Maryam Oroujeni

Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo

Nilvebrant, Johan; Fernandez Moro, Carlos; Papalanis, Eleftherios; Ostad Novin, Masih et al.

Part of Translational Oncology, 2025

• DOI for An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo
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Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Oroujeni, Maryam; Westerlund, Kristina; Papalanis, Eleftherios; van Deventer, Alexander et al.

Part of Journal of Nuclear Medicine, p. 1105-1111, 2025

• DOI for Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

Tolmachev, Vladimir M.; Vorobyeva, Anzhelika; Rosly, Alia Hani Binti; Garousi, Javad et al.

Part of International Journal of Molecular Sciences, 2025

• DOI for Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture
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Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression

Vorobyeva, Anzhelika; Ud-din, Moeen; Schulga, Alexey; Konovalova, Elena et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
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Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
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An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo

Nilvebrant, Johan; Fernandez Moro, Carlos; Papalanis, Eleftherios; Ostad Novin, Masih et al.

Part of Translational Oncology, 2025

• DOI for An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo
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Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Oroujeni, Maryam; Westerlund, Kristina; Papalanis, Eleftherios; van Deventer, Alexander et al.

Part of Journal of Nuclear Medicine, p. 1105-1111, 2025

• DOI for Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting: A Proof-of-Principle Study

Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

Tolmachev, Vladimir M.; Vorobyeva, Anzhelika; Rosly, Alia Hani Binti; Garousi, Javad et al.

Part of International Journal of Molecular Sciences, 2025

• DOI for Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture
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Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression

Vorobyeva, Anzhelika; Ud-din, Moeen; Schulga, Alexey; Konovalova, Elena et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression
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Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
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Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 4038-4048, 2024

• DOI for Evaluation of a novel ¹⁷⁷Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile
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Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation

Oroujeni, Maryam; Carlqvist, Matilda; Ryer, Eva; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2024

• DOI for Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation
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Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting

Westerlund, Kristina; Oroujeni, Maryam; Gestin, Maxime; Clinton, Jacob et al.

Part of ACS Pharmacology & Translational Science, p. 1595-1611, 2024

• DOI for Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting
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Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion

Deyev, Sergey M.; Oroujeni, Maryam; Garousi, Javad; Graeslund, Torbjoern et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion
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Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker

Lundmark, Fanny; Vorobyeva, Anzhelika; Liu, Yongsheng; Lindbo, Sarah et al.

Part of Molecular Medicine Reports, 2024

• DOI for Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Yin, Wen; Xu, Tianqi; Ding, Haozhong; Zhang, Jie et al.

Part of Journal of Controlled Release, p. 515-527, 2023

• DOI for Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Leitao, Charles Dahlsson; Borras, Anna Mestre; Xu, Tianqi; Oroujeni, Maryam et al.

Part of Journal of Controlled Release, p. 185-195, 2023

• DOI for Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Nuclear Medicine and Biology, 2023

• DOI for Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
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Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Rybina, Anstasiya et al.

Part of Theranostics, p. 4858-4871, 2023

• DOI for Phase I clinical evaluation of ^99mTc-labeled Affibody molecule for imaging HER2 expression in breast cancer
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¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry

Abouzayed, Ayman; Seitova, Kamila; Lundmark, Fanny; Bodenko, Vitalina et al.

Part of Frontiers in Oncology, 2023

• DOI for ¹⁷⁷Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
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Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
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Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S. et al.

Part of Pharmaceutics, 2022

• DOI for Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
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Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Pharmaceutics, 2022

• DOI for Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
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Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Liu, Yongsheng; Yu, Shengze; Xu, Tianqi; Bodenko, Vitalina et al.

Part of Pharmaceutics, 2022

• DOI for Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
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Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

Tolmachev, Vladimir; Bodenko, Vitalina; Oroujeni, Maryam; Deyev, Sergey et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Direct In Vivo Comparison of ^99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
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Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Oroujeni, Maryam; Tano, Hanna; Vorobyeva, Anzhelika; Liu, Yongsheng et al.

Part of Journal of Nuclear Medicine, p. 1046-1051, 2022

• DOI for Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

Xu, Tianqi; Ding, Haozhong; Vorobyeva, Anzhelika; Oroujeni, Maryam et al.

Part of Cancers, 2021

• DOI for Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
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Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Garousi, Javad; Ding, Haozhong; von Witting, Emma; Xu, Tianqi et al.

Part of Pharmaceutics, 2021

• DOI for Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein
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Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle

Garousi, Javad; von Witting, Emma; Borin, Jesper; Vorobyeva, Anzhelika et al.

Part of Biomaterials, 2021

• DOI for Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle
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The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Yin, Wen; Xu, Tianqi; Altai, Mohamed; Oroujeni, Maryam et al.

Part of Pharmaceutics, 2021

• DOI for The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
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Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Ding, Haozhong; Xu, Tianqi; Zhang, Jie; Tolmachev, Vladimir et al.

Part of Pharmaceutics, 2021

• DOI for Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
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The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule

Oroujeni, Maryam; Xu, Tianqi; Gagnon, Katherine; Rinne, Sara S. et al.

Part of Pharmaceutics, 2021

• DOI for The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule
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Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Oroujeni, Maryam; Rinne, Sara S.; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Preclinical Evaluation of Tc-99m-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake
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Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Tano, Hanna; Oroujeni, Maryam; Vorobyeva, Anzhelika; Westerlund, Kristina et al.

Part of Cancers, 2021

• DOI for Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting
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Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein

Vorobyeva, Anzhelika; Oroujeni, Maryam; Lindbo, Sarah; Hober, Sophia et al.

Part of Molecules, 2020

• DOI for Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein
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Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart

Oroujeni, Maryam; Abouzayed, Ayman; Lundmark, Fanny; Mitran, Bogdan et al.

Part of Pharmaceutics, 2019

• DOI for Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
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Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6

von Witting, Emma; Garousi, Javad; Lindbo, Sarah; Vorobyeva, Anzhelika et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 109-120, 2019

• DOI for Selection of the optimal macrocyclic chelators for labeling with ¹¹¹In and ⁶⁸Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6
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Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

Garousi, Javad; Lindbo, Sarah; Borin, Jesper; von Witting, Emma et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 37-48, 2019

• DOI for Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours
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PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Summer, D; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of EJNMMI Research, 2018

• DOI for PP15 89Zr-Siderophore-Affibody conjugates for imaging EGFR expression

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules

Oroujeni, Maryam; Andersson, Ken G.; Steinhardt, Xenia; Altai, Mohamed et al.

Part of Amino Acids, p. 981-994, 2018

• DOI for Influence of composition of cysteine-containing peptide-based chelators on biodistribution of ^99mTc-labeled anti-EGFR affibody molecules
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Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

Summer, Dominik; Garousi, Javad; Oroujeni, Maryam; Mitran, Bogdan et al.

Part of Molecular Pharmaceutics, p. 175-185, 2018

• DOI for Cyclic versus Noncyclic Chelating Scaffold for Zr-89-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression
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Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

Oroujeni, Maryam; Garousi, Javad; Andersson, Ken G.; Lofblom, John et al.

Part of CELLS, 2018

• DOI for Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors
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Conjugation of cyclodextrin to magnetic Fe3O4 nanoparticles via polydopamine coating for drug delivery

Oroujeni, Maryam; Kaboudin, Babak; Xia, Wei; Jönsson, Petra et al.

Part of Progress in organic coatings, p. 154-161, 2018

• DOI for Conjugation of cyclodextrin to magnetic Fe3O4 nanoparticles via polydopamine coating for drug delivery

Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Westerlund, Kristina; Altai, Mohamed; Mitran, Bogdan; Konijnenberg, Mark et al.

Part of Journal of Nuclear Medicine, p. 1092-1098, 2018

• DOI for Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle

Selection of the most optimal ADAPT6-based probe for imaging of HER2 using PET and SPECT

Garousi, Javad; Lindbo, S.; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Lindbo, Sarah; Garousi, Javad; Mitran, Bogdan; Vorobyeva, Anzhelika et al.

Part of Molecular Pharmaceutics, p. 2674-2683, 2018

• DOI for Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with ¹¹¹In and ⁶⁸Ga

Comparative evaluation of anti-EFGR affibody molecules labelled with gallium-68 and zirconium-89 using desferrioxamine B as a chelator

Oroujeni, Maryam; Garousi, Javad; Andersson, K.; Löfblom, J. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI for Comparative evaluation of anti-EFGR affibody molecules labelled with gallium-68 and zirconium-89 using desferrioxamine B as a chelator

Influence of composition of cysteine-containing peptide based chelators on biodistribution of Tc-99m-labelled anti-EGFR affibody molecules

Oroujeni, Maryam; Anderson, K. G.; Garousi, Javad; Altai, Mohamed et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2017

Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR: 2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator

Andersson, Ken G.; Oroujeni, Maryam; Garousi, Javad; Mitran, Bogdan et al.

Part of International journal of oncology, p. 2285-2293, 2016

• DOI for Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR: 2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator
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Imaging of EGFR Expression Using 99mTC-Labelled ZEGFR:2377 Affibody Molecule

Oroujeni, Maryam; Andersson, K.; Garousi, Javad; Mitran, Bogdan et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Radiolabelled affibody molecules for imaging EGFR expression in tumours

Oroujeni, Maryam

2021

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