography
Ingela Lanekoff is a Professor of Analytical Chemistry, European Research Council (ERC) grantee, and head of the Center of Excellence “Chemical Mechanisms of Life.” After earning her PhD in Analytical Chemistry from Gothenburg University, Sweden, in 2011, she pursued postdoctoral training at the Pacific Northwest National Laboratory (PNNL) in the United States. In 2014 she moved to Uppsala University on a junior project grant to start her independent research group and was promoted to Professor in 2022.
Research
Professor Lanekoff’s research is centered on designing, building and applying advanced mass spectrometry for analysis of metabolites and lipids in biological systems, such as thin tissue sections, cellular extracts, and individual cells. With the aim to enhance sensitivity and specificity, key innovations from her work include: surface sampling capillary electrophoresis (SS-CE), the direct infusion probe (DIP), pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI), and unique mass spectrometric methods for isomer differentiation using silver ions. Additional developments include single-cell metabolomics and the ion-to-image (i2i) data handling software. Through these tools, Professor Lanekoff continues to push the boundaries of mass spectrometry, to reveal the complex chemistry of biological systems in health and disease.

Publications
Recent publications
Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Part of Acta Neuropathologica, 2025
- DOI for Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Download full text (pdf) of Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Part of Talanta, 2025
- DOI for Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Download full text (pdf) of Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of Talanta Open, 2024
- DOI for Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
- Download full text (pdf) of Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of International Journal of Molecular Sciences, 2024
- DOI for Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Download full text (pdf) of Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
Part of Metabolites, 2024
- DOI for Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Download full text (pdf) of Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
All publications
Articles in journal
Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Part of Acta Neuropathologica, 2025
- DOI for Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Download full text (pdf) of Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Part of Talanta, 2025
- DOI for Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Download full text (pdf) of Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of Talanta Open, 2024
- DOI for Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
- Download full text (pdf) of Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of International Journal of Molecular Sciences, 2024
- DOI for Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Download full text (pdf) of Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
Part of Metabolites, 2024
- DOI for Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Download full text (pdf) of Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
Part of Journal of the American Society for Mass Spectrometry, p. 2518-2524, 2023
- DOI for Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
- Download full text (pdf) of Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
Part of Scientific Reports, 2023
- DOI for Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Download full text (pdf) of Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Part of Metabolites, 2023
- DOI for Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
- Download full text (pdf) of Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Part of Analytical Chemistry, p. 17843-17850, 2023
- DOI for Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
- Download full text (pdf) of Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
Part of Journal of the American Society for Mass Spectrometry, p. 2341-2349, 2023
- DOI for Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
- Download full text (pdf) of Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
Part of Analytical Chemistry, p. 11589-11595, 2023
- DOI for Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
- Download full text (pdf) of Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
Part of Electrophoresis, p. 387-394, 2023
- DOI for Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
- Download full text (pdf) of Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Part of Analytical Chemistry, p. 12875-12883, 2022
- DOI for A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
- Download full text (pdf) of A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Part of Analytical Chemistry, p. 2391-2398, 2022
- DOI for Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
- Download full text (pdf) of Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
Part of Environmental Science and Technology, p. 3096-3105, 2022
Part of Vietnam Journal of Food Control, p. 89-103, 2022
Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Part of Analytical and Bioanalytical Chemistry, p. 7473-7482, 2022
- DOI for Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
- Download full text (pdf) of Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Part of Communications Biology, 2021
- DOI for In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
- Download full text (pdf) of In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
Part of Analytical and Bioanalytical Chemistry, p. 2735-2745, 2021
- DOI for CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
- Download full text (pdf) of CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
Part of Journal of the American Society for Mass Spectrometry, p. 2479-2487, 2020
PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Part of Organs-on-a-Chip, 2020
- DOI for PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
- Download full text (pdf) of PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Part of Analytical and Bioanalytical Chemistry, p. 2809-2816, 2019
- DOI for Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
- Download full text (pdf) of Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Part of Analytical Chemistry, p. 7819-7827, 2019
Part of International Journal of Mass Spectrometry, p. 49-57, 2019
Part of Analytical Chemistry, p. 7246-7252, 2018
Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Part of Analytical Chemistry, p. 2451-2455, 2018
Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Part of The Analyst, p. 3639-3647, 2017
Part of The Analyst, p. 3424-3431, 2017
PACAP suppresses dry eye signs by stimulating tear secretion
Part of Nature Communications, 2016
- DOI for PACAP suppresses dry eye signs by stimulating tear secretion
- Download full text (pdf) of PACAP suppresses dry eye signs by stimulating tear secretion
Part of Scientific Reports, 2016
- DOI for Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
- Download full text (pdf) of Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
Part of The Analyst, p. 3686-3695, 2016
Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Part of Journal of Analytical Methods in Chemistry, 2016
Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Part of Synchrotron Radiation News, p. 10-14, 2015
- DOI for Towards Adaptive, Streaming Analysis of X-ray Tomography Data
- Download full text (pdf) of Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Part of Analytical and Bioanalytical Chemistry, p. 2063-2071, 2015
Part of Analytical Chemistry, p. 1872-80, 2014
Matrix effects in biological mass spectrometry imaging: identification and compensation
Part of The Analyst, p. 3528-3532, 2014
Part of Analytical Chemistry, p. 9596-9603, 2013
C60-ToF SIMS imaging of frozen hydrated HeLa cells
Part of Surface and Interface Analysis, p. 302-304, 2013
Mass spectrometry imaging of freeze-dried membrane phospholipids of dividing Tetrahymena pyriformis
Part of Surface and Interface Analysis, p. 211-214, 2013
Part of The Analyst, p. 1971-1978, 2013
Part of Analytical Chemistry, p. 882-889, 2013
Part of Analytical Chemistry, p. 8351-8356, 2012
Part of Analytical Chemistry, p. 5737-5743, 2012
An in situ fracture device to image lipids in single cells using ToF-SIMS
Part of Surface and Interface Analysis, p. 257-260, 2011
Part of Analytical Chemistry, p. 5337-5343, 2011
HAMLET interacts with lipid membranes and perturbs their structure and integrity.
Part of PLOS ONE, 2010
Part of Analytical Chemistry, p. 6652-9, 2010
Part of Analytical and Bioanalytical Chemistry, p. 3543-3551, 2010
Part of Scandinavian Journal of Gastroenterology, p. 1089-1096, 2002
Articles, review/survey
Single-cell metabolomics: where are we and where are we going?
Part of Current Opinion in Biotechnology, 2022
- DOI for Single-cell metabolomics: where are we and where are we going?
- Download full text (pdf) of Single-cell metabolomics: where are we and where are we going?
Single cell metabolism: current and future trends
Part of Metabolomics, 2022
Advances in mass spectrometry based single-cell metabolomics
Part of The Analyst, p. 782-793, 2019
Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Part of Analytical Chemistry, p. 52-73, 2016
Chapters in book
Part of Advanced Mass Spectrometry-Based Analytical Separation Techniques for Probing the Polar Metabolome, p. 125-164, Royal Society of Chemistry, 2021
Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Part of Advances In Chromatography, Vol 54, p. 43-72, CRC Press, 2018
- DOI for Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
- Download full text (pdf) of Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Part of Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
Part of Methods in molecular biology, p. 99-106, Springer, 2015
Conference papers
Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
Velo and REXAN – Integrated Data Management and High Speed Analysis for Experimental Facilities
Part of Proceeding IEEE International Conference on E-Science 2012, p. 1-9, 2012