Hervé Nicoloff

Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli

Heidarian, Sheida; Hjort, Karin; Nicoloff, Hervé; Andersson, Dan I.

Part of mBio, 2026

• DOI for Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli
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The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing

Jonsson, Sofia; Guliaev, Andrei; Berryhill, Brandon A.; Andersson, Dan I. et al.

Part of Nature Communications, 2026

• DOI for The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing
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Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study

Heyman, Gabriel; Jonsson, Sofia; Fatsis-Kavalopoulos, Nikos; Hjort, Karin et al.

Part of The Lancet Microbe, 2025

• DOI for Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study
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Heteroresistance and clinical outcomes: much still to be understood – Authors' reply

Fatsis-Kavalopoulos, Nikos; Heyman, Gabriel; Hjort, Karin; Jonsson, Sofia et al.

Part of The Lancet Microbe, 2025

• DOI for Heteroresistance and clinical outcomes: much still to be understood – Authors' reply
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Machine learning detection of heteroresistance in Escherichia coli

Guliaev, Andrei; Hjort, Karin; Rossi, Michele; Jonsson, Sofia et al.

Part of EBioMedicine, 2025

• DOI for Machine learning detection of heteroresistance in Escherichia coli
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Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli

Heidarian, Sheida; Hjort, Karin; Nicoloff, Hervé; Andersson, Dan I.

Part of mBio, 2026

• DOI for Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli
• Download full text (pdf) of Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli

The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing

Jonsson, Sofia; Guliaev, Andrei; Berryhill, Brandon A.; Andersson, Dan I. et al.

Part of Nature Communications, 2026

• DOI for The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing
• Download full text (pdf) of The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing

Heteroresistance and clinical outcomes: much still to be understood – Authors' reply

Fatsis-Kavalopoulos, Nikos; Heyman, Gabriel; Hjort, Karin; Jonsson, Sofia et al.

Part of The Lancet Microbe, 2025

• DOI for Heteroresistance and clinical outcomes: much still to be understood – Authors' reply
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Machine learning detection of heteroresistance in Escherichia coli

Guliaev, Andrei; Hjort, Karin; Rossi, Michele; Jonsson, Sofia et al.

Part of EBioMedicine, 2025

• DOI for Machine learning detection of heteroresistance in Escherichia coli
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High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes

Heidarian, Sheida; Guliaev, Andrei; Nicoloff, Hervé; Hjort, Karin et al.

Part of PLoS biology, 2024

• DOI for High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes
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Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

Nicoloff, Hervé; Hjort, Karin; Andersson, Dan I.; Wang, Helen

Part of Nature Communications, 2024

• DOI for Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance
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Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline

Jagdmann, Jennifer; Andersson, Dan I.; Nicoloff, Hervé

Part of PLoS biology, 2022

• DOI for Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline
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A portable epigenetic switch for bistable gene expression in bacteria

Olivenza, David R.; Nicoloff, Hervé; Antonia Sanchez-Romero, Maria; Cota, Ignacio et al.

Part of Scientific Reports, 2019

• DOI for A portable epigenetic switch for bistable gene expression in bacteria
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The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

Nicoloff, Hervé; Hjort, Karin; Levin, Bruce R.; Andersson, Dan I

Part of Nature Microbiology, p. 504-514, 2019

• DOI for The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

Appropriate Regulation of the sigma(E)-Dependent Envelope Stress Response Is Necessary To Maintain Cell Envelope Integrity and Stationary-Phase Survival in Escherichia coli

Nicoloff, Hervé; Gopalkrishnan, Saumya; Ades, Sarah E.

Part of Journal of Bacteriology, 2017

• DOI for Appropriate Regulation of the sigma(E)-Dependent Envelope Stress Response Is Necessary To Maintain Cell Envelope Integrity and Stationary-Phase Survival in Escherichia coli

Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica

Hjort, Karin; Nicoloff, Hervé; Andersson, Dan I.

Part of Molecular Microbiology, p. 274-289, 2016

• DOI for Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica
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Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes

Nicoloff, Herve; Andersson, Dan I.

Part of Journal of Antimicrobial Chemotherapy, p. 100-110, 2016

• DOI for Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes

Lon protease inactivation, or translocation of the lon gene, potentiate bacterial evolution to antibiotic resistance

Nicoloff, Hervé; Andersson, Dan I.

Part of Molecular Microbiology, p. 1233-1248, 2013

• DOI for Lon protease inactivation, or translocation of the lon gene, potentiate bacterial evolution to antibiotic resistance

Mechanisms and clinical relevance of bacterial heteroresistance

Andersson, Dan I; Nicoloff, Hervé; Hjort, Karin

Part of Nature Reviews Microbiology, p. 479-496, 2019

• DOI for Mechanisms and clinical relevance of bacterial heteroresistance

Impact of the pan-genome of Escherichia coli on the potential for de novo antibiotic resistance evolution: Supplemental material: Figure S1

Jagdmann, Jennifer; Andersson, Dan I.; Nicoloff, Hervé

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S11 Table

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S4 Table

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S8 Table

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S10 Table

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S2 Table

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Clonal spread and antibiotic selection of a mutation preventing the evolution of high-level resistance: Supporting information: S1 Data

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Impact of the genetic background on plasmid-borne antibiotic resistance: Supplemental information: Table S1

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Impact of the genetic background on plasmid-borne antibiotic resistance: Supplemental information: Table S7

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Impact of the genetic background on plasmid-borne antibiotic resistance: Supplemental information: Table S2

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Impact of the genetic background on plasmid-borne antibiotic resistance: Supplemental information: Table S6

Jagdmann, Jennifer; Nicoloff, Hervé; Andersson, Dan I.

2022

Impact of the pan-genome of Escherichia coli on the potential for de novo antibiotic resistance evolution: Supplemental material: Table S1.

Jagdmann, Jennifer; Andersson, Dan I.; Nicoloff, Hervé

2022

Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study

Heyman, Gabriel; Jonsson, Sofia; Fatsis-Kavalopoulos, Nikos; Hjort, Karin et al.

Part of The Lancet Microbe, 2025

• DOI for Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study
• Download full text (pdf) of Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study

The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing: Appendix files

Jonsson, Sofia; Guliaev, Andrei; Berryhill, Brandon A.; Andersson, Dan I. et al.

2025