Chuan Jin

Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model

Gao, Menghan; Kechagia, Soultana; Ramachandran, Mohanraj; Anand Manivel, Vivek et al.

Part of Molecular Cancer Therapeutics, p. 469-479, 2026

• DOI for Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse

Yngve, Erik; Eriksson, Malin; Hedin, Anders; Ali, Arwa et al.

Part of Cancer Gene Therapy, p. 297-305, 2025

• DOI for Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
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Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas

Ma, Jing; Sarén, Tina; Jin, Chuan; Kim, Hyeong Su et al.

Part of Cancer Immunology and Immunotherapy, 2025

• DOI for Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Ali, Arwa; Contreras, Paola; Darweesh, Mahmoud; Andersson, Leif et al.

Part of Molecular Therapy Nucleic Acids, 2024

• DOI for Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
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Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment

Ali, Arwa; Gao, Menghan; Iskantar, Alexandros; Wang, Hai et al.

Part of Frontiers in Immunology, 2023

• DOI for Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
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Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model

Gao, Menghan; Kechagia, Soultana; Ramachandran, Mohanraj; Anand Manivel, Vivek et al.

Part of Molecular Cancer Therapeutics, p. 469-479, 2026

• DOI for Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse

Yngve, Erik; Eriksson, Malin; Hedin, Anders; Ali, Arwa et al.

Part of Cancer Gene Therapy, p. 297-305, 2025

• DOI for Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
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Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas

Ma, Jing; Sarén, Tina; Jin, Chuan; Kim, Hyeong Su et al.

Part of Cancer Immunology and Immunotherapy, 2025

• DOI for Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Ali, Arwa; Contreras, Paola; Darweesh, Mahmoud; Andersson, Leif et al.

Part of Molecular Therapy Nucleic Acids, 2024

• DOI for Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
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Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment

Ali, Arwa; Gao, Menghan; Iskantar, Alexandros; Wang, Hai et al.

Part of Frontiers in Immunology, 2023

• DOI for Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
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A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products

Gao, Menghan; Yngve, Erik; Yu, Di; Jin, Chuan

Part of Frontiers in Molecular Biosciences, 2022

• DOI for A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
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Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Jin, Chuan; Ali, Arwa; Iskantar, Alexandros; Fotaki, Grammatiki et al.

Part of Oncoimmunology, 2022

• DOI for Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
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ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Darweesh, Mahmoud; Younis, Shady; Hajikhezri, Zamaneh; Ali, Arwa et al.

Part of Frontiers in Immunology, 2022

• DOI for ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Part of Nature Biomedical Engineering, p. 830-841, 2022

• DOI for CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
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Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus

Ma, Jing; Jin, Chuan; Čančer, Matko; Wang, Hai et al.

Part of MOLECULAR THERAPY-ONCOLYTICS, p. 356-366, 2021

• DOI for Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
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Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Quijano-Rubio, Clara et al.

Part of Cell Death and Disease, 2020

• DOI for Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019

• DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

Part of Oncoimmunology, 2018

• DOI for Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
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Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Fotaki, Grammatiki; Jin, Chuan; Ramachandran, Mohanraj; Kerzeli, Iliana Kyriaki et al.

Part of Oncoimmunology, 2018

• DOI for Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Adenovirus, Semliki Forest virus and vaccinia virus-induced immunogenic cell death augments oncolytic virus immunotherapy

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Essand, Magnus et al.

Part of Scandinavian Journal of Immunology, p. 341-341, 2017

CAR T-Cells with Induced Secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) Yields Improved Anti-Tumor Activity and Reduced Immunosuppression

Essand, Magnus; Ma, Jing; Jin, Chuan; Ramachandran, Mohanraj et al.

Part of Molecular Therapy, p. 288-288, 2017

Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Jin, Chuan; Yu, Di; Essand, Magnus

Part of Immunotherapy, p. 1355-1361, 2016

• DOI for Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Fotaki, Grammatiki; Jin, Chuan; Karlsson-Parra, Alex; Yu, Di et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016

• DOI for Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Berith et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2016

• DOI for Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Jin, Chuan; Fotaki, Grammatiki; Ramachandran, Mohanraj; Nilsson, Berith et al.

Part of EMBO Molecular Medicine, p. 702-711, 2016

• DOI for Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
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Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan et al.

Part of Science Signaling, 2015

• DOI for Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Bo et al.

Part of Human Gene Therapy, 2014

Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Jin, Chuan; Yu, Di; Hillerdal, Victoria; Wallgren, AnnaCarin et al.

Part of Molecular Therapy Methods & Clinical Development, 2014

• DOI for Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Journal of Immunology, p. 2287-2296, 2014

• DOI for Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Adenovirus Encoded Helicobacter pylori Neutrophil Activating Protein Promotes Maturation of DCs with Th-1 Polarization, Improved Antigen Presentation and Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Part of Molecular Therapy, 2014

Allogeneic Lymphocyte-Licensed DCs Expand TCR/CAR-Engineered T Cells, Which Are Insensitive To Oxidative Stress and Immunosuppressive Factors

Jin, Chuan; Yu, Di; Karlsson-Parra, Alex; Essand, Magnus

Part of Molecular Therapy, 2014

Engineering Regulatory Cells With a T Cell Receptor for Controlled Activation

Hillerdal, Victoria; Berglund, David; Boura, Vanessa; Jin, Chuan et al.

Part of Molecular Therapy, 2014

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Part of PLOS ONE, 2013

• DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy

Jin, Chuan; Yu, Di; Čančer, Matko; Nilsson, Berith et al.

Part of Human Gene Therapy, p. 766-775, 2013

• DOI for Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy
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Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Yu, Di; Jin, Chuan; Leja, Justyna; Majdalani, Nadim et al.

Part of Journal of Virology, p. 13114-13123, 2011

• DOI for Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
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Improvement of adoptive T-cell therapy for Cancer

Jin, Chuan

2016

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Tumor antigen-loaded allogeneic dendritic cells augment therapeutic effect of adoptively transferred T-cells by altering tumor immune-microenvironment

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

CD19 CAR T-cells with induced secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) yields improved anti-tumor activity and reduced immunosuppression

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Therapeutic vaccination of HPV-associated tumors using pro-inflammatory allogeneic dendritic cells and an HPV-E6/E7-encoding vector

Fotaki, Grammatiki; Ma, Jing; Jin, Chuan; Karlsson-Parra, Alex et al.

Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma

Sarén, Tina; Ma, Jing; Jin, Chuan; Kim, Hyeongsu et al.