Helena Jernberg Wiklund

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Kalushkova, Antonia; Jernberg Wiklund, Helena

Part of Frontiers in Oncology, 2023

• DOI for The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Part of Cancer Research, p. 4586-4603, 2022

• DOI for Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

Kalushkova, Antonia; Nylund, Patrick; Atienza Párraga, Alba; Lennartsson, Andreas et al.

Part of EPIGENOMES, 2021

• DOI for One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Part of Haematologica, p. 567-577, 2024

• DOI for PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Part of Cancer Research, p. 4586-4603, 2022

• DOI for Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

Kalushkova, Antonia; Nylund, Patrick; Atienza Párraga, Alba; Lennartsson, Andreas et al.

Part of EPIGENOMES, 2021

• DOI for One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Part of Cell Death and Disease, 2021

• DOI for A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Jernberg Wiklund, Helena et al.

Part of Cancer Gene Therapy, p. 948-959, 2020

• DOI for Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40
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GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Weishaupt, Holger; Mainwaring, Oliver; Hutter, Sonja; Kalushkova, Antonia et al.

Part of Neuro-Oncology, p. 137-137, 2018

• DOI for GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Part of Oncotarget, p. 103731-103743, 2017

• DOI for The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Part of Oncotarget, p. 10213-10224, 2017

• DOI for EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
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SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation

Lin, Yingbo; Liu, Hongyu; Waraky, Ahmed; Haglund, Felix et al.

Part of Journal of Cellular Physiology, p. 2722-2730, 2017

• DOI for SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation
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Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Part of Oncotarget, p. 6809-6923, 2016

• DOI for Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

Agarwal, Prasoon; Enroth, Stefan; Teichmann, Martin; Jernberg Wiklund, Helena et al.

Part of Cell Cycle, p. 1558-1571, 2016

• DOI for Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs
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A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment

Zaghlool, Ammar; Halvardson, Jonatan; Zhao, Jin J.; Etemadikhah, Mitra et al.

Part of Human Mutation, p. 964-975, 2016

• DOI for A Role for the Chromatin-Remodeling Factor BAZ1A in Neurodevelopment
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CGGBP1 mitigates cytosine methylation at repetitive DNA sequences

Agarwal, Prasoon; Collier, Paul; Fritz, Markus Hsi-Yang; Benes, Vladimir et al.

Part of BMC Genomics, 2015

• DOI for CGGBP1 mitigates cytosine methylation at repetitive DNA sequences
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Increased resistance to proteaome inhibitors in multiple myeloma mediated by cIAP2: implications for a combinatorial treatment

Fristedt Duvefelt, Charlotte; Lub, Susanne; Prasoon, Agarwal; Arngården, Linda et al.

Part of Oncotarget, p. 20621-20635, 2015

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Part of Journal of Experimental Medicine, p. 833-843, 2015

• DOI for Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
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The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic

Bieghs, Liesbeth; Lub, Susanne; Fostier, Karel; Maes, Ken et al.

Part of Oncotarget, p. 11193-11208, 2014

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Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-kappa B Deregulation in Aggressive Chronic Lymphocytic Leukemia

Mansouri, Larry; Sutton, Lesley-Ann; Ljungström, Viktor; Bondza, Sina et al.

Part of Blood, 2014

Taming the cancer cell: Introduction

Jernberg Wiklund, Helena; Westermark, Bengt

Part of Journal of Internal Medicine, p. 2-4, 2014

• DOI for Taming the cancer cell: Introduction

An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Part of Blood, 2014

Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Karlsson, S. C. Hannah; Lindqvist, A. C.; Fransson, Moa; Paul-Wetterberg, Gabriella et al.

Part of Cancer Gene Therapy, p. 386-393, 2013

• DOI for Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Part of BMC Cancer, p. 318, 2012

• DOI for Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Mantle cell lymphoma displays a homogenous methylation profile: A comparative analysis with chronic lymphocytic leukemia

Halldorsdottir, Anna Margret; Kanduri, Meena; Marincevic, Millaray; Mansouri, Larry et al.

Part of American Journal of Hematology, p. 361-367, 2012

• DOI for Mantle cell lymphoma displays a homogenous methylation profile: A comparative analysis with chronic lymphocytic leukemia

Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model

Kharaziha, Pedram; De Raeve, Hendrik; Fristedt, Charlotte; Li, Qiao et al.

Part of Cancer Research, p. 5348-5362, 2012

• DOI for Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model

The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Lemaire, Miguel; Fristedt, Charlotte; Agarwal, Prasoon; Menu, Eline et al.

Part of Clinical Cancer Research, p. 2230-2239, 2012

• DOI for The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model

Van Valckenborgh, E.; Matsui, W.; Agarwal, Prasoon; Lub, S. et al.

Part of Leukemia, p. 1436-1439, 2012

• DOI for Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model

Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9

Deng, Hua; Lin, Yingbo; Badin, Margherita; Vasilcanu, Daiana et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 667-671, 2011

• DOI for Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9

Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Hashemi, Jamileh; Worrall, Claire; Vasilcanu, Daiana; Fryknäs, Mårten et al.

Part of PLOS ONE, 2011

• DOI for Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Part of PLOS ONE, 2010

• DOI for Polycomb target genes are silenced in multiple myeloma
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IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms

De Bruyne, Elke; Bos, Tomas J.; Schuit, Frans; Van Valckenborgh, Els et al.

Part of Blood, p. 2430-2440, 2010

• DOI for IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Part of Experimental Hematology, p. 1673-1681, 2008

• DOI for Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Menu, Eline; Jernberg-Wiklund, Helena; De Raeve, Hendrik; De Leenheer, Evy et al.

Part of International Journal of Cancer, p. 1857-1861, 2007

• DOI for Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies

Kokhaei, Parviz; Abdalla, Amir Osman; Hansson, Lotta; Mikaelsson, Eva et al.

Part of Clinical Cancer Research, p. 3536-3544, 2007

• DOI for Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies

The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia.

Skogsberg, S; Tobin, G; Kröber, A; Kienle, D et al.

Part of Leukemia, p. 77-81, 2006

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

Strömberg, Thomas; Ekman, Simon; Girnita, Leonard; Dimberg, Lina Y et al.

Part of Blood, p. 669-78, 2006

Interferon-induced sensitization to apoptosis is associated with repressed transcriptional activity of the hTERT promoter in multiple myeloma.

Lindkvist, Anna; Ivarsson, Karolina; Jernberg-Wiklund, Helena; Paulsson-Karlsson, Ylva

Part of Biochem Biophys Res Commun, p. 1141-8, 2006

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

Menu, Eline; Jernberg-Wiklund, Helena; Stromberg, Thomas; De Raeve, Hendrik et al.

Part of Blood, p. 655-60, 2006

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Part of Blood, 2005

• DOI for Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

Strömberg, Thomas; Dimberg, Anna; Hammarberg, Anna; Carlson, Kristina et al.

Part of Blood, p. 3138-47, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Part of Anticancer Drugs, p. 63-70, 2004

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

Spets, Helena; Strömberg, Thomas; Georgii-Hemming, Patrik; Siljason, Jan et al.

Part of Eur J Haematol, p. 76-89, 2002

The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-dent and IL-6-independent human multiple myeloma cell lines.

Georgii-Hemming, P; Stromberg, T; Tiensuu Janson, E; Stridsberg, M et al.

Part of Blood, p. 1724, 1999

Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gammanterleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines.

Spets, H; Georgii-Hemming, P; Siljason, J; Nilsson, K et al.

Part of Blood, p. 2914, 1998

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Soderberg, O et al.

Part of Br J Haematol, p. 126, 1997

Insulin-like growth factor I is a growth- and survival factor in human multiple myeloma cell lines.

Georgii-Hemming, P; Jernberg-Wiklund, H; Ljunggren, Ö; Nilsson, K

Part of Blood, p. 2250, 1996

Cellular death in neuroblastoma: in situ correlation of apoptosis and Bcl-2 expression

Hoehner, Jeff; Hedborg, Fredrik; Jernberg Wiklund, Helena; Olsen, Leif et al.

Part of Int J Cancer, p. 19, 1995

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus.

Welsh, N; Margulis, B; Borg, L A H; Jernberg Wiklund, H et al.

Part of Mol Medicine, p. 806, 1995

A novel human B cell line (U-2904) bearing t(8;14) and t(14;18) translocations.

Sambade, C; Sallstrom, J; Wiklund, H Jernberg; Enblad, G et al.

Part of Int J Cancer, p. 710, 1995

Dormant SOX9-positive cells behind MYC-driven medulloblastoma recurrence

Bolin, Sara; Borgenvik, Anna; Savov, Vasil; Holmberg Olausson, Karl et al.

The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Kalushkova, Antonia; Jernberg Wiklund, Helena

Part of Frontiers in Oncology, 2023

• DOI for The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma
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Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity

Alzrigat, Mohammad; Jernberg Wiklund, Helena; Licht, Jonathan D.

Part of EPIGENOMES, 2018

• DOI for Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity
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Epigenetics in multiple myeloma: From mechanisms to therapy

Alzrigat, Mohammad; Párraga, Alba Atienza; Jernberg-Wiklund, Helena

Part of Seminars in Cancer Biology, p. 101-115, 2018

• DOI for Epigenetics in multiple myeloma: From mechanisms to therapy

Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Part of Advances in Cancer Research, p. 139-165, 2007

• DOI for Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Plasma Cell and Myeloma Cell Lines

Jernberg Wiklund, Helena; Nilsson, Kenneth

Part of Human Cell Culture, Kluwer Academic Publishers, 2000

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

Toward a rational combinaTORial therapy for multiple myeloma

Jernberg Wiklund, Helena; Nilsson, Kenneth

Part of Blood, p. 3845-3846, 2004

The control of proliferation, survival and apoptosis in human multiple myeloma cells in vitro

Nilsson, K; Georgii-Hemming, P; Spets, H; Jernberg-Wiklund, H

Part of MECHANISMS OF B CELL NEOPLASIA 1998, p. 325-333, 1999