Mario Perello

Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Diabetes, obesity and metabolism, p. 4427-4435, 2025

• DOI for Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
• Download full text (pdf) of Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Physiology and Behavior, 2025

• DOI for Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status
• Download full text (pdf) of Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Cassano, Daniela A.; Barrile, Franco; Reynaldo, Mirta; Fernandez, Gimena et al.

Part of Communications Biology, 2025

• DOI for AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice
• Download full text (pdf) of AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor

Cassano, Daniela A.; Aguggia, Julieta; Giovanini, Lucia; Heredia, Florencia et al.

Part of Molecular and Cellular Endocrinology, 2025

• DOI for Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor
• Download full text (pdf) of Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor

Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Fernandez, Gimena; Fittipaldi, Antonela; Lufrano, Daniela; Mustafa, Emilio R. et al.

Part of Endocrinology, 2025

• DOI for Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Diabetes, obesity and metabolism, p. 4427-4435, 2025

• DOI for Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
• Download full text (pdf) of Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Physiology and Behavior, 2025

• DOI for Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status
• Download full text (pdf) of Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Cassano, Daniela A.; Barrile, Franco; Reynaldo, Mirta; Fernandez, Gimena et al.

Part of Communications Biology, 2025

• DOI for AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice
• Download full text (pdf) of AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor

Cassano, Daniela A.; Aguggia, Julieta; Giovanini, Lucia; Heredia, Florencia et al.

Part of Molecular and Cellular Endocrinology, 2025

• DOI for Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor
• Download full text (pdf) of Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor

Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Fernandez, Gimena; Fittipaldi, Antonela; Lufrano, Daniela; Mustafa, Emilio R. et al.

Part of Endocrinology, 2025

• DOI for Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner

Andreoli, María Florencia; Fittipaldi, Antonela S; Castrogiovanni, Daniel; De Francesco, Pablo N et al.

Part of European Journal of Nutrition, p. 751-762, 2024

• DOI for Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner

LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

Andreoli, María Florencia; Kruger, Ana Luz; Sokolov, Aleksandr V.; Rukh, Gull et al.

Part of Diabetes, obesity and metabolism, p. 4734-4743, 2024

• DOI for LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans
• Download full text (pdf) of LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life

Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa; Casado, Carla et al.

Part of Journal of Nutrition, p. 3388-3399, 2024

• DOI for The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life

Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study

Andreoli, María Florencia; Gentreau, Mélissa; Rukh, Gull; Perelló, Mario et al.

Part of Diabetes, obesity and metabolism, p. 3565-3575, 2024

• DOI for Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study
• Download full text (pdf) of Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study

GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice

Cornejo, María Paula; Fernandez, Gimena; Cabral, Agustina; Barrile, Franco et al.

Part of Endocrinology, 2024

• DOI for GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice

Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications

Gomez, Ivana M.; Uriarte, Maia; Fernandez, Gimena; Barrile, Franco et al.

Part of Molecular Metabolism, 2024

• DOI for Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications
• Download full text (pdf) of Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction

Aguggia, Julieta; Fernandez, Gimena; Cassano, Daniela; Mustafá, Emilio R. et al.

Part of Endocrinology, 2024

• DOI for Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

Saenz, Camila; Fernandez, Gimena; Llovera, Ramiro; Tolosa, María J. et al.

Part of Brain Structure and Function, 2024

• DOI for Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain
• Download full text (pdf) of Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

The Pattern of GH Action in the Mouse Brain

Menezes, Filipe; Wasinski, Frederick; de Souza, Gabriel O.; Nunes, Amanda P. et al.

Part of Endocrinology, 2024

• DOI for The Pattern of GH Action in the Mouse Brain

Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Barrile, Franco; Cassano, Daniela; Fernandez, Gimena; De Francesco, Pablo N. et al.

Part of Psychoneuroendocrinology, 2023

• DOI for Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation

Fernandez, Gimena; De Francesco, Pablo N.; Cornejo, Maria P.; Cabral, Agustina et al.

Part of Endocrinology, 2023

• DOI for Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation

Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca_V) Subtypes in mPFC Neurons

McCarthy, Clara Inés; Mustafá, Emilio Román; Cornejo, María Paula; Yaneff, Agustín et al.

Part of Molecular Neurobiology, p. 2644-2660, 2023

• DOI for Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca_V) Subtypes in mPFC Neurons

Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Fittipaldi, Antonela S.; Castrogiovanni, Daniel; Lufrano, Daniela; Saenz, Camila et al.

Part of Life Sciences, 2023

• DOI for Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain

De Francesco, Pablo Nicolas; Fernandez, Gimena; Uriarte, Maia; Urrutia, Leandro et al.

Part of Neuroendocrinology, p. 64-79, 2023

• DOI for Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Fernandez, Gimena; Cabral, Agustina; De Francesco, Pablo N.; Uriarte, Maia et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022

• DOI for GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond

Perello, Mario; Cornejo, Maria P.; De Francesco, Pablo N.; Fernandez, Gimena et al.

Part of IBRO NEUROSCIENCE REPORTS, p. 228-239, 2022

• DOI for The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
• Download full text (pdf) of The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond

Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Peraldi-Roux, Sylvie; Bayle, Morgane; M'Kadmi, Celine; Damian, Marjorie et al.

Part of Biochemical Pharmacology, 2022

• DOI for Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Aguggia, Julieta P.; Cornejo, Maria P.; Fernandez, Gimena; De Francesco, Pablo N. et al.

Part of Psychoneuroendocrinology, 2022

• DOI for Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Brain-acting hepatokines: its impact on energy balance and metabolism

Giovanini, Lucia; Wanionok, Nahuel; Perello, Mario; Cornejo, Maria Paula

Part of Frontiers in Neuroscience, 2025

• DOI for Brain-acting hepatokines: its impact on energy balance and metabolism
• Download full text (pdf) of Brain-acting hepatokines: its impact on energy balance and metabolism

Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism

Perello, Mario

Part of Endocrinology, 2025

• DOI for Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism