Göran Akusjärvi
Professor at Department of Medical Biochemistry and Microbiology; Infection and Immunity; Tanel Punga
- Mobile phone:
- +46 73 102 10 09
- E-mail:
- goran.akusjarvi@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA

Publications
Recent publications
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Part of Journal of Biological Chemistry, 2023
- DOI for The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts
- Download full text (pdf) of The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts
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Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism
Part of Journal of Virology, 2023
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ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
Part of Frontiers in Immunology, 2022
- DOI for ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
- Download full text (pdf) of ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
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Ixovex-1, a novel oncolytic E1B-mutated adenovirus
Part of Cancer Gene Therapy, p. 1628-1635, 2022
- DOI for Ixovex-1, a novel oncolytic E1B-mutated adenovirus
- Download full text (pdf) of Ixovex-1, a novel oncolytic E1B-mutated adenovirus
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The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
Part of Journal of Virology, 2021
- DOI for The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
- Download full text (pdf) of The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
All publications
Articles in journal
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Part of Journal of Biological Chemistry, 2023
- DOI for The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts
- Download full text (pdf) of The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts
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Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism
Part of Journal of Virology, 2023
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ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
Part of Frontiers in Immunology, 2022
- DOI for ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
- Download full text (pdf) of ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
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Ixovex-1, a novel oncolytic E1B-mutated adenovirus
Part of Cancer Gene Therapy, p. 1628-1635, 2022
- DOI for Ixovex-1, a novel oncolytic E1B-mutated adenovirus
- Download full text (pdf) of Ixovex-1, a novel oncolytic E1B-mutated adenovirus
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The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
Part of Journal of Virology, 2021
- DOI for The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
- Download full text (pdf) of The Human Adenovirus 2 Transcriptome: An Amazing Complexity of Alternatively Spliced mRNAs
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Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation
Part of Frontiers in Immunology, 2019
- DOI for Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation
- Download full text (pdf) of Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation
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Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth
Part of Proceedings of the National Academy of Sciences of the United States of America, 2018
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Part of PLOS ONE, 2017
- DOI for Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes
- Download full text (pdf) of Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes
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An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication
Part of RNA, p. 1700-1711, 2017
- DOI for An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication
- Download full text (pdf) of An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication
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Part of Nucleic Acids Research, p. 1731-1742, 2017
- DOI for The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding
- Download full text (pdf) of The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding
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Part of Virology, p. 44-50, 2016
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Part of PLOS ONE, 2016
- DOI for Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases
- Download full text (pdf) of Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases
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Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
Part of Journal of Visualized Experiments, 2015
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Part of Virus Research, p. 133-140, 2015
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Part of Virology, p. 25-35, 2015
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Part of Virology, p. 120-128, 2015
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Part of FEBS Letters, p. 1383-1388, 2015
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Part of PLOS ONE, 2014
- DOI for Small RNA Sequence Analysis of Adenovirus VA RNA-Derived MiRNAs Reveals an Unexpected Serotype-Specific Difference in Structure and Abundance
- Download full text (pdf) of Small RNA Sequence Analysis of Adenovirus VA RNA-Derived MiRNAs Reveals an Unexpected Serotype-Specific Difference in Structure and Abundance
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A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth
Part of Virology, p. 363-371, 2013
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Part of Nucleic Acids Research, p. 4802-4812, 2013
- DOI for The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells
- Download full text (pdf) of The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells
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Part of PLOS ONE, 2012
- DOI for Two Cellular Protein Kinases, DNA-PK and PKA, Phosphorylate the Adenoviral L4-33K Protein and Have Opposite Effects on L1 Alternative RNA Splicing
- Download full text (pdf) of Two Cellular Protein Kinases, DNA-PK and PKA, Phosphorylate the Adenoviral L4-33K Protein and Have Opposite Effects on L1 Alternative RNA Splicing
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Part of Virology, p. 273-281, 2012
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Using the whole-genome sequence to characterize and name human adenoviruses
Part of Journal of Virology, p. 5701-5702, 2011
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Part of Genes & cancer, p. 841-851, 2011
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Single molecule analysis of combinatorial splicing
Part of Nucleic Acids Research, 2010
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Part of Virus Research, p. 220-228, 2010
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Part of Cancer Research, p. 7431-7441, 2010
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Adenovirus E4orf4 induces HPV-16 late L1 mRNA production
Part of Virology, p. 279-290, 2009
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Part of Nucleic Acids Research, p. 6950-6959, 2009
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Part of Biochemical and Biophysical Research Communications - BBRC, p. 517-521, 2008
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Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
Part of Cell Metabolism, p. 26-37, 2008
- DOI for Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
- Download full text (pdf) of Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
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Temporal regulation of adenovirus major late alternative RNA splicing
Part of Frontiers in Bioscience, p. 5006-5015, 2008
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Part of Journal of Virology, p. 10540-10549, 2007
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Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing
Part of Experimental Cell Research, p. 2795-2809, 2007
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Part of Journal of Virology, p. 5010-5020, 2006
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L4-33K, an adenovirus-encoded alternative RNA splicing factor
Part of Journal of Biological Chemistry, p. 36510-36517, 2006
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Part of Virus research, p. 16-23, 2006
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Part of Virus Res, p. 16-23, 2006
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Suppression of RNA interference by adenovirus virus-associated RNA
Part of Journal of Virology, p. 9556-65, 2005
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Part of Endocrinology, p. 2406-2414, 2005
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Part of J Biol Chem, p. 25478-84, 2005
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Part of Journal of General Virology, p. 185-196, 2004
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Part of Biochem J, p. 343-50, 2004
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Remodelling of the host cell RNA splicing machinery during an adenovirusinfection
Part of Current Topics in Microbiology and Immunology, p. 253-286, 2003
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Part of FEBS Letters, p. 214-218, 2003
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Part of FEBS Letters, p. 214-218, 2003
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Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression
Part of Molecular Medicine, p. 733-741, 2002
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Part of Journal of Biological Chemistry, p. 12579-12586, 2002
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Part of Virus Research, p. 197-206, 2002
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Functional inactivation of the SR family of splicing factors during a vaccinia virus infection
Part of EMBO Reports, p. 1088-1093, 2002
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Part of The Journal of Biological Chemistry, p. 12579-12586, 2002
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Part of EMBO Journal, p. 864-871, 2001
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Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner
Part of Molecular and Cellular Biology, p. 3684-3691, 2001
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Adenovirus vector designed for expression of toxic proteins
Part of Journal of Virology, p. 9579-9584, 2001
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The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex
Part of FEBS Letters, p. 248-252, 2000
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Part of Apoptosis (London), p. 355-367, 2000
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Part of Cell growth & differentiation, p. 373-384, 2000
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Functional coexpression of serine protein kinase SRPK1 and its substrateASF/SF2 in Escherichia coli
Part of Nucleic Acids Research, 2000
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Part of Journal of Virology, p. 9002-9009, 2000
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A novel type of splicing enhancer regulating adenovirus pre-mRNA splicing
Part of Molecular and Cellular Biology, p. 2317-2325, 2000
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The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex.
Part of FEBS Letters, p. 248-252, 2000
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A downstream splicing enhancer is essential for in vitro pre-mRNA splicing
Part of FEBS Letters, p. 10-14, 1999
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Part of EMBO Journal, p. 1014-1024, 1999
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Part of Virology, p. 313-321, 1999
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Part of EMBO Journal, p. 1014-1024, 1999
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Part of Journal of Virology, p. 8358-8361, 1998
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Regulation of adenovirus alternative RNAsplicing by dephosphorylation of SR proteins
Part of Nature, p. 185-187, 1998
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AR1 is an integral part of the adenovirus-2 E1A CR3 transactivation domain
Part of Journal of Virology, p. 5978-5983, 1998
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Part of Journal of Virology, p. 8358-8861, 1998
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Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins
Part of Nature, p. 185-187, 1998
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Part of FEBS Letters, p. 111-116, 1997
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Inhibition by SRproteins of splicing of a regulated adenovirus pre-mRNA
Part of Nature, p. 535-538, 1996
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Part of Journal of Virology, p. 3844-6851, 1996
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Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies
Part of Journal of Cell Biology, p. 45-56, 1995
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Enhanced splicing of nonconsensus 3' splice sites late during adenovirus infection
Part of Journal of Virology, p. 7324-7327, 1995
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Part of Nucleic Acids Symposium Series, p. 220-223, 1995
Articles, review/survey
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Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs
Part of Viruses, 2020
- DOI for Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs
- Download full text (pdf) of Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs
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Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
Part of Viruses, 2020
- DOI for Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
- Download full text (pdf) of Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
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Regulation of Human Adenovirus Alternative RNA Splicing by the Adenoviral L4-33K and L4-22K Proteins
Part of International Journal of Molecular Sciences, p. 2893-2912, 2015
- DOI for Regulation of Human Adenovirus Alternative RNA Splicing by the Adenoviral L4-33K and L4-22K Proteins
- Download full text (pdf) of Regulation of Human Adenovirus Alternative RNA Splicing by the Adenoviral L4-33K and L4-22K Proteins
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Old and new functions for the adenovirus virus-associated RNAs
Part of Future Virology, p. 343-356, 2013
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Characterization of RISC-associated adenoviral small RNAs
Part of Methods in molecular biology (Clifton, N.J.), p. 183-198, 2011
Chapters in book
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Regulation of adenovirus alternative RNA splicing by PKA, DNA-PK, PP2A and SR proteins
Part of Virology II: Advanced Issues, iConcept Press, 2014
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In vitro methods to study RNA interference during an adenovirus infection
Part of Adenovirus Methods and Protocols: Volume 2: Ad Proteins, RNA Lifecycle, Host Interactions, and Phylogenetics, p. 47-61, Humana Press Inc, Totowa, NJ, 2007
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Part of Encyclopedia of Life Sciences, p. 1-8, John Wiley, 2007
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Preparation of soluble extracts from adenovirus-infected cells for studies of RNA-splicing
Part of Adenovirus Methods and Protocols, p. 33-46, Springer, 2007
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Preparation of Soluble Extracts From Adenovirus-Infected Cells for Studies of RNA Spicing
Part of Adenovirus Methods and Protocols, p. 33-46, Humana Press Inc, Totowa, NJ, 2007
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Part of Encyclopedia of Life Sciences, Nature Publishing, 2002
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Part of The Encyclopedia of Physical Science and Technology, p. 501-517, Academic Press, San Diego, 2000
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Remodelling of the host cell RNA splicing machinery during an adenovirus infection
Part of Recent research developments in Virology, p. 621, Transworld Research Network, 1999
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Preparation of splicing competent nuclear extracts from adenovirus infected cells
Part of Adenovirus Methods and Protocols, p. 203-216, Humana Press Inc, 1998
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Part of Clinical Virology, ChurchillLivingstone Inc, 1997
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Gene expression, regulation of
Part of Encyclopedia of molecular biology and Molecular Medicine, p. 364-375, VCHPublishers, New York., 1996
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Gene expression, regulation of
Part of The Encyclopedia of Molecular Biology and Biotechnology, p. 346, VCH Publishers, New York., 1995
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Regulation of adenovirus alternative RNA splicing by PKA, DNA-PK, PP2A and SR proteins