Johan Lennerstrand

Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

Akaberi, Dario; Pourghasemi, Monireh; Krambrich, Janina; Berger, Julia et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1-18, 2024

• DOI for Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
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From SARS-CoV-2 to Global Preparedness: A Graphical Interface for Standardised High-Throughput Bioinformatics Analysis in Pandemic Scenarios and Surveillance of Drug Resistance

Cumlin, Tomas; Karlsson, Ida; Haars, Jonathan; Rosengren, Maria et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for From SARS-CoV-2 to Global Preparedness: A Graphical Interface for Standardised High-Throughput Bioinformatics Analysis in Pandemic Scenarios and Surveillance of Drug Resistance
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Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023

Haars, Jonathan; Palanisamy, Navaneethan; Wallin, Frans; Mölling, Paula et al.

Part of Microorganisms, 2023

• DOI for Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023
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Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Howe, Anita Y. M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W. et al.

Part of JHEP Reports, 2022

• DOI for Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
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Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022

• DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
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Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

Akaberi, Dario; Pourghasemi, Monireh; Krambrich, Janina; Berger, Julia et al.

Part of Antimicrobial Agents and Chemotherapy, p. 1-18, 2024

• DOI for Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
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From SARS-CoV-2 to Global Preparedness: A Graphical Interface for Standardised High-Throughput Bioinformatics Analysis in Pandemic Scenarios and Surveillance of Drug Resistance

Cumlin, Tomas; Karlsson, Ida; Haars, Jonathan; Rosengren, Maria et al.

Part of International Journal of Molecular Sciences, 2024

• DOI for From SARS-CoV-2 to Global Preparedness: A Graphical Interface for Standardised High-Throughput Bioinformatics Analysis in Pandemic Scenarios and Surveillance of Drug Resistance
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Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023

Haars, Jonathan; Palanisamy, Navaneethan; Wallin, Frans; Mölling, Paula et al.

Part of Microorganisms, 2023

• DOI for Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023
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Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Howe, Anita Y. M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W. et al.

Part of JHEP Reports, 2022

• DOI for Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
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Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Luttens, Andreas; Gullberg, Hjalmar; Abdurakhmanov, Eldar; Vo, Duy Duc et al.

Part of Journal of the American Chemical Society, p. 2905-2920, 2022

• DOI for Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
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SARS-CoV-2 variants of concern and spike protein mutational dynamics in a Swedish cohort during 2021, studied by Nanopore sequencing

Mannsverk, Steinar; Bergholm, Julia; Palanisamy, Navaneethan; Ellström, Patrik et al.

Part of Virology Journal, 2022

• DOI for SARS-CoV-2 variants of concern and spike protein mutational dynamics in a Swedish cohort during 2021, studied by Nanopore sequencing
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Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein

Lennerstrand, Johan; Palanisamy, Navaneethan

Part of Viruses, 2021

• DOI for Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein
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SHARED: An International Collaboration to Unravel Hepatitis C Resistance

Howe, Anita Y. M.; Ceccherini-Silberstein, Francesca; Dietz, Julia; Popping, Stephanie et al.

Part of Viruses, 2021

• DOI for SHARED: An International Collaboration to Unravel Hepatitis C Resistance
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Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Akaberi, Dario; Bahlstrom, Amanda; Chinthakindi, Praveen K.; Nyman, Tomas et al.

Part of Antiviral Research, 2021

• DOI for Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro

Akaberi, Dario; Krambrich, Janina; Ling, Jiaxin; Chen, Luni et al.

Part of Redox Biology, 2020

• DOI for Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro
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Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease

Akaberi, Dario; Chinthakindi, Praveen K.; Båhlström, Amanda; Palanisamy, Navaneethan et al.

Part of Journal of Biomolecular Structure and Dynamics, p. 5526-5536, 2020

• DOI for Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease
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Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway

Kjellin, Midori; Kileng, Hege; Akaberi, Dario; Palanisamy, Navaneethan et al.

Part of Scandinavian Journal of Gastroenterology, p. 1042-1050, 2019

• DOI for Effect of the baseline Y93H resistance-associated substitution in HCV genotype 3 for direct-acting antiviral treatment: real-life experience from a multicenter study in Sweden and Norway
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A Real World Resistance Profile of Virologic Failures Collected from an International Collaboration (SHARED)

Howe, Anita; Cento, Valeria; Knight, Nathaniel; Dietz, Julia et al.

Part of Hepatology, 2018

The effect of the first-generation HCV-protease inhibitors boceprevir and telaprevir and the relation to baseline NS3 resistance mutations in genotype 1: experience from a small Swedish cohort

Kjellin, Midori; Wesslén, Terése; Löfblad, Erik; Lennerstrand, Johan et al.

Part of Upsala Journal of Medical Sciences, p. 50-56, 2018

• DOI for The effect of the first-generation HCV-protease inhibitors boceprevir and telaprevir and the relation to baseline NS3 resistance mutations in genotype 1: experience from a small Swedish cohort
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Worldwide prevalence of baseline resistance-associated polymorphisms and resistance mutations in HCV against current direct-acting antivirals

Palanisamy, Navaneethan; Kalaghatgi, Prabhav; Akaberi, Dario; Lundkvist, Åke et al.

Part of Antiviral Therapy, p. 485-493, 2018

• DOI for Worldwide prevalence of baseline resistance-associated polymorphisms and resistance mutations in HCV against current direct-acting antivirals

Comparative genome analysis of Alkhumra hemorrhagic fever virus with Kyasanur forest disease and tick-borne encephalitis viruses by the in silico approach

Palanisamy, Navaneethan; Akaberi, Dario; Lennerstrand, Johan; Lundkvist, Åke

Part of Pathogens and Global Health, p. 210-226, 2018

• DOI for Comparative genome analysis of Alkhumra hemorrhagic fever virus with Kyasanur forest disease and tick-borne encephalitis viruses by the in silico approach

Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus

Palanisamy, Navaneethan; Akaberi, Dario; Lennerstrand, Johan

Part of Molecular Phylogenetics and Evolution, p. 58-63, 2018

• DOI for Protein backbone flexibility pattern is evolutionarily conserved in the Flaviviridae family: A case of NS3 protease in Flavivirus and Hepacivirus

Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy.

Kileng, Hege; Kjellin, Midori; Akaberi, Dario; Bergfors, Assar et al.

Part of Scandinavian Journal of Gastroenterology, p. 1347-1353, 2018

• DOI for Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy.
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Biophysical Studies on HCV 1a NS3/4A Protease and Its Catalytic Triad in Wild Type and Mutants by the In Silico Approach.

Palanisamy, Navaneethan; Lennerstrand, Johan

Part of Interdisciplinary sciences: computational life sciences, p. 143-156, 2018

• DOI for Biophysical Studies on HCV 1a NS3/4A Protease and Its Catalytic Triad in Wild Type and Mutants by the In Silico Approach.

Systematic review & expert guidance on methods for sequencing of hepatitis C virus for detection of direct-acting antiviral resistance

Bartlett, S. R.; Grebely, J.; Eltahla, A. A.; Reeves, J. D. et al.

Part of Journal of Hepatology, 2017

• DOI for Systematic review & expert guidance on methods for sequencing of hepatitis C virus for detection of direct-acting antiviral resistance

Computational prediction of Usutu virus E protein B cell and T cell epitopes for potential vaccine development.

Palanisamy, Navaneethan; Lennerstrand, Johan

Part of Scandinavian Journal of Immunology, p. 350-364, 2017

• DOI for Computational prediction of Usutu virus E protein B cell and T cell epitopes for potential vaccine development.

Hepatitis C Genotype 4R Resistance-Associated Polymorphisms: The Achilles Heel of the Nonstructural 5A Inhibitors? Reply

Miller, Veronica; Harrington, Patrick; Howe, Anita; Kieffer, Tara et al.

Part of Hepatology, p. 698-699, 2016

• DOI for Hepatitis C Genotype 4R Resistance-Associated Polymorphisms: The Achilles Heel of the Nonstructural 5A Inhibitors? Reply

Analysis of hepatitis C NS5A resistance associated polymorphisms using ultra deep single molecule real time (SMRT) sequencing

Bergfors, Assar; Leenheer, Daniel; Bergqvist, Anders; Ameur, Adam et al.

Part of Antiviral Research, p. 81-89, 2016

• DOI for Analysis of hepatitis C NS5A resistance associated polymorphisms using ultra deep single molecule real time (SMRT) sequencing

SYBR Green II Dye-Based Real-Time Assay for Measuring Inhibitor Activity Against HIV-1 Reverse Transcriptase

Kokkula, Chakradhar; Palanisamy, Navaneethan; Ericstam, Malin; Lennerstrand, Johan

Part of Molecular Biotechnology, p. 619-625, 2016

• DOI for SYBR Green II Dye-Based Real-Time Assay for Measuring Inhibitor Activity Against HIV-1 Reverse Transcriptase

Transmission of hepatitis C virus among intravenous drug users in the Uppsala region of Sweden

Danielsson, Axel; Palanisamy, Navaneethan; Golbob, Sultan; Yin, Hong et al.

Part of Infection Ecology & Epidemiology, 2014

• DOI for Transmission of hepatitis C virus among intravenous drug users in the Uppsala region of Sweden

Implications of baseline polymorphisms for potential resistance to NS3 protease and NS5A inhibitors in hepatitis C virus genotypes 1a, 2b and 3a

Lindström, I.; Palanisamy, Navaneethan; Kjellin, M.; Danielsson, Axel et al.

Part of Antiviral Therapy, 2013

Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities

Stalhandske, Per; Wang, Liya; Westberg, Sara; von Euler, Henrik et al.

Part of Analytical Biochemistry, p. 155-164, 2013

• DOI for Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities

Implications of baseline polymorphisms for potential resistance to NS3 protease inhibitors in Hepatitis C virus genotypes 1a, 2b and 3a

Palanisamy, Navaneethan; Danielsson, Axel; Kokkula, Chakradhar; Yin, Hong et al.

Part of Antiviral Research, p. 12-17, 2013

• DOI for Implications of baseline polymorphisms for potential resistance to NS3 protease inhibitors in Hepatitis C virus genotypes 1a, 2b and 3a

Detection of Resistance Mutations to Antivirals Oseltamivir and Zanamivir in Avian Influenza A Viruses Isolated from Wild Birds

Orozovic, Goran; Orozovic, Kanita; Lennerstrand, Johan; Olsen, Björn

Part of PLOS ONE, 2011

• DOI for Detection of Resistance Mutations to Antivirals Oseltamivir and Zanamivir in Avian Influenza A Viruses Isolated from Wild Birds
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Environmental Levels of the Antiviral Oseltamivir Induce Development of Resistance Mutation H274Y in Influenza A/H1N1 Virus in Mallards

Järhult, Josef D.; Muradrasoli, Shaman; Wahlgren, John; Söderström, Hanna et al.

Part of PLOS ONE, 2011

• DOI for Environmental Levels of the Antiviral Oseltamivir Induce Development of Resistance Mutation H274Y in Influenza A/H1N1 Virus in Mallards
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Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase

Schinazi, Raymond F.; Massud, Ivana; Rapp, Kimberly L.; Cristiano, Meta et al.

Part of Antimicrobial Agents and Chemotherapy, p. 2054-2060, 2011

• DOI for Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase

Nya antivirala läkemedel mot hepatit C i kliniska studier: Ger hopp om bot - men resistens-problematiken måste bemästras

Lennerstrand, Johan; Bondeson, Kåre; Bergqvist, Anders; Blomberg, Jonas et al.

Part of Läkartidningen, p. 3254-3260, 2009

Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate

Lennerstrand, Johan; Chu, Chung K.; Schinazi, Raymond F.

Part of Antimicrobial Agents and Chemotherapy, p. 2078-2084, 2007

• DOI for Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate
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Influence of naturally occurring insertions in the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and mutation frequencies in vitro

Curr, Kenneth; Tripathi, Snehlata; Lennerstrand, Johan; Larder, Brendan A. et al.

Part of Journal of General Virology, p. 419-428, 2006

• DOI for Influence of naturally occurring insertions in the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and mutation frequencies in vitro
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Use of HIV-1 reverse transcriptase recovered from human plasma for phenotypic drug susceptibility testing

Shao, Xing-Wu; Malmsten, Anders; Lennerstrand, Johan; Sönnerborg, Anders et al.

Part of AIDS, p. 1463-1471, 2003

• DOI for Use of HIV-1 reverse transcriptase recovered from human plasma for phenotypic drug susceptibility testing

Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation

Meyer, Peter R; Lennerstrand, Johan; Matsuura, Suzanne E; Larder, Brendan A et al.

Part of Journal of Virology, p. 3871-3877, 2003

• DOI for Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation

Application of a colorimetric chain-termination assay for characterization of reverse transcriptase from 3-azido-2,3-deoxythymidine-resistant HIV isolates

Shao, X-W; Hjalmarsson, Sandra; Lennerstrand, Johan; Svennerholm, B et al.

Part of Biotechnology and applied biochemistry, p. 155-164, 2002

• DOI for Application of a colorimetric chain-termination assay for characterization of reverse transcriptase from 3-azido-2,3-deoxythymidine-resistant HIV isolates

Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

Lennerstrand, Johan; Hertogs, K; Stammers, D K; Larder, B A

Part of Journal of Virology, p. 7202-7205, 2001

• DOI for Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine

Lennerstrand, Johan; Stammers, D K; Larder, B A

Part of Antimicrobial Agents and Chemotherapy, p. 2144-2146, 2001

• DOI for Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine

The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer

Linderholm, BK; Lindahl, T; Holmberg, Lars; Klaar, S et al.

Part of Cancer Research, p. 2256-2260, 2001

Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors.

Norberg, Torbjörn; Lennerstrand, Johan; Inganäs, Mats; Bergh, Jonas

Part of International Journal of Cancer, p. 376-383, 1998

• DOI for Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors.

A Method for Combined Immunoaffinity Purification and Assay of HIV-1 Reverse Transcriptase Activity Useful for Crude Samples

Lennerstrand, Johan; Rytting, A S; Örvell, C; Gronowitz, J S et al.

Part of Analytical Biochemistry, p. 141-152, 1996

• DOI for A Method for Combined Immunoaffinity Purification and Assay of HIV-1 Reverse Transcriptase Activity Useful for Crude Samples

Prognostic significance of TP53 accumulation in human primary breast cancer: comparison between a rapid quantitative immunoassay and SSCP analysis.

de Witte, H H; Foekens, J A; Lennerstrand, Johan; Smid, M et al.

Part of International Journal of Cancer, p. 125-130, 1996

• DOI for Prognostic significance of TP53 accumulation in human primary breast cancer: comparison between a rapid quantitative immunoassay and SSCP analysis.

Prognostic significance of p53 overexpression in primary breast cancer: a novel luminometric immunoassay applicable on steroid receptor cytosols.

Borg, A; Lennerstrand, Johan; Stenmark-Askmalm, M; Fernö, M et al.

Part of British Journal of Cancer, p. 1013-1017, 1995

• DOI for Prognostic significance of p53 overexpression in primary breast cancer: a novel luminometric immunoassay applicable on steroid receptor cytosols.

HIV-1 reverse transcriptase inhibiting antibody titer in serum: relation to disease progression and to core-antibody levels.

Neumüller, M; Karlsson, A; Lennerstrand, Johan; Källander, C F et al.

Part of Journal of Medical Virology, p. 283-291, 1992

• DOI for HIV-1 reverse transcriptase inhibiting antibody titer in serum: relation to disease progression and to core-antibody levels.

Carrier bound templates for single tube reverse transcriptase assays and for combined purification and activity analyses, with special reference to HIV

Gronowitz, J S; Neumüller, M; Lennerstrand, Johan; Bhikhabhai, R et al.

Part of Biotechnology and applied biochemistry, p. 127-142, 1991

• DOI for Carrier bound templates for single tube reverse transcriptase assays and for combined purification and activity analyses, with special reference to HIV

HIV reverse transcriptase inhibiting antibodies detected by a new technique: relation to p24 and gp41 antibodies, HIV antigenemia and clinical variables.

Neumüller, Magnus; Karlsson, Anders; Lennerstrand, Johan; Källander, Clas F et al.

Part of Journal of Medical Virology, p. 55-63, 1991

• DOI for HIV reverse transcriptase inhibiting antibodies detected by a new technique: relation to p24 and gp41 antibodies, HIV antigenemia and clinical variables.

Sequencing of Hepatitis C Virus for Detection of Resistance to Direct-Acting Antiviral Therapy: A Systematic Review

Bartlett, Sofia R.; Grebely, Jason; Eltahla, Auda A.; Reeves, Jacqueline D. et al.

Part of HEPATOLOGY COMMUNICATIONS, p. 379-390, 2017

• DOI for Sequencing of Hepatitis C Virus for Detection of Resistance to Direct-Acting Antiviral Therapy: A Systematic Review
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Hepatitis C virus drug resistance-associated substitutions: State of the art summary

Lontok, Erik; Harrington, Patrick; Howe, Anita; Kieffer, Tara et al.

Part of Hepatology, p. 1623-1632, 2015

• DOI for Hepatitis C virus drug resistance-associated substitutions: State of the art summary

Approaches for the development of antiviral compounds: the case of hepatitis C virus

Schinazi, Raymond F.; Coats, Steven J.; Bassit, Leda C.; Lennerstrand, Johan et al.

Part of Antiviral Strategies, p. 25-51, Springer Berlin/Heidelberg, 2009

• DOI for Approaches for the development of antiviral compounds: the case of hepatitis C virus
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Assays for reverse transcriptase activity and p53 protein: applications for characterisation of HIV RT mutants and inhibitors and for p53 expression in breast cancer

Lennerstrand, Johan

1996

Determination of Hepatitis C (HCV) Genotypes and Drug Resistances By a Efficient and Cost-effective Sequence Analysis Method: One cDNA synthesis, two assays

Yin, Hong; Lennerstrand, Johan; Bondeson, Kåre

2009

• Download full text (pdf) of Determination of Hepatitis C (HCV) Genotypes and Drug Resistances By a Efficient and Cost-effective Sequence Analysis Method: One cDNA synthesis, two assays

Oseltamivir- and Zanamivir-Resistance Related Mutations in Influenza A Viruses Isolated from Wild Mallards in Sweden Studied by a Colorimetric Neuraminidase Inhibition Assay

Orozovic, Goran; Järhult, Josef D.; Orozovic, Kanita; Tolf, Conny et al.