Erik Sjögren

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020

• DOI for Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico et al.

Part of AAPS Journal, 2019

• DOI for Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian et al.

Part of CPT, p. 878-882, 2019

• DOI for Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
• Download full text (pdf) of Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 70-76, 2018

• DOI for Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Part of Molecular Pharmaceutics, p. 448-458, 2017

• DOI for In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Part of Molecular Pharmaceutics, p. 1763-1778, 2016

• DOI for In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Part of Molecular Pharmaceutics, p. 2026-2039, 2015

• DOI for Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 2702-2726, 2015

• DOI for Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Part of European Journal of Pharmaceutical Sciences, p. 99-151, 2014

• DOI for In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Part of European Journal of Pharmaceutical Sciences, p. 679-698, 2013

• DOI for In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Cordes, Henrik; Annaert, Pieter; Balazki, Pavel; Benamara, Salih et al.

Part of CPT, 2026

• DOI for Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025
• Download full text (pdf) of Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Langeskov, Emilie Salim; Kristensen, Kim; Chopda, Girish; Sjögren, Erik

Part of Pharmaceutics, 2025

• DOI for Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs
• Download full text (pdf) of Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Prieto Garcia, Luna; Nordell, Par; Ahlstrom, Christine; Lennernäs, Hans et al.

Part of AAPS Journal, 2025

• DOI for Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation
• Download full text (pdf) of Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Prieto Garcia, Luna; Nordell, Pär; Ahlström, Christine; Lennernäs, Hans et al.

Part of AAPS Journal, 2025

• DOI for Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications
• Download full text (pdf) of Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

Dallmann, André; Feick, Denise; Balazki, Pavel; Benamara, Salih et al.

Part of CPT, p. 822-827, 2025

• DOI for Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference
• Download full text (pdf) of Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Cordes, Henrik; Annaert, Pieter; Balazki, Pavel; Benamara, Salih et al.

Part of CPT, 2026

• DOI for Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025
• Download full text (pdf) of Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025

Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Langeskov, Emilie Salim; Kristensen, Kim; Chopda, Girish; Sjögren, Erik

Part of Pharmaceutics, 2025

• DOI for Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs
• Download full text (pdf) of Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Prieto Garcia, Luna; Nordell, Par; Ahlstrom, Christine; Lennernäs, Hans et al.

Part of AAPS Journal, 2025

• DOI for Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation
• Download full text (pdf) of Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 1: Model Development and Validation

Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Prieto Garcia, Luna; Nordell, Pär; Ahlström, Christine; Lennernäs, Hans et al.

Part of AAPS Journal, 2025

• DOI for Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications
• Download full text (pdf) of Integrated Physiologically-based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population. Part 2: MIDD and MIPD Applications

Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

Dallmann, André; Feick, Denise; Balazki, Pavel; Benamara, Salih et al.

Part of CPT, p. 822-827, 2025

• DOI for Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference
• Download full text (pdf) of Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Langeskov Salim, Emilie; Kristensen, Kim; Sjögren, Erik

Part of Pharmaceutics, 2025

• DOI for Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs
• Download full text (pdf) of Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

Palic, Semra; Chu, Wan-Yu; Sundar, Shyam; Mondal, Dinesh et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1547-1554, 2024

• DOI for Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia
• Download full text (pdf) of Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

Cloesmeijer, Michael E.; Sjögren, Erik; Koopman, Sjoerd F.; Lenting, Peter. J. et al.

Part of CPT, p. 1630-1640, 2024

• DOI for PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space
• Download full text (pdf) of PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Garcia, Luna Prieto; Vildhede, Anna; Nordell, Pär; Ahlström, Christine et al.

Part of CPT, p. 1029-1043, 2024

• DOI for Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
• Download full text (pdf) of Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Clavero, Ada Lerma; Gråsjö, Johan et al.

Part of Drug Delivery and Translational Research, p. 970-983, 2023

• DOI for Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
• Download full text (pdf) of Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 144-159, 2023

• DOI for Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling

Dong, Jin; Garcia, Luna Prieto; Huang, Yingbo; Tang, Weifeng et al.

Part of Clinical Pharmacology and Therapeutics, p. 825-835, 2023

• DOI for Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling
• Download full text (pdf) of Understanding Statin-Roxadustat Drug–Drug-Disease Interaction Using Physiologically-Based Pharmacokinetic Modeling

Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Part of European Journal of Pharmaceutical Sciences, 2022

• DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
• Download full text (pdf) of Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Overview of authorized drug products for subcutaneous administration: Pharmaceutical, therapeutic, and physicochemical properties

Dubbelboer, Ilse R.; Sjögren, Erik

Part of European Journal of Pharmaceutical Sciences, 2022

• DOI for Overview of authorized drug products for subcutaneous administration: Pharmaceutical, therapeutic, and physicochemical properties
• Download full text (pdf) of Overview of authorized drug products for subcutaneous administration: Pharmaceutical, therapeutic, and physicochemical properties

Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models

Dubbelboer, Ilse R.; Sjögren, Erik

Part of International Journal of Pharmaceutics, 2022

• DOI for Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models
• Download full text (pdf) of Physiological based pharmacokinetic and biopharmaceutics modelling of subcutaneously administered compounds - An overview of in silico models

Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Garcia, Luna Prieto; Lundahl, Anna; Ahlstrom, Christine; Vildhede, Anna et al.

Part of CPT, p. 1194-1209, 2022

• DOI for Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
• Download full text (pdf) of Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
• Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021

• DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
• Download full text (pdf) of In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Part of AAPS Journal, 2020

• DOI for Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
• Download full text (pdf) of Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Part of European journal of pharmaceutics and biopharmaceutics, p. 191-202, 2020

• DOI for Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020

• DOI for Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico et al.

Part of AAPS Journal, 2019

• DOI for Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Part of Journal of Drug Delivery Science and Technology, 2019

• DOI for Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
• Download full text (pdf) of Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Part of Cancers, 2019

• DOI for Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
• Download full text (pdf) of Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian et al.

Part of CPT, p. 878-882, 2019

• DOI for Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
• Download full text (pdf) of Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

Part of Molecular Pharmaceutics, p. 3053-3064, 2019

• DOI for Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror et al.

Part of European Journal of Pain, p. 1767-1779, 2019

• DOI for The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019

• DOI for Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019

• DOI for Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019

• DOI for Rat intestinal drug permeability: A status report and summary of repeated determinations

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Part of Journal of Pharmaceutical Sciences, p. 1765-1771, 2019

• DOI for Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
• Download full text (pdf) of Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Suarez-Sharp, Sandra; Cohen, Michael; Kesisoglou, Filippos; Abend, Andreas et al.

Part of AAPS Journal, 2018

• DOI for Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Part of AAPS Journal, 2018

• DOI for Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
• Download full text (pdf) of Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of Controlled Release, p. 235-247, 2018

• DOI for Single bead investigation of a clinical drug delivery system – a novel release mechanism
• Download full text (pdf) of Single bead investigation of a clinical drug delivery system – a novel release mechanism

Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 19-28, 2018

• DOI for Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 70-76, 2018

• DOI for Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 222-230, 2018

• DOI for Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 239-248, 2018

• DOI for Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

Sjögren, Erik; Kullenberg, T.; Jonzon, B.; Segerdahl, M. et al.

Part of European Journal of Pain, p. 1214-1228, 2018

• DOI for Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 158-168, 2018

• DOI for The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Sjögren, Erik; Halldin, M. M.; Stålberg, O.; Sundgren-Andersson, A. K.

Part of European Journal of Pain, p. 889-903, 2018

• DOI for Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies

Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 1-12, 2018

• DOI for Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

Part of Molecular Pharmaceutics, p. 336-340, 2018

• DOI for Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4243-4251, 2017

• DOI for Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017

• DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
• Download full text (pdf) of Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Part of Molecular Pharmaceutics, p. 448-458, 2017

• DOI for In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4252-4261, 2017

• DOI for Regional Intestinal Permeability in Rats: A Comparison of Methods

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Part of Molecular Pharmaceutics, p. 4233-4242, 2017

• DOI for In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Dubbelboer, Ilse R.; Lilienberg, Elsa; Sjögren, Erik; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 686-698, 2017

• DOI for A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Lilienberg, Elsa; Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmacy and Pharmacology (JPP), p. 135-142, 2017

• DOI for Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models'"

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Part of Molecular Pharmaceutics, p. 340-343, 2017

• DOI for Reply to "Comment on 'In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models'"

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Lennernäs, Hans; Lindahl, A.; Van Peer, A.; Ollier, C. et al.

Part of Molecular Pharmaceutics, p. 1307-1314, 2017

• DOI for In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Part of Molecular Pharmaceutics, p. 3013-3021, 2016

• DOI for Regional Intestinal Permeability of Three Model Drugs in Human

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 3387-3398, 2016

• DOI for In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Part of Molecular Pharmaceutics, p. 3022-3033, 2016

• DOI for Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Sjögren, Erik; Andersson, Sara; Sundgren-Andersson, Anna K.; Halldin, Magnus M. et al.

Part of Journal of Pharmaceutical Sciences, p. 2913-2920, 2016

• DOI for Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Sjögren, Erik; Thorn, Helena; Tannergren, Christer

Part of Molecular Pharmaceutics, p. 1763-1778, 2016

• DOI for In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models

Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs

Sjögren, Erik; Eriksson, Johanna; Vedin, Charlotta; Breitholtz, Katarina et al.

Part of International Journal of Pharmaceutics, p. 361-368, 2016

• DOI for Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 12-20, 2015

• DOI for Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
• Download full text (pdf) of Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

A miniaturized in vitro release method for investigating drug-release mechanisms

Ahnfelt, Emelie; Sjögren, Erik; Axén, N.; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 339-349, 2015

• DOI for A miniaturized in vitro release method for investigating drug-release mechanisms
• Download full text (pdf) of A miniaturized in vitro release method for investigating drug-release mechanisms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Part of Molecular Pharmaceutics, p. 2026-2039, 2015

• DOI for Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Dubbelboer, Ilse R; Lilienberg, Elsa; Ahnfelt, Emelie; Sjögren, Erik et al.

Part of Therapeutic delivery, p. 447-466, 2014

• DOI for Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

Berthelsen, Ragna; Sjögren, Erik; Jacobsen, Jette; Kristensen, Jakob et al.

Part of International Journal of Pharmaceutics, p. 356-365, 2014

• DOI for Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik; Tammela, Teuvo L.; Lennernas, Bo; Taari, Kimmo et al.

Part of Molecular Pharmaceutics, p. 3097-3111, 2014

• DOI for Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Part of European Journal of Pharmaceutical Sciences, p. 99-151, 2014

• DOI for In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Sjögren, Erik; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of European Journal of Pharmaceutical Sciences, p. 214-223, 2014

• DOI for Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Dubbelboer, Ilse R; Lilienberg, Elsa; Hedeland, Mikael; Bondesson, Ulf et al.

Part of Molecular Pharmaceutics, p. 1301-1313, 2014

• DOI for The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Part of European Journal of Pharmaceutical Sciences, p. 679-698, 2013

• DOI for In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Thörn, Helena Anna; Sjögren, Erik; Dickinson, Paul Alfred; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 3034-3045, 2012

• DOI for Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Sjögren, Erik; Bredberg, Ulf; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 823-841, 2012

• DOI for The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation

Sjögren, Erik; Svanberg, Petter; Kanebratt, Kajsa P.

Part of Drug Metabolism And Disposition, p. 2273-2279, 2012

• DOI for Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Sjögren, Erik; Nyberg, Joakim; Magnusson, Mats O.; Lennernäs, Hans et al.

Part of Drug Metabolism And Disposition, p. 858-863, 2011

• DOI for Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Part of Pharmaceutical research, p. 597-607, 2010

• DOI for Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

Arvidsson, Björn; Allard, Erik; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of chromatography. B, p. 291-297, 2009

• DOI for Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Sjögren, Erik; Lennernäs, Hans; Andersson, Tommy B; Gråsjö, Johan et al.

Part of Drug Metabolism And Disposition, p. 47-58, 2009

• DOI for The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics

Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report

Tannergren, Christer; Arora, Sumit; Babiskin, Andrew; Borges, Luiza et al.

Part of Molecular Pharmaceutics, p. 5-27, 2024

• DOI for Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report
• Download full text (pdf) of Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of ADMET & DMPK, p. 375-390, 2020

• DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
• Download full text (pdf) of Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 2702-2726, 2015

• DOI for Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

Sjögren, Erik

2010

• Download full text (pdf) of Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

Diffusion of therapeutic proteins in extracellular matrix mimetic hydrogels: Predicting in vivo absorption after subcutaneous injection

Parlow, Julia; Sjögren, Erik; Al-Tikriti, Yassir; Sjögren, Helen et al.