Elisabet Nielsen

Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.

Part of Antimicrobial Agents and Chemotherapy, 2026

DOI for Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo
Download full text (pdf) of Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Model-based quantification of immune response and anti-staphylococcal activity of afabicin in immunocompetent mouse thigh infections to enable predictions of clinical efficacy

Saporta, Raphael; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R. et al.

Part of Antimicrobial Agents and Chemotherapy, 2026

Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population.

Damgaard, Tobias; Hellborg, Thomas; Larsson, Anders; Eliasson, Erik et al.

Part of BMJ Open, 2026

An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Part of International Journal of Antimicrobial Agents, 2025

Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Melander, Erik; Nielsen, Elisabet I.; Lindqvist, Annika; Hovd, Markus et al.

Part of Basic & Clinical Pharmacology & Toxicology, 2025

Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Part of Journal of Antimicrobial Chemotherapy, p. 79-86, 2025

Predictors of Ability to Work in Multiple Sclerosis

Wellhagen, Gustaf; Ueckert, Sebastian; Nielsen, Elisabet I.; Smith, Carl et al.

Part of CPT, p. 2244-2251, 2025

Comparison of pre-mortem and post-mortem blood concentrations of analgesic and sedative drugs in intensive care patients

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Part of Forensic Science International, 2025

Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care): study protocol for a pre–post intervention trial in older hospitalised patients

Cam, Henrik; Franzon, Kristin; Östman, Victoria; Kälvemark Sporrong, Sofia et al.

Part of BMJ Open, 2025

Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort

Smekal, Anna-Karin; Swartling, Maria; Furebring, Mia; Giske, Christian G et al.

Part of Journal of Antimicrobial Chemotherapy, p. 876-884, 2025

Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients

Smekal, Anna-Karin; Swartling, Maria; Nielsen, Elisabet I.; Furebring, Mia et al.

Part of Scientific Reports, 2025

First dose target attainment with extended infusion regimens of piperacillin and meropenem

Beijer, Gustaf; Swartling, Maria; Nielsen, Elisabet I.; Breuer, Olof et al.

Part of Critical Care, 2025

A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Part of JAC - Antimicrobial Resistance, 2025

Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Swartling, Maria; Hamberg, Anna-Karin; Furebring, Mia; Tängdén, Thomas et al.

Part of International Journal of Clinical Pharmacy, p. 178-186, 2025

Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Bahnasawy, Salma M.; Ahmed, Hifza; Zeitlinger, Markus; Friberg, Lena E. et al.

Part of International Journal of Antimicrobial Agents, 2025

Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Part of International Journal of Antimicrobial Agents, 2025

Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus

Saporta, Raphaël; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3150-3159, 2024

Nya rekommendationer för infusion av betalaktamantibiotika

Gustafsson, Tove; Eliasson, Erik; Furebring, Mia; Nielsen, Elisabet I. et al.

Part of Läkartidningen, 2024

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Part of Upsala Journal of Medical Sciences, 2024

'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Cam, Henrik; Franzon, Kristin; Kälvemark Sporrong, Sofia; Kempen, Thomas Gerardus Hendrik et al.

Part of Health Expectations, 2024

Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Bahnasawy, Salma M.; Parrott, Neil J.; Gijsen, Matthias; Spriet, Isabel et al.

Part of International Journal of Antimicrobial Agents, 2024

Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojevic, Natasa; Dreesen, Erwin; Nielsen, Elisabet et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 556-560, 2024

PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs

Saporta, Raphaël; Nielsen, Elisabet I.; Hansen, Jon U.; Liepinsh, Edgars et al.

Part of International Journal of Antimicrobial Agents, 2024

Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Part of Scientific Reports, 2024

Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Part of Infectious Diseases, p. 451-459, 2024

Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Part of Research in Social and Administrative Pharmacy, p. 216-217, 2024

DOI for Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Bahnasawy, Salma M.; Skorup, Paul; Hanslin, Katja; Lipcsey, Miklós et al.

Part of Cytokine, 2023

Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Swartling, Maria; Tängdén, Thomas; Lipcsey, Miklós; Jönsson, Siv et al.

Part of International Journal of Antimicrobial Agents, 2023

The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Part of BMC Health Services Research, 2023

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Thorsted, Anders; Pham, Anh Duc; Friberg, Lena E.; Nielsen, Elisabet I.

Part of CPT, p. 1972-1987, 2023

Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Part of British Journal of Clinical Pharmacology, p. 1575-1587, 2023

Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Part of The Lancet Microbe, 2022

Population pharmacokinetics of cefotaxime in intensive care patients

Swartling, Maria; Smekal, Anna-Karin; Furebring, Mia; Lipcsey, Miklós et al.

Part of European Journal of Clinical Pharmacology, p. 251-258, 2022

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Part of Nature Chemistry, p. 15-24, 2022

DOI for Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Part of Respiratory Medicine, 2022

Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Johansson, Anna; Ahlner, Johan; Lennborn, Ulrica; Nielsen, Elisabet I. et al.

Part of TOXICOLOGIE ANALYTIQUE ET CLINIQUE, p. 327-337, 2021

DOI for Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Part of JAMA Network Open, 2021

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Part of npj Primary Care Respiratory Medicine, 2021

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Maarbjerg, Sabine F.; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I. et al.

Part of Cancer Reports, 2021

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan et al.

Part of Journal of Clinical Pharmacy and Therapeutics, p. 1021-1029, 2020

Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

Part of International Journal of Antimicrobial Agents, 2020

Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Part of Scientific Reports, 2020

Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

Part of Clinical Microbiology and Infection, p. 1214-1221, 2020

Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Thorsted, Anders; Nielsen, Elisabet I.; Friberg, Lena

Part of International Journal of Antimicrobial Agents, 2020

DOI for Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Part of Haematologica, p. 1443-1453, 2020

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

Thorsted, Anders; Tano, Eva; Kaivonen, Kia; Sjölin, Jan et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Kristoffersson, Anders N.; Bissantz, Caterina; Okujava, Rusudan; Haldimann, Andreas et al.

Part of Journal of Antimicrobial Chemotherapy, p. 400-408, 2020

DOI for A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

Maarbjerg, Sabine F.; Thorsted, Anders; Kristoffersson, Anders; Friberg, Lena E. et al.

Part of Pediatric Blood & Cancer, 2019

DOI for Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Thorsted, Anders; Bouchene, Salim; Tano, Eva; Castegren, Markus et al.

Part of PLOS ONE, 2019

Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels

Kurland, Siri; Furebring, Mia; Löwdin, Elisabeth; Eliasson, E. et al.

Part of Antimicrobial Agents and Chemotherapy, 2019

DOI for Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels

A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

Part of The International Journal of Chronic Obstructive Pulmonary Disease, p. 2451-2460, 2019

Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Part of CPT, p. 894-903, 2019

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen

Thorsted, Anders; Kristoffersson, Anders N.; Maarbjerg, Sabine F.; Schrøder, Henrik et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2984-2993, 2019

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Abrantes, João A.; Jönsson, Siv; Karlsson, Mats; Nielsen, Elisabet I.

Part of British Journal of Clinical Pharmacology, p. 1326-1336, 2019

DOI for Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Netterberg, Ida; Karlsson, Mats O; Nielsen, Elisabet I.; Quartino, Angelica L et al.

Part of British Journal of Clinical Pharmacology, p. 490-500, 2018

DOI for The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Real life experiences of a PK dosing study: Challenges and lessons learned

Mangles, S.; Rea, C.; Madan, B.; Nielsen, Elisabet I. et al.

Part of Haemophilia, 2018

DOI for Real life experiences of a PK dosing study: Challenges and lessons learned

Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Part of European Journal of Clinical Pharmacology, p. 1299-1307, 2018

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Part of International Journal of Antimicrobial Agents, p. 399-406, 2018

DOI for Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Population Pharmacokinetic Analysis of Vaginally and Intravenously Administered Oxytocin in Postmenopausal Women

Nielsen, Elisabet I.; Al-Saqi, Shahla H.; Jonasson, Aino F.; Uvnäs-Moberg, Kerstin

Part of Journal of clinical pharmacology, p. 1573-1581, 2017

DOI for Population Pharmacokinetic Analysis of Vaginally and Intravenously Administered Oxytocin in Postmenopausal Women

Elimination ability of caspofungin in critically ill patients in relation to liver dysfunction in an ICU setting

Kurland, Siri; Furebring, Mia; Löwdin, Elisabeth; Nielsen, Elisabet I. et al.

Part of Mycoses, p. 225-225, 2017

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Nielsen, Elisabet I.; Khan, David D.; Cao, Sha; Lustig, Ulrika et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3108-3116, 2017

DOI for Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains?: External evaluation of a PKPD model describing longitudinal in vitro data

Medication Reviews Bridging Healthcare (MedBridge): Study protocol for a pragmatic cluster-randomised crossover trial

Kempen, Thomas; Bertilsson, Maria; Lindner, Karl-Johan; Sulku, Johanna et al.

Part of Contemporary Clinical Trials, p. 126-132, 2017

DOI for Medication Reviews Bridging Healthcare (MedBridge): Study protocol for a pragmatic cluster-randomised crossover trial

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring

Netterberg, Ida; Nielsen, Elisabet I.; Friberg, Lena E; Karlsson, Mats O.

Part of Cancer Chemotherapy and Pharmacology, p. 343-353, 2017

Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa

Abrantes, João A.; Nielsen, Elisabet I.; Korth-Bradley, J.; Harnisch, L. et al.

Part of Clinical Pharmacology and Therapeutics, p. 977-988, 2017

DOI for Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa

Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study

Senek, Marina; Nielsen, Elisabet I.; Nyholm, Dag

Part of Movement Disorders, p. 283-286, 2017

DOI for Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study

Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

Ungphakorn, Wanchana; Malmberg, Christer; Lagerbäck, Pernilla; Cars, Otto et al.

Part of Journal of Microbiological Methods, p. 69-75, 2017

DOI for Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics

A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

Sadiq, Muhammad W; Nielsen, Elisabet I.; Khachman, Dalia; Conil, Jean-Marie et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 69-79, 2017

Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats

Torres, Bruna G. S.; Helfer, Victoria E.; Bernardes, Priscila M.; Macedo, Alexandre Jose et al.

Part of Antimicrobial Agents and Chemotherapy, 2017

DOI for Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats

A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP

Johansson, Anna; Lindstedt, Daniel; Roman, Markus; Thelander, Gunilla et al.

Part of Forensic Science International, p. 76-82, 2017

DOI for A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP

A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin

Khan, David D.; Friberg, Lena E.; Nielsen, Elisabet I.

Part of Journal of Antimicrobial Chemotherapy, p. 1881-1884, 2016

DOI for A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin

Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

Mohamed, Ami F; Kristoffersson, Anders; Karvanen, Matti; Nielsen, Elisabet et al.

Part of Journal of Antimicrobial Chemotherapy, p. 1279-1290, 2016

DOI for Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model

Population Pharmacokinetics of Plasma-Derived Factor IX: Procedures for Dose Individualization

Brekkan, Ari; Berntorp, Erik; Jensen, Kirsten; Nielsen, Elisabet I et al.

Part of Journal of Thrombosis and Haemostasis, p. 724-732, 2016

DOI for Population Pharmacokinetics of Plasma-Derived Factor IX: Procedures for Dose Individualization

A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure

Ungphakorn, Wanchana; Tängdén, Thomas; Sandegren, Linus; Nielsen, Elisabet I.

Part of Journal of Antimicrobial Chemotherapy, p. 2521-2533, 2016

DOI for A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure

Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants

Germovsek, Eva; Kent, Alison; Metsvaht, Tuuli; Lutsar, Irja et al.

Part of Antimicrobial Agents and Chemotherapy, p. 4869-4877, 2016

DOI for Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

Kristoffersson, Anders; David-Pierson, Pascale; Parrott, Neil J; Kuhlmann, Olaf et al.

Part of Pharmaceutical research, p. 1115-1125, 2016

DOI for Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Khan, David D.; Lagerbäck, Pernilla; Cao, Sha; Lustig, Ulrika et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3051-3060, 2015

DOI for A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

De Cock, Roosmarijn F W; Allegaert, Karel; Sherwin, Catherine M T; Nielsen, Elisabet I et al.

Part of Pharmaceutical research, p. 754-767, 2014

DOI for A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

Population pharmacokinetics of plasma-derived factor IX

Jensen, Kirsten; Jönsson, Siv; Nielsen, Elisabet I.; Berntorp, Erik

Part of Haemophilia, p. 80-80, 2014

Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

Di Paolo, Antonello; Tascini, Carlo; Polillo, Marialuisa; Gemignani, Giulia et al.

Part of International Journal of Antimicrobial Agents, p. 250-255, 2013

DOI for Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections

PK/PD Index Versus Mechanism-Based PKPD Modeling to Describe Antibacterial Efficacy of Ciprofloxacin and Colistin

Khan, David; Friberg, Lena E.; Nielsen, Elisabet I.

Part of Journal of Pharmacokinetics and Pharmacodynamics, 2013

Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

Mohamed, Ami F; Nielsen, Elisabet I; Cars, Otto; Friberg, Lena E

Part of Antimicrobial Agents and Chemotherapy, p. 179-188, 2012

DOI for Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

Pharmacokinetic/Pharmacodynamic (PK/PD) indices of antibiotics predicted by a semi-mechanistic PKPD model: a step toward model-based dose optimization

Nielsen, Elisabet I; Cars, Otto; Friberg, Lena E

Part of Antimicrobial Agents and Chemotherapy, p. 4619-4630, 2011

DOI for Pharmacokinetic/Pharmacodynamic (PK/PD) indices of antibiotics predicted by a semi-mechanistic PKPD model: a step toward model-based dose optimization

Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model

Nielsen, Elisabet I.; Cars, Otto; Friberg, Lena E.

Part of Antimicrobial Agents and Chemotherapy, p. 1571-1579, 2011

DOI for Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model

Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates: Population Modelling of a Prospective Study

Nielsen, Elisabet I.; Sandström, Marie; Honore, Per Hartvig; Ewald, Uwe et al.

Part of Clinical Pharmacokinetics, p. 253-263, 2009

DOI for Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates: Population Modelling of a Prospective Study

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

Nielsen, Elisabet I.; Viberg, Anders; Löwdin, Elisabeth; Cars, Otto et al.

Part of Antimicrobial Agents and Chemotherapy, p. 128-136, 2007

DOI for Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

Direct analysis of artemisinin in plasma and saliva using coupled-column high-performance liquid chromatography with a restricted-access material pre-column

Gordi, Toufigh; Nielsen, Elisabet I; Yu, Zuoxiang; Westerlund, Douglas et al.

Part of Journal of Chromatography B, p. 155-162, 2000

DOI for Direct analysis of artemisinin in plasma and saliva using coupled-column high-performance liquid chromatography with a restricted-access material pre-column

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Simulation-based evaluation of PK/PD indices for meropenem across patient groups and experimental designs

Kristoffersson, Anders; David-Pierson, Pascale; Parrott, Neil; Kuhlmann, Olaf et al.

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