Dag Leonard
Senior Lecturer/Associate Professor Senior lecturer at Department of Medical Sciences; Rheumatology
- Telephone:
- +46 18 471 45 34
- E-mail:
- Dag.Leonard@medsci.uu.se
- Visiting address:
- UAS, ing 100/101, 2 tr
SE-751 85 Uppsala
Sweden - Postal address:
- UAS, Ing 101, 2 tr
SE-751 85 Uppsala
Sweden
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- Academic merits:
- Associate professor
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Keywords
- functional genetics
- precision medicine
- systemic lupus erythematosus
Publications
Selection of publications
- B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus (2023)
- Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus (2021)
- High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus (2020)
- Interferon pathway in SLE (2019)
- Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis (2018)
- Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes (2016)
Recent publications
- Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study (2024)
- A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile (2024)
- Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies (2024)
- Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy (2024)
- B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus (2023)
All publications
Articles
- Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study (2024)
- A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile (2024)
- Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies (2024)
- Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy (2024)
- B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus (2023)
- Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus (2023)
- Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations (2022)
- Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases (2022)
- Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome (2022)
- Mer-tyrosine kinase (2022)
- Variants in BANK1 are associated with lupus nephritis of European ancestry. (2021)
- Contributions of de novo variants to systemic lupus erythematosus (2021)
- C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205 (2021)
- De novo lupus nephritis during treatment with belimumab (2021)
- Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus (2021)
- Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing (2021)
- Quick Systemic Lupus Activity Questionnaire (Q-SLAQ) (2021)
- Clinical Experience of Proteasome Inhibitor Bortezomib Regarding Efficacy and Safety in Severe Systemic Lupus Erythematosus (2021)
- Toll-like receptors revisited (2021)
- NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus (2020)
- High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus (2020)
- Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus (2020)
- Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus (2019)
- A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts (2019)
- The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment (2019)
- Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome (2019)
- Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus (2019)
- Sex differences in clinical presentation of systemic lupus erythematosus (2019)
- Interferon pathway in SLE (2019)
- Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness (2019)
- The risk allele A of rs200395694 associated with SLE in Swedish patients affects on MEF2D gene regulation and alternative splicing (2018)
- ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease (2018)
- The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE (2018)
- DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus (2018)
- Shared and unique patterns of DNA methylation in primary Sjogren's syndrome and systemic lupus erythematosus (2018)
- Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis (2018)
- Novel risk genes for systemic lupus erythematosus predicted by random forest classification (2017)
- SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations (2017)
- Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus (2017)
- A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus (2017)
- High Genetic Risk Score Is Associated with Increased Organ Damage in SLE (2017)
- Direct and indirect costs for systemic lupus erythematosus in Sweden. A nationwide health economic study based on five defined cohorts (2016)
- Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes (2016)
- Early B Cell Factor 1 is Associated to Clinical Manifestations in Primary Sjogren's Syndrome and SLE (2015)
- High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants (2014)
- Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated by RNA-containing immune complexes (2014)
- Activated SLE-T Cells Enhance the Interferon-Alpha Production By Plasmacytoid Dendritic Cells Stimulated By RNA-IC (2014)
- Direct and Indirect Costs For Patients With Systemic Lupus Erythematosus In National Cohorts In Sweden (2013)
- Coronary Heart Disease in Systemic Lupus Erythematosus is Associated with Interferon Regulatory Factor 8 Gene Variants (2013)
- Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants (2013)
- HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus (2013)
- Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus (2013)
- Ischemic vascular disease and antiphospholipid antibodies are associated with HLA-DRB1 *04/*13 alleles in systemic lupus erythematosus (2012)
- IFN-α Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1β and LFA-1 (2011)
- Increased carotid intima thickness and decreased media thickness in premenopausal women with systemic lupus erythematosus (2011)
- A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus (2010)
- Variants in BANK1 are associated with lupus nephritis
- Activated T cells enhance interferon-alpha production by plasmacytoid dendritic cells stimulated by RNA-containing immune complexes
- From genetic predisposition to clinical outcome in systemic lupus erythematosus
Books
