Ekaterina Bezverkhniaia

Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order

Papalanis, Eleftherios; Li, Ruonan; Oroujeni, Maryam; Zhang, Jie et al.

Part of International Journal of Biological Macromolecules, 2026

• DOI for Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order
• Download full text (pdf) of Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order

Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
• Download full text (pdf) of Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

• DOI for Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
• Download full text (pdf) of Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Part of European Journal of Pharmaceutical Sciences, 2025

• DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
• Download full text (pdf) of Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025

• DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
• Download full text (pdf) of Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order

Papalanis, Eleftherios; Li, Ruonan; Oroujeni, Maryam; Zhang, Jie et al.

Part of International Journal of Biological Macromolecules, 2026

• DOI for Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order
• Download full text (pdf) of Tumour accumulation of anti-carcinoembryonic antigen affibody-albumin-binding domain fusion depends on domains' order

Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Tolmachev, Vladimir; Herlina, Amelinda Janice; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A. et al.

Part of International Journal of Molecular Sciences, 2026

• DOI for Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model
• Download full text (pdf) of Efficient ⁶⁸Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2026

• DOI for Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
• Download full text (pdf) of Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Part of European Journal of Pharmaceutical Sciences, 2025

• DOI for Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
• Download full text (pdf) of Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Part of ACS Pharmacology & Translational Science, p. 3600-3612, 2025

• DOI for Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
• Download full text (pdf) of Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Tolmachev, Vladimir M.; Bezverkhniaia, Ekaterina; Papalanis, Eleftherios; Muhammad, Abdullah Mujahid Bin et al.

Part of ACS Pharmacology & Translational Science, p. 3509-3522, 2025

• DOI for Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68
• Download full text (pdf) of Preclinical Positron Emission Tomography Imaging of B7-H3 Expression Using Affibody Molecules Labeled with Gallium-68

Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.
• Download full text (pdf) of Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Part of EJNMMI Research, 2025

• DOI for A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
• Download full text (pdf) of A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
• Download full text (pdf) of RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Medvedeva, Anna; Chernov, Vladimir; Larkina, Maria; Rybina, Anastasiya et al.

Part of ACS Pharmacology & Translational Science, p. 736-747, 2025

• DOI for Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study
• Download full text (pdf) of Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Tolmachev, Vladimir M.; Papalanis, Eleftherios; Bezverkhniaia, Ekaterina A.; Rosly, Alia Hani et al.

Part of ACS Pharmacology & Translational Science, p. 706-717, 2025

• DOI for Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules
• Download full text (pdf) of Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules

Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Kanellopoulos, Panagiotis; Yu, Quanyi; Abouzayed, Abouzayed; Bezverkhniaia, Ekaterina et al.

Part of EJNMMI Radiopharmacy and Chemistry, 2025

• DOI for Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?
• Download full text (pdf) of Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Part of Journal of Controlled Release, p. 468-478, 2024

• DOI for Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
• Download full text (pdf) of Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika et al.

Part of ACS Omega, p. 36122-36133, 2024

• DOI for Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
• Download full text (pdf) of Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Machulkin, Aleksei E.; Petrov, Stanislav A.; Bodenko, Vitalina; Larkina, Mariia S. et al.

Part of ACS Pharmacology & Translational Science, p. 1457-1473, 2024

• DOI for Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Part of ACS Omega, p. 18608-18616, 2024

• DOI for Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
• Download full text (pdf) of Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
• Download full text (pdf) of Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Part of Nuclear Medicine and Biology, 2023

• DOI for Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
• Download full text (pdf) of Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Part of International Journal of Molecular Sciences, 2023

• DOI for Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
• Download full text (pdf) of Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)