Patrick Sandoz

Associate senior lecturer/Assistant Professor at Department of Materials Science and Engineering; Biomedical Engineering

Mobile phone:
+46 70 167 91 55
E-mail:
patrick.sandoz@angstrom.uu.se
Visiting address:
Ångströmlaboratoriet, Regementsvägen 10
Postal address:
Box 35
751 03 UPPSALA

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Keywords

  • microfluidics
  • biomaterials
  • nanotechnology
  • immunology
  • organ-on-chip
  • cancer biology
  • cell signalling
  • microphysiological systems
  • multicellular biophysics
  • innate-like t cells
  • cellular microenvironment

Research

Our research focuses on pioneering interdisciplinary approaches to unravel the structural complexities and signalling dynamics within the cellular microenvironment. Our specific interest lies in understanding the architecture and the biophysical properties within the tumour microenvironments, exploring how they fundamentally influence the immune responses, disease progression and therapeutic outcomes.

To achieve this, we specialize in developing advanced multicellular microphysiological systems that replicate these microenvironments with high fidelity and capture molecular and biophysical signatures. By incorporating biomimetic materials and diverse cell types, our models enable the study of key processes in cancer progression, including molecular signal diffusion, mechanical stress, immune cell infiltration, and metastatic niche formation. Furthermore, our work emphasizes the role of innate-like T cells, such as γδ T cells, in immune responses and explores their activation and functionality in their physiological microenvironment. These MHC-unrestricted cells play important roles as first responders and helper cells in cancer and various types of infection, making them promising candidates for developing novel therapeutic strategies.

By combining materials science, microsystem engineering, cancer biology, immunology, and computational modelling, we aim to address the challenges of recreating the intricate three-dimensional architecture of multicellular environments. Our interdisciplinary work uncovers novel insights into the spatiotemporal dynamics of cancer cell signalling and immune responses, advancing fundamental biological knowledge and driving personalized therapy development. Ultimately, our approach reduces reliance on animal models and expands the potential of smart cell-culture systems for biomedical research

Patrick Sandoz

Publications

Recent publications

All publications

Articles in journal

Articles, review/survey

Conference papers

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