Dag Leonard
Senior Lecturer/Associate Professor Senior lecturer at Department of Medical Sciences; Rheumatology
- Telephone:
- +46 18 471 45 34
- E-mail:
- Dag.Leonard@medsci.uu.se
- Visiting address:
- UAS, ing 100/101, 2 tr
SE-751 85 Uppsala
Sweden - Postal address:
- UAS, Ing 101, 2 tr
SE-751 85 Uppsala
Sweden
Download contact information for Dag Leonard at Department of Medical Sciences; Rheumatology
- Academic merits:
- Associate professor
Keywords
- functional genetics
- systemic lupus erythematosus
- precision medicine

Publications
Selection of publications
Part of Lupus Science and Medicine, 2023
- DOI for B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
- Download full text (pdf) of B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 1183-1189, 2021
- DOI for Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
- Download full text (pdf) of Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 363-369, 2020
- DOI for High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
- Download full text (pdf) of High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
Interferon pathway in SLE: one key to unlocking the mystery of the disease
Part of Lupus Science and Medicine, 2019
- DOI for Interferon pathway in SLE: one key to unlocking the mystery of the disease
- Download full text (pdf) of Interferon pathway in SLE: one key to unlocking the mystery of the disease
Part of Annals of the Rheumatic Diseases, p. 1063-1069, 2018
- DOI for Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
- Download full text (pdf) of Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
Part of Annals of the Rheumatic Diseases, p. 1728-1734, 2016
Recent publications
Part of Clinical and Experimental Rheumatology, p. 316-325, 2025
Part of Arthritis & Rheumatology, p. 212-225, 2025
- DOI for Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
- Download full text (pdf) of Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
Part of Rheumatology, 2024
- DOI for Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus.
- Download full text (pdf) of Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus.
Part of Rheumatology, p. 1104-1112, 2024
- DOI for Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study
- Download full text (pdf) of Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study
Part of Arthritis Research & Therapy, 2024
- DOI for Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
- Download full text (pdf) of Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
All publications
Articles in journal
Part of Clinical and Experimental Rheumatology, p. 316-325, 2025
Part of Arthritis & Rheumatology, p. 212-225, 2025
- DOI for Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
- Download full text (pdf) of Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
Part of Rheumatology, 2024
- DOI for Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus.
- Download full text (pdf) of Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus.
Part of Rheumatology, p. 1104-1112, 2024
- DOI for Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study
- Download full text (pdf) of Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study
Part of Arthritis Research & Therapy, 2024
- DOI for Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
- Download full text (pdf) of Low CD4+T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
Part of Seminars in Arthritis & Rheumatism, 2024
- DOI for Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies: A longitudinal study
- Download full text (pdf) of Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies: A longitudinal study
Part of Journal of Autoimmunity, 2024
- DOI for A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile
- Download full text (pdf) of A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile
Part of Lupus Science and Medicine, 2023
- DOI for B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
- Download full text (pdf) of B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Part of Arthritis Research & Therapy, 2023
- DOI for Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
- Download full text (pdf) of Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
Part of Lupus Science and Medicine, 2022
- DOI for Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
- Download full text (pdf) of Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
Part of Arthritis & Rheumatology, p. 1440-1450, 2022
- DOI for Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
- Download full text (pdf) of Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Part of ACR Open Rheumatology, p. 27-39, 2022
- DOI for Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations
- Download full text (pdf) of Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations
Part of Arthritis & Rheumatology, p. 1842-1850, 2022
- DOI for Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
- Download full text (pdf) of Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
De novo lupus nephritis during treatment with belimumab
Part of Rheumatology, p. 4348-4354, 2021
- DOI for De novo lupus nephritis during treatment with belimumab
- Download full text (pdf) of De novo lupus nephritis during treatment with belimumab
Variants in BANK1 are associated with lupus nephritis of European ancestry.
Part of Genes and Immunity, p. 194-202, 2021
- DOI for Variants in BANK1 are associated with lupus nephritis of European ancestry.
- Download full text (pdf) of Variants in BANK1 are associated with lupus nephritis of European ancestry.
Part of Frontiers in Immunology, 2021
- DOI for Clinical Experience of Proteasome Inhibitor Bortezomib Regarding Efficacy and Safety in Severe Systemic Lupus Erythematosus: A Nationwide Study
- Download full text (pdf) of Clinical Experience of Proteasome Inhibitor Bortezomib Regarding Efficacy and Safety in Severe Systemic Lupus Erythematosus: A Nationwide Study
Part of Annals of the Rheumatic Diseases, p. 1183-1189, 2021
- DOI for Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
- Download full text (pdf) of Interaction between the STAT4rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
Part of Lupus Science and Medicine, 2021
- DOI for Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity
- Download full text (pdf) of Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity
Part of Frontiers in Immunology, 2021
- DOI for C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
- Download full text (pdf) of C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
Part of Annals of the Rheumatic Diseases, p. 109-117, 2021
- DOI for Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
- Download full text (pdf) of Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Contributions of de novo variants to systemic lupus erythematosus
Part of European Journal of Human Genetics, p. 184-193, 2021
- DOI for Contributions of de novo variants to systemic lupus erythematosus
- Download full text (pdf) of Contributions of de novo variants to systemic lupus erythematosus
Toll-like receptors revisited: a possible role for TLR1 in lupus nephritis
Part of Annals of the Rheumatic Diseases, p. 404-406, 2021
- DOI for Toll-like receptors revisited: a possible role for TLR1 in lupus nephritis
- Download full text (pdf) of Toll-like receptors revisited: a possible role for TLR1 in lupus nephritis
Part of Seminars in Arthritis & Rheumatism, p. 1387-1393, 2020
Part of Annals of the Rheumatic Diseases, p. 363-369, 2020
- DOI for High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
- Download full text (pdf) of High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 254-261, 2020
Sex differences in clinical presentation of systemic lupus erythematosus
Part of Biology of Sex Differences, 2019
- DOI for Sex differences in clinical presentation of systemic lupus erythematosus
- Download full text (pdf) of Sex differences in clinical presentation of systemic lupus erythematosus
Part of Annals of the Rheumatic Diseases, p. 1363-1370, 2019
- DOI for Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
- Download full text (pdf) of Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
Part of Lupus, p. 1261-1272, 2019
- DOI for The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment: factors related to damage accrual in two regional cohorts
- Download full text (pdf) of The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment: factors related to damage accrual in two regional cohorts
Part of Frontiers in Immunology, 2019
- DOI for Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness
- Download full text (pdf) of Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness
Part of Frontiers in Immunology, 2019
- DOI for Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome
- Download full text (pdf) of Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome
Part of Human Genetics, p. 141-150, 2019
- DOI for Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
- Download full text (pdf) of Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
Part of European Journal of Human Genetics, p. 432-441, 2019
- DOI for A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
- Download full text (pdf) of A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
Part of Annals of the Rheumatic Diseases, p. 1063-1069, 2018
- DOI for Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
- Download full text (pdf) of Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis
Part of Annals of the Rheumatic Diseases, p. 1070-1077, 2018
- DOI for The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
- Download full text (pdf) of The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
Part of Scandinavian Journal of Rheumatology, p. 3-3, 2018
Part of Annals of the Rheumatic Diseases, p. 736-743, 2018
- DOI for DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
- Download full text (pdf) of DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
Part of Human Gene Therapy, 2018
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Part of Scientific Reports, 2018
- DOI for ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
- Download full text (pdf) of ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus
Part of Arthritis & Rheumatology, 2017
Novel risk genes for systemic lupus erythematosus predicted by random forest classification
Part of Scientific Reports, 2017
- DOI for Novel risk genes for systemic lupus erythematosus predicted by random forest classification
- Download full text (pdf) of Novel risk genes for systemic lupus erythematosus predicted by random forest classification
SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations
Part of Arthritis & Rheumatology, 2017
High Genetic Risk Score Is Associated with Increased Organ Damage in SLE
Part of Arthritis & Rheumatology, 2017
Part of Annals of the Rheumatic Diseases, p. 1607-1613, 2017
Part of Annals of the Rheumatic Diseases, p. 1728-1734, 2016
Early B Cell Factor 1 is Associated to Clinical Manifestations in Primary Sjogren's Syndrome and SLE
Part of Scandinavian Journal of Immunology, p. 416-416, 2015
Part of Scandinavian Journal of Rheumatology, p. 88-89, 2014
High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants
Part of Arthritis & Rheumatology, 2014
Part of Arthritis & Rheumatology, 2014
Part of Rheumatology, p. 345-353, 2013
Part of Annals of the Rheumatic Diseases, p. 1018-1025, 2013
Part of Circulation, p. 255-263, 2013
Part of Arthritis and Rheumatism, 2013
Part of Annals of the Rheumatic Diseases, p. 270-270, 2013
Part of Annals of the Rheumatic Diseases, 2012
Part of Scandinavian Journal of Rheumatology, p. 279-282, 2011
Part of Journal of Immunology, p. 5085-5094, 2011
Part of Annals of the Rheumatic Diseases, p. 834-840, 2010
Articles, review/survey
Interferon pathway in SLE: one key to unlocking the mystery of the disease
Part of Lupus Science and Medicine, 2019
- DOI for Interferon pathway in SLE: one key to unlocking the mystery of the disease
- Download full text (pdf) of Interferon pathway in SLE: one key to unlocking the mystery of the disease
Part of Seminars in Arthritis & Rheumatism, p. 684-690, 2016