Stina Syvänen

Professor at Department of Public Health and Caring Sciences; Molecular Geriatrics / Rudbeck laboratory

Telephone:
+46 18 471 34 05
Mobile phone:
+46 73 469 74 52
E-mail:
stina.syvanen@uu.se
Visiting address:
Dag Hammarskjölds väg 20
Postal address:
Rudbecklaboratoriet
751 85 Uppsala

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Professor Deputy head of department at Department of Public Health and Caring Sciences; Administration

Mobile phone:
+46 73 469 74 52
E-mail:
stina.syvanen@uu.se
Visiting address:
BMC, Husargatan 3
Postal address:
Box 564
751 22 UPPSALA

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Biography

ACADEMIC EDUCATION AND PROFESSIONAL EXPERIENCE

2021-present: Professor and Head of research group Molecular Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University.

2012-2020: Researcher/Assoc Prof, Molecular Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University

2008-2012: Postdoctoral researcher, Division of Pharmacology, Leiden University, The Netherlands.

2006-2007: Visiting scientist at the Neurobiology Research Unit, Copenhagen University. Hospital (Rigshospitalet), Denmark (5 months)

2003-2008: PhD, Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsala University

1997-2003: Master of Science in Chemical Engineering, Uppsala University

1999-2000: One academic year at University of Edinburgh, UK. ERASMUS scholarship.

COMISSION OF TRUST

2025-present: Panel Chair (MH-11) of the Swedish Research Council

2023-present: Member of SciLifeLab committee, Uppsala University

2020-present: Member of the scientific advisory board Swedish Alzheimer Foundation

ACADEMIC HONOR

2023: Eric K Fernström price to a young, especially promising researcher, within medical research

2017: Queen Silvia’s research award to a young researcher within the field of Alzheimer’s disease handed out by Alzheimerfonden

2016: Fondkistan’s research award to young researchers

Research

Our research is focused on understanding the molecular mechanisms behind Alzheimer's disease and other types of dementia. We have generated antibodies that bind specifically to different forms of Aβ or α-synuclein, or other disease relevant proteins such as microglia protein TREM2. Some of the antibodies have also been modified to bind the transferrin receptor (TfR), which is normally involved in iron transport into the brain. The interaction with TfR works like a molecular Trojan horse, which transports the antibody into the brain, where it can bind to its target. This modification increases antibody brain concentration up to 100-fold. These bispecific antibodies have been explored as novel PET radioligands and as immunotherapeutics.

In parallel with the development of brain penetrant antibodies we study changes in the blood-brain barrier (BBB) during neurodegeneration. We also use small molecule PET radioligands to investigate pathology in the ageing brain focusing mainly on protein deposits, neuroinflammation and synaptic dysfunction.

Stina Syvänen

Publications

Selection of publications

Recent publications

All publications

Articles in journal

Articles, review/survey

Chapters in book

Comprehensive doctoral thesis

Conference papers

Manuscripts (preprints)

Monograph licentiate thesis

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