Anna Rostedt Punga
Professor at Department of Medical Sciences; Clinical Neurophysiology
- Telephone:
- +46 18 471 49 41
- E-mail:
- anna.rostedt.punga@uu.se
- Visiting address:
- Rudbecklaboratoriet C11, Dag Hammarsköldsv 20
75237 UPPSALA - Postal address:
- Rudbecklaboratoriet C11, Dag Hammarsköldsv 20
75237 UPPSALA
- Academic merits:
- MD PhD, Associate Professor, Consultant
- CV:
- Download CV
Keywords
- neurofysiologi
- myasthenia gravis
- neuromuskulär
Biography
Anna Rostedt Punga studied medicine with emphasis on research at the faculty of Medicine, Uppsala University, and already then, she started conducting clinical research on myasthenia gravis (MG) in 1999. She spent 3 months at the Duke MG Clinic with Dr Donald Sanders at a scholarship from the Myasthenia Gravis Foundation of America. She later qualified as an MD in 2005 and subsequently defended her PhD thesis with focus on different antibody subtypes MG in the department of Neuroscience, Uppsala University, in 2007. Her postdoctoral studies, that focused on preclinical research on the neuromuscular junction in Basel, rendered an international award from the German Myasthenia Gravis Foundation (Eberhardt Pfleiderer Prize). In 2014 she was granted a highly competitive clinical research grant from the Swedish Research Council (success rate 8%) and then built her own research group/lab on MG and the neuromuscular junction at BMC, Uppsala University.
The research focuses on improving diagnostic and monitoring tools in MG, including biomarkers and neurophysiology, both in-vivo and in-vitro, as well as novel treatment options. At the moment, she holds multiple highly competitive national research grants from the Swedish Research Council and was recently awarded Göran Gustafssons large prize in medicine for my studies in MG. Her team has pioneered the field of microRNA biomarker discovery in MG and has several publications on this topic.
Anna Rostedt Punga combines the role of professor of clinical neurophysiology with a clinical position as consultant clinical neurophysiologist at the Department of Clinical Neurophysiology, Uppsala University Hospital. She also sees MG patients from all over Sweden in the Neurology outpatient unit at Uppsala University hospital. Further, she is the responsible physician for ongoing communication of research to the Swedish NEURO association of MG patients, connecting research with the stakeholder´s community.
She has published more than 50 peer-reviewed original articles as well as 8 review articles and 2 book chapters.

Publications
Recent publications
Part of Frontiers in Immunology, 2025
- DOI for Inflammatory imbalance and activation deficits in T cells of myasthenia gravis patients revealed by proteomic profiling
- Download full text (pdf) of Inflammatory imbalance and activation deficits in T cells of myasthenia gravis patients revealed by proteomic profiling
Chapter Ten - Blood and digital biomarkers in MG
Part of International Review of Neurobiology, p. 205-226, Academic Press, Elsevier, 2025
On the road to blood biomarkers in myasthenia gravis (MG): Beyond clinical scales
Part of Journal of Neuromuscular Diseases, 2025
Part of Clinical Nuclear Medicine, p. 208-213, 2025
Part of iScience, p. 110564, 2024
- DOI for Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
- Download full text (pdf) of Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
All publications
Articles in journal
Part of Frontiers in Immunology, 2025
- DOI for Inflammatory imbalance and activation deficits in T cells of myasthenia gravis patients revealed by proteomic profiling
- Download full text (pdf) of Inflammatory imbalance and activation deficits in T cells of myasthenia gravis patients revealed by proteomic profiling
On the road to blood biomarkers in myasthenia gravis (MG): Beyond clinical scales
Part of Journal of Neuromuscular Diseases, 2025
Part of Clinical Nuclear Medicine, p. 208-213, 2025
Part of iScience, p. 110564, 2024
- DOI for Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
- Download full text (pdf) of Serum protein biomarker profile distinguishes acetylcholine receptor antibody seropositive myasthenia gravis patients from healthy controls.
Part of European Journal of Neurology, 2024
- DOI for Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
- Download full text (pdf) of Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
Part of Journal of Neuroimmunology, 2024
- DOI for Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
- Download full text (pdf) of Elevated C1s/C1-INH in serum and plasma of myasthenia gravis patients
Part of Muscle and Nerve, p. 851-861, 2024
- DOI for Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis
- Download full text (pdf) of Visualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis
Part of Muscle and Nerve, p. 284-289, 2024
- DOI for Short-term changes in serum miRNA levels and patient-reported clinical outcomes in myasthenia gravis.
- Download full text (pdf) of Short-term changes in serum miRNA levels and patient-reported clinical outcomes in myasthenia gravis.
Part of Brain and Behavior, 2024
- DOI for Antibody-positive autoimmune encephalitis and paraneoplastic neurological syndrome: A Swedish case series
- Download full text (pdf) of Antibody-positive autoimmune encephalitis and paraneoplastic neurological syndrome: A Swedish case series
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Part of European Journal of Neurology, 2024
- DOI for Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
- Download full text (pdf) of Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Part of European Journal of Neurology, 2024
- DOI for Response to "More evidence is needed for the association between serum myasthenia gravis and adverse pregnancy, delivery and neonatal outcomes"
- Download full text (pdf) of Response to "More evidence is needed for the association between serum myasthenia gravis and adverse pregnancy, delivery and neonatal outcomes"
Part of Neuromuscular Disorders, p. 334-338, 2023
- DOI for Implementation of tailored exercise programs for MG patients in a gym setting: a pragmatic feasibility case study
- Download full text (pdf) of Implementation of tailored exercise programs for MG patients in a gym setting: a pragmatic feasibility case study
Part of Acta Neurologica Scandinavica, 2023
- DOI for Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
- Download full text (pdf) of Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
Part of European Journal of Neurology, p. 1162-1164, 2023
Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Part of Neuromuscular Disorders, p. 80-83, 2022
- DOI for Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
- Download full text (pdf) of Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Part of Cells, 2022
- DOI for Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
- Download full text (pdf) of Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
Part of JAMA Neurology, p. 1105-1112, 2022
Part of Advanced Functional Materials, 2022
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Part of Journal of Neuroimmunology, 2022
- DOI for Enrichment of serum IgG4 in MuSK myasthenia gravis patients
- Download full text (pdf) of Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Part of European Journal of Neurology, p. 1706-1715, 2021
- DOI for Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
- Download full text (pdf) of Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
Part of Clinical Neurophysiology, p. 1733-1740, 2021
- DOI for Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study
- Download full text (pdf) of Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study
Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Part of Brain and Behavior, 2020
- DOI for Epidemiology of Myasthenia Gravis in Sweden 2006-2016
- Download full text (pdf) of Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Part of Frontiers in Immunology, 2020
- DOI for Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
- Download full text (pdf) of Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
Editorial: Advances in Autoimmune Myasthenia Gravis
Part of Frontiers in Immunology, 2020
- DOI for Editorial: Advances in Autoimmune Myasthenia Gravis
- Download full text (pdf) of Editorial: Advances in Autoimmune Myasthenia Gravis
Flodvåg av långtidssjuka covid-19-patienter väntar
Part of Dagens Nyheter, p. 5-5, 2020
Myasthenia gravis patient and physician opinions about immunosuppressant reduction
Part of Muscle and Nerve, p. 767-772, 2020
Part of Clinical Neurophysiology Practice, p. 46-49, 2020
- DOI for Botulinum toxin injections associated with suspected myasthenia gravis: An underappreciated cause of MG-like clinical presentation
- Download full text (pdf) of Botulinum toxin injections associated with suspected myasthenia gravis: An underappreciated cause of MG-like clinical presentation
Mortality rates and causes of death in Swedish Myasthenia Gravis patients
Part of Neuromuscular Disorders, p. 815-824, 2020
- DOI for Mortality rates and causes of death in Swedish Myasthenia Gravis patients
- Download full text (pdf) of Mortality rates and causes of death in Swedish Myasthenia Gravis patients
miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27
Part of Neuroscience research, p. 46-52, 2020
Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Part of Scientific Reports, 2019
- DOI for Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
- Download full text (pdf) of Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Part of BMJ Open, 2019
- DOI for Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
- Download full text (pdf) of Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
Pattern of Habitual Physical Exercise in Myasthenia Gravis Patients
Part of JOURNAL OF NEUROMUSCULAR DISEASES, p. 85-91, 2019
Cognitive dysfunction in mice with passively induced MuSK antibody seropositive myasthenia gravis
Part of Journal of the Neurological Sciences, p. 15-21, 2019
Facing the challenges of electrodiagnostic studies in the very elderly (>80 years) population
Part of Clinical Neurophysiology, p. 1091-1097, 2019
miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Part of Annals of clinical and translational neurology, p. 243-251, 2019
- DOI for miR-30e-5p as predictor of generalization in ocular myasthenia gravis
- Download full text (pdf) of miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Part of Medicine, 2018
- DOI for The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
- Download full text (pdf) of The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Part of Frontiers in Physiology, 2018
- DOI for Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
- Download full text (pdf) of Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Part of Neurology, 2018
- DOI for Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
- Download full text (pdf) of Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Lifestyle factors and disease-specific differences in subgroups of Swedish Myasthenia Gravis
Part of Acta Neurologica Scandinavica, p. 557-565, 2018
Circulating microRNA plasma profile in MuSK plus myasthenia gravis
Part of Journal of Neuroimmunology, p. 87-91, 2018
Part of Clinical Neurophysiology, p. 1339-1339, 2018
Part of Journal of Neuroimmunology, p. 164-170, 2018
- DOI for Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
- Download full text (pdf) of Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
Part of Brain and Behavior, 2017
- DOI for Diversity in mental fatigue and social profile of patients with myasthenia gravis in two different Northern European countries
- Download full text (pdf) of Diversity in mental fatigue and social profile of patients with myasthenia gravis in two different Northern European countries
Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Part of Scientific Reports, 2017
- DOI for Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
- Download full text (pdf) of Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Part of Clinical Neurophysiology Practice, p. 163-169, 2017
- DOI for High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
- Download full text (pdf) of High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Part of Journal of clinical neurophysiology, p. 400-407, 2017
Part of Muscle and Nerve, p. 207-214, 2017
Compound Motor Action Potential: Electrophysiological Marker for Muscle Training
Part of Journal of clinical neurophysiology, p. 340-345, 2016
Part of Dermatologic Surgery, p. 967-976, 2016
Part of Acta Neurologica Belgica, p. 57-63, 2016
Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
Part of Journal of Neuroimmunology, p. 21-26, 2016
- DOI for Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
- Download full text (pdf) of Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
Part of Clinical Neurophysiology, p. 3480-3484, 2016
Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
Part of Journal of the Neurological Sciences, p. 90-96, 2015
- DOI for Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
- Download full text (pdf) of Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis
Part of Experimental Neurology, p. 29-40, 2015
How clinical trials of myasthenia gravis can inform pre-clinical drug development
Part of Experimental Neurology, p. 78-81, 2015
Part of Acta Dermato-Venereologica, p. 948-951, 2015
- DOI for Regional Diffusion of Botulinum Toxin in Facial Muscles: A Randomised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
- Download full text (pdf) of Regional Diffusion of Botulinum Toxin in Facial Muscles: A Randomised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker
Part of Annals of clinical and translational neurology, p. 49-58, 2014
Part of Acta Dermato-Venereologica, p. 32-37, 2014
Vitamin D deficiency in patients with primary immune-mediated peripheral neuropathies
Part of Journal of the Neurological Sciences, p. 184-188, 2014
Part of Neuroscience research, p. 102-109, 2013
beta-glucans reduce LDL cholesterol in patients with myasthenia gravis
Part of European Journal of Clinical Nutrition, p. 226-227, 2013
Part of European Journal of Neurology, p. 1554-1560, 2012
Part of PLOS ONE, 2012
Part of Journal of the Neurological Sciences, p. 150-157, 2012
Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases
Part of Current opinion in pharmacology (Print), p. 340-346, 2012
Usefulness of assessing repeater F-waves in routine studies
Part of Muscle and Nerve, p. 477-485, 2012
MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity
Part of European Journal of Neuroscience, p. 890-898, 2011
Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice
Part of Experimental Neurology, p. 207-217, 2011
Monozygous twins with neuromuscular transmission defects at opposite sides of the motor endplate
Part of Acta Neurologica Scandinavica, p. 207-211, 2009
Part of Neurological Sciences, p. 121-124, 2008
Part of Muscle and Nerve, p. 300-307, 2007
Validation of the Swedish version of the disease- specific myasthenia gravis questionnaire.
Part of Neurological Sciences, p. 91-96, 2006
Part of Muscle and Nerve, p. 111-115, 2006
Part of Clinical Neurophysiology, p. 1434-1443, 2006
Validation of the Swedish version of the disease-specific Myasthenia Gravis Questionnaire
Part of Neurol Sci, p. 91-96, 2006
Correlation between regional myasthenic weakness and mental aspects of quality of life
Part of Eur J Neurol, p. 191-193, 2006
Part of Clin Neurophysiol, p. 2058-2064, 2005
Part of BMC Neurology
Articles, review/survey
Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Part of Clinical Neurophysiology Practice, p. 169-173, 2023
- DOI for Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
- Download full text (pdf) of Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Part of European Journal of Neurology, p. 266-282, 2023
- DOI for Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
- Download full text (pdf) of Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders
Part of Lancet Neurology, p. 176-188, 2022
Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
Part of Frontiers in Immunology, 2020
- DOI for Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
- Download full text (pdf) of Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Part of Frontiers in Neurology, 2020
- DOI for Myasthenia Gravis and Physical Exercise: A Novel Paradigm
- Download full text (pdf) of Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Circulating microRNAs as potential biomarkers in myasthenia gravis patients.
Part of Annals of the New York Academy of Sciences, p. 33-40, 2018
Advances in autoimmune myasthenia gravis management
Part of Expert Review of Neurotherapeutics, p. 573-588, 2018
Part of Toxins, 2017
- DOI for Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
- Download full text (pdf) of Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
Acetylcholinesterase inhibitors in myasthenia gravis: to be or not to be?
Part of Muscle and Nerve, p. 724-728, 2009
Chapters in book
Chapter Ten - Blood and digital biomarkers in MG
Part of International Review of Neurobiology, p. 205-226, Academic Press, Elsevier, 2025