Mario Perello

Genetic GHSR deficiency and LEAP2 treatment enhance the glucose-lowering effects of liraglutide in male mice in a metabolic state-dependent manner

Cassano, Daniela A.; Fernandez, Gimena; Cornejo, Maria P.; Sheybani-Deloui, Sepideh et al.

Part of Life Sciences, 2026

• DOI for Genetic GHSR deficiency and LEAP2 treatment enhance the glucose-lowering effects of liraglutide in male mice in a metabolic state-dependent manner
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LEAP2 mediates long-term inhibition of orexigenic neurons of the hypothalamus in mice

Giovanini, Lucia; Cornejo, Maria P.; Gomez, Ivana M.; Wanionok, Nahuel et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2026

• DOI for LEAP2 mediates long-term inhibition of orexigenic neurons of the hypothalamus in mice

Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake

Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa; Casado, Carla et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake
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Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic women

Andreoli, María Florencia; De Francesco, Pablo N.; Zhou, Wei; Titova, Olga et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic women
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Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice

Cornejo, Maria Paula; Lopez-vicchi, Felicitas; de Winne, Catalina; Pascual, Florencia et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice

Genetic GHSR deficiency and LEAP2 treatment enhance the glucose-lowering effects of liraglutide in male mice in a metabolic state-dependent manner

Cassano, Daniela A.; Fernandez, Gimena; Cornejo, Maria P.; Sheybani-Deloui, Sepideh et al.

Part of Life Sciences, 2026

• DOI for Genetic GHSR deficiency and LEAP2 treatment enhance the glucose-lowering effects of liraglutide in male mice in a metabolic state-dependent manner
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LEAP2 mediates long-term inhibition of orexigenic neurons of the hypothalamus in mice

Giovanini, Lucia; Cornejo, Maria P.; Gomez, Ivana M.; Wanionok, Nahuel et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2026

• DOI for LEAP2 mediates long-term inhibition of orexigenic neurons of the hypothalamus in mice

Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake

Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa; Casado, Carla et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake
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Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic women

Andreoli, María Florencia; De Francesco, Pablo N.; Zhou, Wei; Titova, Olga et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic women
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Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice

Cornejo, Maria Paula; Lopez-vicchi, Felicitas; de Winne, Catalina; Pascual, Florencia et al.

Part of Journal of neuroendocrinology, 2026

• DOI for Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice

Persistent neuropathic pain selectively impairs hedonic and motivational aspects of eating: Insights from a mouse model

Valdivia, Spring; Agostino, Patricia Veronica; Reynaldo, Mirta; Singh, Sudhuman et al.

Part of Journal of Pain, 2026

• DOI for Persistent neuropathic pain selectively impairs hedonic and motivational aspects of eating: Insights from a mouse model

Ghrelin-induced food intake in male mice requires peripheral extrahepatic GHR signaling

Barrile, Franco; Cornejo, Maria Paula; De Francesco, Pablo N.; de Souza, Gabriel O. et al.

Part of Endocrinology, 2026

• DOI for Ghrelin-induced food intake in male mice requires peripheral extrahepatic GHR signaling

Liver-expressed antimicrobial peptide 2 (LEAP2)

Andreoli, María Florencia; De Francesco, Pablo N.; Perello, Mario

Part of Trends in endocrinology and metabolism, p. 1054-1055, 2025

• DOI for Liver-expressed antimicrobial peptide 2 (LEAP2)
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Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Diabetes, obesity and metabolism, p. 4427-4435, 2025

• DOI for Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men
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Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

Andreoli, María Florencia; De Francesco, Pablo N.; Titova, Olga E; Perello, Mario et al.

Part of Physiology and Behavior, 2025

• DOI for Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status
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AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice

Cassano, Daniela A.; Barrile, Franco; Reynaldo, Mirta; Fernandez, Gimena et al.

Part of Communications Biology, 2025

• DOI for AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice
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Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor

Cassano, Daniela A.; Aguggia, Julieta; Giovanini, Lucia; Heredia, Florencia et al.

Part of Molecular and Cellular Endocrinology, 2025

• DOI for Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor
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Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Fernandez, Gimena; Fittipaldi, Antonela; Lufrano, Daniela; Mustafa, Emilio R. et al.

Part of Endocrinology, 2025

• DOI for Mini-ghrelins: Functional Characterization of N-terminal Peptides Derived From Ghrelin Proteolysis in Male Samples

Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner

Andreoli, María Florencia; Fittipaldi, Antonela S; Castrogiovanni, Daniel; De Francesco, Pablo N et al.

Part of European Journal of Nutrition, p. 751-762, 2024

• DOI for Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner

LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

Andreoli, María Florencia; Kruger, Ana Luz; Sokolov, Aleksandr V.; Rukh, Gull et al.

Part of Diabetes, obesity and metabolism, p. 4734-4743, 2024

• DOI for LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans
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The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life

Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa; Casado, Carla et al.

Part of Journal of Nutrition, p. 3388-3399, 2024

• DOI for The Concentration of Liver-Expressed Antimicrobial Peptide 2 in Human Milk and Infant Plasma Is Positively Associated with Adiposity and Body Weight in the First Year of Life

Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study

Andreoli, María Florencia; Gentreau, Mélissa; Rukh, Gull; Perelló, Mario et al.

Part of Diabetes, obesity and metabolism, p. 3565-3575, 2024

• DOI for Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study
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Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications

Gomez, Ivana M.; Uriarte, Maia; Fernandez, Gimena; Barrile, Franco et al.

Part of Molecular Metabolism, 2024

• DOI for Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications
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GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice

Cornejo, María Paula; Fernandez, Gimena; Cabral, Agustina; Barrile, Franco et al.

Part of Endocrinology, 2024

• DOI for GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction

Aguggia, Julieta; Fernandez, Gimena; Cassano, Daniela; Mustafá, Emilio R. et al.

Part of Endocrinology, 2024

• DOI for Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain

Saenz, Camila; Fernandez, Gimena; Llovera, Ramiro; Tolosa, María J. et al.

Part of Brain Structure and Function, 2024

• DOI for Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain
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The Pattern of GH Action in the Mouse Brain

Menezes, Filipe; Wasinski, Frederick; de Souza, Gabriel O.; Nunes, Amanda P. et al.

Part of Endocrinology, 2024

• DOI for The Pattern of GH Action in the Mouse Brain

Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Barrile, Franco; Cassano, Daniela; Fernandez, Gimena; De Francesco, Pablo N. et al.

Part of Psychoneuroendocrinology, 2023

• DOI for Ghrelin's orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation

Fernandez, Gimena; De Francesco, Pablo N.; Cornejo, Maria P.; Cabral, Agustina et al.

Part of Endocrinology, 2023

• DOI for Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation

Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca_V) Subtypes in mPFC Neurons

McCarthy, Clara Inés; Mustafá, Emilio Román; Cornejo, María Paula; Yaneff, Agustín et al.

Part of Molecular Neurobiology, p. 2644-2660, 2023

• DOI for Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (Ca_V) Subtypes in mPFC Neurons

Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Fittipaldi, Antonela S.; Castrogiovanni, Daniel; Lufrano, Daniela; Saenz, Camila et al.

Part of Life Sciences, 2023

• DOI for Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain

De Francesco, Pablo Nicolas; Fernandez, Gimena; Uriarte, Maia; Urrutia, Leandro et al.

Part of Neuroendocrinology, p. 64-79, 2023

• DOI for Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Fernandez, Gimena; Cabral, Agustina; De Francesco, Pablo N.; Uriarte, Maia et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2022

• DOI for GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond

Perello, Mario; Cornejo, Maria P.; De Francesco, Pablo N.; Fernandez, Gimena et al.

Part of IBRO NEUROSCIENCE REPORTS, p. 228-239, 2022

• DOI for The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
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Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Peraldi-Roux, Sylvie; Bayle, Morgane; M'Kadmi, Celine; Damian, Marjorie et al.

Part of Biochemical Pharmacology, 2022

• DOI for Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Aguggia, Julieta P.; Cornejo, Maria P.; Fernandez, Gimena; De Francesco, Pablo N. et al.

Part of Psychoneuroendocrinology, 2022

• DOI for Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Brain-acting hepatokines: its impact on energy balance and metabolism

Giovanini, Lucia; Wanionok, Nahuel; Perello, Mario; Cornejo, Maria Paula

Part of Frontiers in Neuroscience, 2025

• DOI for Brain-acting hepatokines: its impact on energy balance and metabolism
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Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism

Perello, Mario

Part of Endocrinology, 2025

• DOI for Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism