Ingela Lanekoff
Professor at Department of Chemistry for Life Sciences; Analytical Chemistry; Lanekoff group
- Telephone:
- +46 18 471 36 73
- E-mail:
- ingela.lanekoff@kemi.uu.se
- Visiting address:
- Husargatan 3 (D5)
752 37 Uppsala - Postal address:
- Box 599
75124 Uppsala
Short presentation
Professor Lanekoff works with innovative mass spectrometry and specializes in developing and applying advanced mass spectrometry techniques for spatial and cellular metabolomics. Her work includes developing surface sampling capillary electrophoresis (SS-CE), direct infusion probe (DIP), pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI), ion-to-image (i2i) data-handling software, single-cell metabolomics, and silver-doped methods for isomer differentiation.
Keywords
- analytical chemistry
- mass spectrometry
- mass spectrometry imaging (msi)
- nanospray desorption electrospray ionization (nano-desi)
- surface sampling capillary electrophoresis mass spectrometry
- direct infusion probe (dip)
- spatial metabolomics
- single-cell metabolomics
- ion-to-image (i2i)
Biography
Ingela Lanekoff is a Professor of Analytical Chemistry, European Research Council (ERC) grantee, and head of the Center of Excellence “Chemical Mechanisms of Life.” After earning her PhD in Analytical Chemistry from Gothenburg University, Sweden, in 2011, she pursued postdoctoral training at the Pacific Northwest National Laboratory (PNNL) in the United States. In 2014 she moved to Uppsala University on a junior project grant to start her independent research group and was promoted to Professor in 2022.
Research
Professor Lanekoff’s research is centered on designing, building and applying advanced mass spectrometry for analysis of metabolites and lipids in biological systems, such as thin tissue sections, cellular extracts, and individual cells. With the aim to enhance sensitivity and specificity, key innovations from her work include: surface sampling capillary electrophoresis (SS-CE), the direct infusion probe (DIP), pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI), and unique mass spectrometric methods for isomer differentiation using silver ions. Additional developments include single-cell metabolomics and the ion-to-image (i2i) data handling software. Through these tools, Professor Lanekoff continues to push the boundaries of mass spectrometry, to reveal the complex chemistry of biological systems in health and disease.

Publications
Recent publications
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Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
Part of Acta Neuropathologica, 2026
- DOI for Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
- Download full text (pdf) of Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
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CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
Part of Analytical Chemistry, p. 5561-5569, 2026
- DOI for CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
- Download full text (pdf) of CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
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Part of eBioMedicine, 2026
- DOI for Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
- Download full text (pdf) of Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
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Part of Angewandte Chemie International Edition, 2026
- DOI for Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
- Download full text (pdf) of Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
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Part of Talanta, 2026
- DOI for Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Download full text (pdf) of Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
All publications
Articles in journal
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Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
Part of Acta Neuropathologica, 2026
- DOI for Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
- Download full text (pdf) of Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation
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CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
Part of Analytical Chemistry, p. 5561-5569, 2026
- DOI for CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
- Download full text (pdf) of CellMate-A Deep Learning-Assisted Single-Cell Data Processing Platform
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Part of eBioMedicine, 2026
- DOI for Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
- Download full text (pdf) of Metabolomic signatures of SSRI exposure during neural differentiation and correlation of lysophosphatidylcholines with early symptoms of neurodevelopmental disorders
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Part of Angewandte Chemie International Edition, 2026
- DOI for Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
- Download full text (pdf) of Multiplexed tandem mass spectrometry imaging enables large-scale isomer mapping and annotation in tissues
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Part of Talanta, 2026
- DOI for Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
- Download full text (pdf) of Quantitative approaches for spatial metabolomics with isomer differentiation using surface sampling capillary electrophoresis mass spectrometry
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Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
Part of Analytical Chemistry, p. 11572-11580, 2025
- DOI for Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
- Download full text (pdf) of Standard Addition as a Method for Quantitative Mass Spectrometry Imaging
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Part of Analytica Chimica Acta, 2025
- DOI for Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
- Download full text (pdf) of Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations
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Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
Part of Acta Neuropathologica, 2025
- DOI for Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
- Download full text (pdf) of Spatial mapping of the AA-PGE2-EP axis in multiple sclerosis lesions
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Part of Talanta, 2025
- DOI for Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
- Download full text (pdf) of Spatial metabolomics platform combining mass spectrometry imaging and in-depth chemical characterization with capillary electrophoresis
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Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of Talanta Open, 2024
- DOI for Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
- Download full text (pdf) of Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
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Part of International Journal of Molecular Sciences, 2024
- DOI for Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Download full text (pdf) of Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
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Part of Metabolites, 2024
- DOI for Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Download full text (pdf) of Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
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Part of Electrophoresis, p. 387-394, 2023
- DOI for Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
- Download full text (pdf) of Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
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Part of Analytical Chemistry, p. 17843-17850, 2023
- DOI for Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
- Download full text (pdf) of Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging
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Part of Journal of the American Society for Mass Spectrometry, p. 2518-2524, 2023
- DOI for Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
- Download full text (pdf) of Global and Spatial Metabolomics of Individual Cells Using a Tapered Pneumatically Assisted nano-DESI Probe
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Part of Scientific Reports, 2023
- DOI for Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Download full text (pdf) of Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
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Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Part of Metabolites, 2023
- DOI for Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
- Download full text (pdf) of Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
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Part of Journal of the American Society for Mass Spectrometry, p. 2341-2349, 2023
- DOI for Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
- Download full text (pdf) of Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization
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Part of Analytical Chemistry, p. 11589-11595, 2023
- DOI for Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
- Download full text (pdf) of Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
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A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Part of Analytical Chemistry, p. 12875-12883, 2022
- DOI for A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
- Download full text (pdf) of A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
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Part of Environmental Science and Technology, p. 3096-3105, 2022
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Part of Analytical Chemistry, p. 2391-2398, 2022
- DOI for Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
- Download full text (pdf) of Host-Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
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Part of Vietnam Journal of Food Control, p. 89-103, 2022
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Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Part of Analytical and Bioanalytical Chemistry, p. 7473-7482, 2022
- DOI for Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
- Download full text (pdf) of Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
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Part of Communications Biology, 2021
- DOI for In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
- Download full text (pdf) of In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
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Part of Analytical and Bioanalytical Chemistry, p. 2735-2745, 2021
- DOI for CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
- Download full text (pdf) of CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
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Part of Journal of the American Society for Mass Spectrometry, p. 2479-2487, 2020
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Part of Organs-on-a-Chip, 2020
- DOI for PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
- Download full text (pdf) of PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
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Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Part of Analytical and Bioanalytical Chemistry, p. 2809-2816, 2019
- DOI for Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
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Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Part of Analytical Chemistry, p. 7819-7827, 2019
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Part of International Journal of Mass Spectrometry, p. 49-57, 2019
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Part of Analytical Chemistry, p. 7246-7252, 2018
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Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Part of Analytical Chemistry, p. 2451-2455, 2018
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Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Part of The Analyst, p. 3639-3647, 2017
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Part of The Analyst, p. 3424-3431, 2017
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PACAP suppresses dry eye signs by stimulating tear secretion
Part of Nature Communications, 2016
- DOI for PACAP suppresses dry eye signs by stimulating tear secretion
- Download full text (pdf) of PACAP suppresses dry eye signs by stimulating tear secretion
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Part of Scientific Reports, 2016
- DOI for Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
- Download full text (pdf) of Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site
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Part of The Analyst, p. 3686-3695, 2016
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Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Part of Journal of Analytical Methods in Chemistry, 2016
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Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Part of Synchrotron Radiation News, p. 10-14, 2015
- DOI for Towards Adaptive, Streaming Analysis of X-ray Tomography Data
- Download full text (pdf) of Towards Adaptive, Streaming Analysis of X-ray Tomography Data
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Part of Analytical and Bioanalytical Chemistry, p. 2063-2071, 2015
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Part of Analytical Chemistry, p. 1872-80, 2014
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Matrix effects in biological mass spectrometry imaging: identification and compensation
Part of The Analyst, p. 3528-3532, 2014
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Part of Analytical Chemistry, p. 9596-9603, 2013
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C60-ToF SIMS imaging of frozen hydrated HeLa cells
Part of Surface and Interface Analysis, p. 302-304, 2013
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Mass spectrometry imaging of freeze-dried membrane phospholipids of dividing Tetrahymena pyriformis
Part of Surface and Interface Analysis, p. 211-214, 2013
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Part of The Analyst, p. 1971-1978, 2013
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Part of Analytical Chemistry, p. 882-889, 2013
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Part of Analytical Chemistry, p. 8351-8356, 2012
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Part of Analytical Chemistry, p. 5737-5743, 2012
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An in situ fracture device to image lipids in single cells using ToF-SIMS
Part of Surface and Interface Analysis, p. 257-260, 2011
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Part of Analytical Chemistry, p. 5337-5343, 2011
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HAMLET interacts with lipid membranes and perturbs their structure and integrity.
Part of PLOS ONE, 2010
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Part of Analytical Chemistry, p. 6652-9, 2010
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Part of Analytical and Bioanalytical Chemistry, p. 3543-3551, 2010
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Part of Scandinavian Journal of Gastroenterology, p. 1089-1096, 2002
Articles, review/survey
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Single cell metabolism: current and future trends
Part of Metabolomics, 2022
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Single-cell metabolomics: where are we and where are we going?
Part of Current Opinion in Biotechnology, 2022
- DOI for Single-cell metabolomics: where are we and where are we going?
- Download full text (pdf) of Single-cell metabolomics: where are we and where are we going?
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Advances in mass spectrometry based single-cell metabolomics
Part of The Analyst, p. 782-793, 2019
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Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Part of Analytical Chemistry, p. 52-73, 2016
Chapters in book
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Matrix Effects Free Imaging of Thin Tissue Sections Using Pneumatically Assisted Nano-DESI MSI
Part of Imaging Mass Spectrometry, p. 107-121, Humana Press, 2023
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Part of Advanced Mass Spectrometry-Based Analytical Separation Techniques for Probing the Polar Metabolome, p. 125-164, Royal Society of Chemistry, 2021
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Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Part of Advances In Chromatography, Vol 54, p. 43-72, CRC Press, 2018
- DOI for Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
- Download full text (pdf) of Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
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Part of Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
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Part of Methods in molecular biology, p. 99-106, Springer, 2015
Conference papers
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Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
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Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
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Velo and REXAN – Integrated Data Management and High Speed Analysis for Experimental Facilities
Part of Proceeding IEEE International Conference on E-Science 2012, p. 1-9, 2012