Mats Hellström

No association between temozolomide maintenance and survival after first-line treatment in primary CNS lymphoma

Chowdhury, Nashif; Niemi, Jenni; Babačić, Haris; Rantakylö, Hanna-Maija et al.

Part of HemaSphere, 2026

• DOI for No association between temozolomide maintenance and survival after first-line treatment in primary CNS lymphoma
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The FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework

Abel, Edvard; Ostling, Paivi; Hult, Ebba Hallersjo; Kulbacka, Katarzyna et al.

Part of Acta Oncologica, p. 268-272, 2026

• DOI for The FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework
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Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers

Åkerrén Ögren, Jim; Ekström, Joakim; Rameika, Natallia; Torell, Emma et al.

Part of Molecular Cancer, 2026

• DOI for Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers
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Neoehrlichia mikurensis infection associated with lymphoma or mimicking lymphoma in two cohorts of Swedish patients

Wenneras, Christine; Alsalihi, Rima; Karlsson, Veronica; Lewerin, Catharina et al.

Part of Leukemia and Lymphoma, p. 1327-1334, 2026

• DOI for Neoehrlichia mikurensis infection associated with lymphoma or mimicking lymphoma in two cohorts of Swedish patients
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scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025

• DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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No association between temozolomide maintenance and survival after first-line treatment in primary CNS lymphoma

Chowdhury, Nashif; Niemi, Jenni; Babačić, Haris; Rantakylö, Hanna-Maija et al.

Part of HemaSphere, 2026

• DOI for No association between temozolomide maintenance and survival after first-line treatment in primary CNS lymphoma
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The FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework

Abel, Edvard; Ostling, Paivi; Hult, Ebba Hallersjo; Kulbacka, Katarzyna et al.

Part of Acta Oncologica, p. 268-272, 2026

• DOI for The FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework
• Download full text (pdf) of The FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework

Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers

Åkerrén Ögren, Jim; Ekström, Joakim; Rameika, Natallia; Torell, Emma et al.

Part of Molecular Cancer, 2026

• DOI for Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers
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Neoehrlichia mikurensis infection associated with lymphoma or mimicking lymphoma in two cohorts of Swedish patients

Wenneras, Christine; Alsalihi, Rima; Karlsson, Veronica; Lewerin, Catharina et al.

Part of Leukemia and Lymphoma, p. 1327-1334, 2026

• DOI for Neoehrlichia mikurensis infection associated with lymphoma or mimicking lymphoma in two cohorts of Swedish patients
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scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025

• DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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Feasibility and outcome of genomics-guided treatment selection in advanced cancer: the MEGALiT explorative clinical trial

Ny, Lars; Fagman, Henrik; Botling, Johan; Mantovaara, Loviisa et al.

Part of Acta Oncologica, p. 742-750, 2025

• DOI for Feasibility and outcome of genomics-guided treatment selection in advanced cancer: the MEGALiT explorative clinical trial
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Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment

Badillo-Godinez, Oscar; Niemi, Jenni; Helfridsson, Liam; Karimi, Shokoufeh et al.

Part of Journal for ImmunoTherapy of Cancer, 2025

• DOI for Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
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Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers

Forsgren, Elin; Ekberg, Sara; Smedby, Karin E.; Nylund, Patrick et al.

Part of British Journal of Haematology, p. 1794-1803, 2024

• DOI for Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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Splenic marginal zone lymphoma in Sweden 2000–2020: Increasing rituximab use and better survival in the elderly

Junlén, Henna‐Riikka; Sonnevi, Kristina; Lindén, Ola; Hellström, Mats et al.

Part of eJHaem, p. 647-655, 2023

• DOI for Splenic marginal zone lymphoma in Sweden 2000–2020: Increasing rituximab use and better survival in the elderly
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Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babacic, Haris; Galardi, Silvia; Umer, Husen M.; Hellström, Mats et al.

Part of Molecular Oncology, p. 238-260, 2023

• DOI for Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
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Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC

Hasselblatt, Martin; Thomas, Christian; Federico, Aniello; Bens, Susanne et al.

Part of Neuropathology and Applied Neurobiology, 2022

• DOI for Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC
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Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis

Nitzsche, Anja; Pietilä, Riikka; Love, Dominic T.; Testini, Chiara et al.

Part of EMBO Reports, 2021

• DOI for Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis
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Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Simonds, Erin F.; Lu, Edbert D.; Badillo, Oscar; Karimi, Shokoufeh et al.

Part of Journal for ImmunoTherapy of Cancer, 2021

• DOI for Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma
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Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2

Testini, Chiara; Smith, Ross O.; Jin, Yi; Martinsson, Pernilla et al.

Part of EMBO Reports, 2019

• DOI for Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2
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Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018

• DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Pandzic, Tatjana; Rendo, Verónica; Lim, Jinyeong; Larsson, Chatarina et al.

Part of Oncotarget, p. 98646-98659, 2017

• DOI for Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema

Egaña, Isabel; Kaito, Hiroshi; Nitzsche, Anja; Becker, Lore et al.

Part of Scientific Reports, 2017

• DOI for Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
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Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Pandzic, Tatjana; Larsson, Jimmy; He, Liqun; Kundu, Snehangshu et al.

Part of Clinical Cancer Research, p. 6217-6227, 2016

• DOI for Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro

Heiss, Maximilian; Hellstrom, Mats; Kalen, Mattias; May, Tobias et al.

Part of The FASEB Journal, p. 3076-3084, 2015

• DOI for Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Part of Journal of Experimental Medicine, p. 833-843, 2015

• DOI for Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
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Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-kappa B Deregulation in Aggressive Chronic Lymphocytic Leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Part of Blood, 2014

Improving Pancreatic Islet Engraftment after Islet Transplantation through Administration of Gamma-Secretase Inhibitor DAPT

Hjelmqvist, Daisy; Hellström, Mats; Lau, Joey

Part of Journal of endocrinology and diabetes mellitus, p. 65-69, 2014

• DOI for Improving Pancreatic Islet Engraftment after Islet Transplantation through Administration of Gamma-Secretase Inhibitor DAPT
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Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

Wallgard, Elisabet; Nitzsche, Anja; Larsson, Jimmy; Guo, Xiaoyuan et al.

Part of Developmental Dynamics, p. 770-786, 2012

• DOI for Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Gaengel, Konstantin; Niaudet, Colin; Hagikura, Kazuhiro; Siemsen, Barbara Lavina et al.

Part of Developmental Cell, p. 587-599, 2012

• DOI for The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

Kalén, Mattias; Heikura, Tommi; Karvinen, Henna; Nitzsche, Anja et al.

Part of PLOS ONE, 2011

• DOI for Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma.

Haller, B K; Bråve, A; Wallgard, Elisabet; Roswall, P et al.

Part of Oncogene, p. 4276-86, 2010

• DOI for Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma.

Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets.

Kalén, Mattias; Wallgard, Elisabet; Asker, Noomi; Nasevicius, Aidas et al.

Part of Chemistry and Biology, p. 432-41, 2009

• DOI for Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets.

Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.

Wallgard, Elisabet; Larsson, Erik; He, Liqun; Hellström, Mats et al.

Part of Arteriosclerosis, Thrombosis and Vascular Biology, p. 1469-76, 2008

• DOI for Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.

Tammela, Tuomas; Zarkada, Georgia; Wallgard, Elisabet; Murtomäki, Aino et al.

Part of Nature, p. 656-60, 2008

• DOI for Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.

Hellström, Mats; Phng, Li-Kun; Hofmann, Jennifer J; Wallgard, Elisabet et al.

Part of Nature, p. 776-80, 2007

• DOI for Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.

Exploring dendritic cell subtypes in cancer immunotherapy: unraveling the role of mature regulatory dendritic cells

Badillo, Oscar; Helfridsson, Liam; Niemi, Jenni; Hellström, Mats

Part of Upsala Journal of Medical Sciences, 2024

• DOI for Exploring dendritic cell subtypes in cancer immunotherapy: unraveling the role of mature regulatory dendritic cells
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Notch as a hub for signaling in angiogenesis

Benedito, Rui; Hellström, Mats

Part of Experimental Cell Research, p. 1281-1288, 2013

• DOI for Notch as a hub for signaling in angiogenesis

Paladin (Pald1) regulates endothelial sprouting, VE-cadherin junction stability and vascular permeability

Nitzsche, Anja; Testini, Chiara; Ekvärn, Elisabet; Larsson, Jimmy et al.

Comprehensive blood plasma proteomics identifies VSIG4 and CD169 as prospective biomarkers for high-risk of early relapse in mantle cell lymphoma

Nylund, Patrick; Selvin, Tove; Nikkarinen, Anna; Ly, Ann-Marie et al.